Motif ID: RXRG_dimer.p3

Z-value: 0.612


Transcription factors associated with RXRG_dimer.p3:

Gene SymbolEntrez IDGene Name
NR1H2 7376 nuclear receptor subfamily 1, group H, member 2
PPARA 5465 peroxisome proliferator-activated receptor alpha
PPARG 5468 peroxisome proliferator-activated receptor gamma
RXRA 6256 retinoid X receptor, alpha
RXRB 6257 retinoid X receptor, beta
RXRG 6258 retinoid X receptor, gamma

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RXRAchr9_+_137218324-0.631.8e-04Click!
PPARGchr3_+_12329332,
chr3_+_12392993
-0.532.3e-03Click!
NR1H2chr19_+_508796810.393.1e-02Click!
RXRBchr6_-_331683690.384.0e-02Click!
PPARAchr22_+_46546498-0.261.6e-01Click!
RXRGchr1_-_1654144990.067.6e-01Click!


Activity profile for motif RXRG_dimer.p3.

activity profile for motif RXRG_dimer.p3


Sorted Z-values histogram for motif RXRG_dimer.p3

Sorted Z-values for motif RXRG_dimer.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of RXRG_dimer.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_74764394 2.935 GDA
guanine deaminase
chr9_+_74764382 2.910 GDA
guanine deaminase
chr9_+_74764266 2.803 NM_001242505
NM_001242506
NM_004293
GDA


guanine deaminase


chr19_+_50016490 1.140 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr19_+_50016500 1.120 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr1_+_61547625 1.002 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr2_+_28113598 0.990 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr2_-_28113211 0.954 NM_022128
RBKS
ribokinase
chr4_+_30722191 0.912 PCDH7
protocadherin 7
chr14_-_21572374 0.893


chr3_-_48936227 0.838 NM_000387
SLC25A20
solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
chr2_-_27603249 0.774 NM_001201459
ZNF513
zinc finger protein 513
chr20_-_20033005 0.719 CRNKL1
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
chr19_+_50016435 0.705 NM_004107
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr3_-_49314281 0.695 NM_198562
C3orf62
chromosome 3 open reading frame 62
chr4_+_30721865 0.682 NM_032456
NM_001173523
NM_002589
NM_032457
PCDH7



protocadherin 7



chr2_-_207024103 0.674 NM_001199981
NM_001199982
NM_001199983
NM_005006
NDUFS1



NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)



chr2_-_27603584 0.636 NM_144631
ZNF513
zinc finger protein 513
chr5_-_42811959 0.596 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr2_+_109065665 0.570 GCC2
GRIP and coiled-coil domain containing 2
chr1_-_217250230 0.538 NM_001243507
NM_001243509
ESRRG

estrogen-related receptor gamma

chr15_+_82555101 0.538 NM_001008226
FAM154B
family with sequence similarity 154, member B
chr2_+_109065576 0.533 NM_181453
GCC2
GRIP and coiled-coil domain containing 2
chr6_+_143999058 0.520 NM_001100164
NM_001100165
PHACTR2

phosphatase and actin regulator 2

chr7_-_65447187 0.519 GUSB
glucuronidase, beta
chr19_+_50016606 0.512 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr20_+_20033157 0.503 NM_015585
C20orf26
chromosome 20 open reading frame 26
chr11_-_123756339 0.492 NM_001013743
TMEM225
transmembrane protein 225
chr5_+_172484353 0.479 C5orf41
chromosome 5 open reading frame 41
chr17_+_26800657 0.472 NM_001145975
NM_001145976
NM_003984
SLC13A2


solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2


chr2_-_219432955 0.454 NM_020935
USP37
ubiquitin specific peptidase 37
chr16_+_30710461 0.450 NM_006662
SRCAP
Snf2-related CREBBP activator protein
chr7_-_72936538 0.445 BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr19_+_2328628 0.442 NM_001077238
NM_152988
SPPL2B

signal peptide peptidase-like 2B

chr2_-_178257380 0.442 LOC100130691
uncharacterized LOC100130691
chr9_-_139137646 0.433 NM_181701
QSOX2
quiescin Q6 sulfhydryl oxidase 2
chr2_+_28113655 0.408 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr13_+_100741268 0.403 NM_000282
NM_001127692
NM_001178004
PCCA


propionyl CoA carboxylase, alpha polypeptide


chr8_-_80942488 0.401 NM_014018
MRPS28
mitochondrial ribosomal protein S28
chr12_-_54121203 0.391 NM_001143682
NM_020898
CALCOCO1

calcium binding and coiled-coil domain 1

chr2_+_28113612 0.379 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr6_-_146285225 0.377 NM_001042683
NM_173082
SHPRH

