Motif ID: TBX4,5.p2

Z-value: 1.449


Transcription factors associated with TBX4,5.p2:

Gene SymbolEntrez IDGene Name
TBX4 9496 T-box 4
TBX5 6910 T-box 5

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TBX5chr12_-_114843888-0.319.8e-02Click!
TBX4chr17_+_59529778-0.125.3e-01Click!


Activity profile for motif TBX4,5.p2.

activity profile for motif TBX4,5.p2


Sorted Z-values histogram for motif TBX4,5.p2

Sorted Z-values for motif TBX4,5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TBX4,5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_34397786 17.452 NM_032596
C9orf24
chromosome 9 open reading frame 24
chr1_+_38022514 8.671 NM_003462
DNALI1
dynein, axonemal, light intermediate chain 1
chr11_+_73358593 5.483 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr16_-_52581713 5.268 NM_001146188
TOX3
TOX high mobility group box family member 3
chr4_-_149363498 4.632 NM_000901
NM_001166104
NR3C2

nuclear receptor subfamily 3, group C, member 2

chr12_+_56661026 4.562 NM_001099337
COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr16_+_67465019 4.375 NM_000196
HSD11B2
hydroxysteroid (11-beta) dehydrogenase 2
chr3_+_238274 4.246 NM_001253387
NM_006614
CHL1

cell adhesion molecule with homology to L1CAM (close homolog of L1)

chr1_-_167906277 4.147 NM_001143674
NM_015415
BRP44

brain protein 44

chr14_-_106774311 4.092 IGHA1
immunoglobulin heavy constant alpha 1
chr4_-_177116713 3.928 NM_144644
SPATA4
spermatogenesis associated 4
chr16_+_57406398 3.858 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr12_+_69742130 3.729 NM_000239
LYZ
lysozyme
chr9_-_117156684 3.721 NM_030767
AKNA
AT-hook transcription factor
chr19_+_859673 3.543 CFD
complement factor D (adipsin)
chr14_-_54421269 3.485 NM_130851
BMP4
bone morphogenetic protein 4
chr19_+_859658 3.387 NM_001928
CFD
complement factor D (adipsin)
chr14_-_65438794 3.361 NM_198686
RAB15
RAB15, member RAS onocogene family
chr10_+_114135013 3.337 NM_203380
ACSL5
acyl-CoA synthetase long-chain family member 5
chr2_+_29204163 3.253 NM_199280
FAM179A
family with sequence similarity 179, member A
chr15_-_93631751 3.210 NM_001166287
RGMA
RGM domain family, member A
chr19_+_50706868 3.095 NM_001077186
NM_001145809
NM_024729
MYH14


myosin, heavy chain 14, non-muscle


chr19_+_50796820 3.052 MYH14
myosin, heavy chain 14, non-muscle
chr20_+_44098392 2.900 NM_006103
WFDC2
WAP four-disulfide core domain 2
chr6_-_43478423 2.842 NM_001012974
LRRC73
leucine rich repeat containing 73
chr1_+_118148506 2.825 NM_017709
FAM46C
family with sequence similarity 46, member C
chr3_-_120400957 2.818 HGD
homogentisate 1,2-dioxygenase
chr12_+_69742140 2.753 LYZ
lysozyme
chr1_+_26737306 2.719 LIN28A
lin-28 homolog A (C. elegans)
chr3_-_197676755 2.718 NM_001134435
IQCG
IQ motif containing G
chr13_+_35516390 2.685 NM_015678
NBEA
neurobeachin
chr7_+_105603656 2.673 NM_152750
CDHR3
cadherin-related family member 3
chr3_-_50383009 2.582 NM_015896
ZMYND10
zinc finger, MYND-type containing 10
chr16_+_82068830 2.564 NM_002153
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr11_-_26593667 2.561 NM_001135091
NM_001135092
NM_145650
MUC15


