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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for AIRE

Z-value: 0.60

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Transcription factors associated with AIRE

Gene Symbol Gene ID Gene Info
AIRE
ENSG00000160224.12 autoimmune regulator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
AIREhg19_v2_chr21_+_45705752_457057670.384.1e-02Click!

Activity profile of AIRE motif

Sorted Z-values of AIRE motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_57524061 2.49 ENST00000508121.1
HOPX
HOP homeobox
chr12_-_25101920 1.73 ENST00000539780.1
ENST00000546285.1
ENST00000342945.5
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr8_+_54764346 1.53 ENST00000297313.3
ENST00000344277.6
RGS20
regulator of G-protein signaling 20
chr12_+_75874984 1.28 ENST00000550491.1
GLIPR1
GLI pathogenesis-related 1
chr21_-_44495919 1.20 ENST00000398158.1
CBS
cystathionine-beta-synthase
chr12_+_75874580 1.12 ENST00000456650.3
GLIPR1
GLI pathogenesis-related 1
chr21_-_44495964 1.05 ENST00000398168.1
ENST00000398165.3
CBS
cystathionine-beta-synthase
chr21_+_30502806 1.04 ENST00000399928.1
ENST00000399926.1
MAP3K7CL
MAP3K7 C-terminal like
chr14_-_55658323 1.02 ENST00000554067.1
ENST00000247191.2
DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr20_+_44637526 1.01 ENST00000372330.3
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr14_-_55658252 1.01 ENST00000395425.2
DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr16_+_11439286 1.00 ENST00000312499.5
ENST00000576027.1
RMI2
RecQ mediated genome instability 2
chr4_-_104119528 0.98 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
CENPE
centromere protein E, 312kDa
chr1_+_165864821 0.97 ENST00000470820.1
UCK2
uridine-cytidine kinase 2
chr21_+_39644305 0.94 ENST00000398930.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr21_+_39644214 0.93 ENST00000438657.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr17_+_7210294 0.91 ENST00000336452.7
EIF5A
eukaryotic translation initiation factor 5A
chr21_+_39644172 0.91 ENST00000398932.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr11_+_35211511 0.91 ENST00000524922.1
CD44
CD44 molecule (Indian blood group)
chr21_+_39644395 0.90 ENST00000398934.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr12_+_75874460 0.89 ENST00000266659.3
GLIPR1
GLI pathogenesis-related 1
chr1_-_161208013 0.76 ENST00000515452.1
ENST00000367983.4
NR1I3
nuclear receptor subfamily 1, group I, member 3
chr6_-_39290744 0.74 ENST00000507712.1
KCNK16
potassium channel, subfamily K, member 16
chr12_-_11139511 0.74 ENST00000506868.1
TAS2R50
taste receptor, type 2, member 50
chr16_+_32077386 0.70 ENST00000354689.6
IGHV3OR16-9
immunoglobulin heavy variable 3/OR16-9 (non-functional)
chr9_-_70178815 0.65 ENST00000377420.1
FOXD4L5
forkhead box D4-like 5
chr5_-_77844974 0.65 ENST00000515007.2
LHFPL2
lipoma HMGIC fusion partner-like 2
chr9_+_42717234 0.63 ENST00000377590.1
FOXD4L2
forkhead box D4-like 2
chr8_-_7309887 0.61 ENST00000458665.1
ENST00000528168.1
SPAG11B
sperm associated antigen 11B
chr9_-_70429731 0.60 ENST00000377413.1
FOXD4L4
forkhead box D4-like 4
chr9_-_113761720 0.60 ENST00000541779.1
ENST00000374430.2
LPAR1
lysophosphatidic acid receptor 1
chr19_+_45418067 0.60 ENST00000589078.1
ENST00000586638.1
APOC1
apolipoprotein C-I
chr15_-_99789736 0.56 ENST00000560235.1
ENST00000394132.2
ENST00000560860.1
ENST00000558078.1
ENST00000394136.1
ENST00000262074.4
ENST00000558613.1
ENST00000394130.1
ENST00000560772.1
TTC23
tetratricopeptide repeat domain 23
chr4_-_120222076 0.56 ENST00000504110.1
C4orf3
chromosome 4 open reading frame 3
chr3_-_121468513 0.55 ENST00000494517.1
ENST00000393667.3
GOLGB1
golgin B1
chr2_-_225811747 0.55 ENST00000409592.3
DOCK10
dedicator of cytokinesis 10
chr3_-_121468602 0.54 ENST00000340645.5
GOLGB1
golgin B1
chr22_+_36649056 0.53 ENST00000397278.3
ENST00000422706.1
ENST00000426053.1
ENST00000319136.4
APOL1
