Motif ID: TCF4_dimer.p2

Z-value: 1.920


Transcription factors associated with TCF4_dimer.p2:

Gene SymbolEntrez IDGene Name
TCF4 6925 transcription factor 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TCF4chr18_-_53257033-0.461.1e-02Click!


Activity profile for motif TCF4_dimer.p2.

activity profile for motif TCF4_dimer.p2


Sorted Z-values histogram for motif TCF4_dimer.p2

Sorted Z-values for motif TCF4_dimer.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TCF4_dimer.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_91505215 6.871 LUM
lumican
chr12_-_91505541 6.670 NM_002345
 LUM
lumican
chr17_-_39274587 4.166 NM_033059
 KRTAP4-11
keratin associated protein 4-11
chr10_-_135150368 4.158 CALY
calcyon neuron-specific vesicular protein
chr10_-_135150474 3.963 NM_015722
 CALY
calcyon neuron-specific vesicular protein
chr5_+_148520985 3.270 NM_014945
 ABLIM3
actin binding LIM protein family, member 3
chr8_+_102504661 3.175 NM_024915
 GRHL2
grainyhead-like 2 (Drosophila)
chr8_+_102504836 2.955 GRHL2
grainyhead-like 2 (Drosophila)
chr5_+_173472692 2.722 NM_015980
 HMP19
HMP19 protein
chr1_-_27339326 2.545 NM_052943
 FAM46B
family with sequence similarity 46, member B
chr21_+_37507209 2.491 NM_001236
 CBR3
carbonyl reductase 3
chr2_+_33359607 2.343 NM_000627
NM_001166264
NM_001166265
NM_001166266
 LTBP1



latent transforming growth factor beta binding protein 1



chr4_+_75310852 2.320 NM_001657
 AREG
amphiregulin
chr17_-_39324423 2.202 NM_033187
 KRTAP4-3
keratin associated protein 4-3
chr3_-_111314181 2.117 NM_024508
 ZBED2
zinc finger, BED-type containing 2
chr20_-_590909 2.099 NM_004609
 TCF15
transcription factor 15 (basic helix-loop-helix)
chr16_+_68771304 2.075 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chrX_+_16804531 2.068 NM_001168683
NM_018360
 TXLNG

taxilin gamma

chr1_+_182992694 2.066


chr6_-_45983279 2.065 NM_016929
 CLIC5
chloride intracellular channel 5

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 100 entries
enrichment   p-value GO term description
2.49 2.65e-02 GO:0050999 regulation of nitric-oxide synthase activity
1.69 4.62e-02 GO:0031098 stress-activated protein kinase signaling cascade
1.66 9.48e-04 GO:0071902 positive regulation of protein serine/threonine kinase activity
1.63 2.26e-02 GO:0043406 positive regulation of MAP kinase activity
1.62 6.01e-03 GO:0006936 muscle contraction
1.61 3.45e-03 GO:0003012 muscle system process
1.55 1.16e-02 GO:0010817 regulation of hormone levels
1.52 1.02e-02 GO:0048011 nerve growth factor receptor signaling pathway
1.50 1.57e-02 GO:0006897 endocytosis
1.50 1.57e-02 GO:0010324 membrane invagination
1.48 4.25e-03 GO:0040012 regulation of locomotion
1.47 1.02e-03 GO:0044057 regulation of system process
1.46 2.42e-06 GO:0048585 negative regulation of response to stimulus
1.46 4.51e-03 GO:0022603 regulation of anatomical structure morphogenesis
1.46 9.89e-03 GO:0051270 regulation of cellular component movement
1.46 2.26e-02 GO:0030334 regulation of cell migration
1.45 7.93e-03 GO:0045860 positive regulation of protein kinase activity
1.45 4.35e-02 GO:2000145 regulation of cell motility
1.44 3.35e-04 GO:0009968 negative regulation of signal transduction
1.44 1.10e-02 GO:0033674 positive regulation of kinase activity

Gene overrepresentation in compartment category:

Showing 1 to 20 of 34 entries
enrichment   p-value GO term description
1.70 4.90e-02 GO:0030139 endocytic vesicle
1.65 9.74e-03 GO:0030016 myofibril
1.63 7.44e-03 GO:0043292 contractile fiber
1.53 1.26e-02 GO:0070161 anchoring junction
1.52 5.44e-04 GO:0016323 basolateral plasma membrane
1.51 1.28e-04 GO:0012506 vesicle membrane
1.49 4.03e-04 GO:0030659 cytoplasmic vesicle membrane
1.46 2.22e-04 GO:0044433 cytoplasmic vesicle part
1.36 7.96e-03 GO:0031012 extracellular matrix
1.34 6.72e-07 GO:0005626 insoluble fraction
1.34 1.37e-06 GO:0005624 membrane fraction
1.33 9.21e-06 GO:0031410 cytoplasmic vesicle
1.33 1.36e-05 GO:0031988 membrane-bounded vesicle
1.33 1.78e-05 GO:0016023 cytoplasmic membrane-bounded vesicle
1.33 2.61e-02 GO:0043005 neuron projection
1.33 3.92e-02 GO:0009986 cell surface
1.32 1.51e-05 GO:0031982 vesicle
1.27 1.60e-05 GO:0000267 cell fraction
1.26 3.13e-02 GO:0030054 cell junction
1.25 2.45e-04 GO:0044421 extracellular region part

Gene overrepresentation in function category:

Showing 1 to 15 of 15 entries
enrichment   p-value GO term description
1.52 4.32e-02 GO:0005085 guanyl-nucleotide exchange factor activity
1.32 1.82e-02 GO:0060589 nucleoside-triphosphatase regulator activity
1.31 2.76e-02 GO:0030695 GTPase regulator activity
1.30 7.37e-03 GO:0008324 cation transmembrane transporter activity
1.29 3.18e-05 GO:0022857 transmembrane transporter activity
1.29 1.26e-04 GO:0022891 substrate-specific transmembrane transporter activity
1.28 1.29e-03 GO:0015075 ion transmembrane transporter activity
1.28 3.81e-02 GO:0008092 cytoskeletal protein binding
1.25 5.57e-04 GO:0005102 receptor binding
1.24 1.42e-03 GO:0022892 substrate-specific transporter activity
1.24 2.99e-03 GO:0030234 enzyme regulator activity
1.24 2.92e-02 GO:0042802 identical protein binding
1.21 4.19e-03 GO:0005215 transporter activity
1.11 2.32e-11 GO:0005515 protein binding
1.04 2.13e-02 GO:0005488 binding