Motif ID: SOX17.p2

Z-value: 1.437


Transcription factors associated with SOX17.p2:

Gene SymbolEntrez IDGene Name
SOX17 64321 SRY (sex determining region Y)-box 17

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX17chr8_+_553704940.658.8e-05Click!


Activity profile for motif SOX17.p2.

activity profile for motif SOX17.p2


Sorted Z-values histogram for motif SOX17.p2

Sorted Z-values for motif SOX17.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX17.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_8113862 6.970 NM_004217
AURKB
aurora kinase B
chr1_+_151032866 6.699 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr5_+_68462948 6.514 CCNB1
cyclin B1
chr1_+_151032880 6.261 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr20_+_37554954 5.762 NM_030919
FAM83D
family with sequence similarity 83, member D
chr10_+_102106958 5.701 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr2_+_27008881 5.270 NM_001809
NM_001042426
CENPA

centromere protein A

chr3_-_52567708 5.248 NM_001134231
NT5DC2
5'-nucleotidase domain containing 2
chr20_+_37555055 5.198 FAM83D
family with sequence similarity 83, member D
chr10_+_102106771 5.137 NM_005063
SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr3_-_52567809 5.136 NT5DC2
5'-nucleotidase domain containing 2
chr11_-_66725790 5.080 NM_000920
NM_001040716
PC

pyruvate carboxylase

chr1_+_151032683 5.046 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_-_26232890 4.950 NM_001145454
NM_005563
STMN1

stathmin 1

chr10_+_102107074 4.902 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr1_-_26232643 4.897 NM_203401
STMN1
stathmin 1
chr5_+_68462985 4.870 CCNB1
cyclin B1
chr7_-_27135524 4.755 NM_005522
NM_153620
HOXA1

homeobox A1

chr7_+_27135672 4.730 HOTAIRM1
HOXA transcript antisense RNA, myeloid-specific 1 (non-protein coding)
chr2_+_27008912 4.691 CENPA
centromere protein A
chr14_+_24641204 4.534 NM_001048205
NM_005132
REC8

REC8 homolog (yeast)

chr1_-_26233367 4.518 NM_203399
STMN1
stathmin 1
chr1_+_43824598 4.383 NM_001255
CDC20
cell division cycle 20 homolog (S. cerevisiae)
chr17_+_57232859 4.373 NM_018304
PRR11
proline rich 11
chr7_+_134464417 4.208 CALD1
caldesmon 1
chr8_+_86376130 4.044 NM_000067
CA2
carbonic anhydrase II
chr2_+_70142303 3.963 MXD1
MAX dimerization protein 1
chr14_+_24641084 3.943 REC8
REC8 homolog (yeast)
chr6_+_80714389 3.929 TTK
TTK protein kinase
chr10_+_102107001 3.822 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr4_-_122744782 3.760 CCNA2
cyclin A2
chr12_-_6960406 3.699 NM_031299
CDCA3
cell division cycle associated 3
chr2_+_75061234 3.614 HK2
hexokinase 2
chr2_+_70142236 3.605 MXD1
MAX dimerization protein 1
chr5_+_68462836 3.593 NM_031966
CCNB1
cyclin B1
chr3_-_185826748 3.581 NM_004454
ETV5
ets variant 5
chr12_-_25055228 3.518 NM_001178094
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr4_-_122744978 3.480 NM_001237
CCNA2
cyclin A2
chr6_-_30655078 3.322 NM_001134870
PPP1R18
protein phosphatase 1, regulatory subunit 18
chr6_-_30654978 3.273 PPP1R18
protein phosphatase 1, regulatory subunit 18
chr7_+_134464161 3.261 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr22_+_31477231 3.223 NM_006932
NM_134269
NM_134270
SMTN


smoothelin


chr10_+_102107256 3.125


chr1_-_154946830 3.098 SHC1
SHC (Src homology 2 domain containing) transforming protein 1
chr4_-_80993713 3.087 ANTXR2
anthrax toxin receptor 2
chr4_+_156680125 3.075 NM_000857
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr12_-_6961044 3.010 CDCA3
cell division cycle associated 3
chr11_-_61584228 3.000 FADS1
fatty acid desaturase 1
chr6_+_74405764 2.944 CD109
CD109 molecule
chr7_+_134464372 2.917 CALD1
caldesmon 1
chr17_-_48262900 2.906 COL1A1
collagen, type I, alpha 1
chr6_+_74405505 2.848 NM_001159587
NM_001159588
NM_133493
CD109