SNF2 histone linker PHD RING helicase

chr22_-_44893179 0.373 LDOC1L
leucine zipper, down-regulated in cancer 1-like
chr18_-_51750460 0.368 MBD2
methyl-CpG binding domain protein 2
chr5_+_42548314 0.365 NM_001242403
GHR
growth hormone receptor
chr18_+_54318561 0.361 NM_015285
NM_052834
WDR7

WD repeat domain 7

chr16_-_4401265 0.349 NM_016069
PAM16
presequence translocase-associated motor 16 homolog (S. cerevisiae)
chr19_+_10197023 0.347 C19orf66
chromosome 19 open reading frame 66
chr22_+_30163351 0.346 NM_001003684
NM_013387
UQCR10

ubiquinol-cytochrome c reductase, complex III subunit X

chr7_-_139763520 0.335 NM_022750
PARP12
poly (ADP-ribose) polymerase family, member 12
chr19_+_10196972 0.333 C19orf66
chromosome 19 open reading frame 66
chr1_+_101491401 0.332


chr2_+_28113481 0.327 NM_199193
NM_199194
NM_004899
NM_199191
NM_199192
BRE




brain and reproductive organ-expressed (TNFRSF1A modulator)




chr10_+_104005307 0.310 GBF1
golgi brefeldin A resistant guanine nucleotide exchange factor 1
chrX_-_122866881 0.303 THOC2
THO complex 2
chr22_+_41865112 0.299 NM_001098
ACO2
aconitase 2, mitochondrial
chr10_+_102732285 0.295 NM_001203244
NM_017893
SEMA4G

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G

chr1_-_6761839 0.292 DNAJC11
DnaJ (Hsp40) homolog, subfamily C, member 11
chr1_-_6761878 0.290 DNAJC11
DnaJ (Hsp40) homolog, subfamily C, member 11
chr12_-_51420097 0.283 NM_000617
NM_001174126
NM_001174127
NM_001174128
SLC11A2



solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2



chr19_+_2328679 0.277 SPPL2B
signal peptide peptidase-like 2B
chr19_+_6372805 0.269 ALKBH7
alkB, alkylation repair homolog 7 (E. coli)
chr22_-_41864656 0.269 NM_032758
PHF5A
PHD finger protein 5A
chr2_+_219433302 0.264 RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr19_+_54606141 0.263 NM_004542
NDUFA3
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
chr12_+_67663147 0.253 CAND1
cullin-associated and neddylation-dissociated 1
chr7_+_129015483 0.246 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr17_+_7812703 0.243 CHD3
chromodomain helicase DNA binding protein 3
chr1_+_45097669 0.242 RNF220
ring finger protein 220
chrX_-_108868250 0.242 NM_012282
KCNE1L
KCNE1-like
chr16_+_4714709 0.240 MGRN1
mahogunin, ring finger 1
chr11_+_118868861 0.233 CCDC84
coiled-coil domain containing 84
chr19_+_6372720 0.231 ALKBH7
alkB, alkylation repair homolog 7 (E. coli)
chr7_-_65447206 0.224 GUSB
glucuronidase, beta
chr2_-_159312955 0.221 NM_001171637
NM_138803
CCDC148

coiled-coil domain containing 148

chr12_+_12223872 0.220 NM_138723
BCL2L14
BCL2-like 14 (apoptosis facilitator)
chr7_-_25164902 0.215 NM_018947
CYCS
cytochrome c, somatic
chr17_-_2614926 0.214 NM_015229
KIAA0664
KIAA0664
chr2_+_198364720 0.214 NM_001202485
NM_002157
HSPE1-MOB4
HSPE1
HSPE1-MOB4 readthrough
heat shock 10kDa protein 1 (chaperonin 10)
chr17_-_36105005 0.210 NM_000458
NM_001165923
HNF1B