apolipoprotein L, 1
chr8_+_7716700 0.53 ENST00000454911.2
ENST00000326625.5
SPAG11A
sperm associated antigen 11A
chrX_-_49041242 0.52 ENST00000453382.1
ENST00000540849.1
ENST00000536904.1
ENST00000432913.1
PRICKLE3
prickle homolog 3 (Drosophila)
chr9_-_21482312 0.52 ENST00000448696.3
IFNE
interferon, epsilon
chr10_-_75682535 0.50 ENST00000409178.1
C10orf55
chromosome 10 open reading frame 55
chr19_+_45417812 0.50 ENST00000592535.1
APOC1
apolipoprotein C-I
chr10_-_101841588 0.49 ENST00000370418.3
CPN1
carboxypeptidase N, polypeptide 1
chr19_-_48753064 0.49 ENST00000520153.1
ENST00000357778.5
ENST00000520015.1
CARD8
caspase recruitment domain family, member 8
chr16_+_446713 0.49 ENST00000397722.1
ENST00000454619.1
NME4
NME/NM23 nucleoside diphosphate kinase 4
chr2_-_136633940 0.47 ENST00000264156.2
MCM6
minichromosome maintenance complex component 6
chr17_-_39150385 0.46 ENST00000391586.1
KRTAP3-3
keratin associated protein 3-3
chr19_+_45417921 0.46 ENST00000252491.4
ENST00000592885.1
ENST00000589781.1
APOC1
apolipoprotein C-I
chr7_-_36764142 0.45 ENST00000258749.5
ENST00000535891.1
AOAH
acyloxyacyl hydrolase (neutrophil)
chr12_+_10658489 0.45 ENST00000538173.1
EIF2S3L
Putative eukaryotic translation initiation factor 2 subunit 3-like protein
chr1_-_161207986 0.44 ENST00000506209.1
ENST00000367980.2
NR1I3
nuclear receptor subfamily 1, group I, member 3
chr2_-_208994548 0.43 ENST00000282141.3
CRYGC
crystallin, gamma C
chr14_-_106668095 0.43 ENST00000390606.2
IGHV3-20
immunoglobulin heavy variable 3-20
chr8_+_128748308 0.43 ENST00000377970.2
MYC
v-myc avian myelocytomatosis viral oncogene homolog
chr20_-_43150601 0.43 ENST00000541235.1
ENST00000255175.1
ENST00000342374.4
SERINC3
serine incorporator 3
chr2_-_202508169 0.42 ENST00000409883.2
TMEM237
transmembrane protein 237
chr20_+_44036900 0.41 ENST00000443296.1
DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr9_+_90112117 0.40 ENST00000358077.5
DAPK1
death-associated protein kinase 1
chr15_-_22448819 0.39 ENST00000604066.1
IGHV1OR15-1
immunoglobulin heavy variable 1/OR15-1 (non-functional)
chr19_-_59084922 0.39 ENST00000215057.2
ENST00000599369.1
MZF1
myeloid zinc finger 1
chr12_-_11287243 0.38 ENST00000539585.1
TAS2R30
taste receptor, type 2, member 30
chr19_-_23869970 0.37 ENST00000601010.1
ZNF675
zinc finger protein 675
chr7_-_36764004 0.37 ENST00000431169.1
AOAH
acyloxyacyl hydrolase (neutrophil)
chr3_-_33686925 0.37 ENST00000485378.2
ENST00000313350.6
ENST00000487200.1
CLASP2
cytoplasmic linker associated protein 2
chr14_-_106967788 0.36 ENST00000390622.2
IGHV1-46
immunoglobulin heavy variable 1-46
chr3_-_139199565 0.36 ENST00000511956.1
RBP2
retinol binding protein 2, cellular
chrM_-_14670 0.36 ENST00000361681.2
MT-ND6
mitochondrially encoded NADH dehydrogenase 6
chr1_+_248201474 0.35 ENST00000366479.2
OR2L2
olfactory receptor, family 2, subfamily L, member 2
chr2_+_201981527 0.35 ENST00000441224.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr20_+_44036620 0.34 ENST00000372710.3
DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr19_-_48753028 0.33 ENST00000522431.1
CARD8
caspase recruitment domain family, member 8
chr12_-_6579833 0.33 ENST00000396308.3
VAMP1
vesicle-associated membrane protein 1 (synaptobrevin 1)
chr14_-_107283278 0.33 ENST00000390639.2
IGHV7-81
immunoglobulin heavy variable 7-81 (non-functional)
chr4_-_114682936 0.33 ENST00000454265.2
ENST00000429180.1
ENST00000418639.2
ENST00000394526.2
ENST00000296402.5
CAMK2D
calcium/calmodulin-dependent protein kinase II delta
chr19_-_47249679 0.32 ENST00000263280.6
STRN4
striatin, calmodulin binding protein 4
chr11_-_85376121 0.32 ENST00000527447.1
CREBZF
CREB/ATF bZIP transcription factor
chr6_+_42584847 0.32 ENST00000372883.3
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr14_-_75330537 0.32 ENST00000556084.2
ENST00000556489.2
ENST00000445876.1
PROX2
prospero homeobox 2
chr12_+_20848486 0.32 ENST00000545102.1
SLCO1C1
