Motif ID: UUGUUCG

Z-value: 0.806


Mature miRNA associated with seed UUGUUCG:

NamemiRBase Accession
hsa-miR-375 MIMAT0000728



Activity profile for motif UUGUUCG.

activity profile for motif UUGUUCG


Sorted Z-values histogram for motif UUGUUCG

Sorted Z-values for motif UUGUUCG



Network of associatons between targets according to the STRING database.



First level regulatory network of UUGUUCG

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_137475076 1.897 NM_003551
NME5
non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)
chr4_+_72052354 1.799 NM_001098484
NM_001134742
SLC4A4

solute carrier family 4, sodium bicarbonate cotransporter, member 4

chr1_+_38022514 1.509 NM_003462
DNALI1
dynein, axonemal, light intermediate chain 1
chr13_+_36050885 1.486 NM_001204197
NBEA
neurobeachin
chr14_+_74486049 1.420 NM_025057
C14orf45
chromosome 14 open reading frame 45
chr1_+_78956727 1.363 NM_000959
NM_001039585
PTGFR

prostaglandin F receptor (FP)

chr17_+_7761063 1.288 NM_144607
CYB5D1
cytochrome b5 domain containing 1
chr13_+_35516390 1.213 NM_015678
NBEA
neurobeachin
chr7_-_131241321 1.144 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr4_+_72204769 1.079 NM_003759
SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr7_-_102715014 0.986 NM_145032
FBXL13
F-box and leucine-rich repeat protein 13
chr14_+_74111577 0.953 NM_001201366
NM_031427
DNAL1

dynein, axonemal, light chain 1

chr7_-_102715171 0.901 NM_001111038
FBXL13
F-box and leucine-rich repeat protein 13
chr3_-_45883562 0.888 NM_020347
LZTFL1
leucine zipper transcription factor-like 1
chr1_+_18807423 0.886 NM_152375
KLHDC7A
kelch domain containing 7A
chr6_-_80247103 0.869 NM_001122769
NM_181714
LCA5

Leber congenital amaurosis 5

chr4_+_95679075 0.833 NM_001203
BMPR1B
bone morphogenetic protein receptor, type IB
chr6_-_132272311 0.796 NM_001901
CTGF
connective tissue growth factor
chr1_-_236445294 0.765 NM_019891
ERO1LB
ERO1-like beta (S. cerevisiae)
chr20_+_9049660 0.760 NM_001172646
PLCB4
phospholipase C, beta 4
chr7_-_130080823 0.747 NM_018718
CEP41
centrosomal protein 41kDa
chr19_-_50316360 0.747 NM_001171937
NM_025129
FUZ

fuzzy homolog (Drosophila)

chr20_+_9288446 0.727 NM_000933
PLCB4
phospholipase C, beta 4
chr2_-_68384575 0.707 NM_138458
WDR92
WD repeat domain 92
chr10_+_114133838 0.697 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr3_+_119421865 0.681 NM_033364
C3orf15
chromosome 3 open reading frame 15
chr20_+_9198036 0.678 NM_182797
PLCB4
phospholipase C, beta 4
chr10_+_114135013 0.675 NM_203380
ACSL5
acyl-CoA synthetase long-chain family member 5
chr3_+_100328432 0.660 NM_032787
GPR128
G protein-coupled receptor 128
chr11_-_115375065 0.659 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chr10_+_114135937 0.639 NM_016234
ACSL5
acyl-CoA synthetase long-chain family member 5
chr1_+_61547625 0.635 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr6_-_166075520 0.628 NM_006661
NM_001130690
PDE10A

phosphodiesterase 10A

chrX_-_112066353 0.625 NM_001113490
AMOT
angiomotin
chr5_+_149109814 0.608 NM_001172698
NM_133263
PPARGC1B

peroxisome proliferator-activated receptor gamma, coactivator 1 beta

chr5_+_149151502 0.598 NM_001172699
PPARGC1B
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
chr1_+_61542928 0.583 NM_001145511
NFIA
nuclear factor I/A
chr8_+_101170510 0.576 NM_003114
SPAG1
sperm associated antigen 1
chr2_+_149632772 0.564 NM_004522
KIF5C
kinesin family member 5C
chr8_+_101170231 0.562 NM_172218
SPAG1
sperm associated antigen 1
chr3_+_179370779 0.562 NM_003940
USP13
ubiquitin specific peptidase 13 (isopeptidase T-3)
chr1_+_213031596 0.556 NM_014053
FLVCR1
feline leukemia virus subgroup C cellular receptor 1
chr9_+_74729510 0.547 NM_001242507
GDA
guanine deaminase
chrX_+_53449804 0.544 NM_144968
NM_001031745
RIBC1

