Motif ID: bHLH_family.p2

Z-value: 1.245


Transcription factors associated with bHLH_family.p2:

Gene SymbolEntrez IDGene Name
ARNTL 406 aryl hydrocarbon receptor nuclear translocator-like
ARNTL2 56938 aryl hydrocarbon receptor nuclear translocator-like 2
CLOCK 9575 clock homolog (mouse)
HES6 55502 hairy and enhancer of split 6 (Drosophila)
HEY1 23462 hairy/enhancer-of-split related with YRPW motif 1
HEY2 23493 hairy/enhancer-of-split related with YRPW motif 2
HEYL 26508 hairy/enhancer-of-split related with YRPW motif-like
ID1 3397 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
MITF 4286 microphthalmia-associated transcription factor
MLXIPL 51085 MLX interacting protein-like
MNT 4335 MAX binding protein
MXD3 83463 MAX dimerization protein 3
MXD4 10608 MAX dimerization protein 4
MXI1 4601 MAX interactor 1
NPAS2 4862 neuronal PAS domain protein 2
OLIG1 116448 oligodendrocyte transcription factor 1
OLIG2 10215 oligodendrocyte lineage transcription factor 2
TFE3 7030 transcription factor binding to IGHM enhancer 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MXI1chr10_+_111969988,
chr10_+_111985628
-0.604.4e-04Click!
ARNTLchr11_+_132993910.422.1e-02Click!
ARNTL2chr12_-_27599557-0.384.0e-02Click!
MITFchr3_+_699857500.384.1e-02Click!
MLXIPLchr7_-_73038814-0.364.8e-02Click!
ID1chr20_+_30193083-0.301.1e-01Click!
HEY2chr6_+_1260707380.291.1e-01Click!
HEYLchr1_-_40098639-0.271.5e-01Click!
MNTchr17_-_2304217-0.222.3e-01Click!
CLOCKchr4_-_564129680.222.5e-01Click!
TFE3chrX_-_48900752-0.212.6e-01Click!
MXD4chr4_-_2263808-0.173.6e-01Click!
NPAS2chr2_+_101436491-0.115.8e-01Click!
HES6chr2_-_2391485450.105.9e-01Click!
OLIG1chr21_+_34442446-0.105.9e-01Click!
OLIG2chr21_+_34398210-0.096.4e-01Click!
MXD3chr5_-_176739291-0.096.5e-01Click!
HEY1chr8_-_806798970.019.8e-01Click!


Activity profile for motif bHLH_family.p2.

activity profile for motif bHLH_family.p2


Sorted Z-values histogram for motif bHLH_family.p2

Sorted Z-values for motif bHLH_family.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of bHLH_family.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_58146110 5.154 CDK4
cyclin-dependent kinase 4
chr12_-_58146118 5.107 NM_000075
CDK4
cyclin-dependent kinase 4
chr12_-_58146025 4.872 CDK4
cyclin-dependent kinase 4
chr12_-_58146108 3.512 CDK4
cyclin-dependent kinase 4
chr11_+_61560401 2.840 FEN1
flap structure-specific endonuclease 1
chr2_-_10588451 2.520 NM_002539
ODC1
ornithine decarboxylase 1
chr17_+_39382878 2.500 NM_031961
KRTAP9-2
keratin associated protein 9-2
chr5_-_172755195 2.319 STC2
stanniocalcin 2
chr11_+_61560352 2.284 FEN1
flap structure-specific endonuclease 1
chr16_+_89778242 1.999 LOC100128881
uncharacterized LOC100128881
chr11_+_61560108 1.988 NM_004111
FEN1
flap structure-specific endonuclease 1
chr3_+_99536667 1.933 NM_032359
C3orf26
chromosome 3 open reading frame 26
chr5_-_172755418 1.883 STC2
stanniocalcin 2
chr2_+_172864803 1.872 NM_199227
METAP1D
methionyl aminopeptidase type 1D (mitochondrial)
chr5_+_150827138 1.860 NM_078483
SLC36A1
solute carrier family 36 (proton/amino acid symporter), member 1
chr2_-_10588273 1.830 ODC1
ornithine decarboxylase 1
chrX_-_100603956 1.789 NM_004085
TIMM8A
translocase of inner mitochondrial membrane 8 homolog A (yeast)
chr17_+_39261640 1.737 NM_001146041
KRTAP4-9
keratin associated protein 4-9
chr1_-_26233367 1.720 NM_203399
STMN1
stathmin 1
chr14_-_20923266 1.686 NM_017807
OSGEP
O-sialoglycoprotein endopeptidase

