Motif ID: STAT2,4,6.p2

Z-value: 1.523


Transcription factors associated with STAT2,4,6.p2:

Gene SymbolEntrez IDGene Name
STAT2 6773 signal transducer and activator of transcription 2, 113kDa
STAT4 6775 signal transducer and activator of transcription 4
STAT6 6778 signal transducer and activator of transcription 6, interleukin-4 induced

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
STAT2chr12_-_567539160.383.7e-02Click!
STAT6chr12_-_575040880.319.5e-02Click!
STAT4chr2_-_192015733-0.241.9e-01Click!


Activity profile for motif STAT2,4,6.p2.

activity profile for motif STAT2,4,6.p2


Sorted Z-values histogram for motif STAT2,4,6.p2

Sorted Z-values for motif STAT2,4,6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT2,4,6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_89562103 3.490 NM_002048
GAS1
growth arrest-specific 1
chr3_-_187463227 2.391 BCL6
B-cell CLL/lymphoma 6
chr14_+_95078713 2.044 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr19_-_44860798 1.940 NM_001083335
NM_013380
ZFP112

zinc finger protein 112 homolog (mouse)

chr12_-_7245048 1.929 C1R
complement component 1, r subcomponent
chr12_-_7245006 1.927 NM_001733
C1R
complement component 1, r subcomponent
chr5_-_149792370 1.849 NM_001025158
NM_001025159
NM_004355
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr6_+_32821924 1.849 NM_002800
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
chr19_-_49567123 1.743 NM_006179
NTF4
neurotrophin 4
chr3_-_148939784 1.680 NM_000096
CP
ceruloplasmin (ferroxidase)
chr13_-_36705432 1.594 DCLK1
doublecortin-like kinase 1
chr3_-_187463474 1.580 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr12_+_93964801 1.518 SOCS2
suppressor of cytokine signaling 2
chr17_-_80291639 1.491 SECTM1
secreted and transmembrane 1
chr8_-_10512616 1.483 NM_178857
RP1L1
retinitis pigmentosa 1-like 1
chr6_-_28304151 1.454 NM_001243241
NM_001243242
NM_001243244
NM_030899
ZNF323



zinc finger protein 323



chr11_+_76745434 1.451 NM_138706
B3GNT6
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase)
chr17_-_80291610 1.446 SECTM1
secreted and transmembrane 1
chr17_+_38171613 1.422 NM_000759
NM_001178147
NM_172219
NM_172220
CSF3



colony stimulating factor 3 (granulocyte)



chr10_+_115511212 1.409 NM_001193434
NM_001193435
NM_024889
C10orf81


chromosome 10 open reading frame 81


chr17_-_76356153 1.406 NM_003955
SOCS3
suppressor of cytokine signaling 3
chr11_-_93276513 1.405 NM_020179
C11orf75
chromosome 11 open reading frame 75
chr6_+_32407618 1.349 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr11_-_102668822 1.315 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr16_-_52581713 1.290 NM_001146188
TOX3
TOX high mobility group box family member 3
chr3_-_158450271 1.278 NM_002888
NM_206963
RARRES1

retinoic acid receptor responder (tazarotene induced) 1

chr3_-_158450230 1.250 RARRES1
retinoic acid receptor responder (tazarotene induced) 1
chr19_+_10381516 1.242 NM_000201
ICAM1
intercellular adhesion molecule 1
chr3_-_158450205 1.214 RARRES1
retinoic acid receptor responder (tazarotene induced) 1
chr11_-_102826433 1.212 NM_002427
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr9_+_132251323 1.194 LOC100506190
uncharacterized LOC100506190
chr5_+_172483285 1.177 NM_001168393
NM_001168394
NM_153607
C5orf41


chromosome 5 open reading frame 41


chr16_+_19422056 1.171 NM_001105248
NM_001105249
TMC5

transmembrane channel-like 5

chr19_+_10381763 1.169 ICAM1
intercellular adhesion molecule 1
chr17_+_1646129 1.159 NM_000934
NM_001165921
SERPINF2