RIB43A domain with coiled-coils 1

chrX_+_16964730 0.541 NM_001080975
NM_004726
REPS2

RALBP1 associated Eps domain containing 2

chr19_-_14316980 0.517 NM_001008701
NM_014921
LPHN1

latrophilin 1

chr7_+_76751933 0.512 NM_020879
CCDC146
coiled-coil domain containing 146
chr7_+_90338711 0.505 NM_012395
CDK14
cyclin-dependent kinase 14
chr2_-_190649075 0.492 NM_001128150
NM_016467
ORMDL1

ORM1-like 1 (S. cerevisiae)

chr10_+_16478941 0.492 NM_001001484
NM_030664
PTER

phosphotriesterase related

chr10_+_124768401 0.489 NM_001609
ACADSB
acyl-CoA dehydrogenase, short/branched chain
chr22_-_42343079 0.479 NM_001002876
NM_024053
CENPM

centromere protein M

chr1_+_61547388 0.476 NM_001145512
NFIA
nuclear factor I/A
chr20_+_51588945 0.474 NM_173485
TSHZ2
teashirt zinc finger homeobox 2
chr3_-_114343791 0.472 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr8_-_94753211 0.470 NM_203390
RBM12B
RNA binding motif protein 12B
chr4_-_79860369 0.469 NM_001040202
PAQR3
progestin and adipoQ receptor family member III
chr3_-_160117314 0.468 NM_001190241
NM_020800
IFT80

intraflagellar transport 80 homolog (Chlamydomonas)

chr5_+_134240752 0.451 NM_032151
PCBD2
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2
chr3_+_197687070 0.449 NM_001136049
NM_033029
LMLN

leishmanolysin-like (metallopeptidase M8 family)

chr22_-_42336222 0.443 NM_001110215
CENPM
centromere protein M
chr3_-_160101443 0.442 NM_001190242
IFT80
intraflagellar transport 80 homolog (Chlamydomonas)
chr3_-_114343052 0.439 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr20_+_51801821 0.438 NM_001193421
TSHZ2
teashirt zinc finger homeobox 2
chr7_-_32534869 0.436 NM_001130710
NM_001139499
LSM5

LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)

chr7_+_17338182 0.434 NM_001621
AHR
aryl hydrocarbon receptor
chrX_-_112084006 0.432 NM_133265
AMOT
angiomotin
chr11_-_74178593 0.431 NM_005472
KCNE3
potassium voltage-gated channel, Isk-related family, member 3
chr15_+_57210823 0.431 NM_003205
NM_207036
NM_207037
NM_207038
TCF12



transcription factor 12



chr18_-_53255734 0.424 NM_001083962
NM_001243230
NM_003199
TCF4


transcription factor 4


chr2_-_213403280 0.421 NM_001042599
NM_005235
ERBB4

v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

chr5_+_76506705 0.419 NM_001029851
NM_001029852
NM_001029853
NM_001029854
NM_003719
PDE8B




phosphodiesterase 8B




chr11_-_105892908 0.419 NM_032424
KIAA1826
KIAA1826
chr5_-_121414011 0.410 NM_002317
LOX
lysyl oxidase
chr5_-_121412805 0.405 NM_001178102
LOX
lysyl oxidase
chr8_-_80679897 0.403 NM_001040708
NM_012258
HEY1

hairy/enhancer-of-split related with YRPW motif 1

chr15_-_44069501 0.401 NM_025165
ELL3
elongation factor RNA polymerase II-like 3
chr6_+_149068148 0.401 NM_005715
UST
uronyl-2-sulfotransferase
chr6_-_119252887 0.399 NM_017696
MCM9
minichromosome maintenance complex component 9
chr3_-_114478117 0.396 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr12_+_56414688 0.394 NM_022465
IKZF4
IKAROS family zinc finger 4 (Eos)
chr3_-_114102488 0.384 NM_001164342
ZBTB20
zinc finger and BTB domain containing 20
chr15_+_74610881 0.375 NM_182791
CCDC33
coiled-coil domain containing 33
chr17_-_36105005 0.374 NM_000458
NM_001165923
HNF1B