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 31 entries
enrichment   p-value GO term description
3.21 1.72e-02 GO:0015682 ferric iron transport
3.21 1.72e-02 GO:0033572 transferrin transport
2.19 4.77e-04 GO:0042254 ribosome biogenesis
2.02 1.33e-02 GO:0006403 RNA localization
1.99 3.55e-02 GO:0050657 nucleic acid transport
1.99 3.55e-02 GO:0050658 RNA transport
1.99 3.55e-02 GO:0051236 establishment of RNA localization
1.98 9.19e-03 GO:0015931 nucleobase, nucleoside, nucleotide and nucleic acid transport
1.92 1.11e-03 GO:0034470 ncRNA processing
1.80 4.13e-04 GO:0034660 ncRNA metabolic process
1.80 1.57e-02 GO:0022613 ribonucleoprotein complex biogenesis
1.77 1.92e-02 GO:0071843 cellular component biogenesis at cellular level
1.58 4.98e-02 GO:0015672 monovalent inorganic cation transport
1.52 2.46e-06 GO:0055085 transmembrane transport
1.51 3.44e-04 GO:0006396 RNA processing
1.47 2.31e-02 GO:0016071 mRNA metabolic process
1.29 1.04e-03 GO:0016070 RNA metabolic process
1.28 3.63e-05 GO:0090304 nucleic acid metabolic process
1.27 1.46e-03 GO:0010467 gene expression
1.25 1.94e-05 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 25 entries
enrichment   p-value GO term description
4.38 3.55e-02 GO:0005732 small nucleolar ribonucleoprotein complex
3.37 5.15e-03 GO:0044452 nucleolar part
1.73 1.28e-08 GO:0005730 nucleolus
1.40 7.12e-11 GO:0031981 nuclear lumen
1.38 1.22e-06 GO:0005654 nucleoplasm
1.36 8.34e-12 GO:0031974 membrane-enclosed lumen
1.36 5.76e-11 GO:0070013 intracellular organelle lumen
1.36 1.37e-10 GO:0044428 nuclear part
1.35 8.83e-11 GO:0043233 organelle lumen
1.34 4.22e-02 GO:0031967 organelle envelope
1.21 3.86e-04 GO:0043228 non-membrane-bounded organelle
1.21 3.86e-04 GO:0043232 intracellular non-membrane-bounded organelle
1.19 9.34e-05 GO:0032991 macromolecular complex
1.18 2.04e-03 GO:0043234 protein complex
1.17 2.47e-08 GO:0044422 organelle part
1.17 3.26e-08 GO:0044446 intracellular organelle part
1.14 8.22e-05 GO:0005634 nucleus
1.11 3.56e-06 GO:0005737 cytoplasm
1.11 1.29e-02 GO:0044444 cytoplasmic part
1.10 2.45e-11 GO:0005622 intracellular

Gene overrepresentation in function category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
1.36 4.30e-03 GO:0022891 substrate-specific transmembrane transporter activity
1.31 2.46e-02 GO:0022857 transmembrane transporter activity
1.30 2.69e-02 GO:0022892 substrate-specific transporter activity
1.27 3.98e-02 GO:0005215 transporter activity
1.16 4.02e-11 GO:0005515 protein binding
1.07 2.10e-05 GO:0005488 binding