Motif ID: RUNX1..3.p2

Z-value: 1.109


Transcription factors associated with RUNX1..3.p2:

Gene SymbolEntrez IDGene Name
RUNX1 861 runt-related transcription factor 1
RUNX2 860 runt-related transcription factor 2
RUNX3 864 runt-related transcription factor 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RUNX3chr1_-_252914740.495.6e-03Click!
RUNX2chr6_+_45389818-0.402.8e-02Click!
RUNX1chr21_-_36260086-0.173.6e-01Click!


Activity profile for motif RUNX1..3.p2.

activity profile for motif RUNX1..3.p2


Sorted Z-values histogram for motif RUNX1..3.p2

Sorted Z-values for motif RUNX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RUNX1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_29641068 2.421 EVI2B
ecotropic viral integration site 2B
chr2_-_216300770 1.933 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
 FN1





fibronectin 1





chr20_-_23967431 1.874 NM_178312
 GGTLC1
gamma-glutamyltransferase light chain 1
chr3_+_100328432 1.841 NM_032787
 GPR128
G protein-coupled receptor 128
chr7_+_37723378 1.528


chr8_+_39771327 1.432 NM_002164
 IDO1
indoleamine 2,3-dioxygenase 1
chr22_+_22988781 1.326 NM_199127
 GGTLC2
gamma-glutamyltransferase light chain 2
chr3_-_150920946 1.320 NM_013308
 GPR171
G protein-coupled receptor 171
chr17_+_56232493 1.280 NM_012374
 OR4D1
olfactory receptor, family 4, subfamily D, member 1
chr3_-_71179736 1.073 FOXP1
forkhead box P1
chr19_+_56989482 1.060 LOC100128252
uncharacterized LOC100128252
chr17_+_9745847 1.016 GLP2R
glucagon-like peptide 2 receptor
chr12_+_15125955 0.994 NM_006205
 PDE6H
phosphodiesterase 6H, cGMP-specific, cone, gamma
chr17_-_29641094 0.972 NM_006495
 EVI2B
ecotropic viral integration site 2B
chr2_-_216300444 0.953 FN1
fibronectin 1
chr19_-_41356193 0.953 NM_000762
 CYP2A6
cytochrome P450, family 2, subfamily A, polypeptide 6
chr13_+_113741668 0.923 MCF2L
MCF.2 cell line derived transforming sequence-like
chr2_-_216241321 0.898 FN1
fibronectin 1
chr14_+_24540742 0.884 NM_006032
 CPNE6
copine VI (neuronal)
chr15_-_93631751 0.860 NM_001166287
 RGMA
RGM domain family, member A

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 58 entries
enrichment   p-value GO term description
3.92 1.62e-02 GO:0048145 regulation of fibroblast proliferation
3.69 4.37e-03 GO:0002761 regulation of myeloid leukocyte differentiation
3.11 1.08e-02 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
3.02 1.69e-02 GO:0002250 adaptive immune response
2.31 4.04e-05 GO:0048534 hemopoietic or lymphoid organ development
2.24 1.16e-02 GO:0046649 lymphocyte activation
2.18 2.06e-04 GO:0002520 immune system development
2.18 2.92e-03 GO:0030097 hemopoiesis
2.17 1.06e-02 GO:0051249 regulation of lymphocyte activation
2.16 8.68e-03 GO:0002253 activation of immune response
2.08 9.53e-03 GO:0050865 regulation of cell activation
2.07 2.02e-02 GO:0002694 regulation of leukocyte activation
1.99 1.23e-02 GO:0050778 positive regulation of immune response
1.97 1.48e-05 GO:0001775 cell activation
1.94 3.65e-16 GO:0002376 immune system process
1.94 7.82e-09 GO:0006955 immune response
1.90 7.75e-05 GO:0008284 positive regulation of cell proliferation
1.89 9.57e-04 GO:0002684 positive regulation of immune system process
1.89 1.87e-02 GO:0051240 positive regulation of multicellular organismal process
1.88 8.55e-07 GO:0002682 regulation of immune system process

Gene overrepresentation in compartment category:

Showing 1 to 14 of 14 entries
enrichment   p-value GO term description
2.58 2.94e-04 GO:0009897 external side of plasma membrane
1.87 3.84e-09 GO:0005615 extracellular space
1.79 4.44e-03 GO:0009986 cell surface
1.71 2.96e-08 GO:0044421 extracellular region part
1.63 4.46e-08 GO:0031226 intrinsic to plasma membrane
1.61 2.11e-07 GO:0005887 integral to plasma membrane
1.52 8.23e-10 GO:0005576 extracellular region
1.41 1.22e-06 GO:0044459 plasma membrane part
1.21 1.77e-03 GO:0005886 plasma membrane
1.20 3.33e-03 GO:0071944 cell periphery
1.18 1.27e-03 GO:0031224 intrinsic to membrane
1.18 1.70e-03 GO:0016021 integral to membrane
1.15 2.62e-03 GO:0044425 membrane part
1.13 5.76e-03 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
9.57 1.80e-02 GO:0003840 gamma-glutamyltransferase activity
4.31 3.82e-04 GO:0003823 antigen binding
2.36 4.38e-04 GO:0005126 cytokine receptor binding
2.31 4.02e-04 GO:0005125 cytokine activity
1.53 4.73e-04 GO:0005102 receptor binding
1.35 7.75e-03 GO:0004872 receptor activity
1.29 2.13e-02 GO:0004871 signal transducer activity
1.29 2.13e-02 GO:0060089 molecular transducer activity