HNF1 homeobox B

chr1_-_213189087 0.372 NM_144567
ANGEL2
angel homolog 2 (Drosophila)
chr1_+_89990396 0.370 NM_001134476
LRRC8B
leucine rich repeat containing 8 family, member B
chr13_-_36429798 0.370 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr13_-_95364248 0.369 NM_007084
SOX21
SRY (sex determining region Y)-box 21
chrX_+_69674914 0.366 NM_001166278
DLG3
discs, large homolog 3 (Drosophila)
chr9_+_74764266 0.364 NM_001242505
NM_001242506
NM_004293
GDA


guanine deaminase


chr18_+_13218777 0.363 NM_181481
NM_181482
C18orf1

chromosome 18 open reading frame 1

chr10_+_96305521 0.360 NM_018063
HELLS
helicase, lymphoid-specific
chrX_+_69664704 0.358 NM_021120
DLG3
discs, large homolog 3 (Drosophila)
chr3_-_114790221 0.352 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr2_+_183943286 0.350 NM_001142314
NM_080876
DUSP19

dual specificity phosphatase 19

chr12_-_76742165 0.350 NM_024685
BBS10
Bardet-Biedl syndrome 10
chr5_+_153825497 0.347 NM_001131062
NM_001131063
NM_024632
SAP30L


SAP30-like


chr7_+_155089483 0.345 NM_005542
NM_198336
NM_198337
INSIG1


insulin induced gene 1


chr7_+_75831194 0.345 NM_001110199
SRRM3
serine/arginine repetitive matrix 3
chr2_-_222436996 0.342 NM_004438
EPHA4
EPH receptor A4
chr4_+_128802015 0.334 NM_001190799
NM_014264
PLK4

polo-like kinase 4

chr22_+_29168628 0.332 NM_173510
CCDC117
coiled-coil domain containing 117
chr9_+_214860 0.330 NM_203447
DOCK8
dedicator of cytokinesis 8
chr5_-_180688095 0.325 NM_032765
TRIM52
tripartite motif containing 52
chr17_+_7482804 0.324 NM_001251
NM_001040059
CD68

CD68 molecule

chr18_+_13611664 0.320 NM_001003674
NM_001003675
C18orf1

chromosome 18 open reading frame 1

chr1_-_86861923 0.319 NM_001007022
NM_001184765
NM_001184766
NM_020729
ODF2L



outer dense fiber of sperm tails 2-like



chr1_-_173962050 0.319 NM_172071
RC3H1
ring finger and CCCH-type domains 1
chr3_-_135914654 0.316 NM_018133
MSL2
male-specific lethal 2 homolog (Drosophila)
chr13_-_29292961 0.313 NM_001135919
NM_181785
SLC46A3

solute carrier family 46, member 3

chr4_+_15683265 0.313 NM_001145191
FAM200B
family with sequence similarity 200, member B
chr2_+_242641310 0.312 NM_032329
ING5
inhibitor of growth family, member 5
chr4_-_104020964 0.311 NM_020139
BDH2
3-hydroxybutyrate dehydrogenase, type 2
chr4_-_125633716 0.305 NM_001167882
NM_020337
ANKRD50

ankyrin repeat domain 50

chr11_-_86666211 0.305 NM_012193
FZD4
frizzled family receptor 4
chr18_+_13620866 0.304 NM_004338
NM_181483
C18orf1

chromosome 18 open reading frame 1

chr16_-_81110803 0.304 NM_001100873
NM_152337
C16orf46

chromosome 16 open reading frame 46

chr9_+_115983807 0.303 NM_001859
SLC31A1
solute carrier family 31 (copper transporters), member 1
chr18_-_30050394 0.302 NM_001242409
NM_022751
FAM59A

family with sequence similarity 59, member A

chr9_+_273025 0.300 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr10_-_126849556 0.300 NM_001083914
CTBP2
C-terminal binding protein 2
chrX_+_72782961 0.297 NM_001039840
CHIC1
cysteine-rich hydrophobic domain 1
chr3_-_182880463 0.297 NM_014398
LAMP3
lysosomal-associated membrane protein 3
chr1_-_174992552 0.293 NM_022100
MRPS14
mitochondrial ribosomal protein S14
chr15_+_57511616 0.292 NM_207040
TCF12
transcription factor 12
chr4_-_53525316 0.291 NM_022832
USP46
ubiquitin specific peptidase 46
chr1_-_226926875 0.288 NM_002221
ITPKB
inositol-trisphosphate 3-kinase B
chr3_+_32148000 0.288 NM_015141
GPD1L
glycerol-3-phosphate dehydrogenase 1-like
chr4_+_128802064 0.288 NM_001190801
PLK4
polo-like kinase 4
chr14_+_31028328 0.286 NM_017769
G2E3
G2/M-phase specific E3 ubiquitin protein ligase
chr3_+_133502876 0.286 NM_021203
SRPRB
signal recognition particle receptor, B subunit
chr7_+_56032065 0.286 NM_001202469
NM_001483
GBAS

glioblastoma amplified sequence

chr5_-_146833150 0.282 NM_001387
DPYSL3
dihydropyrimidinase-like 3
chrX_+_69672110 0.281 NM_020730
DLG3
discs, large homolog 3 (Drosophila)
chr13_-_52585472 0.279 NM_000053
NM_001005918
NM_001243182
ATP7B