HNF1 homeobox B

chr1_+_43855549 0.209 NM_015284
SZT2
seizure threshold 2 homolog (mouse)
chr19_+_44100734 0.203 NM_001145347
ZNF576
zinc finger protein 576
chr19_+_10362912 0.199 MRPL4
mitochondrial ribosomal protein L4
chr7_-_65447233 0.198 NM_000181
GUSB
glucuronidase, beta
chr11_+_118868841 0.198 NM_198489
CCDC84
coiled-coil domain containing 84
chr7_-_65447162 0.195 GUSB
glucuronidase, beta
chr3_-_14166292 0.194 CHCHD4
coiled-coil-helix-coiled-coil-helix domain containing 4
chrX_-_153191686 0.191 ARHGAP4
Rho GTPase activating protein 4
chr1_-_55089068 0.190 NM_176782
FAM151A
family with sequence similarity 151, member A
chr6_-_39693110 0.187 NM_145027
KIF6
kinesin family member 6
chr1_-_6761897 0.186 NM_018198
DNAJC11
DnaJ (Hsp40) homolog, subfamily C, member 11
chr12_+_67663060 0.185 NM_018448
CAND1
cullin-associated and neddylation-dissociated 1
chr17_+_40440481 0.185 STAT5A
signal transducer and activator of transcription 5A
chr19_+_10362886 0.185 MRPL4
mitochondrial ribosomal protein L4
chr1_-_173886401 0.185 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr3_-_194392938 0.182 LSG1
large subunit GTPase 1 homolog (S. cerevisiae)
chr2_+_198365113 0.182 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr11_+_118230348 0.181 UBE4A
ubiquitination factor E4A
chr9_+_91933384 0.180 NM_024077
SECISBP2
SECIS binding protein 2
chr3_-_194392913 0.180 LSG1
large subunit GTPase 1 homolog (S. cerevisiae)
chr10_+_114133838 0.180 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr21_+_45432202 0.178 NM_003274
TRAPPC10
trafficking protein particle complex 10
chr12_-_51422012 0.178 NM_001174125
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr12_-_95467104 0.177 NM_001032287
NM_001127362
NM_003297
NR2C1


nuclear receptor subfamily 2, group C, member 1


chr16_-_30596808 0.176 NM_152458
ZNF785
zinc finger protein 785
chr3_+_31574119 0.172 STT3B
STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)
chr2_-_176046120 0.172 NM_001002258
NM_001190329
NM_001689
ATP5G3


ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)


chr15_+_43885251 0.169 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr19_-_45579687 0.169 NM_145288
ZNF296
zinc finger protein 296
chr4_-_4543690 0.168 STX18
syntaxin 18
chr6_+_33172418 0.167 NM_014234
HSD17B8
hydroxysteroid (17-beta) dehydrogenase 8
chr3_+_139654001 0.167 NM_022131
CLSTN2
calsyntenin 2
chr19_+_45394522 0.166 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr17_-_7123368 0.164 NM_001365
DLG4
discs, large homolog 4 (Drosophila)
chr9_+_74764354 0.164 GDA
guanine deaminase
chr3_-_52312257 0.164 WDR82
WD repeat domain 82
chr2_+_198365012 0.163 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr17_-_8198124 0.162 NM_201520
SLC25A35
solute carrier family 25, member 35
chr2_-_19558371 0.161 NM_145260
OSR1
odd-skipped related 1 (Drosophila)
chr3_-_14166246 0.160 CHCHD4
coiled-coil-helix-coiled-coil-helix domain containing 4
chr11_-_45939361 0.159 PEX16
peroxisomal biogenesis factor 16
chr7_-_107204705 0.156 NM_001161520
NM_006348
NM_181733
COG5


component of oligomeric golgi complex 5


chr7_-_72936592 0.155 NM_032408
BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr2_-_73460326 0.154 NM_032319
PRADC1
protease-associated domain containing 1
chr19_+_1205773 0.153 NM_000455
STK11
serine/threonine kinase 11
chrX_-_153191710 0.151 NM_001164741
NM_001666
ARHGAP4