solute carrier organic anion transporter family, member 1C1
chr16_+_50059125 0.31 ENST00000427478.2
CNEP1R1
CTD nuclear envelope phosphatase 1 regulatory subunit 1
chr1_-_243326612 0.31 ENST00000492145.1
ENST00000490813.1
ENST00000464936.1
CEP170
centrosomal protein 170kDa
chr16_-_31147020 0.30 ENST00000568261.1
ENST00000567797.1
ENST00000317508.6
PRSS8
protease, serine, 8
chr16_+_56672571 0.30 ENST00000290705.8
MT1A
metallothionein 1A
chr6_+_160327974 0.30 ENST00000252660.4
MAS1
MAS1 oncogene
chr2_+_204732487 0.30 ENST00000302823.3
CTLA4
cytotoxic T-lymphocyte-associated protein 4
chr8_-_16043780 0.30 ENST00000445506.2
MSR1
macrophage scavenger receptor 1
chr1_+_36038971 0.29 ENST00000373235.3
TFAP2E
transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)
chr22_+_36649170 0.29 ENST00000438034.1
ENST00000427990.1
ENST00000347595.7
ENST00000397279.4
ENST00000433768.1
ENST00000440669.2
APOL1
apolipoprotein L, 1
chr6_+_26538566 0.29 ENST00000377575.2
HMGN4
high mobility group nucleosomal binding domain 4
chr15_+_85523671 0.28 ENST00000310298.4
ENST00000557957.1
PDE8A
phosphodiesterase 8A
chr22_-_32767017 0.28 ENST00000400234.1
RFPL3S
RFPL3 antisense
chr4_-_120243545 0.28 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chr2_+_234686976 0.27 ENST00000389758.3
MROH2A
maestro heat-like repeat family member 2A
chrX_-_139866723 0.26 ENST00000370532.2
CDR1
cerebellar degeneration-related protein 1, 34kDa
chr1_-_52456352 0.26 ENST00000371655.3
RAB3B
RAB3B, member RAS oncogene family
chr19_-_23869999 0.25 ENST00000601935.1
ENST00000359788.4
ENST00000600313.1
ENST00000596211.1
ENST00000599168.1
ZNF675
zinc finger protein 675
chr11_-_18956556 0.25 ENST00000302797.3
MRGPRX1
MAS-related GPR, member X1
chr8_-_7220490 0.25 ENST00000400078.2
ZNF705G
zinc finger protein 705G
chr19_-_36304201 0.25 ENST00000301175.3
PRODH2
proline dehydrogenase (oxidase) 2
chr17_-_295730 0.24 ENST00000329099.4
FAM101B
family with sequence similarity 101, member B
chr22_+_40322623 0.24 ENST00000399090.2
GRAP2
GRB2-related adaptor protein 2
chr19_-_16606988 0.24 ENST00000269881.3
CALR3
calreticulin 3
chr4_+_71587669 0.24 ENST00000381006.3
ENST00000226328.4
RUFY3
RUN and FYVE domain containing 3
chr12_+_7282795 0.24 ENST00000266546.6
CLSTN3
calsyntenin 3
chr22_+_40322595 0.23 ENST00000420971.1
ENST00000544756.1
GRAP2
GRB2-related adaptor protein 2
chr14_-_65409438 0.23 ENST00000557049.1
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr6_-_32806506 0.23 ENST00000374897.2
ENST00000452392.2
TAP2
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Uncharacterized protein
chr2_+_219840955 0.22 ENST00000598002.1
ENST00000432733.1
LINC00608
long intergenic non-protein coding RNA 608
chr6_+_167525277 0.21 ENST00000400926.2
CCR6
chemokine (C-C motif) receptor 6
chr14_-_46185155 0.21 ENST00000555442.1
RP11-369C8.1
RP11-369C8.1
chr2_-_166060571 0.21 ENST00000360093.3
SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr5_+_32788945 0.20 ENST00000326958.1
AC026703.1
AC026703.1
chr5_-_36242119 0.20 ENST00000511088.1
ENST00000282512.3
ENST00000506945.1
NADK2
NAD kinase 2, mitochondrial
chr4_-_17513851 0.20 ENST00000281243.5
QDPR
quinoid dihydropteridine reductase
chr9_-_4666421 0.19 ENST00000381895.5
SPATA6L
spermatogenesis associated 6-like
chr1_+_152627927 0.19 ENST00000444515.1
ENST00000536536.1
LINC00302
long intergenic non-protein coding RNA 302
chr6_-_33864684 0.19 ENST00000506222.2
ENST00000533304.1
LINC01016
long intergenic non-protein coding RNA 1016
chr1_+_100810575 0.18 ENST00000542213.1
CDC14A
cell division cycle 14A
chr1_+_241815577 0.18 ENST00000366552.2
ENST00000437684.2
WDR64
WD repeat domain 64
chr2_-_166060552 0.17 ENST00000283254.7
ENST00000453007.1
SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr11_+_6947647 0.17 ENST00000278319.5
ZNF215
zinc finger protein 215
chr5_+_122181279 0.16 ENST00000395451.4
ENST00000506996.1
SNX24
sorting nexin 24
chr20_+_54823788 0.15 ENST00000243911.2
MC3R
melanocortin 3 receptor