mucin 15, cell surface associated


chr11_-_63381485 2.559 PLA2G16
phospholipase A2, group XVI
chr9_-_117150217 2.446 AKNA
AT-hook transcription factor
chrX_-_48693934 2.433 NM_013271
PCSK1N
proprotein convertase subtilisin/kexin type 1 inhibitor
chr2_+_219536719 2.417 NM_001243313
NM_015690
STK36

serine/threonine kinase 36

chr11_+_71791376 2.406 NM_001145307
NM_001145308
NM_001205138
NM_145309
LRTOMT



leucine rich transmembrane and 0-methyltransferase domain containing



chr11_-_63381840 2.399 PLA2G16
phospholipase A2, group XVI
chr11_+_6260321 2.379 NM_001037329
CNGA4
cyclic nucleotide gated channel alpha 4
chr2_-_207630009 2.341 NM_001039845
MDH1B
malate dehydrogenase 1B, NAD (soluble)
chr1_+_118148668 2.328 FAM46C
family with sequence similarity 46, member C
chr3_+_238535 2.317 CHL1
cell adhesion molecule with homology to L1CAM (close homolog of L1)
chr12_+_56660913 2.231 COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr16_-_66959418 2.147 NM_001128850
NM_004165
RRAD

Ras-related associated with diabetes

chr11_+_118978087 2.138 NM_014807
C2CD2L
C2CD2-like
chr12_+_131438451 2.068 NM_198827
GPR133
G protein-coupled receptor 133
chr2_+_121103670 2.059 NM_002193
INHBB
inhibin, beta B
chr12_+_56660724 2.016 COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr2_-_61697899 2.011 USP34
ubiquitin specific peptidase 34
chr10_+_12391728 1.957 CAMK1D
calcium/calmodulin-dependent protein kinase ID
chr2_-_170550859 1.953 NM_001085447
C2orf77
chromosome 2 open reading frame 77
chr4_-_75719686 1.952 NM_001729
BTC
betacellulin
chr12_+_56660548 1.897 NM_144576
COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr6_+_39760772 1.895 NM_015345
DAAM2
dishevelled associated activator of morphogenesis 2
chr15_-_40857229 1.884 NM_001080791
NM_001080792
NM_052849
C15orf57


chromosome 15 open reading frame 57


chr6_+_26368405 1.882 NM_001197246
BTN3A2
butyrophilin, subfamily 3, member A2
chr22_+_39883228 1.876 NM_001098270
MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr18_-_45663667 1.858 NM_001039360
ZBTB7C
zinc finger and BTB domain containing 7C
chr2_+_10861740 1.836 NM_001039362
NM_144583
ATP6V1C2

ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2

chr16_-_776366 1.835 NM_001031737
CCDC78
coiled-coil domain containing 78
chr19_+_41594367 1.832 NM_000766
CYP2A13
cytochrome P450, family 2, subfamily A, polypeptide 13
chr14_-_92333856 1.809 NM_001128596
TC2N
tandem C2 domains, nuclear
chr17_+_14204326 1.807 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr2_-_217560247 1.807 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr16_+_82068910 1.791 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr7_-_131241321 1.789 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr1_-_26633110 1.788 NM_001077262
NM_183008
UBXN11

UBX domain protein 11

chr12_-_71551778 1.782 NM_004616
TSPAN8
tetraspanin 8
chr17_-_47439326 1.763 NM_001145365
NM_014897
ZNF652

zinc finger protein 652

chr14_+_95078713 1.759 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr10_-_13544944 1.745 NM_001100912
NM_152751
BEND7