CD109 molecule


chr22_+_38142245 2.811 TRIOBP
TRIO and F-actin binding protein
chr17_-_8055684 2.797 NM_002616
PER1
period homolog 1 (Drosophila)
chr9_-_99180661 2.764 NM_153695
ZNF367
zinc finger protein 367
chr12_-_89746238 2.744 DUSP6
dual specificity phosphatase 6
chr2_+_10262694 2.708 NM_001165931
RRM2
ribonucleotide reductase M2
chr6_+_74405933 2.669 CD109
CD109 molecule
chr4_+_75310852 2.640 NM_001657
AREG
amphiregulin
chr14_+_85996454 2.602 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr1_+_6052758 2.525 KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr1_-_154946859 2.485 NM_001130041
NM_001202859
NM_003029
SHC1


SHC (Src homology 2 domain containing) transforming protein 1


chr1_-_153521717 2.475 NM_002960
S100A3
S100 calcium binding protein A3
chr16_+_11439279 2.469 NM_152308
RMI2
RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae)
chr1_-_154946801 2.447 SHC1
SHC (Src homology 2 domain containing) transforming protein 1
chr2_+_10262853 2.442 NM_001034
RRM2
ribonucleotide reductase M2
chr11_-_2162340 2.438 NM_001127598
IGF2
insulin-like growth factor 2 (somatomedin A)
chr16_-_67217403 2.408 KIAA0895L
KIAA0895-like
chr20_+_44441334 2.406 UBE2C
ubiquitin-conjugating enzyme E2C
chr20_+_44441247 2.406 NM_007019
NM_181799
NM_181800
NM_181802
NM_181803
UBE2C




ubiquitin-conjugating enzyme E2C




chr16_+_2479387 2.404 NM_001761
CCNF
cyclin F
chr17_+_38444130 2.403 CDC6
cell division cycle 6 homolog (S. cerevisiae)
chr6_+_80714321 2.395 NM_001166691
NM_003318
TTK

TTK protein kinase

chr16_-_84651639 2.374 NM_021149
COTL1
coactosin-like 1 (Dictyostelium)
chr15_+_59397276 2.369 NM_004701
CCNB2
cyclin B2
chr16_+_11439311 2.367 RMI2
RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae)
chr15_+_39873276 2.362 NM_003246
THBS1
thrombospondin 1
chr6_-_53213699 2.335 ELOVL5
ELOVL fatty acid elongase 5
chr16_+_2479417 2.321 CCNF
cyclin F
chr1_+_151032150 2.293 NM_006818
MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr3_-_149086884 2.290 TM4SF1
transmembrane 4 L six family member 1
chr6_+_74405909 2.288 CD109
CD109 molecule
chr2_+_70142152 2.269 NM_001202513
NM_001202514
NM_002357
MXD1


MAX dimerization protein 1


chr1_-_93342706 2.256 NM_001252271
FAM69A
family with sequence similarity 69, member A
chr16_-_75529278 2.246


chr17_-_38210611 2.239 MED24
mediator complex subunit 24
chr6_+_20402040 2.155 NM_001949
E2F3
E2F transcription factor 3
chr2_-_208031570 2.143 KLF7
Kruppel-like factor 7 (ubiquitous)
chr1_-_197115566 2.122 NM_001206846
NM_018136
ASPM

asp (abnormal spindle) homolog, microcephaly associated (Drosophila)

chrX_+_136648313 2.119 NM_003413
ZIC3
Zic family member 3
chr17_+_65373362 2.111 PITPNC1
phosphatidylinositol transfer protein, cytoplasmic 1
chr2_-_234763145 2.111 HJURP
Holliday junction recognition protein
chr2_-_234763182 2.101 NM_018410
HJURP
Holliday junction recognition protein
chr12_-_89746244 2.074 NM_001946
NM_022652
DUSP6

dual specificity phosphatase 6

chr2_-_220094354 2.037 NM_001077198
NM_024085
ATG9A

ATG9 autophagy related 9 homolog A (S. cerevisiae)

chr3_+_51422691 2.034 NM_006010
MANF
mesencephalic astrocyte-derived neurotrophic factor
chr22_+_38142230 2.032 NM_007032
NM_138632
TRIOBP

