Motif ID: ZIC1..3.p2

Z-value: 1.202


Transcription factors associated with ZIC1..3.p2:

Gene SymbolEntrez IDGene Name
ZIC1 7545 Zic family member 1 (odd-paired homolog, Drosophila)
ZIC2 7546 Zic family member 2 (odd-paired homolog, Drosophila)
ZIC3 7547 Zic family member 3 (odd-paired homolog, Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ZIC3chrX_+_1366483130.479.2e-03Click!
ZIC1chr3_+_1471271510.202.9e-01Click!
ZIC2chr13_+_100633977,
chr13_+_100634257		-0.009.9e-01Click!


Activity profile for motif ZIC1..3.p2.

activity profile for motif ZIC1..3.p2


Sorted Z-values histogram for motif ZIC1..3.p2

Sorted Z-values for motif ZIC1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZIC1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_26205327 3.433 KIF3C
kinesin family member 3C
chrX_-_15872921 2.318 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr19_-_51456159 2.220 NM_001077491
NM_001077492
NM_012427
 KLK5


kallikrein-related peptidase 5


chrX_-_15872905 2.142


chr16_+_3405888 2.066 NM_012368
 OR2C1
olfactory receptor, family 2, subfamily C, member 1
chr19_-_41859519 1.855 TGFB1
transforming growth factor, beta 1
chr2_-_26205437 1.817 NM_002254
 KIF3C
kinesin family member 3C
chr15_+_39873276 1.565 NM_003246
 THBS1
thrombospondin 1
chrX_-_15872882 1.492 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr17_+_39968961 1.387 NM_021939
 FKBP10
FK506 binding protein 10, 65 kDa
chr2_+_70142303 1.332 MXD1
MAX dimerization protein 1
chr1_+_150521786 1.253 NM_019032
NM_025008
 ADAMTSL4

ADAMTS-like 4

chr22_-_37823503 1.246 NM_052906
 ELFN2
extracellular leucine-rich repeat and fibronectin type III domain containing 2
chr19_-_44285012 1.224 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr10_-_90712510 1.185 NM_001613
 ACTA2
actin, alpha 2, smooth muscle, aorta
chr1_-_205391180 1.166 NM_001001552
NM_001199050
NM_001199051
NM_001199052
 LEMD1



LEM domain containing 1



chr5_-_157002739 1.157 NM_033274
 ADAM19
ADAM metallopeptidase domain 19
chr1_+_38158176 1.133 CDCA8
cell division cycle associated 8
chr1_+_38158129 1.126 NM_018101
 CDCA8
cell division cycle associated 8
chr21_-_28217692 1.125 NM_006988
 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 97 entries
enrichment   p-value GO term description
4.43 4.13e-04 GO:0009954 proximal/distal pattern formation
2.35 1.91e-03 GO:0010769 regulation of cell morphogenesis involved in differentiation
2.33 2.37e-03 GO:0022604 regulation of cell morphogenesis
2.27 9.37e-04 GO:0031344 regulation of cell projection organization
2.26 1.08e-02 GO:0010975 regulation of neuron projection development
2.13 4.42e-05 GO:0051129 negative regulation of cellular component organization
2.11 3.08e-02 GO:0043406 positive regulation of MAP kinase activity
2.09 2.89e-02 GO:0034330 cell junction organization
2.06 1.88e-03 GO:0045664 regulation of neuron differentiation
2.04 1.83e-02 GO:0071902 positive regulation of protein serine/threonine kinase activity
2.00 4.74e-06 GO:0007411 axon guidance
1.98 9.83e-04 GO:0050767 regulation of neurogenesis
1.97 2.10e-04 GO:0051960 regulation of nervous system development
1.88 2.67e-06 GO:0048667 cell morphogenesis involved in neuron differentiation
1.87 5.59e-04 GO:0060284 regulation of cell development
1.86 9.28e-06 GO:0007409 axonogenesis
1.85 1.73e-03 GO:0022603 regulation of anatomical structure morphogenesis
1.81 3.21e-05 GO:0048812 neuron projection morphogenesis
1.80 4.26e-07 GO:0048666 neuron development
1.79 3.99e-02 GO:0045596 negative regulation of cell differentiation

Gene overrepresentation in compartment category:

Showing 1 to 20 of 29 entries
enrichment   p-value GO term description
5.31 1.00e-02 GO:0001518 voltage-gated sodium channel complex
2.50 4.14e-04 GO:0005925 focal adhesion
2.38 1.34e-03 GO:0005924 cell-substrate adherens junction
2.36 1.08e-03 GO:0030055 cell-substrate junction
2.25 1.36e-04 GO:0005912 adherens junction
2.18 1.43e-03 GO:0034703 cation channel complex
2.13 3.89e-04 GO:0070161 anchoring junction
1.90 1.38e-02 GO:0030424 axon
1.88 4.19e-02 GO:0030136 clathrin-coated vesicle
1.84 9.80e-03 GO:0034702 ion channel complex
1.78 4.85e-02 GO:0030135 coated vesicle
1.72 5.56e-07 GO:0030054 cell junction
1.70 1.09e-02 GO:0015629 actin cytoskeleton
1.70 1.95e-02 GO:0012506 vesicle membrane
1.70 2.76e-02 GO:0030659 cytoplasmic vesicle membrane
1.67 1.17e-02 GO:0044433 cytoplasmic vesicle part
1.60 8.16e-03 GO:0045202 synapse
1.58 1.66e-02 GO:0043005 neuron projection
1.41 2.07e-06 GO:0005856 cytoskeleton
1.37 2.56e-02 GO:0042995 cell projection

Gene overrepresentation in function category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
5.12 7.21e-03 GO:0005248 voltage-gated sodium channel activity
2.59 3.67e-03 GO:0005262 calcium channel activity
2.13 3.17e-03 GO:0022843 voltage-gated cation channel activity
1.87 5.47e-04 GO:0005261 cation channel activity
1.66 2.61e-02 GO:0016563 transcription activator activity
1.55 2.71e-04 GO:0043565 sequence-specific DNA binding
1.52 4.19e-06 GO:0001071 nucleic acid binding transcription factor activity
1.52 4.19e-06 GO:0003700 sequence-specific DNA binding transcription factor activity
1.42 2.14e-02 GO:0042802 identical protein binding
1.38 6.83e-03 GO:0030528 transcription regulator activity
1.20 4.85e-13 GO:0005515 protein binding
1.08 3.13e-06 GO:0005488 binding