BEN domain containing 7

chr10_+_94608224 1.729 NM_019053
EXOC6
exocyst complex component 6
chr3_-_183273407 1.700 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chrX_-_151999259 1.695 NM_004344
CETN2
centrin, EF-hand protein, 2
chr1_-_151345156 1.694 NM_003944
SELENBP1
selenium binding protein 1
chr1_+_26737232 1.688 NM_024674
LIN28A
lin-28 homolog A (C. elegans)
chr11_+_1889902 1.665 NM_001013253
LSP1
lymphocyte-specific protein 1
chr7_-_100026284 1.634 NM_017984
ZCWPW1
zinc finger, CW type with PWWP domain 1
chr1_-_207095198 1.618 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr5_+_140165875 1.586 NM_018900
NM_031410
NM_031411
PCDHA1


protocadherin alpha 1


chr1_-_27953046 1.577 NM_001042729
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr11_-_75236418 1.561 NM_030792
GDPD5
glycerophosphodiester phosphodiesterase domain containing 5
chr10_+_114135965 1.559 ACSL5
acyl-CoA synthetase long-chain family member 5
chr1_-_204329043 1.554 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr22_-_50971007 1.554 NM_001014440
ODF3B
outer dense fiber of sperm tails 3B
chr17_+_68100994 1.553 NM_170742
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr19_-_41388656 1.549 NM_000764
NM_030589
CYP2A7

cytochrome P450, family 2, subfamily A, polypeptide 7

chr20_-_3149070 1.537 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr19_-_48823331 1.534 NM_144577
CCDC114
coiled-coil domain containing 114
chr1_+_16062808 1.528 NM_207348
SLC25A34
solute carrier family 25, member 34
chr11_-_33913835 1.518 NM_005574
LMO2
LIM domain only 2 (rhombotin-like 1)
chr17_+_68165660 1.516 NM_000891
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr5_-_134914968 1.504 NM_004887
CXCL14
chemokine (C-X-C motif) ligand 14
chr17_-_34328607 1.499 CCL14-CCL15
CCL14-CCL15 readthrough
chr15_+_44581045 1.496 CASC4
cancer susceptibility candidate 4
chr11_-_33891258 1.495 LMO2
LIM domain only 2 (rhombotin-like 1)
chr1_+_210501595 1.486 NM_001122834
NM_001170564
HHAT

hedgehog acyltransferase

chr17_+_1633754 1.486 WDR81
WD repeat domain 81
chr7_+_30174343 1.481 NM_152793
C7orf41
chromosome 7 open reading frame 41
chr16_-_81110803 1.468 NM_001100873
NM_152337
C16orf46

chromosome 16 open reading frame 46

chr12_-_122107559 1.466 NM_173855
MORN3
MORN repeat containing 3
chr11_-_119252267 1.454 USP2
ubiquitin specific peptidase 2
chrX_-_117250624 1.453 NM_001168302
NM_001168303
KLHL13

kelch-like 13 (Drosophila)

chr5_+_139027955 1.440 CXXC5
CXXC finger protein 5
chr1_+_43638000 1.439 NM_001167965
NM_001195831
NM_152498
WDR65


WD repeat domain 65


chr17_-_34329083 1.431 NM_032965
CCL15
chemokine (C-C motif) ligand 15
chr4_-_105412466 1.412 NM_025212
CXXC4
CXXC finger protein 4
chr15_-_43513024 1.403 EPB42
erythrocyte membrane protein band 4.2
chr12_-_68726036 1.387 NM_001205028
NM_001205029
NM_017440
NM_020128
MDM1



Mdm1 nuclear protein homolog (mouse)



chr10_+_114135937 1.386 NM_016234
ACSL5
acyl-CoA synthetase long-chain family member 5
chr11_-_34533117 1.385 NM_001243081
NM_198381
ELF5

E74-like factor 5 (ets domain transcription factor)

chr1_+_46640748 1.370 NM_005727
TSPAN1
tetraspanin 1
chrX_+_152240726 1.363 NM_001170944
NM_001242319
NM_032882
PNMA6C
PNMA6D
PNMA6A
paraneoplastic antigen like 6C
paraneoplastic antigen like 6D
paraneoplastic antigen like 6A
chr17_-_38073792 1.362 NM_018530
GSDMB
gasdermin B
chr15_-_43559054 1.361 NM_004245
NM_201631
TGM5