TRIO and F-actin binding protein

chr8_-_9009050 2.030 NM_001201329
PPP1R3B
protein phosphatase 1, regulatory subunit 3B
chr11_-_28129646 2.027 KIF18A
kinesin family member 18A
chr1_+_45205466 2.023 NM_006845
KIF2C
kinesin family member 2C
chr2_-_9771101 2.015 NM_006826
YWHAQ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
chr3_+_51422716 2.008 MANF
mesencephalic astrocyte-derived neurotrophic factor
chr17_+_38444134 2.000 NM_001254
CDC6
cell division cycle 6 homolog (S. cerevisiae)
chr16_-_88729487 1.987 NM_002461
MVD
mevalonate (diphospho) decarboxylase
chr2_-_9770999 1.977 YWHAQ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
chr14_+_20937537 1.958 NM_000270
PNP
purine nucleoside phosphorylase
chr12_-_8815479 1.949 MFAP5
microfibrillar associated protein 5
chr15_-_64673569 1.928 NM_001029989
NM_014736
KIAA0101

KIAA0101

chr16_+_69139466 1.926 NM_001199280
HAS3
hyaluronan synthase 3
chr17_+_38444151 1.916 CDC6
cell division cycle 6 homolog (S. cerevisiae)
chr11_-_28129701 1.914 NM_031217
KIF18A
kinesin family member 18A
chr1_+_116654375 1.910 NM_152367
MAB21L3
mab-21-like 3 (C. elegans)
chr6_-_35696359 1.908 NM_001145775
FKBP5
FK506 binding protein 5
chr11_-_2152960 1.907 IGF2
insulin-like growth factor 2 (somatomedin A)
chr16_+_30194925 1.885 CORO1A
coronin, actin binding protein, 1A
chr2_+_239756672 1.882 NM_057179
TWIST2
twist homolog 2 (Drosophila)
chr8_+_26435339 1.875 NM_001386
DPYSL2
dihydropyrimidinase-like 2
chr10_+_17271276 1.868 VIM
vimentin
chrX_+_152954965 1.867 NM_001142806
SLC6A8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr16_-_84651519 1.865 COTL1
coactosin-like 1 (Dictyostelium)
chr11_-_28129687 1.863 KIF18A
kinesin family member 18A
chrX_+_82763268 1.849 NM_000307
POU3F4
POU class 3 homeobox 4
chr19_-_14228560 1.812 PRKACA
protein kinase, cAMP-dependent, catalytic, alpha
chr4_-_80994309 1.809 NM_001145794
NM_058172
ANTXR2

anthrax toxin receptor 2

chr17_-_57232524 1.806 SKA2
spindle and kinetochore associated complex subunit 2
chr4_-_80994183 1.795


chr10_+_17271277 1.790 VIM
vimentin
chr12_+_110011499 1.789 NM_000431
NM_001114185
MVK

mevalonate kinase

chr10_+_17271302 1.788 VIM
vimentin
chr20_+_44441671 1.779 NM_181801
UBE2C
ubiquitin-conjugating enzyme E2C
chr8_+_26435920 1.774 NM_001244604
DPYSL2
dihydropyrimidinase-like 2
chr12_-_89745997 1.769 DUSP6
dual specificity phosphatase 6
chr5_-_176836535 1.767 NM_000505
F12
coagulation factor XII (Hageman factor)
chr4_-_103266577 1.764 NM_001135146
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr19_+_1450208 1.732 APC2
adenomatosis polyposis coli 2
chr1_+_209602164 1.713 NM_001104548
MIR205HG
MIR205 host gene (non-protein coding)
chr15_+_90118740 1.712 NM_152259
C15orf42
chromosome 15 open reading frame 42
chr18_+_21718930 1.712 NM_012189
NM_138643
NM_153768
NM_153769
NM_153770
CABYR