ATPase, Cu++ transporting, beta polypeptide


chr7_-_32529972 0.278 NM_012322
LSM5
LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr4_+_85504056 0.276 NM_001263
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr10_+_104613966 0.275 NM_001136200
NM_144591
C10orf32-AS3MT
C10orf32

C10orf32-AS3MT readthrough
chromosome 10 open reading frame 32

chr1_+_57110745 0.275 NM_006252
PRKAA2
protein kinase, AMP-activated, alpha 2 catalytic subunit
chr5_-_34915713 0.273 NM_002853
RAD1
RAD1 homolog (S. pombe)
chr11_+_68079999 0.269 NM_002335
LRP5
low density lipoprotein receptor-related protein 5
chr1_-_21503352 0.269 NM_001198801
NM_001198802
EIF4G3

eukaryotic translation initiation factor 4 gamma, 3

chr10_-_52383611 0.265 NM_147156
SGMS1
sphingomyelin synthase 1
chr1_+_90024271 0.263 NM_015350
LRRC8B
leucine rich repeat containing 8 family, member B
chrX_+_95939661 0.263 NM_006729
NM_007309
DIAPH2

diaphanous homolog 2 (Drosophila)

chr12_+_38710556 0.257 NM_001013620
ALG10B
asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog B (yeast)
chr11_-_73309090 0.255 NM_015159
FAM168A
family with sequence similarity 168, member A
chr1_+_101003692 0.254 NM_022049
GPR88
G protein-coupled receptor 88
chr6_+_30295007 0.254 NM_172016
TRIM39
tripartite motif containing 39
chr12_-_57472573 0.253 NM_001130963
NM_015257
TMEM194A

transmembrane protein 194A

chr14_+_32047121 0.250 NM_001201573
NUBPL
nucleotide binding protein-like
chr3_-_52719514 0.247 NM_018313
PBRM1
polybromo 1
chr5_-_146889618 0.244 NM_001197294
DPYSL3
dihydropyrimidinase-like 3
chr9_-_135230358 0.243 NM_015046
SETX
senataxin
chr1_-_77685076 0.242 NM_005482
PIGK
phosphatidylinositol glycan anchor biosynthesis, class K
chr1_+_180601121 0.241 NM_001135669
NM_004736
XPR1

xenotropic and polytropic retrovirus receptor 1

chr1_+_113933474 0.240 NM_001142782
NM_152900
MAGI3

membrane associated guanylate kinase, WW and PDZ domain containing 3

chr14_+_32030579 0.239 NM_025152
NUBPL
nucleotide binding protein-like
chr5_-_59783885 0.238 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr13_+_73633097 0.237 NM_001730
KLF5
Kruppel-like factor 5 (intestinal)
chr6_+_30294620 0.237 NM_021253
TRIM39
tripartite motif containing 39
chr11_-_125933186 0.234 NM_001243597
NM_016952
CDON

Cdon homolog (mouse)

chr14_-_89020888 0.233 NM_007039
PTPN21
protein tyrosine phosphatase, non-receptor type 21
chr5_+_112312392 0.230 NM_001242377
NM_152624
DCP2

DCP2 decapping enzyme homolog (S. cerevisiae)

chr13_+_39261172 0.228 NM_207361
FREM2
FRAS1 related extracellular matrix protein 2
chr5_+_145583131 0.226 NM_018989
RBM27
RNA binding motif protein 27
chr2_+_46926049 0.224 NM_014011
SOCS5
suppressor of cytokine signaling 5
chr3_+_58223228 0.223 NM_020676
ABHD6
abhydrolase domain containing 6
chr19_+_10543110 0.221 NM_001111309
PDE4A
phosphodiesterase 4A, cAMP-specific
chr5_-_145562235 0.219 NM_020117
LARS
leucyl-tRNA synthetase
chr3_-_114866090 0.218 NM_015642
ZBTB20
zinc finger and BTB domain containing 20
chr4_+_48343502 0.217 NM_020846
SLAIN2
SLAIN motif family, member 2
chr5_-_58334936 0.217 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr8_+_67624652 0.215 NM_001033578
SGK3
serum/glucocorticoid regulated kinase family, member 3
chr2_-_172750724 0.214 NM_003705
SLC25A12
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
chr21_+_38455246 0.212 NM_003316
TTC3
tetratricopeptide repeat domain 3
chr16_+_2587951 0.211 NM_002613
NM_031268
PDPK1