transglutaminase 5

chr5_-_134914447 1.356 CXCL14
chemokine (C-X-C motif) ligand 14
chr6_+_17282294 1.346 NM_001143941
RBM24
RNA binding motif protein 24
chr6_-_3157696 1.341 NM_001069
TUBB2A
tubulin, beta 2A class IIa
chr9_+_976963 1.330 NM_021240
DMRT3
doublesex and mab-3 related transcription factor 3
chr16_+_810764 1.328 NM_005823
NM_001177355
MSLN

mesothelin

chr1_-_57285368 1.322 NM_001004303
C1orf168
chromosome 1 open reading frame 168
chr14_+_23352430 1.308 NM_173527
REM2
RAS (RAD and GEM)-like GTP binding 2
chr9_-_75567915 1.303 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr6_-_109762373 1.303 NM_001111298
NM_173672
PPIL6

peptidylprolyl isomerase (cyclophilin)-like 6

chr11_-_119234628 1.301 USP2
ubiquitin specific peptidase 2
chr10_+_124768401 1.295 NM_001609
ACADSB
acyl-CoA dehydrogenase, short/branched chain
chr1_+_151483861 1.282 NM_020770
CGN
cingulin
chr1_-_85930610 1.278 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr5_+_42549657 1.273 NM_001242404
GHR
growth hormone receptor
chr14_+_45431333 1.260 NM_015091
FAM179B
family with sequence similarity 179, member B
chr10_+_70587293 1.259 NM_001130159
NM_001130160
NM_001130161
NM_152709
STOX1



storkhead box 1



chr9_-_80263222 1.258 NM_004297
GNA14
guanine nucleotide binding protein (G protein), alpha 14
chr11_-_59633942 1.252 NM_001062
TCN1
transcobalamin I (vitamin B12 binding protein, R binder family)
chr17_+_55334373 1.246 NM_170721
MSI2
musashi homolog 2 (Drosophila)
chr17_+_4675175 1.244 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr12_-_71551564 1.243 TSPAN8
tetraspanin 8
chr4_+_25657434 1.228 NM_001177998
NM_006424
SLC34A2

solute carrier family 34 (sodium phosphate), member 2

chr8_-_17270800 1.226 MTMR7
myotubularin related protein 7
chr12_-_25706177 1.212 NM_152590
NM_001145728
NM_001145729
IFLTD1


intermediate filament tail domain containing 1


chr8_-_74659082 1.196 NM_001164380
NM_001164381
NM_001164382
NM_001164383
NM_001164385
NM_014393
STAU2





staufen, RNA binding protein, homolog 2 (Drosophila)





chr7_+_30951414 1.184 NM_198098
AQP1
aquaporin 1 (Colton blood group)
chr5_+_140571903 1.169 NM_018930
PCDHB10
protocadherin beta 10
chr19_+_9435370 1.167 NM_001202425
ZNF559-ZNF177
ZNF559-ZNF177 readthrough
chr14_-_24664606 1.164 TM9SF1
transmembrane 9 superfamily member 1
chrX_-_62648209 1.164 LOC92249
uncharacterized LOC92249
chr1_+_85527992 1.152 NM_145172
WDR63
WD repeat domain 63
chr3_+_169755733 1.143 NM_014373
GPR160
G protein-coupled receptor 160
chr11_+_67776016 1.142 NM_001161473
ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chr22_-_42486766 1.134 NM_002490
NDUFA6
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa
chr15_+_75287829 1.133 NM_001178111
NM_001178112
NM_138967
SCAMP5