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

chr13_-_36705513 1.127 NM_004734
DCLK1
doublecortin-like kinase 1
chr4_+_75858205 1.123 NM_015393
PARM1
prostate androgen-regulated mucin-like protein 1
chr5_-_149792276 1.113 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr19_-_55973048 1.097 NM_001136201
NM_001136202
NM_024710
ISOC2


isochorismatase domain containing 2


chr4_+_70861647 1.077 NM_001009181
NM_003154
STATH

statherin

chr19_+_4343523 1.076 NM_001159846
NM_032868
MPND

MPN domain containing

chr12_+_12938540 1.075 NM_030817
APOLD1
apolipoprotein L domain containing 1
chr9_-_4152182 1.071 NM_152629
GLIS3
GLIS family zinc finger 3
chr8_-_110661007 1.067 NM_001099747
NM_001099748
NM_001099749
NM_001099750
NM_017786
SYBU




syntabulin (syntaxin-interacting)




chr11_+_65271145 1.058


chr11_-_102668892 1.035 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr22_-_36019363 1.024 NM_203377
MB
myoglobin
chr19_+_44556163 1.010 NM_013361
ZNF223
zinc finger protein 223
chr5_-_121414011 1.010 NM_002317
LOX
lysyl oxidase
chr3_-_112564789 1.009 NM_001008784
NM_001199215
CD200R1L

CD200 receptor 1-like

chr5_-_180018465 1.005 NM_052863
SCGB3A1
secretoglobin, family 3A, member 1
chr6_-_34524083 1.000 NM_001252294
NM_012391
SPDEF

SAM pointed domain containing ets transcription factor

chr6_+_83903031 0.970 NM_033411
RWDD2A
RWD domain containing 2A
chr5_+_42549657 0.966 NM_001242404
GHR
growth hormone receptor
chr7_+_80275634 0.961 NM_001127443
NM_001127444
CD36

CD36 molecule (thrombospondin receptor)

chr1_+_151630710 0.940 SNX27
sorting nexin family member 27
chr12_+_11802905 0.930 ETV6
ets variant 6
chr17_+_1646290 0.926 NM_001165920
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr12_+_7167979 0.911 NM_001734
NM_201442
C1S

complement component 1, s subcomponent

chr8_+_75896707 0.910 NM_031461
CRISPLD1
cysteine-rich secretory protein LCCL domain containing 1
chr1_-_153931077 0.907 CRTC2
CREB regulated transcription coactivator 2
chr19_+_44716683 0.898 NM_182490
ZNF227
zinc finger protein 227
chrX_-_48776282 0.897 NM_006875
PIM2
pim-2 oncogene
chr7_-_16921596 0.884 NM_176813
AGR3
anterior gradient 3 homolog (Xenopus laevis)
chr6_-_27440459 0.874 NM_007149
ZNF184
zinc finger protein 184
chr8_+_1952875 0.873 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr1_+_153940345 0.864 NM_130898
CREB3L4
cAMP responsive element binding protein 3-like 4
chr6_-_119670897 0.854 NM_005907
MAN1A1
mannosidase, alpha, class 1A, member 1
chr19_-_37019169 0.853 NM_001012756
NM_001166036
NM_001166037
NM_001166038
ZNF260



zinc finger protein 260



chr5_-_140013285 0.850 NM_001040021
NM_001174104
NM_001174105
CD14


CD14 molecule


chrY_+_21729214 0.840 TXLNG2P
taxilin gamma 2, pseudogene
chr3_-_71294229 0.838 NM_001244814
FOXP1
forkhead box P1
chr17_+_68100994 0.835 NM_170742
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr5_-_140013034 0.830 NM_000591
CD14
CD14 molecule
chr6_-_28303910 0.830 NM_001135216
NM_001243243
ZNF323