calcium binding tyrosine-(Y)-phosphorylation regulated




chr2_+_102314162 1.698 NM_001242560
NM_004834
NM_145686
NM_001242559
NM_145687
MAP4K4




mitogen-activated protein kinase kinase kinase kinase 4




chr9_+_137218324 1.692 RXRA
retinoid X receptor, alpha
chr7_-_50861114 1.676 NM_001001555
GRB10
growth factor receptor-bound protein 10
chr17_-_57232799 1.674 NM_001100595
NM_182620
SKA2

spindle and kinetochore associated complex subunit 2

chr8_+_126010748 1.672 SQLE
squalene epoxidase
chr7_-_50860665 1.663 GRB10
growth factor receptor-bound protein 10
chr1_-_221915458 1.663 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr16_+_838634 1.660 CHTF18
CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
chr1_+_45205533 1.658 KIF2C
kinesin family member 2C
chr20_-_56285576 1.646 NM_199169
NM_199170
PMEPA1

prostate transmembrane protein, androgen induced 1

chr17_+_16945766 1.643 NM_015134
NM_201274
MPRIP

myosin phosphatase Rho interacting protein

chr1_-_221915393 1.642 DUSP10
dual specificity phosphatase 10
chr6_+_74405856 1.635 CD109
CD109 molecule
chr1_-_243418675 1.628 NM_001042404
NM_001042405
NM_014812
CEP170


centrosomal protein 170kDa


chr12_-_8815266 1.626 MFAP5
microfibrillar associated protein 5
chr11_-_61584451 1.622 NM_013402
FADS1
fatty acid desaturase 1
chr8_+_126010719 1.606 NM_003129
SQLE
squalene epoxidase
chr16_+_30194730 1.600 NM_001193333
NM_007074
CORO1A

coronin, actin binding protein, 1A

chr1_-_221915426 1.597 DUSP10
dual specificity phosphatase 10
chr11_+_13690246 1.591 FAR1
fatty acyl CoA reductase 1
chr7_+_100797685 1.587 NM_001283
AP1S1
adaptor-related protein complex 1, sigma 1 subunit
chr6_-_27114577 1.581 NM_080593
HIST1H2BK
histone cluster 1, H2bk
chr16_+_838610 1.581 NM_022092
CHTF18
CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
chr11_+_62186506 1.556 NM_003357
SCGB1A1
secretoglobin, family 1A, member 1 (uteroglobin)
chr7_-_83824216 1.552 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chrX_-_15872905 1.540


chr21_-_16437125 1.536 NM_003489
NRIP1
nuclear receptor interacting protein 1
chrX_-_15872921 1.535 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr6_+_114178516 1.528 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr2_-_26205437 1.526 NM_002254
KIF3C
kinesin family member 3C
chr10_+_17271956 1.517 VIM
vimentin
chr17_-_38574042 1.509 NM_001067
TOP2A
topoisomerase (DNA) II alpha 170kDa
chr3_+_189349215 1.493 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chr6_+_24775640 1.490 NM_001251991
GMNN
geminin, DNA replication inhibitor
chr4_-_74864296 1.489 NM_002994
CXCL5
chemokine (C-X-C motif) ligand 5
chr6_-_53213747 1.481 NM_001242828
NM_001242830
NM_001242831
NM_021814
ELOVL5



ELOVL fatty acid elongase 5



chr15_-_34610928 1.478 NM_005135
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr4_+_166248816 1.475 NM_001017369
NM_006745
MSMO1

methylsterol monooxygenase 1

chr5_+_54398473 1.475 NM_006144
GZMA
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
chr7_-_41742666 1.463 NM_002192
INHBA
inhibin, beta A
chr20_-_52790511 1.460 NM_000782
NM_001128915
CYP24A1

cytochrome P450, family 24, subfamily A, polypeptide 1

chr13_+_52586516 1.452 NM_001004127
ALG11
asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast)
chr1_-_6545521 1.435 PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr7_+_77167351 1.432 NM_001131008
NM_001131009
PTPN12

