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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for ALX1_ARX

Z-value: 0.45

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Transcription factors associated with ALX1_ARX

Gene Symbol Gene ID Gene Info
ALX1
ENSG00000180318.3 ALX homeobox 1
ARX
ENSG00000004848.6 aristaless related homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ARXhg19_v2_chrX_-_25034065_25034088-0.222.4e-01Click!
ALX1hg19_v2_chr12_+_85673868_85673885-0.019.5e-01Click!

Activity profile of ALX1_ARX motif

Sorted Z-values of ALX1_ARX motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_102413726 1.33 ENST00000350878.4
MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr6_+_34204642 1.24 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1
high mobility group AT-hook 1
chr1_+_50569575 0.99 ENST00000371827.1
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr4_+_69313145 0.98 ENST00000305363.4
TMPRSS11E
transmembrane protease, serine 11E
chr1_+_84630645 0.75 ENST00000394839.2
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr1_-_94147385 0.74 ENST00000260502.6
BCAR3
breast cancer anti-estrogen resistance 3
chr10_-_75226166 0.71 ENST00000544628.1
PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr7_-_93520259 0.68 ENST00000222543.5
TFPI2
tissue factor pathway inhibitor 2
chr3_-_141747950 0.65 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr4_+_169013666 0.64 ENST00000359299.3
ANXA10
annexin A10
chr17_+_39261584 0.63 ENST00000391415.1
KRTAP4-9
keratin associated protein 4-9
chr10_+_69865866 0.62 ENST00000354393.2
MYPN
myopalladin
chr1_-_151148492 0.61 ENST00000295314.4
TMOD4
tropomodulin 4 (muscle)
chr8_-_10512569 0.61 ENST00000382483.3
RP1L1
retinitis pigmentosa 1-like 1
chr1_-_151148442 0.59 ENST00000441701.1
ENST00000416280.2
TMOD4
tropomodulin 4 (muscle)
chr7_-_93520191 0.56 ENST00000545378.1
TFPI2
tissue factor pathway inhibitor 2
chr2_-_31440377 0.53 ENST00000444918.2
ENST00000403897.3
CAPN14
calpain 14
chr1_+_154401791 0.51 ENST00000476006.1
IL6R
interleukin 6 receptor
chr17_-_60885700 0.48 ENST00000583600.1
MARCH10
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
chr17_-_60885659 0.48 ENST00000311269.5
MARCH10
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
chrX_+_107288239 0.48 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chr6_-_66417107 0.47 ENST00000370621.3
ENST00000370618.3
ENST00000503581.1
ENST00000393380.2
EYS
eyes shut homolog (Drosophila)
chr8_-_91095099 0.47 ENST00000265431.3
CALB1
calbindin 1, 28kDa
chr5_-_39270725 0.46 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
FYB
FYN binding protein
chrX_+_107288197 0.46 ENST00000415430.3
VSIG1
V-set and immunoglobulin domain containing 1
chr15_+_42066632 0.45 ENST00000457542.2
ENST00000221214.6
ENST00000260357.7
ENST00000456763.2
MAPKBP1
mitogen-activated protein kinase binding protein 1
chr12_-_89746173 0.45 ENST00000308385.6
DUSP6
dual specificity phosphatase 6
chr19_+_7030589 0.43 ENST00000329753.5
MBD3L5
methyl-CpG binding domain protein 3-like 5
chrY_-_6742068 0.42 ENST00000215479.5
AMELY
amelogenin, Y-linked
chr3_+_111393501 0.41 ENST00000393934.3
PLCXD2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr14_-_95236551 0.39 ENST00000238558.3
GSC
goosecoid homeobox
chr10_-_29923893 0.38 ENST00000355867.4
SVIL
supervillin
chr2_-_145278475 0.38 ENST00000558170.2
ZEB2
zinc finger E-box binding homeobox 2
chr19_-_7040190 0.38 ENST00000381394.4
MBD3L4
methyl-CpG binding domain protein 3-like 4
chr18_+_616672 0.37 ENST00000338387.7
CLUL1
clusterin-like 1 (retinal)
chr19_+_7049332 0.36 ENST00000381393.3
MBD3L2
methyl-CpG binding domain protein 3-like 2
chr2_+_228678550 0.35 ENST00000409189.3
ENST00000358813.4
CCL20
chemokine (C-C motif) ligand 20
chr2_+_65215604 0.35 ENST00000531327.1
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr8_-_122653630 0.34 ENST00000303924.4
HAS2
hyaluronan synthase 2
chr19_-_6393465 0.33 ENST00000394456.5
GTF2F1
general transcription factor IIF, polypeptide 1, 74kDa
chr1_+_62439037 0.33 ENST00000545929.1
INADL
InaD-like (Drosophila)
chr5_+_36152179 0.33 ENST00000508514.1
ENST00000513151.1
ENST00000546211.1
SKP2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr18_+_616711 0.32 ENST00000579494.1
CLUL1
clusterin-like 1 (retinal)
chr6_+_26199737 0.32 ENST00000359985.1
HIST1H2BF
histone cluster 1, H2bf
chr9_+_124329336 0.30 ENST00000394340.3
ENST00000436835.1
ENST00000259371.2
DAB2IP
DAB2 interacting protein
chr17_+_3118915 0.30 ENST00000304094.1
OR1A1
olfactory receptor, family 1, subfamily A, member 1
chr19_-_6393216 0.30 ENST00000595047.1
GTF2F1
general transcription factor IIF, polypeptide 1, 74kDa
chr17_+_74463650 0.30 ENST00000392492.3
AANAT
aralkylamine N-acetyltransferase
chr18_-_19994830 0.30 ENST00000525417.1
CTAGE1
cutaneous T-cell lymphoma-associated antigen 1
chr1_+_206557366 0.29 ENST00000414007.1
ENST00000419187.2
SRGAP2
SLIT-ROBO Rho GTPase activating protein 2
chr7_+_138915102 0.28 ENST00000486663.1
UBN2
ubinuclein 2
chr5_+_36152091 0.28 ENST00000274254.5
SKP2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr18_-_44181442 0.28 ENST00000398722.4
LOXHD1
lipoxygenase homology domains 1
chr14_-_81425828 0.28 ENST00000555529.1
ENST00000556042.1
ENST00000556981.1
CEP128
centrosomal protein 128kDa
chr1_+_92632542 0.27 ENST00000409154.4
ENST00000370378.4
KIAA1107
KIAA1107
chr9_+_77230499 0.26 ENST00000396204.2
RORB
RAR-related orphan receptor B
chr3_-_141747439 0.26 ENST00000467667.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr7_-_14880892 0.26 ENST00000406247.3
ENST00000399322.3
ENST00000258767.5
DGKB
diacylglycerol kinase, beta 90kDa
chr17_-_3030875 0.26 ENST00000328890.2
OR1G1
olfactory receptor, family 1, subfamily G, member 1
chr14_+_57671888 0.25 ENST00000391612.1
AL391152.1
AL391152.1
chr2_+_58655461 0.25 ENST00000429095.1
ENST00000429664.1
ENST00000452840.1
AC007092.1
long intergenic non-protein coding RNA 1122
chr5_+_36152163 0.24 ENST00000274255.6
SKP2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr17_-_39023462 0.24 ENST00000251643.4
KRT12
keratin 12
chr1_-_21377383 0.24 ENST00000374935.3
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr3_+_121774202 0.24 ENST00000469710.1
ENST00000493101.1
ENST00000330540.2
ENST00000264468.5
CD86
CD86 molecule
chr12_+_1099675 0.23 ENST00000545318.2
ERC1
ELKS/RAB6-interacting/CAST family member 1
chr4_-_143227088 0.23 ENST00000511838.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr14_+_24099318 0.22 ENST00000432832.2
DHRS2
dehydrogenase/reductase (SDR family) member 2
chr15_-_34331243 0.22 ENST00000306730.3
AVEN
apoptosis, caspase activation inhibitor
chr12_-_52946923 0.22 ENST00000267119.5
KRT71
keratin 71
chrX_+_11311533 0.22 ENST00000380714.3
ENST00000380712.3
ENST00000348912.4
AMELX
amelogenin, X-linked
chr8_+_77318769 0.22 ENST00000518732.1
RP11-706J10.1
long intergenic non-protein coding RNA 1111
chr6_-_26199499 0.21 ENST00000377831.5
HIST1H3D
histone cluster 1, H3d
chrX_+_38211777 0.20 ENST00000039007.4
OTC
ornithine carbamoyltransferase
chr1_-_234667504 0.20 ENST00000421207.1
ENST00000435574.1
RP5-855F14.1
RP5-855F14.1
chr1_-_200379180 0.19 ENST00000294740.3
ZNF281
zinc finger protein 281
chr6_-_26199471 0.19 ENST00000341023.1
HIST1H2AD
histone cluster 1, H2ad
chr12_-_57873631 0.19 ENST00000393791.3
ENST00000356411.2
ENST00000552249.1
ARHGAP9
Rho GTPase activating protein 9
chr2_+_234600253 0.19 ENST00000373424.1
ENST00000441351.1
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr12_-_118797475 0.19 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAOK3
TAO kinase 3
chr11_+_55029628 0.19 ENST00000417545.2
TRIM48
tripartite motif containing 48
chr1_+_52682052 0.18 ENST00000371591.1
ZFYVE9
zinc finger, FYVE domain containing 9
chr12_+_59989918 0.18 ENST00000547379.1
ENST00000549465.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr10_+_18689637 0.17 ENST00000377315.4
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr10_-_50396425 0.17 ENST00000374148.1
C10orf128
chromosome 10 open reading frame 128
chr2_+_54683419 0.17 ENST00000356805.4
SPTBN1
spectrin, beta, non-erythrocytic 1
chr18_+_10471826 0.17 ENST00000584596.2
APCDD1
adenomatosis polyposis coli down-regulated 1
chr3_+_130569429 0.17 ENST00000505330.1
ENST00000504381.1
ENST00000507488.2
ENST00000393221.4
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr15_+_80733570 0.16 ENST00000533983.1
ENST00000527771.1
ENST00000525103.1
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr4_-_122854612 0.16 ENST00000264811.5
TRPC3
transient receptor potential cation channel, subfamily C, member 3
chr12_-_67197760 0.16 ENST00000539540.1
ENST00000540433.1
ENST00000541947.1
ENST00000538373.1
GRIP1
glutamate receptor interacting protein 1
chr2_+_161993465 0.16 ENST00000457476.1
TANK
TRAF family member-associated NFKB activator
chr5_+_59783941 0.16 ENST00000506884.1
ENST00000504876.2
PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr4_-_103940791 0.16 ENST00000510559.1
ENST00000394789.3
ENST00000296422.7
SLC9B1
solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1
chr12_+_122688090 0.15 ENST00000324189.4
ENST00000546192.1
B3GNT4
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
chr9_-_27005686 0.15 ENST00000380055.5
LRRC19
leucine rich repeat containing 19
chr3_-_124774802 0.15 ENST00000311127.4
HEG1
heart development protein with EGF-like domains 1
chr2_-_166930131 0.15 ENST00000303395.4
ENST00000409050.1
ENST00000423058.2
ENST00000375405.3
SCN1A
sodium channel, voltage-gated, type I, alpha subunit
chr3_-_33759699 0.15 ENST00000399362.4
ENST00000359576.5
ENST00000307312.7
CLASP2
cytoplasmic linker associated protein 2
chrX_+_119737806 0.15 ENST00000371317.5
MCTS1
malignant T cell amplified sequence 1
chr4_-_119759795 0.15 ENST00000419654.2
SEC24D
SEC24 family member D
chr1_-_200379129 0.15 ENST00000367353.1
ZNF281
zinc finger protein 281
chr6_-_107235331 0.15 ENST00000433965.1
ENST00000430094.1
RP1-60O19.1
RP1-60O19.1
chr2_+_185463093 0.14 ENST00000302277.6
ZNF804A
zinc finger protein 804A
chr12_-_57873329 0.14 ENST00000424809.2
ARHGAP9
Rho GTPase activating protein 9
chr12_+_104337515 0.14 ENST00000550595.1
HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr11_+_55578854 0.13 ENST00000333973.2
OR5L1
olfactory receptor, family 5, subfamily L, member 1
chr4_+_156824840 0.13 ENST00000536354.2
TDO2
tryptophan 2,3-dioxygenase
chr10_-_112064665 0.13 ENST00000369603.5
SMNDC1
survival motor neuron domain containing 1
chr1_-_110933611 0.13 ENST00000472422.2
ENST00000437429.2
SLC16A4
solute carrier family 16, member 4
chr3_-_87325728 0.13 ENST00000350375.2
POU1F1
POU class 1 homeobox 1
chr3_-_194188956 0.13 ENST00000256031.4
ENST00000446356.1
ATP13A3
ATPase type 13A3
chr3_+_12329397 0.13 ENST00000397015.2
PPARG
peroxisome proliferator-activated receptor gamma
chr6_+_12007963 0.12 ENST00000607445.1
RP11-456H18.2
RP11-456H18.2
chr3_+_12329358 0.12 ENST00000309576.6
PPARG
peroxisome proliferator-activated receptor gamma
chr6_-_99797522 0.12 ENST00000389677.5
FAXC
failed axon connections homolog (Drosophila)
chr7_+_93535817 0.12 ENST00000248572.5
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr8_+_39792474 0.11 ENST00000502986.2
IDO2
indoleamine 2,3-dioxygenase 2
chr4_+_95128748 0.11 ENST00000359052.4
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr3_-_101039402 0.11 ENST00000193391.7
IMPG2
interphotoreceptor matrix proteoglycan 2
chr4_-_89951028 0.11 ENST00000506913.1
FAM13A
family with sequence similarity 13, member A
chr8_-_62602327 0.11 ENST00000445642.3
ENST00000517847.2
ENST00000389204.4
ENST00000517661.1
ENST00000517903.1
ENST00000522603.1
ENST00000522349.1
ENST00000522835.1
ENST00000541428.1
ENST00000518306.1
ASPH
aspartate beta-hydroxylase
chr14_+_95078714 0.11 ENST00000393078.3
ENST00000393080.4
ENST00000467132.1
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr10_-_50396407 0.11 ENST00000374153.2
ENST00000374151.3
C10orf128
chromosome 10 open reading frame 128
chr11_+_128563652 0.11 ENST00000527786.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr5_+_38148582 0.10 ENST00000508853.1
CTD-2207A17.1
CTD-2207A17.1
chr6_+_26087646 0.10 ENST00000309234.6
HFE
hemochromatosis
chr1_+_44679159 0.10 ENST00000315913.5
ENST00000372289.2
DMAP1
DNA methyltransferase 1 associated protein 1
chr3_-_87325612 0.10 ENST00000561167.1
ENST00000560656.1
ENST00000344265.3
POU1F1
POU class 1 homeobox 1
chr1_+_104615595 0.10 ENST00000418362.1
RP11-364B6.1
RP11-364B6.1
chr18_+_66465302 0.10 ENST00000360242.5
ENST00000358653.5
CCDC102B
coiled-coil domain containing 102B
chr5_+_59783540 0.10 ENST00000515734.2
PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr17_-_39254391 0.10 ENST00000333822.4
KRTAP4-8
keratin associated protein 4-8
chr2_+_75873902 0.10 ENST00000393909.2
ENST00000358788.6
ENST00000409374.1
MRPL19
mitochondrial ribosomal protein L19
chr12_+_18414446 0.10 ENST00000433979.1
PIK3C2G
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
chr17_-_71228357 0.10 ENST00000583024.1
ENST00000403627.3
ENST00000405159.3
ENST00000581110.1
FAM104A
family with sequence similarity 104, member A
chr1_+_44679113 0.10 ENST00000361745.6
ENST00000446292.1
ENST00000440641.1
ENST00000436069.1
ENST00000437511.1
DMAP1
DNA methyltransferase 1 associated protein 1
chr5_-_9630463 0.10 ENST00000382492.2
TAS2R1
taste receptor, type 2, member 1
chr3_-_98241760 0.10 ENST00000507874.1
ENST00000502299.1
ENST00000508659.1
ENST00000510545.1
ENST00000511667.1
ENST00000394185.2
ENST00000394181.2
ENST00000508902.1
ENST00000341181.6
ENST00000437922.1
ENST00000394180.2
CLDND1
claudin domain containing 1
chr4_-_174320687 0.10 ENST00000296506.3
SCRG1
stimulator of chondrogenesis 1
chr7_+_107224364 0.10 ENST00000491150.1
BCAP29
B-cell receptor-associated protein 29
chr1_+_192127578 0.10 ENST00000367460.3
RGS18
regulator of G-protein signaling 18
chr4_-_143226979 0.09 ENST00000514525.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr6_-_150067696 0.09 ENST00000340413.2
ENST00000367403.3
NUP43
nucleoporin 43kDa
chr6_-_107235287 0.09 ENST00000436659.1
ENST00000428750.1
ENST00000427903.1
RP1-60O19.1
RP1-60O19.1
chr3_-_9291063 0.09 ENST00000383836.3
SRGAP3
SLIT-ROBO Rho GTPase activating protein 3
chr11_+_62496114 0.09 ENST00000532583.1
TTC9C
tetratricopeptide repeat domain 9C
chr5_+_145826867 0.09 ENST00000296702.5
ENST00000394421.2
TCERG1
transcription elongation regulator 1
chr4_+_109571740 0.09 ENST00000361564.4
OSTC
oligosaccharyltransferase complex subunit (non-catalytic)
chr19_-_54619006 0.09 ENST00000391759.1
TFPT
TCF3 (E2A) fusion partner (in childhood Leukemia)
chr1_+_186798073 0.09 ENST00000367466.3
ENST00000442353.2
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr3_-_47934234 0.09 ENST00000420772.2
MAP4
microtubule-associated protein 4
chr10_+_53806501 0.09 ENST00000373975.2
PRKG1
protein kinase, cGMP-dependent, type I
chr3_-_190167571 0.08 ENST00000354905.2
TMEM207
transmembrane protein 207
chr6_-_117150198 0.08 ENST00000310357.3
ENST00000368549.3
ENST00000530250.1
GPRC6A
G protein-coupled receptor, family C, group 6, member A
chr2_+_161993412 0.08 ENST00000259075.2
ENST00000432002.1
TANK
TRAF family member-associated NFKB activator
chr11_+_113779704 0.08 ENST00000537778.1
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
chrX_-_11284095 0.08 ENST00000303025.6
ENST00000534860.1
ARHGAP6
Rho GTPase activating protein 6
chr5_+_137203465 0.08 ENST00000239926.4
MYOT
myotilin
chr16_+_1728257 0.08 ENST00000248098.3
ENST00000562684.1
ENST00000561516.1
ENST00000382711.5
ENST00000566742.1
HN1L
hematological and neurological expressed 1-like
chr1_-_178840157 0.08 ENST00000367629.1
ENST00000234816.2
ANGPTL1
angiopoietin-like 1
chr8_-_86253888 0.08 ENST00000522389.1
ENST00000432364.2
ENST00000517618.1
CA1
carbonic anhydrase I
chr4_+_109571800 0.08 ENST00000512478.2
OSTC
oligosaccharyltransferase complex subunit (non-catalytic)
chr12_-_112123524 0.08 ENST00000327551.6
BRAP
BRCA1 associated protein
chr13_+_53602894 0.08 ENST00000219022.2
OLFM4
olfactomedin 4
chr12_+_10163231 0.08 ENST00000396502.1
ENST00000338896.5
CLEC12B
C-type lectin domain family 12, member B
chr11_-_92931098 0.08 ENST00000326402.4
SLC36A4
solute carrier family 36 (proton/amino acid symporter), member 4
chr2_-_55496174 0.07 ENST00000417363.1
ENST00000412530.1
ENST00000394600.3
ENST00000366137.2
ENST00000420637.1
MTIF2
mitochondrial translational initiation factor 2
chr19_-_38183201 0.07 ENST00000590008.1
ENST00000358582.4
ZNF781
zinc finger protein 781
chr10_-_31146615 0.07 ENST00000444692.2
ZNF438
zinc finger protein 438
chr10_+_89420706 0.07 ENST00000427144.2
PAPSS2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr1_+_186265399 0.07 ENST00000367486.3
ENST00000367484.3
ENST00000533951.1
ENST00000367482.4
ENST00000367483.4
ENST00000367485.4
ENST00000445192.2
PRG4
proteoglycan 4
chr6_-_133055896 0.07 ENST00000367927.5
ENST00000425515.2
ENST00000207771.3
ENST00000392393.3
ENST00000450865.2
ENST00000392394.2
VNN3
vanin 3
chr8_+_38677850 0.07 ENST00000518809.1
ENST00000520611.1
TACC1
transforming, acidic coiled-coil containing protein 1
chr3_-_167191814 0.07 ENST00000466903.1
ENST00000264677.4
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr10_+_97803151 0.07 ENST00000403870.3
ENST00000265992.5
ENST00000465148.2
ENST00000534974.1
CCNJ
cyclin J
chr11_-_13517565 0.07 ENST00000282091.1
ENST00000529816.1
PTH
parathyroid hormone
chr3_-_196242233 0.07 ENST00000397537.2
SMCO1
single-pass membrane protein with coiled-coil domains 1
chr4_+_95128996 0.06 ENST00000457823.2
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr2_+_152214098 0.06 ENST00000243347.3
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr1_-_12946025 0.06 ENST00000235349.5
PRAMEF4
PRAME family member 4
chr14_-_81893734 0.06 ENST00000555447.1
STON2
stonin 2
chr4_+_88571429 0.06 ENST00000339673.6
ENST00000282479.7
DMP1
dentin matrix acidic phosphoprotein 1
chr1_+_158978768 0.06 ENST00000447473.2
IFI16
interferon, gamma-inducible protein 16
chr11_+_120973375 0.06 ENST00000264037.2
TECTA
tectorin alpha
chr18_-_13915530 0.06 ENST00000327606.3
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr4_+_118955500 0.06 ENST00000296499.5
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr3_+_159943362 0.06 ENST00000326474.3
C3orf80
chromosome 3 open reading frame 80
chr8_-_6420930 0.06 ENST00000325203.5
ANGPT2
angiopoietin 2
chr6_+_3259122 0.05 ENST00000438998.2
ENST00000380305.4
PSMG4
proteasome (prosome, macropain) assembly chaperone 4
chr5_-_126409159 0.05 ENST00000607731.1
ENST00000535381.1
ENST00000296662.5
ENST00000509733.3
C5orf63
chromosome 5 open reading frame 63
chr1_-_110155671 0.05 ENST00000351050.3
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr11_+_95523621 0.05 ENST00000325542.5
ENST00000325486.5
ENST00000544522.1
ENST00000541365.1
CEP57
centrosomal protein 57kDa
chr2_-_89160770 0.05 ENST00000390240.2
IGKJ3
immunoglobulin kappa joining 3
chr3_-_141747459 0.05 ENST00000477292.1
ENST00000478006.1
ENST00000495310.1
ENST00000486111.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr9_+_42671887 0.05 ENST00000456520.1
ENST00000377391.3
CBWD7
COBW domain containing 7
chr11_+_85359062 0.05 ENST00000532180.1
TMEM126A
transmembrane protein 126A
chr15_+_44092784 0.05 ENST00000458412.1
HYPK
huntingtin interacting protein K
chr7_-_7575477 0.05 ENST00000399429.3
COL28A1
collagen, type XXVIII, alpha 1
chr11_+_85359002 0.05 ENST00000528105.1
ENST00000304511.2
TMEM126A
transmembrane protein 126A

Network of associatons between targets according to the STRING database.

First level regulatory network of ALX1_ARX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.2 0.5 GO:0002384 hepatic immune response(GO:0002384)
0.2 0.8 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.1 0.4 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.1 0.4 GO:0014034 neural crest cell fate commitment(GO:0014034)
0.1 1.2 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 0.4 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.1 0.3 GO:0045226 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.1 0.8 GO:0097338 response to clozapine(GO:0097338)
0.1 0.3 GO:0030187 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.1 0.3 GO:0003363 lamellipodium assembly involved in ameboidal cell migration(GO:0003363) extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration(GO:0021816)
0.1 0.2 GO:0002644 negative regulation of tolerance induction(GO:0002644) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.1 0.4 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 0.4 GO:0015808 L-alanine transport(GO:0015808)
0.1 0.2 GO:0070781 arginine biosynthetic process via ornithine(GO:0042450) response to biotin(GO:0070781)
0.1 0.5 GO:1900425 negative regulation of defense response to bacterium(GO:1900425)
0.1 0.2 GO:2000230 negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.1 0.3 GO:0043553 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1 0.7 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.1 0.2 GO:0060133 somatotropin secreting cell development(GO:0060133)
0.1 0.5 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.1 0.1 GO:2001186 negative regulation of CD8-positive, alpha-beta T cell activation(GO:2001186)
0.1 0.2 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.1 1.3 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 0.2 GO:0002188 translation reinitiation(GO:0002188)
0.0 1.0 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 1.2 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.0 0.1 GO:0031247 actin rod assembly(GO:0031247)
0.0 0.1 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.0 0.2 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.0 0.2 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.6 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0 0.2 GO:0030311 poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0 0.3 GO:0035881 amacrine cell differentiation(GO:0035881)
0.0 1.2 GO:0071498 cellular response to fluid shear stress(GO:0071498)
0.0 0.6 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 0.2 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.0 0.1 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.0 0.2 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.0 0.2 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.0 0.2 GO:0010615 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.0 0.1 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.0 0.7 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.2 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.1 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.0 0.5 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.1 GO:1900158 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.0 1.0 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.4 GO:0034505 tooth mineralization(GO:0034505)
0.0 0.1 GO:0070124 mitochondrial translational initiation(GO:0070124)
0.0 0.1 GO:0000103 sulfate assimilation(GO:0000103)
0.0 0.5 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.0 0.0 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837) negative regulation of protein localization to chromosome, telomeric region(GO:1904815)
0.0 0.2 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.0 0.7 GO:0042461 photoreceptor cell development(GO:0042461)
0.0 0.1 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.0 0.1 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.2 GO:0043615 astrocyte cell migration(GO:0043615)
0.0 0.2 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.1 GO:0050928 negative regulation of positive chemotaxis(GO:0050928)
0.0 0.2 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 0.2 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.5 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.1 GO:2000389 regulation of neutrophil extravasation(GO:2000389)
0.0 0.1 GO:0002767 immune response-inhibiting cell surface receptor signaling pathway(GO:0002767)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.1 0.5 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.1 1.2 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 0.3 GO:1990032 parallel fiber(GO:1990032)
0.1 0.7 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.4 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.8 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.5 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.2 GO:0032437 cuticular plate(GO:0032437)
0.0 0.3 GO:0044327 dendritic spine head(GO:0044327)
0.0 1.2 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.1 GO:1990357 terminal web(GO:1990357)
0.0 0.1 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.0 0.2 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.1 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.2 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.6 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.2 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.9 GO:0045095 keratin filament(GO:0045095)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0019981 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.2 1.3 GO:0004111 creatine kinase activity(GO:0004111)
0.1 0.4 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.1 0.5 GO:0005499 vitamin D binding(GO:0005499)
0.1 0.3 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 1.2 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 0.6 GO:0030345 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.1 0.3 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.1 0.4 GO:0022858 L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.1 0.7 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 0.6 GO:0019211 phosphatase activator activity(GO:0019211)
0.1 0.2 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.1 0.3 GO:0017161 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.0 0.2 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.2 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
0.0 0.3 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.0 0.8 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.2 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 0.2 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0 1.2 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.1 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 1.2 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.2 GO:0050544 arachidonic acid binding(GO:0050544) DBD domain binding(GO:0050692)
0.0 0.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 1.0 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.1 GO:0004020 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.0 0.2 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.6 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.1 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.0 0.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.2 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 0.1 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.0 0.2 GO:0042301 phosphate ion binding(GO:0042301)
0.0 1.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.0 GO:0070052 collagen V binding(GO:0070052)
0.0 0.2 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.1 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.5 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.1 GO:0046790 virion binding(GO:0046790)
0.0 0.6 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.2 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.2 GO:0043522 leucine zipper domain binding(GO:0043522)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 ST STAT3 PATHWAY STAT3 Pathway
0.0 0.9 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.8 PID IL3 PATHWAY IL3-mediated signaling events
0.0 1.3 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 0.8 PID MYC PATHWAY C-MYC pathway
0.0 1.2 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 0.8 PID CDC42 REG PATHWAY Regulation of CDC42 activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.4 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.5 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.6 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 1.3 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.4 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.3 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.9 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.5 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.2 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.2 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.3 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.2 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.6 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters