Motif ID: SP1.p2

Z-value: 1.856


Transcription factors associated with SP1.p2:

Gene SymbolEntrez IDGene Name
SP1 6667 Sp1 transcription factor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SP1chr12_+_537744220.242.1e-01Click!


Activity profile for motif SP1.p2.

activity profile for motif SP1.p2


Sorted Z-values histogram for motif SP1.p2

Sorted Z-values for motif SP1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SP1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_51487070 11.779 NM_139277
NM_001207053
NM_001243126
NM_005046
 KLK7



kallikrein-related peptidase 7



chr6_-_4135701 8.856 NM_001166010
NM_006117
NM_206836
 ECI2


enoyl-CoA delta isomerase 2


chr8_-_144650998 8.417 C8orf73
chromosome 8 open reading frame 73
chrX_+_43514157 7.940 MAOA
monoamine oxidase A
chr19_+_54371150 7.098 MYADM
myeloid-associated differentiation marker
chr6_+_37137882 7.074 NM_001243186
NM_002648
 PIM1

pim-1 oncogene

chr19_+_54371125 6.371 NM_001020819
NM_138373
 MYADM

myeloid-associated differentiation marker

chr8_+_86376130 6.299 NM_000067
 CA2
carbonic anhydrase II
chr9_+_131183225 6.130 CERCAM
cerebral endothelial cell adhesion molecule
chr19_+_54371170 5.953 MYADM
myeloid-associated differentiation marker
chr9_+_131183122 5.836 CERCAM
cerebral endothelial cell adhesion molecule
chr17_-_76921076 5.350 TIMP2
TIMP metallopeptidase inhibitor 2
chr10_-_15210610 5.292 NM_004808
 NMT2
N-myristoyltransferase 2
chr22_-_43583132 5.262 NM_015140
 TTLL12
tubulin tyrosine ligase-like family, member 12
chr20_+_31870940 5.144 NM_033197
 BPIFB1
BPI fold containing family B, member 1
chr6_+_34205029 5.125 HMGA1
high mobility group AT-hook 1
chr22_-_43583058 5.080 TTLL12
tubulin tyrosine ligase-like family, member 12
chr19_-_55658310 4.936 TNNT1
troponin T type 1 (skeletal, slow)
chr8_-_144650884 4.746 C8orf73
chromosome 8 open reading frame 73
chr11_+_65686727 4.727 NM_006442
 DRAP1
DR1-associated protein 1 (negative cofactor 2 alpha)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 144 entries
enrichment   p-value GO term description
1.55 8.51e-04 GO:0007265 Ras protein signal transduction
1.53 6.83e-03 GO:0031098 stress-activated protein kinase signaling cascade
1.49 5.90e-03 GO:0022604 regulation of cell morphogenesis
1.49 8.88e-03 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.46 4.68e-02 GO:0010975 regulation of neuron projection development
1.45 1.60e-02 GO:0006184 GTP catabolic process
1.43 7.91e-05 GO:0051129 negative regulation of cellular component organization
1.43 1.92e-02 GO:0031344 regulation of cell projection organization
1.42 3.21e-04 GO:0048011 nerve growth factor receptor signaling pathway
1.42 3.07e-02 GO:0046039 GTP metabolic process
1.34 6.80e-05 GO:0007264 small GTPase mediated signal transduction
1.33 2.81e-02 GO:0030036 actin cytoskeleton organization
1.33 3.79e-02 GO:0000165 MAPKKK cascade
1.32 1.43e-02 GO:0071900 regulation of protein serine/threonine kinase activity
1.31 7.34e-04 GO:0006397 mRNA processing
1.30 7.85e-04 GO:0009968 negative regulation of signal transduction
1.30 1.74e-02 GO:0009259 ribonucleotide metabolic process
1.30 2.22e-02 GO:0009150 purine ribonucleotide metabolic process
1.30 2.89e-02 GO:0060284 regulation of cell development
1.30 4.65e-02 GO:0030029 actin filament-based process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 40 entries
enrichment   p-value GO term description
1.72 3.68e-02 GO:0008287 protein serine/threonine phosphatase complex
1.32 4.64e-03 GO:0044440 endosomal part
1.31 8.23e-03 GO:0010008 endosome membrane
1.26 9.65e-04 GO:0005768 endosome
1.22 6.12e-17 GO:0005829 cytosol
1.22 1.41e-09 GO:0005654 nucleoplasm
1.22 1.65e-04 GO:0031975 envelope
1.22 1.75e-04 GO:0031967 organelle envelope
1.21 8.25e-04 GO:0044451 nucleoplasm part
1.21 4.80e-02 GO:0005740 mitochondrial envelope
1.20 2.46e-02 GO:0044431 Golgi apparatus part
1.19 4.09e-13 GO:0031974 membrane-enclosed lumen
1.19 3.57e-05 GO:0005783 endoplasmic reticulum
1.19 4.59e-03 GO:0031410 cytoplasmic vesicle
1.19 7.33e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
1.18 4.29e-12 GO:0043233 organelle lumen
1.18 6.20e-12 GO:0070013 intracellular organelle lumen
1.18 3.07e-11 GO:0044428 nuclear part
1.18 2.39e-09 GO:0031981 nuclear lumen
1.18 2.85e-04 GO:0005794 Golgi apparatus

Gene overrepresentation in function category:

Showing 1 to 20 of 23 entries
enrichment   p-value GO term description
1.46 2.26e-02 GO:0017124 SH3 domain binding
1.39 1.50e-09 GO:0019904 protein domain specific binding
1.26 4.00e-03 GO:0004674 protein serine/threonine kinase activity
1.23 1.71e-02 GO:0060589 nucleoside-triphosphatase regulator activity
1.22 4.17e-02 GO:0030695 GTPase regulator activity
1.21 7.53e-03 GO:0004672 protein kinase activity
1.21 3.51e-02 GO:0008092 cytoskeletal protein binding
1.20 7.65e-04 GO:0016301 kinase activity
1.20 1.84e-03 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.19 4.38e-04 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.18 1.75e-02 GO:0019899 enzyme binding
1.16 2.60e-09 GO:0000166 nucleotide binding
1.16 8.61e-07 GO:0032553 ribonucleotide binding
1.16 8.61e-07 GO:0032555 purine ribonucleotide binding
1.16 1.47e-06 GO:0017076 purine nucleotide binding
1.16 2.41e-06 GO:0035639 purine ribonucleoside triphosphate binding
1.15 2.52e-04 GO:0032559 adenyl ribonucleotide binding
1.15 3.15e-04 GO:0030554 adenyl nucleotide binding
1.15 7.17e-04 GO:0005524 ATP binding
1.14 2.84e-36 GO:0005515 protein binding