chr13_-_46756351 0.15 ENST00000323076.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr22_+_25202232 0.15 ENST00000400358.4
ENST00000400359.4
SGSM1
small G protein signaling modulator 1
chr16_-_28503327 0.15 ENST00000535392.1
ENST00000395653.4
CLN3
ceroid-lipofuscinosis, neuronal 3
chr3_-_36781352 0.15 ENST00000416516.2
DCLK3
doublecortin-like kinase 3
chr6_+_36839616 0.14 ENST00000359359.2
ENST00000510325.2
C6orf89
chromosome 6 open reading frame 89
chr20_-_33735070 0.14 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chr16_+_72088376 0.14 ENST00000570083.1
ENST00000355906.5
ENST00000398131.2
ENST00000569639.1
ENST00000564499.1
ENST00000357763.4
ENST00000562526.1
ENST00000565574.1
ENST00000568417.2
ENST00000356967.5
HP
HPR
haptoglobin
haptoglobin-related protein
chr4_+_71588372 0.14 ENST00000536664.1
RUFY3
RUN and FYVE domain containing 3
chr10_-_46030787 0.14 ENST00000395769.2
MARCH8
membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
chr1_-_152297679 0.13 ENST00000368799.1
FLG
filaggrin
chr12_-_50677255 0.13 ENST00000551691.1
ENST00000394943.3
ENST00000341247.4
LIMA1
LIM domain and actin binding 1
chr2_+_207804278 0.13 ENST00000272852.3
CPO
carboxypeptidase O
chr18_-_37380230 0.13 ENST00000591629.1
LINC00669
long intergenic non-protein coding RNA 669
chr20_-_43093968 0.12 ENST00000306731.4
ENST00000372910.3
C20orf62
chromosome 20 open reading frame 62
chr12_-_64784471 0.12 ENST00000333722.5
C12orf56
chromosome 12 open reading frame 56
chr5_+_122181184 0.11 ENST00000513881.1
SNX24
sorting nexin 24
chr7_+_20686946 0.11 ENST00000443026.2
ENST00000406935.1
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr3_-_121264848 0.11 ENST00000264233.5
POLQ
polymerase (DNA directed), theta
chr18_+_39766626 0.10 ENST00000593234.1
ENST00000585627.1
ENST00000591199.1
ENST00000586990.1
ENST00000593051.1
ENST00000593316.1
ENST00000591381.1
ENST00000585639.1
ENST00000589068.1
LINC00907
long intergenic non-protein coding RNA 907
chr15_-_38519066 0.10 ENST00000561320.1
ENST00000561161.1
RP11-346D14.1
RP11-346D14.1
chr7_-_55606346 0.09 ENST00000545390.1
VOPP1
vesicular, overexpressed in cancer, prosurvival protein 1
chr8_+_104384616 0.09 ENST00000520337.1
CTHRC1
collagen triple helix repeat containing 1
chr17_+_36452989 0.08 ENST00000312513.5
ENST00000582535.1
MRPL45
mitochondrial ribosomal protein L45
chr1_-_52344471 0.08 ENST00000352171.7
ENST00000354831.7
NRD1
nardilysin (N-arginine dibasic convertase)
chr6_+_118869452 0.08 ENST00000357525.5
PLN
phospholamban
chr15_-_83209210 0.07 ENST00000561157.1
ENST00000330244.6
RPS17L
ribosomal protein S17-like
chr11_-_5345582 0.07 ENST00000328813.2
OR51B2
olfactory receptor, family 51, subfamily B, member 2
chr6_-_169582835 0.07 ENST00000564830.1
RP11-417E7.2
RP11-417E7.2
chr14_+_45605127 0.07 ENST00000556036.1
ENST00000267430.5
FANCM
Fanconi anemia, complementation group M
chr11_+_30252549 0.07 ENST00000254122.3
ENST00000417547.1
FSHB
follicle stimulating hormone, beta polypeptide
chr9_+_117904097 0.06 ENST00000374016.1
DEC1
deleted in esophageal cancer 1
chr2_+_1417228 0.06 ENST00000382269.3
ENST00000337415.3
ENST00000345913.4
ENST00000346956.3
ENST00000349624.3
ENST00000539820.1
ENST00000329066.4
ENST00000382201.3
TPO
thyroid peroxidase
chr1_+_207669573 0.06 ENST00000400960.2
ENST00000534202.1
CR1
complement component (3b/4b) receptor 1 (Knops blood group)
chr5_-_107703556 0.06 ENST00000496714.1
FBXL17
F-box and leucine-rich repeat protein 17
chrX_+_70503433 0.06 ENST00000276079.8
ENST00000373856.3
ENST00000373841.1
ENST00000420903.1
NONO
non-POU domain containing, octamer-binding
chr2_+_166150541 0.06 ENST00000283256.6
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr19_-_36643329 0.05 ENST00000589154.1
COX7A1
cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
chr3_-_133648656 0.05 ENST00000408895.2
C3orf36
chromosome 3 open reading frame 36
chr6_+_22221010 0.05 ENST00000567753.1
RP11-524C21.2
RP11-524C21.2