3-phosphoinositide dependent protein kinase-1

chr21_-_36421586 0.210 NM_001754
RUNX1
runt-related transcription factor 1
chr1_+_236958539 0.210 NM_000254
MTR
5-methyltetrahydrofolate-homocysteine methyltransferase
chr3_-_13114547 0.208 NM_001134382
IQSEC1
IQ motif and Sec7 domain 1
chr12_-_131002409 0.207 NM_015347
RIMBP2
RIMS binding protein 2
chr2_-_219432955 0.206 NM_020935
USP37
ubiquitin specific peptidase 37
chr1_+_244515936 0.206 NM_001012970
C1orf100
chromosome 1 open reading frame 100
chr8_+_67687415 0.206 NM_013257
NM_170709
SGK3

serum/glucocorticoid regulated kinase family, member 3

chr2_+_139259349 0.204 NM_001001664
SPOPL
speckle-type POZ protein-like
chr11_+_93474717 0.202 NM_014039
C11orf54
chromosome 11 open reading frame 54
chr3_-_135913276 0.200 NM_001145417
MSL2
male-specific lethal 2 homolog (Drosophila)
chr17_-_62502410 0.199 NM_004396
DDX5
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
chr5_-_32174397 0.198 NM_022130
GOLPH3
golgi phosphoprotein 3 (coat-protein)
chr21_-_38338618 0.197 NM_001242784
HLCS
holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
chr6_-_143266283 0.196 NM_006734
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr4_-_53522756 0.195 NM_001134223
USP46
ubiquitin specific peptidase 46
chr8_+_98787808 0.194 NM_018407
LAPTM4B
lysosomal protein transmembrane 4 beta
chr4_+_159131400 0.193 NM_018342
TMEM144
transmembrane protein 144
chr14_+_32183774 0.193 NM_001201574
NUBPL
nucleotide binding protein-like
chr22_-_41842853 0.193 NM_016272
TOB2
transducer of ERBB2, 2
chr5_+_49962771 0.190 NM_001178056
NM_024615
PARP8

poly (ADP-ribose) polymerase family, member 8

chr5_+_148651395 0.189 NM_001146337
NM_152406
AFAP1L1

actin filament associated protein 1-like 1

chrX_-_108976509 0.188 NM_004458
NM_022977
ACSL4

acyl-CoA synthetase long-chain family member 4

chr16_-_12897693 0.188 NM_001099455
NM_018340
CPPED1

calcineurin-like phosphoesterase domain containing 1


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.41 1.77e-03 GO:0044260 cellular macromolecule metabolic process
2.59 2.46e-03 GO:0072358 cardiovascular system development
2.59 2.46e-03 GO:0072359 circulatory system development
1.29 9.53e-03 GO:0044237 cellular metabolic process
1.75 1.23e-02 GO:0009653 anatomical structure morphogenesis
1.66 1.26e-02 GO:0006464 protein modification process
2.61 2.12e-02 GO:0009792 embryo development ending in birth or egg hatching
1.62 2.44e-02 GO:0043412 macromolecule modification
35.93 3.31e-02 GO:0021563 glossopharyngeal nerve development
35.93 3.31e-02 GO:0021615 glossopharyngeal nerve morphogenesis
2.82 3.40e-02 GO:0001944 vasculature development
2.89 3.73e-02 GO:0001568 blood vessel development
1.41 4.90e-02 GO:0080090 regulation of primary metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.19 1.85e-06 GO:0044424 intracellular part
1.23 4.68e-06 GO:0043229 intracellular organelle
1.23 5.92e-06 GO:0043226 organelle
1.26 6.95e-06 GO:0043231 intracellular membrane-bounded organelle
1.26 7.93e-06 GO:0043227 membrane-bounded organelle
1.18 1.10e-05 GO:0005622 intracellular
1.31 2.70e-03 GO:0005634 nucleus
1.29 6.77e-03 GO:0044446 intracellular organelle part
1.28 1.12e-02 GO:0044422 organelle part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.15 9.29e-04 GO:0005488 binding
5.39 1.37e-02 GO:0004221 ubiquitin thiolesterase activity
11.23 1.93e-02 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
1.22 1.93e-02 GO:0005515 protein binding
1.78 3.73e-02 GO:0030528 transcription regulator activity