Motif ID: TLX2.p2

Z-value: 1.165


Transcription factors associated with TLX2.p2:

Gene SymbolEntrez IDGene Name
TLX2 3196 T-cell leukemia homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TLX2chr2_+_747415650.125.4e-01Click!


Activity profile for motif TLX2.p2.

activity profile for motif TLX2.p2


Sorted Z-values histogram for motif TLX2.p2

Sorted Z-values for motif TLX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_153029987 3.946 NM_005988
 SPRR2A
small proline-rich protein 2A
chr1_+_152486977 3.575 NM_019060
 CRCT1
cysteine-rich C-terminal 1
chr12_-_91505215 3.522 LUM
lumican
chr1_-_205391180 3.102 NM_001001552
NM_001199050
NM_001199051
NM_001199052
 LEMD1



LEM domain containing 1



chr1_+_152881022 2.873 NM_005547
 IVL
involucrin
chr9_+_131191206 2.714 CERCAM
cerebral endothelial cell adhesion molecule
chr22_+_31478845 2.514 NM_001207017
 SMTN
smoothelin
chr8_+_86376130 2.503 NM_000067
 CA2
carbonic anhydrase II
chr7_+_48128939 2.503 UPP1
uridine phosphorylase 1
chr14_+_54863672 2.169 NM_001130851
NM_005192
 CDKN3

cyclin-dependent kinase inhibitor 3

chr18_-_28681885 2.102 NM_004949
NM_024422
 DSC2

desmocollin 2

chr1_-_24469571 1.954 NM_021258
 IL22RA1
interleukin 22 receptor, alpha 1
chr14_+_55034633 1.935 SAMD4A
sterile alpha motif domain containing 4A
chr5_-_39270708 1.920 NM_001243093
 FYB
FYN binding protein
chr7_+_37723378 1.868


chr19_+_676346 1.772 NM_005860
 FSTL3
follistatin-like 3 (secreted glycoprotein)
chr1_-_153433104 1.722 NM_002963
 S100A7
S100 calcium binding protein A7
chr1_-_153085963 1.713 NM_001014450
 SPRR2A
SPRR2F
small proline-rich protein 2A
small proline-rich protein 2F
chr18_+_29027731 1.700 NM_001944
 DSG3
desmoglein 3
chr4_+_156680603 1.699 GUCY1B3
guanylate cyclase 1, soluble, beta 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 29 entries
enrichment   p-value GO term description
2.76 5.34e-03 GO:0006415 translational termination
2.75 9.49e-03 GO:0019080 viral genome expression
2.75 9.49e-03 GO:0019083 viral transcription
2.60 1.16e-02 GO:0043241 protein complex disassembly
2.60 1.16e-02 GO:0043624 cellular protein complex disassembly
2.57 4.06e-03 GO:0032984 macromolecular complex disassembly
2.57 4.06e-03 GO:0034623 cellular macromolecular complex disassembly
2.52 2.16e-02 GO:0006414 translational elongation
2.32 2.36e-04 GO:0022411 cellular component disassembly
2.32 2.36e-04 GO:0071845 cellular component disassembly at cellular level
2.20 4.38e-02 GO:0031016 pancreas development
1.66 1.43e-02 GO:0007599 hemostasis
1.63 3.81e-02 GO:0007596 blood coagulation
1.63 3.81e-02 GO:0050817 coagulation
1.60 1.61e-02 GO:0042060 wound healing
1.49 7.04e-03 GO:0009611 response to wounding
1.41 1.03e-02 GO:0002376 immune system process
1.35 4.22e-08 GO:0048856 anatomical structure development
1.35 4.57e-07 GO:0048731 system development
1.33 6.81e-08 GO:0007275 multicellular organismal development

Gene overrepresentation in compartment category:

Showing 1 to 20 of 26 entries
enrichment   p-value GO term description
3.85 9.83e-04 GO:0022625 cytosolic large ribosomal subunit
3.43 5.18e-05 GO:0015934 large ribosomal subunit
2.88 2.73e-05 GO:0005925 focal adhesion
2.83 2.52e-05 GO:0005924 cell-substrate adherens junction
2.82 2.20e-03 GO:0022626 cytosolic ribosome
2.73 6.54e-05 GO:0030055 cell-substrate junction
2.30 1.72e-04 GO:0070161 anchoring junction
2.25 1.17e-03 GO:0044445 cytosolic part
2.17 5.18e-03 GO:0005912 adherens junction
1.87 1.37e-02 GO:0016323 basolateral plasma membrane
1.80 3.34e-03 GO:0005578 proteinaceous extracellular matrix
1.76 1.43e-03 GO:0031012 extracellular matrix
1.73 3.09e-02 GO:0015629 actin cytoskeleton
1.52 1.42e-02 GO:0030054 cell junction
1.44 1.39e-03 GO:0044421 extracellular region part
1.37 7.85e-06 GO:0005829 cytosol
1.34 2.68e-02 GO:0031226 intrinsic to plasma membrane
1.34 3.04e-02 GO:0005887 integral to plasma membrane
1.32 1.06e-04 GO:0044459 plasma membrane part
1.32 9.15e-03 GO:0005856 cytoskeleton

Gene overrepresentation in function category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
2.20 6.39e-03 GO:0003735 structural constituent of ribosome
1.75 1.25e-02 GO:0003779 actin binding
1.66 7.97e-04 GO:0008092 cytoskeletal protein binding
1.17 8.95e-07 GO:0005515 protein binding