Motif ID: UAAGACU

Z-value: 0.553


Mature miRNA associated with seed UAAGACU:

NamemiRBase Accession
hsa-miR-499-5p MIMAT0002870



Activity profile for motif UAAGACU.

activity profile for motif UAAGACU


Sorted Z-values histogram for motif UAAGACU

Sorted Z-values for motif UAAGACU



Network of associatons between targets according to the STRING database.



First level regulatory network of UAAGACU

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrY_+_15016018 1.620 NM_001122665
DDX3Y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chrY_+_15016698 1.074 NM_004660
DDX3Y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr2_-_86565205 0.888 NM_001164730
REEP1
receptor accessory protein 1
chr2_-_86564632 0.772 NM_001164731
NM_001164732
NM_022912
REEP1


receptor accessory protein 1


chr11_+_111848008 0.667 NM_033425
DIXDC1
DIX domain containing 1
chr8_+_67976561 0.572 NM_024790
CSPP1
centrosome and spindle pole associated protein 1
chr11_+_111807857 0.479 NM_001037954
DIXDC1
DIX domain containing 1
chr7_+_90338711 0.450 NM_012395
CDK14
cyclin-dependent kinase 14
chr15_-_48470453 0.440 NM_016132
MYEF2
myelin expression factor 2
chr11_+_19734821 0.383 NM_001244963
NM_145117
NM_182964
NAV2


neuron navigator 2


chr14_-_61115906 0.380 NM_005982
SIX1
SIX homeobox 1
chr16_+_54965110 0.371 NM_001252197
NM_005853
IRX5

iroquois homeobox 5

chr20_+_51588945 0.370 NM_173485
TSHZ2
teashirt zinc finger homeobox 2
chr7_+_114055048 0.368 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr20_+_51801821 0.356 NM_001193421
TSHZ2
teashirt zinc finger homeobox 2
chr6_-_166075520 0.354 NM_006661
NM_001130690
PDE10A

phosphodiesterase 10A

chr8_-_23712297 0.349 NM_003155
STC1
stanniocalcin 1
chrX_+_17393537 0.346 NM_198270
NHS
Nance-Horan syndrome (congenital cataracts and dental anomalies)
chr4_-_100485173 0.342 NM_001134665
NM_001134666
RG9MTD2

RNA (guanine-9-) methyltransferase domain containing 2

chrX_+_17653412 0.342 NM_001136024
NHS
Nance-Horan syndrome (congenital cataracts and dental anomalies)
chr12_-_26277807 0.338 NM_030762
BHLHE41
basic helix-loop-helix family, member e41
chr4_-_100484824 0.334 NM_152292
RG9MTD2
RNA (guanine-9-) methyltransferase domain containing 2
chr13_+_100258886 0.333 NM_206808
CLYBL
citrate lyase beta like
chr11_+_19372270 0.327 NM_001111018
NAV2
neuron navigator 2
chrX_-_34675366 0.318 NM_031442
TMEM47
transmembrane protein 47
chr1_-_45956795 0.307 NM_007170
TESK2
testis-specific kinase 2
chr5_+_176237435 0.303 NM_133369
UNC5A
unc-5 homolog A (C. elegans)
chr7_+_102073953 0.301 NM_001126340
NM_032831
ORAI2

ORAI calcium release-activated calcium modulator 2

chr6_+_72926462 0.300 NM_001168410
RIMS1
regulating synaptic membrane exocytosis 1
chr1_+_26438267 0.287 NM_001243533
NM_152835
PDIK1L

PDLIM1 interacting kinase 1 like

chr11_-_70507911 0.287 NM_133266
SHANK2
SH3 and multiple ankyrin repeat domains 2
chr18_-_74207145 0.281 NM_014643
ZNF516
zinc finger protein 516
chr16_-_46655303 0.270 NM_024745
SHCBP1
SHC SH2-domain binding protein 1
chr5_+_56471272 0.257 NM_001127235
GPBP1
GC-rich promoter binding protein 1
chrX_-_112066353 0.252 NM_001113490
AMOT
angiomotin
chr1_-_151431892 0.246 NM_001194937
NM_001194938
NM_015100
NM_145796
POGZ



pogo transposable element with ZNF domain



chr1_-_151414641 0.241 NM_207171
POGZ
pogo transposable element with ZNF domain
chr12_+_99038918 0.239 NM_001160
NM_013229
NM_181861
NM_181868
NM_181869
APAF1




apoptotic peptidase activating factor 1




chr11_-_70935807 0.236 NM_012309
SHANK2
SH3 and multiple ankyrin repeat domains 2
chr7_+_155089483 0.234 NM_005542
NM_198336
NM_198337
INSIG1


insulin induced gene 1


chr8_+_16884745 0.227 NM_181723
EFHA2
EF-hand domain family, member A2
chr2_+_204192915 0.226 NM_005759
ABI2
abl-interactor 2
chr17_+_58677489 0.224 NM_003620
PPM1D
protein phosphatase, Mg2+/Mn2+ dependent, 1D
chr3_+_43328001 0.219 NM_001100594
NM_017719
SNRK

