Motif ID: SREBF1,2.p2

Z-value: 1.255


Transcription factors associated with SREBF1,2.p2:

Gene SymbolEntrez IDGene Name
SREBF1 6720 sterol regulatory element binding transcription factor 1
SREBF2 6721 sterol regulatory element binding transcription factor 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SREBF1chr17_-_17740309-0.684.3e-05Click!
SREBF2chr22_+_42229105-0.301.0e-01Click!


Activity profile for motif SREBF1,2.p2.

activity profile for motif SREBF1,2.p2


Sorted Z-values histogram for motif SREBF1,2.p2

Sorted Z-values for motif SREBF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SREBF1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_10764449 14.923 LOC147727
uncharacterized LOC147727
chr9_-_138391696 11.299 NM_001048265
NM_144654
 C9orf116

chromosome 9 open reading frame 116

chr22_-_41593466 9.033


chr1_-_42921676 6.650 ZMYND12
zinc finger, MYND-type containing 12
chr1_-_207119707 6.232 NM_002644
 PIGR
polymeric immunoglobulin receptor
chr1_+_183605207 6.203 NM_015149
 RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr20_-_39317875 5.825 NM_005461
 MAFB
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr7_+_23286386 5.026 GPNMB
glycoprotein (transmembrane) nmb
chr7_+_23286384 4.752 GPNMB
glycoprotein (transmembrane) nmb
chr12_+_50355278 4.677 NM_001651
 AQP5
aquaporin 5
chr7_+_23286390 4.581 GPNMB
glycoprotein (transmembrane) nmb
chr7_+_106685007 4.453 NM_002736
 PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II, beta
chr19_+_14544100 4.417 NM_002741
 PKN1
protein kinase N1
chr4_-_16085309 4.259 PROM1
prominin 1
chr15_-_50978921 4.073 TRPM7
transient receptor potential cation channel, subfamily M, member 7
chrX_+_55744049 3.919 NM_006064
NM_016656
 RRAGB

Ras-related GTP binding B

chr22_+_35777087 3.854 HMOX1
heme oxygenase (decycling) 1
chr17_+_17876126 3.835 NM_001130090
NM_001130091
NM_001130092
NM_031294
 LRRC48



leucine rich repeat containing 48



chr1_-_109656478 3.821 NM_001122961
 C1orf194
chromosome 1 open reading frame 194
chr12_-_63328663 3.820 NM_020700
 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 14 of 14 entries
enrichment   p-value GO term description
6.38 6.19e-05 GO:0015682 ferric iron transport
6.38 6.19e-05 GO:0033572 transferrin transport
4.91 4.25e-02 GO:0015988 energy coupled proton transport, against electrochemical gradient
4.91 4.25e-02 GO:0015991 ATP hydrolysis coupled proton transport
4.30 5.59e-03 GO:0007033 vacuole organization
4.17 7.46e-04 GO:0006818 hydrogen transport
3.88 1.02e-02 GO:0006826 iron ion transport
3.81 1.29e-02 GO:0015992 proton transport
3.47 2.37e-02 GO:0055072 iron ion homeostasis
3.06 8.69e-03 GO:0000041 transition metal ion transport
1.25 6.74e-03 GO:0044260 cellular macromolecule metabolic process
1.22 2.45e-04 GO:0044237 cellular metabolic process
1.18 3.58e-03 GO:0008152 metabolic process
1.17 4.00e-02 GO:0044238 primary metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 31 entries
enrichment   p-value GO term description
6.63 1.04e-03 GO:0033176 proton-transporting V-type ATPase complex
3.77 4.28e-02 GO:0016469 proton-transporting two-sector ATPase complex
3.02 6.42e-06 GO:0044437 vacuolar part
2.97 2.78e-05 GO:0005774 vacuolar membrane
2.92 1.12e-11 GO:0005773 vacuole
2.77 4.81e-03 GO:0005770 late endosome
2.71 9.57e-08 GO:0000323 lytic vacuole
2.71 9.57e-08 GO:0005764 lysosome
2.71 1.04e-02 GO:0005765 lysosomal membrane
1.85 3.99e-03 GO:0005768 endosome
1.63 8.69e-03 GO:0044451 nucleoplasm part
1.57 5.35e-05 GO:0005654 nucleoplasm
1.49 2.05e-07 GO:0031974 membrane-enclosed lumen
1.49 2.24e-07 GO:0043233 organelle lumen
1.49 5.11e-07 GO:0070013 intracellular organelle lumen
1.45 1.91e-04 GO:0031981 nuclear lumen
1.39 5.08e-04 GO:0044428 nuclear part
1.32 2.22e-02 GO:0031090 organelle membrane
1.29 1.36e-08 GO:0044446 intracellular organelle part
1.28 5.77e-08 GO:0044422 organelle part

Gene overrepresentation in function category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
1.82 4.66e-02 GO:0003712 transcription cofactor activity
1.82 4.97e-02 GO:0000988 protein binding transcription factor activity
1.82 4.97e-02 GO:0000989 transcription factor binding transcription factor activity
1.14 4.66e-02 GO:0005515 protein binding
1.08 2.29e-02 GO:0005488 binding