Motif ID: RREB1.p2

Z-value: 2.424


Transcription factors associated with RREB1.p2:

Gene SymbolEntrez IDGene Name
RREB1 6239 ras responsive element binding protein 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RREB1chr6_+_71077990.365.1e-02Click!


Activity profile for motif RREB1.p2.

activity profile for motif RREB1.p2


Sorted Z-values histogram for motif RREB1.p2

Sorted Z-values for motif RREB1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RREB1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_152486073 7.412 NM_004988
 MAGEA1
melanoma antigen family A, 1 (directs expression of antigen MZ2-E)
chr10_-_135150474 6.816 NM_015722
 CALY
calcyon neuron-specific vesicular protein
chrX_+_151903218 6.523 NM_001102576
NM_153478
 CSAG1

chondrosarcoma associated gene 1

chr10_-_135150368 5.139 CALY
calcyon neuron-specific vesicular protein
chr19_-_55658310 4.696 TNNT1
troponin T type 1 (skeletal, slow)
chr7_-_752083 4.341 PRKAR1B
protein kinase, cAMP-dependent, regulatory, type I, beta
chr6_-_30654406 4.179 PPP1R18
protein phosphatase 1, regulatory subunit 18
chr11_-_125366048 3.770 NM_005103
NM_022549
 FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr3_-_48632592 3.747 NM_000094
 COL7A1
collagen, type VII, alpha 1
chr21_-_47604360 3.671 NM_001142854
NM_032261
 C21orf56

chromosome 21 open reading frame 56

chr21_-_47604340 3.604 C21orf56
chromosome 21 open reading frame 56
chr21_-_47604300 3.562 C21orf56
chromosome 21 open reading frame 56
chr19_-_51456159 3.448 NM_001077491
NM_001077492
NM_012427
 KLK5


kallikrein-related peptidase 5


chr2_-_216300770 3.383 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
 FN1





fibronectin 1





chr3_-_106959476 3.321


chr22_-_43583132 3.309 NM_015140
 TTLL12
tubulin tyrosine ligase-like family, member 12
chr8_+_86376130 3.052 NM_000067
 CA2
carbonic anhydrase II
chr22_-_43583058 2.867 TTLL12
tubulin tyrosine ligase-like family, member 12
chr5_-_136834887 2.753 NM_004598
 SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chrX_-_153881757 2.701 NM_020994
NM_172377
 CTAG2

cancer/testis antigen 2


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 145 entries
enrichment   p-value GO term description
2.08 7.07e-07 GO:0030900 forebrain development
2.08 3.45e-03 GO:0043410 positive regulation of MAPKKK cascade
2.04 4.87e-04 GO:0010769 regulation of cell morphogenesis involved in differentiation
2.02 6.61e-04 GO:0022604 regulation of cell morphogenesis
1.87 5.38e-03 GO:0034330 cell junction organization
1.84 4.45e-04 GO:0043408 regulation of MAPKKK cascade
1.82 9.86e-13 GO:0019226 transmission of nerve impulse
1.82 9.86e-13 GO:0035637 multicellular organismal signaling
1.81 1.10e-10 GO:0007268 synaptic transmission
1.80 1.75e-07 GO:0007411 axon guidance
1.77 5.92e-05 GO:0045596 negative regulation of cell differentiation
1.76 4.77e-03 GO:0007517 muscle organ development
1.74 5.21e-07 GO:0007420 brain development
1.74 4.90e-06 GO:0051093 negative regulation of developmental process
1.73 3.92e-08 GO:0007409 axonogenesis
1.72 2.92e-08 GO:0048812 neuron projection morphogenesis
1.72 3.23e-08 GO:0048667 cell morphogenesis involved in neuron differentiation
1.71 2.37e-04 GO:0061061 muscle structure development
1.70 1.37e-13 GO:0030182 neuron differentiation
1.70 7.23e-09 GO:0031175 neuron projection development

Gene overrepresentation in compartment category:

Showing 1 to 20 of 23 entries
enrichment   p-value GO term description
2.49 3.55e-02 GO:0005581 collagen
2.24 2.88e-02 GO:0005901 caveola
1.84 8.83e-04 GO:0005912 adherens junction
1.75 2.80e-03 GO:0070161 anchoring junction
1.50 2.26e-02 GO:0015629 actin cytoskeleton
1.49 3.17e-03 GO:0009986 cell surface
1.48 2.31e-03 GO:0043005 neuron projection
1.46 4.21e-02 GO:0044433 cytoplasmic vesicle part
1.42 2.10e-02 GO:0045202 synapse
1.42 4.42e-02 GO:0031012 extracellular matrix
1.40 1.07e-03 GO:0030054 cell junction
1.38 6.24e-05 GO:0005626 insoluble fraction
1.38 1.03e-04 GO:0005624 membrane fraction
1.36 1.44e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
1.34 3.42e-03 GO:0031988 membrane-bounded vesicle
1.32 7.51e-03 GO:0031410 cytoplasmic vesicle
1.31 2.54e-04 GO:0000267 cell fraction
1.31 1.35e-02 GO:0031982 vesicle
1.24 5.87e-06 GO:0044459 plasma membrane part
1.20 1.85e-03 GO:0005829 cytosol

Gene overrepresentation in function category:

Showing 1 to 20 of 21 entries
enrichment   p-value GO term description
4.42 2.24e-02 GO:0005283 sodium:amino acid symporter activity
2.38 2.59e-02 GO:0001948 glycoprotein binding
1.75 2.23e-02 GO:0022843 voltage-gated cation channel activity
1.59 3.47e-10 GO:0043565 sequence-specific DNA binding
1.58 6.28e-04 GO:0003779 actin binding
1.58 1.09e-02 GO:0005096 GTPase activator activity
1.53 5.53e-03 GO:0016563 transcription activator activity
1.47 2.21e-09 GO:0001071 nucleic acid binding transcription factor activity
1.47 2.21e-09 GO:0003700 sequence-specific DNA binding transcription factor activity
1.46 3.52e-03 GO:0042803 protein homodimerization activity
1.46 3.96e-03 GO:0019904 protein domain specific binding
1.46 1.32e-02 GO:0008047 enzyme activator activity
1.41 6.61e-05 GO:0042802 identical protein binding
1.40 7.07e-03 GO:0008092 cytoskeletal protein binding
1.40 3.03e-02 GO:0030695 GTPase regulator activity
1.39 2.11e-06 GO:0030528 transcription regulator activity
1.35 1.40e-02 GO:0046983 protein dimerization activity
1.33 1.23e-02 GO:0019899 enzyme binding
1.28 2.70e-02 GO:0030234 enzyme regulator activity
1.18 1.71e-18 GO:0005515 protein binding