SNF related kinase

chr21_-_19191643 0.213 NM_001100420
NM_001100421
NM_017447
C21orf91


chromosome 21 open reading frame 91


chr10_-_35930357 0.211 NM_031866
FZD8
frizzled family receptor 8
chr6_+_72922513 0.210 NM_001168407
NM_001168408
RIMS1

regulating synaptic membrane exocytosis 1

chr12_-_76478737 0.207 NM_004537
NM_139207
NAP1L1

nucleosome assembly protein 1-like 1

chr6_+_72596648 0.206 NM_014989
RIMS1
regulating synaptic membrane exocytosis 1
chr6_+_76311617 0.204 NM_001100409
NM_015571
SENP6

SUMO1/sentrin specific peptidase 6

chr12_+_68042493 0.198 NM_003583
NM_006482
DYRK2

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2

chr6_+_72926144 0.196 NM_001168409
RIMS1
regulating synaptic membrane exocytosis 1
chr10_-_75255747 0.193 NM_001142353
NM_001142354
NM_021132
PPP3CB


protein phosphatase 3, catalytic subunit, beta isozyme


chrX_-_112084006 0.193 NM_133265
AMOT
angiomotin
chr5_+_56469655 0.192 NM_001203246
NM_022913
GPBP1

GC-rich promoter binding protein 1

chr3_-_18466759 0.190 NM_001195470
NM_002971
SATB1

SATB homeobox 1

chr5_+_56509900 0.186 NM_001127236
GPBP1
GC-rich promoter binding protein 1
chr6_+_3118861 0.185 NM_004332
BPHL
biphenyl hydrolase-like (serine hydrolase)
chr7_-_139876718 0.179 NM_030647
JHDM1D
jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae)
chr4_+_48343502 0.179 NM_020846
SLAIN2
SLAIN motif family, member 2
chr22_-_46933066 0.174 NM_014246
CELSR1
cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
chr4_-_87374282 0.169 NM_002753
MAPK10
mitogen-activated protein kinase 10
chr12_+_122459791 0.167 NM_001024808
NM_020993
BCL7A

B-cell CLL/lymphoma 7A

chr7_-_30029284 0.164 NM_001145515
NM_014766
NM_001145513
SCRN1


secernin 1


chr4_-_87028805 0.163 NM_138981
MAPK10
mitogen-activated protein kinase 10
chr12_-_49582800 0.158 NM_006009
TUBA1A
tubulin, alpha 1a
chr14_+_90863302 0.157 NM_006888
CALM1
calmodulin 1 (phosphorylase kinase, delta)
chr15_+_57210823 0.157 NM_003205
NM_207036
NM_207037
NM_207038
TCF12



transcription factor 12



chr17_+_29718641 0.155 NM_032932
RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr6_-_99797530 0.154 NM_032511
C6orf168
chromosome 6 open reading frame 168
chr10_-_27149989 0.151 NM_001012750
NM_001012751
NM_001012752
NM_001178116
NM_001178119
NM_001178120
NM_001178121
NM_001178122
NM_001178123
NM_001178124
NM_001178125
NM_005470
ABI1











abl-interactor 1











chrX_-_154114431 0.149 NM_019863
F8
coagulation factor VIII, procoagulant component
chr11_-_86666211 0.146 NM_012193
FZD4
frizzled family receptor 4
chrX_+_38663072 0.145 NM_021242
MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chr15_-_45815001 0.144 NM_013309
SLC30A4
solute carrier family 30 (zinc transporter), member 4
chr7_-_30029904 0.142 NM_001145514
SCRN1
secernin 1
chr7_-_106301329 0.139 NM_175884
C7orf74
chromosome 7 open reading frame 74
chr17_-_8534008 0.138 NM_005964
MYH10
myosin, heavy chain 10, non-muscle
chr12_-_95945226 0.133 NM_032147
USP44
ubiquitin specific peptidase 44
chr3_-_15563160 0.132 NM_005677
NM_080539
COLQ

collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase

chr9_+_71819926 0.132 NM_001170415
NM_001170416
TJP2

tight junction protein 2 (zona occludens 2)

chr3_-_15540378 0.130 NM_080538
COLQ
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
chr6_+_133562488 0.126 NM_004100
NM_172103
NM_172105
EYA4


eyes absent homolog 4 (Drosophila)


chr4_-_87281374 0.120 NM_138980
NM_138982
MAPK10

mitogen-activated protein kinase 10

chr12_-_95942570 0.118 NM_001042403
USP44
ubiquitin specific peptidase 44
chrX_+_30671456 0.118 NM_000167
NM_001128127
NM_001205019
NM_203391
GK



glycerol kinase



chr6_+_73076431 0.116 NM_001168411
RIMS1
regulating synaptic membrane exocytosis 1
chr15_+_57511616 0.116 NM_207040
TCF12
transcription factor 12
chr2_+_139259349 0.114 NM_001001664
SPOPL
speckle-type POZ protein-like
chrX_-_154250769 0.113 NM_000132
F8
coagulation factor VIII, procoagulant component
chr1_-_108507474 0.112 NM_006113
VAV3
vav 3 guanine nucleotide exchange factor
chr1_-_39338976 0.109 NM_012333
MYCBP
c-myc binding protein
chr9_-_74383301 0.109 NM_001135820
NM_013390
TMEM2

transmembrane protein 2

chr11_-_129872719 0.106 NM_020228
NM_199437
PRDM10

PR domain containing 10

chr3_-_18480203 0.101 NM_001131010
SATB1
SATB homeobox 1
chr3_-_125094003 0.101 NM_021964
ZNF148
zinc finger protein 148
chr2_+_32288579 0.100 NM_014946
NM_199436
SPAST

spastin

chr8_+_58906968 0.100 NM_147189
FAM110B
family with sequence similarity 110, member B
chr22_-_45404785 0.098 NM_001242450
PHF21B
PHD finger protein 21B
chr13_+_49684388 0.098 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr17_-_47841517 0.095 NM_030802
FAM117A
family with sequence similarity 117, member A
chr13_+_49549953 0.095 NM_001079673
FNDC3A
fibronectin type III domain containing 3A
chrX_+_38660653 0.092 NM_001098790
NM_001098791
MID1IP1

MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))

chr4_+_103790125 0.092 NM_001008388
CISD2
CDGSH iron sulfur domain 2
chr1_-_70820363 0.092 NM_030816
ANKRD13C
ankyrin repeat domain 13C
chr7_+_107384278 0.090 NM_024814
CBLL1
Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1
chr9_+_71736179 0.088 NM_001170414
TJP2
tight junction protein 2 (zona occludens 2)
chr18_-_25757351 0.088 NM_001792
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr5_-_58295758 0.087 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr5_-_126366439 0.085 NM_178450
MARCH3
membrane-associated ring finger (C3HC4) 3
chr1_-_212965104 0.085 NM_001042549
NM_015471
NSL1

NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)

chr1_-_92351613 0.084 NM_001195683
NM_003243
TGFBR3

transforming growth factor, beta receptor III

chr16_-_80837878 0.083 NM_152342
CDYL2
chromodomain protein, Y-like 2
chr5_-_59783885 0.082 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr22_+_30279064 0.081 NM_021090
NM_153050
NM_153051
MTMR3


myotubularin related protein 3


chrX_-_24045302 0.080 NM_030624
KLHL15
kelch-like 15 (Drosophila)
chr5_-_58334936 0.080 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr3_-_37034609 0.077 NM_014805
EPM2AIP1
EPM2A (laforin) interacting protein 1
chr5_-_90679115 0.076 NM_020801
ARRDC3
arrestin domain containing 3
chr5_-_58571916 0.076 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr22_-_32146119 0.074 NM_173566
PRR14L
proline rich 14-like
chr2_+_66662516 0.073 NM_002398
MEIS1
Meis homeobox 1
chr5_-_59189620 0.073 NM_001104631
PDE4D
phosphodiesterase 4D, cAMP-specific
chr11_-_129817300 0.072 NM_199438
NM_199439
PRDM10

