Motif ID: TFAP2B.p2

Z-value: 1.879


Transcription factors associated with TFAP2B.p2:

Gene SymbolEntrez IDGene Name
TFAP2B 7021 transcription factor AP-2 beta (activating enhancer binding protein 2 beta)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP2Bchr6_+_50786438-0.058.0e-01Click!


Activity profile for motif TFAP2B.p2.

activity profile for motif TFAP2B.p2


Sorted Z-values histogram for motif TFAP2B.p2

Sorted Z-values for motif TFAP2B.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2B.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_22469414 7.726 NM_030761
 WNT4
wingless-type MMTV integration site family, member 4
chr5_-_180018465 6.201 NM_052863
 SCGB3A1
secretoglobin, family 3A, member 1
chr16_-_52580805 4.725 NM_001080430
 TOX3
TOX high mobility group box family member 3
chr7_+_152161119 4.622 LOC100128822
uncharacterized LOC100128822
chr2_+_97481977 4.423 NM_017623
NM_199078
 CNNM3

cyclin M3

chr6_+_19837599 4.344 NM_001546
 ID4
inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
chr7_-_158380360 4.007 NM_002847
NM_130842
NM_130843
 PTPRN2


protein tyrosine phosphatase, receptor type, N polypeptide 2


chr1_+_205538164 3.787 MFSD4
major facilitator superfamily domain containing 4
chr1_+_205538111 3.684 NM_181644
 MFSD4
major facilitator superfamily domain containing 4
chr19_+_708766 3.494 NM_001040134
NM_002579
 PALM

paralemmin

chr19_+_45504686 3.459 NM_006509
 RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr16_+_67465019 3.321 NM_000196
 HSD11B2
hydroxysteroid (11-beta) dehydrogenase 2
chr19_-_3028901 2.984 NM_003260
 TLE2
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chr2_+_121103670 2.845 NM_002193
 INHBB
inhibin, beta B
chr1_+_228871109 2.776 RHOU
ras homolog gene family, member U
chr19_+_34972866 2.718 NM_001080436
 WTIP
Wilms tumor 1 interacting protein
chr7_+_4722091 2.623 FOXK1
forkhead box K1
chr11_-_33890931 2.479 LMO2
LIM domain only 2 (rhombotin-like 1)
chr12_+_102091399 2.457 NM_020244
 CHPT1
choline phosphotransferase 1
chr8_+_136469557 2.448 NM_006558
 KHDRBS3
KH domain containing, RNA binding, signal transduction associated 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 86 entries
enrichment   p-value GO term description
2.52 3.05e-02 GO:0045646 regulation of erythrocyte differentiation
2.05 2.35e-02 GO:0045767 regulation of anti-apoptosis
1.88 3.77e-03 GO:0007173 epidermal growth factor receptor signaling pathway
1.47 1.62e-03 GO:0032446 protein modification by small protein conjugation
1.47 2.93e-02 GO:0043193 positive regulation of gene-specific transcription
1.45 1.08e-02 GO:0016567 protein ubiquitination
1.45 1.32e-02 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
1.44 8.79e-04 GO:0051098 regulation of binding
1.43 5.36e-04 GO:0016568 chromatin modification
1.43 2.14e-02 GO:0051101 regulation of DNA binding
1.43 3.49e-02 GO:0090046 regulation of transcription regulator activity
1.42 2.18e-03 GO:0070647 protein modification by small protein conjugation or removal
1.37 2.45e-03 GO:0032583 regulation of gene-specific transcription
1.36 2.73e-02 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.36 2.75e-02 GO:0009792 embryo development ending in birth or egg hatching
1.35 1.89e-02 GO:0009968 negative regulation of signal transduction
1.32 9.01e-04 GO:0010629 negative regulation of gene expression
1.32 5.26e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.32 4.54e-02 GO:0023057 negative regulation of signaling
1.31 7.67e-04 GO:0010628 positive regulation of gene expression

Gene overrepresentation in compartment category:

Showing 1 to 20 of 28 entries
enrichment   p-value GO term description
1.80 1.54e-02 GO:0031256 leading edge membrane
1.53 1.22e-03 GO:0031252 cell leading edge
1.27 9.80e-04 GO:0044451 nucleoplasm part
1.26 1.62e-02 GO:0044431 Golgi apparatus part
1.22 1.64e-03 GO:0005794 Golgi apparatus
1.21 2.30e-04 GO:0005654 nucleoplasm
1.20 2.56e-05 GO:0012505 endomembrane system
1.19 3.22e-07 GO:0044428 nuclear part
1.19 1.81e-05 GO:0031981 nuclear lumen
1.16 1.82e-04 GO:0070013 intracellular organelle lumen
1.16 2.65e-04 GO:0005829 cytosol
1.16 3.23e-04 GO:0031090 organelle membrane
1.15 1.28e-14 GO:0005634 nucleus
1.15 4.21e-04 GO:0031974 membrane-enclosed lumen
1.15 5.43e-04 GO:0043233 organelle lumen
1.13 7.21e-27 GO:0043231 intracellular membrane-bounded organelle
1.13 1.01e-26 GO:0043227 membrane-bounded organelle
1.13 5.40e-25 GO:0005737 cytoplasm
1.13 7.49e-13 GO:0044444 cytoplasmic part
1.13 1.99e-11 GO:0044446 intracellular organelle part

Gene overrepresentation in function category:

Showing 1 to 20 of 24 entries
enrichment   p-value GO term description
2.07 3.23e-03 GO:0046332 SMAD binding
1.64 4.93e-02 GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
1.56 2.72e-04 GO:0010843 promoter binding
1.54 3.27e-04 GO:0000975 regulatory region DNA binding
1.54 3.27e-04 GO:0001067 regulatory region nucleic acid binding
1.54 3.27e-04 GO:0044212 transcription regulatory region DNA binding
1.42 1.91e-02 GO:0019787 small conjugating protein ligase activity
1.41 1.02e-02 GO:0016881 acid-amino acid ligase activity
1.37 9.80e-03 GO:0016563 transcription activator activity
1.37 1.85e-02 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.37 2.39e-02 GO:0008134 transcription factor binding
1.34 2.38e-03 GO:0019904 protein domain specific binding
1.25 4.32e-03 GO:0016301 kinase activity
1.24 9.66e-04 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.24 1.17e-02 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.22 4.85e-02 GO:0019899 enzyme binding
1.20 1.43e-02 GO:0030528 transcription regulator activity
1.19 7.44e-05 GO:0016740 transferase activity
1.16 1.43e-26 GO:0005515 protein binding
1.14 1.50e-03 GO:0000166 nucleotide binding