Rho GTPase activating protein 4

chr15_-_100273620 0.147 NM_152449
LYSMD4
LysM, putative peptidoglycan-binding, domain containing 4
chr9_-_140513049 0.145 C9orf37
chromosome 9 open reading frame 37
chr14_-_95623665 0.144 NM_177438
DICER1
dicer 1, ribonuclease type III
chr4_+_140587086 0.143 MGST2
microsomal glutathione S-transferase 2
chr6_-_108395854 0.141 OSTM1
osteopetrosis associated transmembrane protein 1
chr10_+_104005254 0.133 NM_001199378
NM_001199379
NM_004193
GBF1


golgi brefeldin A resistant guanine nucleotide exchange factor 1


chr18_+_29598444 0.127 NM_017831
RNF125
ring finger protein 125
chr1_+_44679111 0.126 NM_001034023
NM_001034024
NM_019100
DMAP1


DNA methyltransferase 1 associated protein 1


chr5_-_74807448 0.126 NM_005713
NM_031361
COL4A3BP

collagen, type IV, alpha 3 (Goodpasture antigen) binding protein

chr12_-_7125727 0.124 NM_005768
LPCAT3
lysophosphatidylcholine acyltransferase 3
chr1_-_111970354 0.123 NM_002557
OVGP1
oviductal glycoprotein 1, 120kDa
chr15_-_100273540 0.123 LYSMD4
LysM, putative peptidoglycan-binding, domain containing 4
chr10_-_52645384 0.122 A1CF
APOBEC1 complementation factor
chr16_+_4475804 0.122 NM_001135110
NM_005147
DNAJA3

DnaJ (Hsp40) homolog, subfamily A, member 3

chr20_+_30945988 0.121 NM_001164603
NM_015338
ASXL1

additional sex combs like 1 (Drosophila)

chr3_-_14166370 0.120 NM_001098502
NM_144636
CHCHD4

coiled-coil-helix-coiled-coil-helix domain containing 4

chr7_-_25164869 0.119 CYCS
cytochrome c, somatic
chr18_+_47340328 0.118


chr3_-_14166228 0.116 CHCHD4
coiled-coil-helix-coiled-coil-helix domain containing 4
chr20_-_36661822 0.115 NM_014657
TTI1
TELO2 interacting protein 1
chrX_-_122866888 0.114 NM_001081550
THOC2
THO complex 2
chr19_+_45394642 0.113 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr17_+_73996986 0.113 NM_001258
CDK3
cyclin-dependent kinase 3
chr20_-_44485953 0.110 NM_005469
ACOT8
acyl-CoA thioesterase 8
chr9_+_104296120 0.109 NM_019592
RNF20
ring finger protein 20
chr7_-_100844192 0.109 NM_178176
MOGAT3
monoacylglycerol O-acyltransferase 3
chr2_+_219646448 0.108 NM_000784
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr1_-_95538443 0.107 NM_144988
ALG14
asparagine-linked glycosylation 14 homolog (S. cerevisiae)
chr12_-_51419923 0.107 NM_001174129
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr8_+_96037186 0.107 NM_152416
C8orf38
chromosome 8 open reading frame 38
chr10_+_695887 0.104 C10orf108
chromosome 10 open reading frame 108
chr20_+_42187705 0.103 SGK2
serum/glucocorticoid regulated kinase 2
chr16_-_3493489 0.102 NM_152457
ZNF597
zinc finger protein 597
chr4_+_4543718 0.101 LOC100507266
uncharacterized LOC100507266
chr1_+_160313061 0.100 NM_015331
NCSTN
nicastrin
chr22_-_51021200 0.100 CHKB
choline kinase beta
chr11_-_116708334 0.100 NM_000039
APOA1
apolipoprotein A-I
chr6_-_108395923 0.099 OSTM1
osteopetrosis associated transmembrane protein 1
chr7_+_99933734 0.097 PILRB
paired immunoglobin-like type 2 receptor beta
chr22_-_31742329 0.096 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr20_+_37590969 0.096 NM_001190809
NM_021931
DHX35