PR domain containing 10

chr3_+_14989076 0.072 NM_003298
NR2C2
nuclear receptor subfamily 2, group C, member 2
chr4_+_56212381 0.072 NM_024592
SRD5A3
steroid 5 alpha-reductase 3
chr22_-_45405780 0.070 NM_001135862
PHF21B
PHD finger protein 21B
chr1_-_108231122 0.069 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr22_-_45405429 0.069 NM_138415
PHF21B
PHD finger protein 21B
chr4_+_71200670 0.068 NM_033122
CABS1
calcium-binding protein, spermatid-specific 1
chr15_-_49338496 0.068 NM_001193489
NM_014701
SECISBP2L

SECIS binding protein 2-like

chr13_-_107220444 0.067 NM_018011
ARGLU1
arginine and glutamate rich 1
chr3_-_71803513 0.067 NM_001134649
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr9_+_128509616 0.066 NM_006195
PBX3
pre-B-cell leukemia homeobox 3
chr4_+_37455551 0.065 NM_001104629
C4orf19
chromosome 4 open reading frame 19
chr3_+_61547179 0.064 NM_002841
PTPRG
protein tyrosine phosphatase, receptor type, G
chr5_-_58652671 0.062 NM_001197219
PDE4D
phosphodiesterase 4D, cAMP-specific
chr11_+_74459900 0.061 NM_001098638
RNF169
ring finger protein 169
chr12_+_32654976 0.060 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr5_+_122110737 0.060 NM_003100
SNX2
sorting nexin 2
chr10_+_98592658 0.060 NM_032440
LCOR
ligand dependent nuclear receptor corepressor
chr5_+_60628085 0.060 NM_020928
ZSWIM6
zinc finger, SWIM-type containing 6
chr4_+_37585854 0.059 NM_018302
C4orf19
chromosome 4 open reading frame 19
chr12_+_46123495 0.059 NM_152641
ARID2
AT rich interactive domain 2 (ARID, RFX-like)
chr17_+_49337892 0.056 NM_016001
UTP18
UTP18 small subunit (SSU) processome component homolog (yeast)
chr1_-_205782135 0.055 NM_173854
SLC41A1
solute carrier family 41, member 1
chr1_+_100598705 0.054 NM_019083
CCDC76
coiled-coil domain containing 76
chr10_+_112631552 0.054 NM_001199492
NM_014456
NM_145341
PDCD4


programmed cell death 4 (neoplastic transformation inhibitor)


chr15_+_101142754 0.053 NM_024708
NM_198243
ASB7

ankyrin repeat and SOCS box containing 7

chr19_+_32836500 0.053 NM_001136156
NM_014910
ZNF507

zinc finger protein 507

chr16_+_55542909 0.053 NM_017839
LPCAT2
lysophosphatidylcholine acyltransferase 2
chr5_-_79286793 0.053 NM_001010891
NM_001167741
MTX3

metaxin 3

chr16_-_69166492 0.052 NM_001039690
CHTF8
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
chr16_+_9185534 0.051 NM_014117
C16orf72
chromosome 16 open reading frame 72
chr7_-_44924946 0.050 NM_033224
PURB
purine-rich element binding protein B
chr3_-_71803923 0.048 NM_173359
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr2_+_228029280 0.048 NM_000091
COL4A3
collagen, type IV, alpha 3 (Goodpasture antigen)
chr6_-_159065739 0.048 NM_006519
DYNLT1
dynein, light chain, Tctex-type 1
chr7_+_86781644 0.047 NM_001142326
NM_001142327
DMTF1

cyclin D binding myb-like transcription factor 1

chr5_-_114880536 0.047 NM_020177
FEM1C
fem-1 homolog c (C. elegans)
chr1_-_92371558 0.046 NM_001195684
TGFBR3
transforming growth factor, beta receptor III
chr17_-_46178559 0.046 NM_006807
CBX1
chromobox homolog 1
chr3_-_71774407 0.045 NM_001134651
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr15_-_56535475 0.044 NM_022841
RFX7
regulatory factor X, 7
chr11_-_85376159 0.043 NM_001039618
CREBZF
CREB/ATF bZIP transcription factor
chr22_+_21213248 0.043 NM_004782
SNAP29
synaptosomal-associated protein, 29kDa
chr1_+_145611018 0.042 NM_014455
RNF115
ring finger protein 115
chr16_+_53088791 0.041 NM_025134
CHD9
chromodomain helicase DNA binding protein 9
chr5_+_112043188 0.041 NM_001127511
APC
adenomatous polyposis coli
chr3_+_186501360 0.041 NM_001967
EIF4A2
eukaryotic translation initiation factor 4A2
chr4_-_170192193 0.041 NM_020870
SH3RF1
SH3 domain containing ring finger 1
chr9_+_128510477 0.040 NM_001134778
PBX3
pre-B-cell leukemia homeobox 3
chr16_-_69166062 0.040 NM_001040146
CHTF8
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
chr7_+_86781869 0.039 NM_021145
DMTF1
cyclin D binding myb-like transcription factor 1
chr3_-_56717132 0.039 NM_001112736
FAM208A
family with sequence similarity 208, member A
chr2_+_42396392 0.038 NM_001145076
NM_019063
EML4