zinc finger protein 323

chr6_-_32821743 0.828 NM_000593
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr12_+_58138663 0.827 NM_005981
TSPAN31
tetraspanin 31
chr5_-_121413906 0.819 LOX
lysyl oxidase
chr15_+_71184781 0.808 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr5_-_121413967 0.789 LOX
lysyl oxidase
chr3_-_46505077 0.782 NM_001199149
LTF
lactotransferrin
chr3_+_171561138 0.780 NM_001164436
TMEM212
transmembrane protein 212
chr8_+_124084936 0.779 WDR67
WD repeat domain 67
chr2_+_149894980 0.773 NM_177964
LYPD6B
LY6/PLAUR domain containing 6B
chr3_-_167371701 0.768 WDR49
WD repeat domain 49
chr11_-_27681195 0.759 NM_001143816
NM_170735
BDNF

brain-derived neurotrophic factor

chr14_+_67999915 0.755 NM_020715
PLEKHH1
pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
chr6_+_31913852 0.754 CFB
complement factor B
chr1_+_201979689 0.749 NM_001114309
NM_004433
ELF3

E74-like factor 3 (ets domain transcription factor, epithelial-specific )

chr5_-_140012730 0.732 CD14
CD14 molecule
chr6_-_32821592 0.728 TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr6_+_31913763 0.728 CFB
complement factor B
chr11_+_1244292 0.725 NM_002458
MUC5B
mucin 5B, oligomeric mucus/gel-forming
chr12_+_53895065 0.711 TARBP2
TAR (HIV-1) RNA binding protein 2
chr19_+_44669214 0.704 NM_001146220
NM_001032373
NM_001032374
NM_015919
NM_001032372
ZNF226




zinc finger protein 226




chr4_-_122085475 0.700 NM_024873
TNIP3
TNFAIP3 interacting protein 3
chr12_+_56414688 0.692 NM_022465
IKZF4
IKAROS family zinc finger 4 (Eos)
chr1_+_149871154 0.689 NM_016074
BOLA1
bolA homolog 1 (E. coli)
chrX_+_54835492 0.688 NM_201222
MAGED2
melanoma antigen family D, 2
chr19_-_3047632 0.685 NM_001144761
TLE2
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chr6_-_29527701 0.680 NM_006398
UBD
ubiquitin D
chr2_+_219187858 0.679 NM_022572
PNKD
paroxysmal nonkinesigenic dyskinesia
chr19_-_17516383 0.677 NM_004335
BST2
bone marrow stromal cell antigen 2
chr12_-_7261788 0.677 NM_016546
C1RL
complement component 1, r subcomponent-like
chr19_+_58144510 0.675 NM_006385
NM_198855
ZNF211

zinc finger protein 211

chr19_+_751108 0.674 NM_173481
C19orf21
chromosome 19 open reading frame 21
chr10_+_95848811 0.671 NM_001165979
PLCE1
phospholipase C, epsilon 1
chr17_+_40440481 0.669 STAT5A
signal transducer and activator of transcription 5A
chr6_-_31845446 0.669 NM_001178045
SLC44A4
solute carrier family 44, member 4
chrX_+_57313109 0.666 NM_174912
FAAH2
fatty acid amide hydrolase 2
chr12_+_11802642 0.665 ETV6
ets variant 6
chr1_-_51787881 0.660 NM_001080494
TTC39A
tetratricopeptide repeat domain 39A
chr16_+_57728711 0.658 NM_032269
CCDC135
coiled-coil domain containing 135
chrX_-_117107700 0.656 NM_033495
NM_001168300
KLHL13

kelch-like 13 (Drosophila)

chr17_-_80291903 0.656 NM_003004
SECTM1
secreted and transmembrane 1
chr6_+_31913708 0.649 NM_001710
CFB
complement factor B
chr20_-_44175995 0.642 NM_001198986
NM_020398
SPINLW1-WFDC6
SPINLW1
SPINLW1-WFDC6 readthrough
serine peptidase inhibitor-like, with Kunitz and WAP domains 1 (eppin)
chr6_-_83903632 0.640 NM_001199917
PGM3
phosphoglucomutase 3
chr14_-_21270537 0.634 NM_198232
RNASE1
ribonuclease, RNase A family, 1 (pancreatic)
chr2_+_228678556 0.633 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr13_+_36050885 0.633 NM_001204197
NBEA
neurobeachin
chr11_+_73357222 0.625 NM_001130033
NM_021200
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chrY_+_22737610 0.623 NM_004681
EIF1AY
eukaryotic translation initiation factor 1A, Y-linked
chr12_+_133656984 0.621 NM_003440
ZNF140
zinc finger protein 140
chr19_+_17530856 0.614 NM_138401
FAM125A
family with sequence similarity 125, member A
chr16_-_28550227 0.612 NUPR1
nuclear protein, transcriptional regulator, 1
chr17_+_37783176 0.601 NM_032192
PPP1R1B
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr4_+_72052354 0.601 NM_001098484
NM_001134742
SLC4A4