secretory carrier membrane protein 5


chr3_+_169755782 1.131 GPR160
G protein-coupled receptor 160
chr11_-_33891485 1.125 NM_001142315
LMO2
LIM domain only 2 (rhombotin-like 1)
chr11_+_1886394 1.125 NM_001242932
LSP1
lymphocyte-specific protein 1
chr3_-_66550844 1.118 NM_015541
LRIG1
leucine-rich repeats and immunoglobulin-like domains 1
chr22_-_50970542 1.114 ODF3B
outer dense fiber of sperm tails 3B
chr5_-_133304274 1.110 NM_020199
C5orf15
chromosome 5 open reading frame 15
chr9_-_75568232 1.110 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr7_-_138363789 1.109 NM_001139456
SVOPL
SVOP-like
chr7_+_70597788 1.105 NM_022479
WBSCR17
Williams-Beuren syndrome chromosome region 17
chr1_+_110082493 1.097 NM_031936
GPR61
G protein-coupled receptor 61
chr15_-_93632161 1.097 NM_020211
RGMA
RGM domain family, member A
chr8_-_102803438 1.096 NM_032041
NCALD
neurocalcin delta
chr2_-_61697846 1.096 NM_014709
USP34
ubiquitin specific peptidase 34
chr3_+_129159075 1.095 IFT122
intraflagellar transport 122 homolog (Chlamydomonas)
chr18_-_52969714 1.089 NM_001243236
TCF4
transcription factor 4
chr11_+_73661363 1.082 NM_153614
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr5_-_138719018 1.080 NM_005847
NM_152685
SLC23A1

solute carrier family 23 (nucleobase transporters), member 1

chr12_+_53817638 1.079 NM_001164690
NM_001164691
NM_020547
AMHR2


anti-Mullerian hormone receptor, type II


chr6_-_46825942 1.078 GPR116
G protein-coupled receptor 116
chr16_-_66730466 1.077 NM_178818
NM_181521
CMTM4

CKLF-like MARVEL transmembrane domain containing 4

chr12_+_51318743 1.077 METTL7A
methyltransferase like 7A
chr16_+_24267672 1.071 CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr2_-_190445466 1.056 SLC40A1
solute carrier family 40 (iron-regulated transporter), member 1
chr12_+_6420098 1.055 NM_001144856
PLEKHG6
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr5_-_138718941 1.052 SLC23A1
solute carrier family 23 (nucleobase transporters), member 1
chr2_+_230787195 1.052 NM_174899
FBXO36
F-box protein 36
chr14_+_105452615 1.051 NM_174891
C14orf79
chromosome 14 open reading frame 79
chr12_+_6419601 1.049 NM_018173
PLEKHG6
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr1_+_104159953 1.045 NM_000699
AMY2A
amylase, alpha 2A (pancreatic)
chr8_-_102803196 1.041 NCALD
neurocalcin delta
chr17_+_62075710 1.025 NM_001164257
NM_001191029
NM_001191030
NM_001191031
C17orf72



chromosome 17 open reading frame 72



chr11_+_61447816 1.024 NM_006133
DAGLA
diacylglycerol lipase, alpha
chr22_-_36013303 1.023 NM_005368
NM_203378
MB

myoglobin

chr17_+_7608413 1.023 NM_001406
EFNB3
ephrin-B3
chr12_-_63328663 1.021 NM_020700
PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr16_+_28877586 1.019 SH2B1
SH2B adaptor protein 1
chr17_-_38074842 1.016 NM_001042471
NM_001165958
NM_001165959
GSDMB


gasdermin B


chr5_-_42811959 1.015 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr2_+_102770401 1.010 NM_000877
IL1R1
interleukin 1 receptor, type I
chr1_+_9599520 1.004 NM_032315
SLC25A33
solute carrier family 25, member 33
chr8_+_21912327 1.001 NM_001114136
NM_001114139
EPB49

erythrocyte membrane protein band 4.9 (dematin)

chr15_+_44580954 0.996 CASC4
cancer susceptibility candidate 4
chr17_-_34328530 0.988 CCL14-CCL15
CCL15
CCL14-CCL15 readthrough
chemokine (C-C motif) ligand 15
chr12_+_113623364 0.982 NM_032848
C12orf52
chromosome 12 open reading frame 52
chr2_-_190445612 0.977 SLC40A1
solute carrier family 40 (iron-regulated transporter), member 1
chr4_-_147866963 0.969 NM_031956
TTC29
tetratricopeptide repeat domain 29
chr2_-_145090028 0.968 GTDC1
glycosyltransferase-like domain containing 1

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.97 3.13e-02 GO:0005932 microtubule basal body

Nothing significant found in function category.