DEAH (Asp-Glu-Ala-His) box polypeptide 35

chr3_-_194392881 0.095 LSG1
large subunit GTPase 1 homolog (S. cerevisiae)
chr15_+_96873845 0.095 NM_021005
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr19_-_55580896 0.092 NM_138412
RDH13
retinol dehydrogenase 13 (all-trans/9-cis)
chr19_+_2328685 0.086 SPPL2B
signal peptide peptidase-like 2B
chr3_-_14988939 0.085 LOC100505641
uncharacterized LOC100505641
chr20_+_43160435 0.084 NM_007066
NM_181804
NM_181805
PKIG


protein kinase (cAMP-dependent, catalytic) inhibitor gamma


chr15_+_57210852 0.082 TCF12
transcription factor 12
chr19_+_6372443 0.082 NM_032306
ALKBH7
alkB, alkylation repair homolog 7 (E. coli)
chr17_+_7123246 0.081 ACADVL
acyl-CoA dehydrogenase, very long chain
chr5_+_1801493 0.081 NM_004553
NDUFS6
NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
chrX_-_153191644 0.081 ARHGAP4
Rho GTPase activating protein 4
chr15_-_102192337 0.081 NM_025141
NM_078474
TM2D3

TM2 domain containing 3

chr19_-_18335302 0.080 NM_001098819
PDE4C
phosphodiesterase 4C, cAMP-specific
chr2_+_159313407 0.080 PKP4
plakophilin 4
chr7_+_193112 0.079 FAM20C
family with sequence similarity 20, member C
chr7_+_120628722 0.077 NM_024913
C7orf58
chromosome 7 open reading frame 58
chr5_-_74807421 0.075 COL4A3BP
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
chr17_-_8198605 0.075 SLC25A35
solute carrier family 25, member 35
chr22_-_51021255 0.074 CHKB
choline kinase beta
chr14_-_106174914 0.073 IGHA1
immunoglobulin heavy constant alpha 1
chr6_-_33771756 0.073 NM_001040109
NM_001184698
NM_002418
MLN


motilin


chr9_-_27005649 0.072 NM_022901
LRRC19
leucine rich repeat containing 19
chr12_+_50135953 0.072 TMBIM6
transmembrane BAX inhibitor motif containing 6
chr1_-_6052410 0.070 NPHP4
nephronophthisis 4
chr19_+_17420216 0.070 NM_024050
DDA1
DET1 and DDB1 associated 1
chr1_-_101491308 0.070 NM_001077394
NM_001077395
NM_015958
DPH5


DPH5 homolog (S. cerevisiae)


chr3_-_150264264 0.065 SERP1
stress-associated endoplasmic reticulum protein 1
chr9_+_109686436 0.063 ZNF462
zinc finger protein 462
chr6_-_108395918 0.063 OSTM1
osteopetrosis associated transmembrane protein 1
chr2_-_198364997 0.063 NM_199440
HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr3_-_194393205 0.062 NM_018385
LSG1
large subunit GTPase 1 homolog (S. cerevisiae)
chr19_+_39390567 0.062 NM_002503
NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr13_+_21714709 0.061 SAP18
Sin3A-associated protein, 18kDa

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.74 4.26e-02 GO:0032787 monocarboxylic acid metabolic process
3.96 4.78e-02 GO:0015980 energy derivation by oxidation of organic compounds
36.19 4.82e-02 GO:0006101 citrate metabolic process
36.19 4.82e-02 GO:0072350 tricarboxylic acid metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
5.11 2.61e-06 GO:0005743 mitochondrial inner membrane
4.03 9.67e-06 GO:0005740 mitochondrial envelope
4.68 9.85e-06 GO:0019866 organelle inner membrane
3.32 2.17e-05 GO:0044429 mitochondrial part
3.82 1.00e-04 GO:0031966 mitochondrial membrane
2.91 6.82e-04 GO:0031967 organelle envelope
2.86 9.14e-04 GO:0031975 envelope
2.25 1.44e-03 GO:0005739 mitochondrion
1.31 1.56e-03 GO:0043231 intracellular membrane-bounded organelle
1.31 1.67e-03 GO:0043227 membrane-bounded organelle
1.24 1.47e-02 GO:0043229 intracellular organelle
1.24 1.64e-02 GO:0043226 organelle
3.72 3.12e-02 GO:0005759 mitochondrial matrix

Nothing significant found in function category.