solute carrier family 4, sodium bicarbonate cotransporter, member 4

chr14_+_21538339 0.601 NM_018071
ARHGEF40
Rho guanine nucleotide exchange factor (GEF) 40
chr8_+_124084898 0.599 NM_001145088
NM_145647
WDR67

WD repeat domain 67

chr21_+_42733916 0.598 NM_002463
LOC100131190
MX2
uncharacterized LOC100131190
myxovirus (influenza virus) resistance 2 (mouse)
chr6_+_43399488 0.598 NM_033450
ABCC10
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
chr18_+_61582744 0.595 NM_005024
SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chrX_-_63450486 0.594 NM_130388
ASB12
ankyrin repeat and SOCS box containing 12
chr19_+_37709068 0.586 ZNF383
zinc finger protein 383
chr1_+_233086319 0.573 NM_032324
NTPCR
nucleoside-triphosphatase, cancer-related
chr20_+_62694456 0.572 TCEA2
transcription elongation factor A (SII), 2
chr1_+_22970117 0.571 NM_001114101
NM_172369
C1QC

complement component 1, q subcomponent, C chain

chr11_-_72852957 0.571 NM_014824
FCHSD2
FCH and double SH3 domains 2
chr11_-_85437457 0.570 NM_206927
NM_206928
SYTL2

synaptotagmin-like 2

chr19_+_2476122 0.568 NM_015675
GADD45B
growth arrest and DNA-damage-inducible, beta
chr1_-_23886284 0.568 NM_002167
ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chrY_-_21906628 0.565 NM_001146705
NM_001146706
NM_004653
KDM5D


lysine (K)-specific demethylase 5D


chr4_+_130017281 0.562 NM_001099783
C4orf33
chromosome 4 open reading frame 33
chr5_+_93954352 0.561 NM_032290
ANKRD32
ankyrin repeat domain 32
chr19_-_44439410 0.560 NM_003425
ZNF45
zinc finger protein 45
chr3_+_159557745 0.559 SCHIP1
schwannomin interacting protein 1
chr12_+_111051831 0.556 NM_001082537
NM_001082538
NM_001173976
NM_024549
NM_001173975
TCTN1




tectonic family member 1




chr1_+_205473768 0.554 CDK18
cyclin-dependent kinase 18
chrX_-_133119475 0.551 GPC3
glypican 3
chr6_+_33257350 0.551 NM_014260
PFDN6
prefoldin subunit 6
chr10_+_17851342 0.551 NM_002438
MRC1
mannose receptor, C type 1
chr17_+_32582295 0.549 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr6_+_133562510 0.545 EYA4
eyes absent homolog 4 (Drosophila)
chr3_-_122512526 0.543 NM_024610
HSPBAP1
HSPB (heat shock 27kDa) associated protein 1
chr17_+_37783202 0.543 PPP1R1B
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr11_+_118175294 0.540 NM_000733
CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chrX_+_152770083 0.538 BGN
biglycan
chr19_+_44645728 0.532 ZNF234
zinc finger protein 234
chr12_+_53895376 0.527 NM_134324
TARBP2
TAR (HIV-1) RNA binding protein 2
chr1_+_233086372 0.526 NTPCR
nucleoside-triphosphatase, cancer-related
chr4_+_113218498 0.523 NM_001102406
NM_025144
ALPK1

alpha-kinase 1

chr8_+_110346549 0.521 NM_001193557
NM_020189
ENY2

enhancer of yellow 2 homolog (Drosophila)