chr9_-_104198042 0.05 ENST00000374855.4
ALDOB
aldolase B, fructose-bisphosphate
chr12_-_6579808 0.05 ENST00000535180.1
ENST00000400911.3
VAMP1
vesicle-associated membrane protein 1 (synaptobrevin 1)
chr4_-_88450612 0.05 ENST00000418378.1
ENST00000282470.6
SPARCL1
SPARC-like 1 (hevin)
chr1_-_35497506 0.05 ENST00000317538.5
ENST00000373340.2
ENST00000357182.4
ZMYM6
zinc finger, MYM-type 6
chr3_+_88199099 0.04 ENST00000486971.1
C3orf38
chromosome 3 open reading frame 38
chr8_+_24241789 0.03 ENST00000256412.4
ENST00000538205.1
ADAMDEC1
ADAM-like, decysin 1
chr10_-_46030841 0.03 ENST00000453424.2
MARCH8
membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
chr2_-_89568263 0.03 ENST00000473726.1
IGKV1-33
immunoglobulin kappa variable 1-33
chr1_+_207669613 0.02 ENST00000367049.4
ENST00000529814.1
CR1
complement component (3b/4b) receptor 1 (Knops blood group)
chr12_-_75603482 0.02 ENST00000341669.3
ENST00000298972.1
ENST00000350228.2
KCNC2
potassium voltage-gated channel, Shaw-related subfamily, member 2
chr8_-_141774467 0.02 ENST00000520151.1
ENST00000519024.1
ENST00000519465.1
PTK2
protein tyrosine kinase 2
chr12_-_76462713 0.02 ENST00000552056.1
NAP1L1
nucleosome assembly protein 1-like 1
chr11_+_64794875 0.02 ENST00000377244.3
ENST00000534637.1
ENST00000524831.1
SNX15
sorting nexin 15
chr14_+_21236586 0.02 ENST00000326783.3
EDDM3B
epididymal protein 3B
chr4_-_47465666 0.02 ENST00000381571.4
COMMD8
COMM domain containing 8
chrX_-_102941596 0.02 ENST00000441076.2
ENST00000422355.1
ENST00000442614.1
ENST00000422154.2
ENST00000451301.1
MORF4L2
mortality factor 4 like 2
chr1_+_206223941 0.01 ENST00000367126.4
AVPR1B
arginine vasopressin receptor 1B
chr3_+_46412345 0.01 ENST00000292303.4
CCR5
chemokine (C-C motif) receptor 5 (gene/pseudogene)
chr19_-_10491234 0.00 ENST00000524462.1
ENST00000531836.1
ENST00000525621.1
TYK2
tyrosine kinase 2
chr7_-_149194843 0.00 ENST00000458143.2
ENST00000340622.3
ZNF746
zinc finger protein 746
chr3_+_107318157 0.00 ENST00000406780.1
BBX
bobby sox homolog (Drosophila)

Network of associatons between targets according to the STRING database.

First level regulatory network of AIRE

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0006535 cysteine biosynthetic process from serine(GO:0006535)
0.5 3.0 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.4 1.6 GO:0010900 negative regulation of phosphatidylcholine catabolic process(GO:0010900)
0.3 1.7 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.2 1.0 GO:0006238 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
0.2 0.6 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.1 0.4 GO:0090094 metanephric cap development(GO:0072185) metanephric cap morphogenesis(GO:0072186) metanephric cap mesenchymal cell proliferation involved in metanephros development(GO:0090094)
0.1 1.0 GO:0051549 positive regulation of keratinocyte migration(GO:0051549)
0.1 0.9 GO:0045905 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.1 0.9 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 0.5 GO:0030070 insulin processing(GO:0030070)
0.1 2.5 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.1 0.2 GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476)
0.1 3.7 GO:0010107 potassium ion import(GO:0010107)
0.1 0.6 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.1 0.2 GO:0051066 dihydrobiopterin metabolic process(GO:0051066)
0.1 0.3 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 0.4 GO:0009597 detection of virus(GO:0009597)
0.1 0.3 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.1 0.3 GO:0051944 peptidyl-cysteine methylation(GO:0018125) positive regulation of neurotransmitter uptake(GO:0051582) positive regulation of dopamine uptake involved in synaptic transmission(GO:0051586) positive regulation of catecholamine uptake involved in synaptic transmission(GO:0051944)