echinoderm microtubule associated protein like 4

chr16_+_81478774 0.038 NM_198390
CMIP
c-Maf inducing protein
chr13_+_50571137 0.036 NM_001007278
NM_005798
NM_052811
NM_213590
TRIM13



tripartite motif containing 13



chr1_+_19923457 0.036 NM_001204088
NM_001204089
NM_001032363
NM_001204082
NM_001204083
C1orf151-NBL1

MINOS1


C1orf151-NBL1 readthrough

mitochondrial inner membrane organizing system 1


chr11_-_123525300 0.035 NM_001040151
NM_018400
SCN3B

sodium channel, voltage-gated, type III, beta

chr8_-_117887045 0.034 NM_006265
RAD21
RAD21 homolog (S. pombe)
chr3_-_56698073 0.033 NM_015224
FAM208A
family with sequence similarity 208, member A
chr7_-_120498128 0.033 NM_012338
TSPAN12
tetraspanin 12
chr5_+_102594406 0.033 NM_033211
C5orf30
chromosome 5 open reading frame 30
chr2_+_174219537 0.031 NM_031942
NM_145810
CDCA7

cell division cycle associated 7

chr1_+_110527327 0.031 NM_001242673
NM_006621
AHCYL1

adenosylhomocysteinase-like 1

chr6_+_73331570 0.031 NM_001160130
NM_001160132
NM_001160133
NM_001160134
NM_019842
KCNQ5




potassium voltage-gated channel, KQT-like subfamily, member 5




chr15_-_64648359 0.031 NM_022048
CSNK1G1
casein kinase 1, gamma 1
chr2_+_239229140 0.030 NM_001139490
NM_015650
TRAF3IP1

TNF receptor-associated factor 3 interacting protein 1

chr17_-_46178761 0.030 NM_001127228
CBX1
chromobox homolog 1
chr16_+_1664640 0.029 NM_020825
CRAMP1L
Crm, cramped-like (Drosophila)
chr8_+_48920969 0.029 NM_003350
UBE2V2
ubiquitin-conjugating enzyme E2 variant 2
chr11_+_9685624 0.029 NM_015055
SWAP70
SWAP switching B-cell complex 70kDa subunit
chr5_-_59064437 0.028 NM_001197218
PDE4D
phosphodiesterase 4D, cAMP-specific
chr10_+_98592015 0.028 NM_001170765
NM_001170766
LCOR

ligand dependent nuclear receptor corepressor

chr9_-_74979829 0.027 NM_001102420
NM_001102421
NM_006007
ZFAND5


zinc finger, AN1-type domain 5


chr3_+_29322802 0.027 NM_001003792
NM_001003793
NM_001177711
NM_001177712
NM_014483
RBMS3




RNA binding motif, single stranded interacting protein 3




chr21_+_34697197 0.026 NM_000629
IFNAR1
interferon (alpha, beta and omega) receptor 1
chr10_+_94050858 0.026 NM_017824
MARCH5
membrane-associated ring finger (C3HC4) 5
chr6_-_13711643 0.026 NM_005493
RANBP9
RAN binding protein 9

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
6.97 4.59e-03 GO:0043010 camera-type eye development
4.38 1.59e-02 GO:0007423 sensory organ development
5.47 3.20e-02 GO:0001654 eye development
1.69 3.69e-02 GO:0016043 cellular component organization
1.67 4.43e-02 GO:0071840 cellular component organization or biogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
10.29 3.46e-05 GO:0030027 lamellipodium
1.26 1.89e-04 GO:0044424 intracellular part
1.24 6.58e-04 GO:0005622 intracellular
1.30 1.64e-03 GO:0043229 intracellular organelle
1.29 1.83e-03 GO:0043226 organelle
1.32 2.86e-03 GO:0043227 membrane-bounded organelle
1.31 5.23e-03 GO:0043231 intracellular membrane-bounded organelle
4.83 1.71e-02 GO:0031252 cell leading edge
1.42 4.33e-02 GO:0005634 nucleus

Nothing significant found in function category.