chr6_-_56258891 0.519 COL21A1
collagen, type XXI, alpha 1
chr6_-_79787784 0.518 PHIP
pleckstrin homology domain interacting protein
chr1_+_160370363 0.514 NM_020335
VANGL2
vang-like 2 (van gogh, Drosophila)
chrX_-_38186619 0.513 RPGR
retinitis pigmentosa GTPase regulator
chr5_+_42550181 0.510 NM_001242405
GHR
growth hormone receptor
chr6_+_138188352 0.506 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr18_-_53177999 0.506 NM_001243231
TCF4
transcription factor 4
chr6_+_33257408 0.506 NM_001185181
PFDN6
prefoldin subunit 6
chr12_+_7013896 0.505 NM_001135217
NM_006992
NM_201650
LRRC23


leucine rich repeat containing 23


chr5_+_49962771 0.503 NM_001178056
NM_024615
PARP8

poly (ADP-ribose) polymerase family, member 8

chr21_-_31588242 0.502 NM_199328
CLDN8
claudin 8
chr15_-_71184611 0.500 NM_020147
THAP10
THAP domain containing 10
chr19_+_35773409 0.500 NM_021175
HAMP
hepcidin antimicrobial peptide
chr9_-_34397786 0.500 NM_032596
C9orf24
chromosome 9 open reading frame 24
chr19_+_14551080 0.499 NM_213560
PKN1
protein kinase N1
chr19_+_4791727 0.496 NM_018708
FEM1A
fem-1 homolog a (C. elegans)
chr6_-_79787887 0.496 PHIP
pleckstrin homology domain interacting protein
chr6_+_130339715 0.495 NM_001007102
NM_032438
L3MBTL3

l(3)mbt-like 3 (Drosophila)

chrX_+_115567746 0.494 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr19_+_58816714 0.493 ERVK3-1
endogenous retrovirus group K3, member 1
chr5_+_49962920 0.490 PARP8
poly (ADP-ribose) polymerase family, member 8
chr20_+_58571416 0.490 NM_021810
CDH26
cadherin 26
chr19_-_14260728 0.487 LPHN1
latrophilin 1
chr2_-_55459406 0.487 NM_152385
C2orf63
chromosome 2 open reading frame 63
chr12_-_9268522 0.484 NM_000014
A2M
alpha-2-macroglobulin
chr5_-_147211235 0.483 NM_003122
SPINK1
serine peptidase inhibitor, Kazal type 1
chr7_+_138818489 0.480 NM_001144920
NM_001144923
NM_024926
TTC26


tetratricopeptide repeat domain 26


chr19_+_58816757 0.479 ERVK3-1
endogenous retrovirus group K3, member 1
chr12_-_42877785 0.476 NM_001144882
NM_001144883
PRICKLE1

prickle homolog 1 (Drosophila)

chr3_+_179370779 0.476 NM_003940
USP13
ubiquitin specific peptidase 13 (isopeptidase T-3)
chr22_+_38598065 0.475 MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr1_-_23885916 0.474 ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr5_+_133861685 0.470 NM_015288
PHF15
PHD finger protein 15
chr6_+_133562488 0.466 NM_004100
NM_172103
NM_172105
EYA4


eyes absent homolog 4 (Drosophila)


chr3_-_194392938 0.466 LSG1
large subunit GTPase 1 homolog (S. cerevisiae)
chr12_+_60083125 0.465 NM_004731
SLC16A7
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
chr18_-_24722757 0.464 NM_001243848
CHST9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.75 1.22e-03 GO:0045087 innate immune response
1.45 2.22e-02 GO:0006955 immune response

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.11 4.26e-05 GO:0043231 intracellular membrane-bounded organelle
1.11 5.70e-05 GO:0043227 membrane-bounded organelle
1.14 1.46e-03 GO:0005634 nucleus
1.08 6.46e-03 GO:0043229 intracellular organelle
1.08 6.58e-03 GO:0043226 organelle
1.06 3.20e-02 GO:0044424 intracellular part
1.06 3.63e-02 GO:0005622 intracellular

Nothing significant found in function category.