0.1 0.2 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.0 0.5 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.1 GO:0036512 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.0 0.1 GO:2000296 negative regulation of hydrogen peroxide catabolic process(GO:2000296)
0.0 0.3 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.0 0.2 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.0 0.5 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.5 GO:0006228 UTP biosynthetic process(GO:0006228)
0.0 0.7 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.1 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.0 0.3 GO:1903944 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.0 0.5 GO:1901725 regulation of histone deacetylase activity(GO:1901725)
0.0 0.3 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
0.0 0.4 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.0 1.0 GO:0000732 strand displacement(GO:0000732)
0.0 0.1 GO:0045957 regulation of complement activation, alternative pathway(GO:0030451) negative regulation of complement activation, alternative pathway(GO:0045957)
0.0 1.1 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 1.8 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.1 GO:0086092 regulation of the force of heart contraction by cardiac conduction(GO:0086092) regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877) regulation of calcium ion import into sarcoplasmic reticulum(GO:1902080) negative regulation of calcium ion import into sarcoplasmic reticulum(GO:1902081)
0.0 0.2 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 0.4 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.0 0.4 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.2 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)
0.0 0.5 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 0.3 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.1 GO:0048749 compound eye development(GO:0048749)
0.0 0.3 GO:0050713 negative regulation of interleukin-1 beta secretion(GO:0050713)
0.0 0.3 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.0 0.3 GO:0010867 positive regulation of triglyceride biosynthetic process(GO:0010867)
0.0 0.3 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 0.8 GO:0019835 cytolysis(GO:0019835)
0.0 1.0 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 0.1 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.0 0.1 GO:0043932 ossification involved in bone remodeling(GO:0043932)
0.0 0.3 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.2 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.1 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0 0.4 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.3 GO:1901032 negative regulation of response to reactive oxygen species(GO:1901032) negative regulation of hydrogen peroxide-induced cell death(GO:1903206)
0.0 0.3 GO:0071294 cellular response to zinc ion(GO:0071294)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 2.0 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 1.0 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 0.3 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.1 0.9 GO:0005642 annulate lamellae(GO:0005642)
0.1 2.4 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.0 1.8 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 3.6 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 0.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.2 GO:0042825 TAP complex(GO:0042825)
0.0 0.5 GO:0042555 MCM complex(GO:0042555)
0.0 0.4 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.4 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.3 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 0.3 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
0.0 0.7 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.2 GO:0060091 kinocilium(GO:0060091)
0.0 1.1 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.3 GO:0031265 CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342)
0.0 0.2 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.4 GO:0071437 invadopodium(GO:0071437)