protein tyrosine phosphatase, non-receptor type 12

chr10_+_17271859 1.430 VIM
vimentin
chr16_+_838645 1.430 CHTF18
CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
chr3_-_139258531 1.429 NM_001130992
NM_001130993
NM_002899
RBP1


retinol binding protein 1, cellular


chr14_-_94423766 1.425 NM_016150
ASB2
ankyrin repeat and SOCS box containing 2
chr16_-_67217825 1.417 NM_001040715
KIAA0895L
KIAA0895-like
chr2_-_61765345 1.407 XPO1
exportin 1 (CRM1 homolog, yeast)
chrX_+_151999565 1.407 NSDHL
NAD(P) dependent steroid dehydrogenase-like
chr1_+_45205558 1.406 KIF2C
kinesin family member 2C
chr9_+_80911990 1.405 NM_021154
NM_058179
PSAT1

phosphoserine aminotransferase 1

chr6_+_160182988 1.381 NM_005891
ACAT2
acetyl-CoA acetyltransferase 2
chr3_-_87040246 1.381 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr15_+_41625152 1.366 NUSAP1
nucleolar and spindle associated protein 1
chr12_+_110011616 1.360 MVK
mevalonate kinase
chr1_-_236030170 1.358


chr19_+_17420352 1.354 DDA1
DET1 and DDB1 associated 1
chr1_+_109419601 1.347 NM_013296
GPSM2
G-protein signaling modulator 2
chr20_+_3776905 1.334 CDC25B
cell division cycle 25 homolog B (S. pombe)
chr17_+_33914320 1.325 AP2B1
adaptor-related protein complex 2, beta 1 subunit

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.31 7.28e-08 GO:0007275 multicellular organismal development
1.29 9.17e-08 GO:0032502 developmental process
1.30 9.52e-07 GO:0048856 anatomical structure development
1.32 1.49e-06 GO:0048731 system development
1.38 5.91e-06 GO:0030154 cell differentiation
1.36 2.00e-05 GO:0048869 cellular developmental process
1.43 2.83e-05 GO:0007399 nervous system development
1.09 5.06e-05 GO:0009987 cellular process
1.17 3.10e-03 GO:0032501 multicellular organismal process
1.13 3.76e-03 GO:0050789 regulation of biological process
1.22 5.55e-03 GO:0016043 cellular component organization
1.30 8.42e-03 GO:0048513 organ development
1.45 9.57e-03 GO:0048468 cell development
1.52 1.20e-02 GO:0030182 neuron differentiation
1.47 1.33e-02 GO:0051128 regulation of cellular component organization
1.13 1.35e-02 GO:0050794 regulation of cellular process
2.50 1.40e-02 GO:0006334 nucleosome assembly
1.44 1.54e-02 GO:0022008 neurogenesis
1.49 1.91e-02 GO:0071844 cellular component assembly at cellular level
1.20 1.98e-02 GO:0071840 cellular component organization or biogenesis
1.11 2.28e-02 GO:0065007 biological regulation
1.40 2.39e-02 GO:0022607 cellular component assembly
1.24 2.65e-02 GO:0071842 cellular component organization at cellular level
2.33 2.90e-02 GO:0065004 protein-DNA complex assembly
2.28 3.24e-02 GO:0071824 protein-DNA complex subunit organization
2.34 3.83e-02 GO:0034728 nucleosome organization
1.64 4.05e-02 GO:0007409 axonogenesis
2.37 4.13e-02 GO:0031497 chromatin assembly
1.62 4.33e-02 GO:0048667 cell morphogenesis involved in neuron differentiation
1.32 4.62e-02 GO:0009653 anatomical structure morphogenesis
1.43 4.67e-02 GO:0048699 generation of neurons

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.98 1.09e-03 GO:0000786 nucleosome
2.33 1.23e-02 GO:0032993 protein-DNA complex
1.67 3.94e-02 GO:0015629 actin cytoskeleton

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.14 9.76e-05 GO:0005515 protein binding
1.54 1.23e-02 GO:0008092 cytoskeletal protein binding