Motif ID: SRF.p3

Z-value: 2.198


Transcription factors associated with SRF.p3:

Gene SymbolEntrez IDGene Name
SRF 6722 serum response factor (c-fos serum response element-binding transcription factor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SRFchr6_+_431392010.532.4e-03Click!


Activity profile for motif SRF.p3.

activity profile for motif SRF.p3


Sorted Z-values histogram for motif SRF.p3

Sorted Z-values for motif SRF.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of SRF.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_137801166 21.770 EGR1
early growth response 1
chr5_+_137801178 14.083 NM_001964
EGR1
early growth response 1
chr11_-_65667858 12.953 FOSL1
FOS-like antigen 1
chr22_+_31480981 12.344 NM_001207018
SMTN
smoothelin
chr6_+_151561094 12.175 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr14_-_94443065 10.295 NM_001202429
ASB2
ankyrin repeat and SOCS box containing 2
chr11_-_65667860 9.390 NM_005438
FOSL1
FOS-like antigen 1
chr2_+_74120132 9.374 ACTG2
actin, gamma 2, smooth muscle, enteric
chr2_+_74120092 9.331 NM_001199893
NM_001615
ACTG2

actin, gamma 2, smooth muscle, enteric

chr2_-_161056762 8.831 ITGB6
integrin, beta 6
chr11_-_65667809 8.594 FOSL1
FOS-like antigen 1
chr14_-_94442894 7.681 ASB2
ankyrin repeat and SOCS box containing 2
chr19_+_16178170 6.821 NM_001145160
TPM4
tropomyosin 4
chr10_+_112257624 6.767 NM_004419
DUSP5
dual specificity phosphatase 5
chr2_-_161056573 6.174 NM_000888
ITGB6
integrin, beta 6
chr12_+_75874512 5.935 NM_006851
GLIPR1
GLI pathogenesis-related 1
chrX_-_153602928 5.475 FLNA
filamin A, alpha
chr19_+_54372659 5.156 NM_001020821
NM_001020818
MYADM

myeloid-associated differentiation marker

chr1_-_168106810 5.051 GPR161
G protein-coupled receptor 161
chr3_-_123339423 4.821 NM_053031
NM_053032
MYLK

myosin light chain kinase


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 27 entries
enrichment   p-value GO term description
17.30 2.13e-07 GO:0070252 actin-mediated cell contraction
16.75 5.82e-10 GO:0030048 actin filament-based movement
15.99 3.81e-06 GO:0030049 muscle filament sliding
15.99 3.81e-06 GO:0033275 actin-myosin filament sliding
10.40 1.83e-15 GO:0006936 muscle contraction
9.94 1.19e-15 GO:0003012 muscle system process
8.65 2.58e-04 GO:0007015 actin filament organization
6.38 4.45e-03 GO:0032970 regulation of actin filament-based process
5.92 2.52e-02 GO:0032956 regulation of actin cytoskeleton organization
5.84 4.51e-09 GO:0030029 actin filament-based process
5.36 1.73e-04 GO:0007517 muscle organ development
4.82 2.21e-02 GO:0040017 positive regulation of locomotion
4.52 6.90e-04 GO:0030036 actin cytoskeleton organization
4.32 5.77e-04 GO:0061061 muscle structure development
4.06 2.78e-03 GO:0010035 response to inorganic substance
3.24 1.70e-03 GO:0007010 cytoskeleton organization
2.22 2.49e-02 GO:0022607 cellular component assembly
2.17 1.17e-04 GO:0003008 system process
1.98 1.80e-03 GO:0048513 organ development
1.84 2.51e-05 GO:0048856 anatomical structure development

Gene overrepresentation in compartment category:

Showing 1 to 20 of 28 entries
enrichment   p-value GO term description
21.91 3.05e-09 GO:0032432 actin filament bundle
21.12 4.82e-08 GO:0001725 stress fiber
20.22 7.83e-03 GO:0005865 striated muscle thin filament
20.22 7.83e-03 GO:0031672 A band
19.92 9.02e-09 GO:0042641 actomyosin
14.61 3.15e-02 GO:0005859 muscle myosin complex
13.15 4.88e-02 GO:0016460 myosin II complex
11.60 2.58e-03 GO:0005884 actin filament
9.89 3.07e-10 GO:0044449 contractile fiber part
9.63 4.77e-10 GO:0030016 myofibril
9.62 1.08e-10 GO:0043292 contractile fiber
9.24 1.19e-04 GO:0016459 myosin complex
8.72 7.04e-07 GO:0030017 sarcomere
8.22 1.97e-02 GO:0031674 I band
7.36 2.12e-16 GO:0015629 actin cytoskeleton
7.30 7.50e-05 GO:0005925 focal adhesion
6.95 1.24e-04 GO:0005924 cell-substrate adherens junction
6.70 1.82e-04 GO:0030055 cell-substrate junction
6.06 3.65e-02 GO:0033267 axon part
5.30 7.10e-04 GO:0005912 adherens junction

Gene overrepresentation in function category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
16.43 2.05e-02 GO:0000146 microfilament motor activity
13.76 3.44e-06 GO:0008307 structural constituent of muscle
13.15 8.08e-03 GO:0017022 myosin binding
8.85 3.25e-03 GO:0051015 actin filament binding
4.82 1.36e-07 GO:0003779 actin binding
4.73 1.34e-02 GO:0005516 calmodulin binding
3.45 6.05e-06 GO:0008092 cytoskeletal protein binding
2.74 2.15e-03 GO:0005198 structural molecule activity
1.32 4.76e-03 GO:0005515 protein binding