0.0 1.0 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.4 GO:0035869 ciliary transition zone(GO:0035869)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0004122 cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809)
0.3 1.7 GO:0052655 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.3 0.8 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.2 3.7 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.2 1.2 GO:0004882 androgen receptor activity(GO:0004882)
0.2 1.0 GO:0043515 kinetochore binding(GO:0043515)
0.2 1.6 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.1 1.0 GO:0004849 uridine kinase activity(GO:0004849)
0.1 0.6 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 0.2 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.1 0.5 GO:1901612 cardiolipin binding(GO:1901612)
0.1 0.3 GO:0032089 NACHT domain binding(GO:0032089)
0.1 1.1 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.9 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.2 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433)
0.0 0.3 GO:0070728 leucine binding(GO:0070728)
0.0 0.3 GO:0001595 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0 0.2 GO:0070404 NADH binding(GO:0070404)
0.0 0.2 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0 0.3 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.7 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 1.8 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.5 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 1.0 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.4 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.1 GO:0004877 complement component C4b receptor activity(GO:0001861) complement component C3b receptor activity(GO:0004877)
0.0 0.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.5 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.3 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.1 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.1 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 0.4 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.3 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.3 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.4 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.3 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 0.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.2 GO:0019841 retinol binding(GO:0019841)
0.0 0.3 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 0.1 GO:0004447 iodide peroxidase activity(GO:0004447)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.7 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.9 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 2.0 PID AURORA A PATHWAY Aurora A signaling
0.0 1.5 ST G ALPHA I PATHWAY G alpha i Pathway
0.0 0.5 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.0 PID PLK1 PATHWAY PLK1 signaling events
0.0 2.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.7 PID IFNG PATHWAY IFN-gamma pathway
0.0 0.3 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.7 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 1.7 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 2.2 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.9 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.7 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 1.5 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 1.0 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.5 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.4 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 1.0 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.9 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 3.3 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 1.2 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.5 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.3 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.3 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis