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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for ALX1_ARX
Z-value: 0.45
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Transcription factors associated with ALX1_ARX
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ARX | hg19_v2_chrX_-_25034065_25034088 | -0.22 | 2.4e-01 | Click! |
| ALX1 | hg19_v2_chr12_+_85673868_85673885 | -0.01 | 9.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_102413726 Show fit | 1.33 |
ENST00000350878.4
|
mitogen-activated protein kinase kinase kinase kinase 4 |
|
| chr6_+_34204642 Show fit | 1.24 |
ENST00000347617.6
ENST00000401473.3 ENST00000311487.5 ENST00000447654.1 ENST00000395004.3 |
high mobility group AT-hook 1 |
|
| chr1_+_50569575 Show fit | 0.99 |
ENST00000371827.1
|
ELAV like neuron-specific RNA binding protein 4 |
|
| chr4_+_69313145 Show fit | 0.98 |
ENST00000305363.4
|
transmembrane protease, serine 11E |
|
| chr1_+_84630645 Show fit | 0.75 |
ENST00000394839.2
|
protein kinase, cAMP-dependent, catalytic, beta |
|
| chr1_-_94147385 Show fit | 0.74 |
ENST00000260502.6
|
breast cancer anti-estrogen resistance 3 |
|
| chr10_-_75226166 Show fit | 0.71 |
ENST00000544628.1
|
protein phosphatase 3, catalytic subunit, beta isozyme |
|
| chr7_-_93520259 Show fit | 0.68 |
ENST00000222543.5
|
tissue factor pathway inhibitor 2 |
|
| chr3_-_141747950 Show fit | 0.65 |
ENST00000497579.1
|
transcription factor Dp-2 (E2F dimerization partner 2) |
|
| chr4_+_169013666 Show fit | 0.64 |
ENST00000359299.3
|
annexin A10 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ALX1_ARX
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.3 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.2 | 1.2 | GO:0090402 | oncogene-induced cell senescence(GO:0090402) |
| 0.1 | 1.2 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 0.0 | 1.2 | GO:0006346 | methylation-dependent chromatin silencing(GO:0006346) |
| 0.0 | 1.2 | GO:0071498 | cellular response to fluid shear stress(GO:0071498) |
| 0.0 | 1.0 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
| 0.0 | 1.0 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.2 | 0.8 | GO:0071460 | cellular response to cell-matrix adhesion(GO:0071460) |
| 0.1 | 0.8 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.1 | 0.7 | GO:0001915 | negative regulation of T cell mediated cytotoxicity(GO:0001915) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.2 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.0 | 1.2 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 0.0 | 0.9 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 0.8 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 0.8 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.1 | 0.7 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.2 | 0.6 | GO:0005674 | transcription factor TFIIF complex(GO:0005674) |
| 0.0 | 0.6 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.1 | 0.5 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.0 | 0.5 | GO:0097431 | mitotic spindle pole(GO:0097431) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.2 | 1.3 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.1 | 1.2 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.0 | 1.2 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.0 | 1.2 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.0 | 1.0 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.0 | 0.8 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.1 | 0.7 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.1 | 0.6 | GO:0030345 | extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345) |
| 0.1 | 0.6 | GO:0019211 | phosphatase activator activity(GO:0019211) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.0 | 1.2 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 0.9 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 0.8 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 0.8 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 0.8 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 0.5 | ST STAT3 PATHWAY | STAT3 Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 1.2 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.0 | 0.9 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.0 | 0.6 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.0 | 0.6 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.0 | 0.5 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 0.5 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.0 | 0.4 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.0 | 0.4 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.0 | 0.3 | REACTOME HYALURONAN METABOLISM | Genes involved in Hyaluronan metabolism |