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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for ATF2_ATF1_ATF3
Z-value: 0.97
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Transcription factors associated with ATF2_ATF1_ATF3
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000115966.12 | activating transcription factor 2 | |
| ENSG00000123268.4 | activating transcription factor 1 | |
| ENSG00000162772.12 | activating transcription factor 3 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ATF3 | hg19_v2_chr1_+_212738676_212738755 | -0.54 | 2.1e-03 | Click! |
| ATF1 | hg19_v2_chr12_+_51158263_51158395 | 0.28 | 1.4e-01 | Click! |
| ATF2 | hg19_v2_chr2_-_176032843_176032941 | 0.17 | 3.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ATF2_ATF1_ATF3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 9.8 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) |
| 1.0 | 7.9 | GO:0042695 | thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744) |
| 0.4 | 6.4 | GO:0051315 | attachment of mitotic spindle microtubules to kinetochore(GO:0051315) |
| 0.2 | 4.5 | GO:0030214 | hyaluronan catabolic process(GO:0030214) |
| 0.9 | 4.3 | GO:1904744 | positive regulation of telomeric DNA binding(GO:1904744) |
| 1.3 | 3.8 | GO:0052047 | interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) |
| 0.2 | 3.7 | GO:0000050 | urea cycle(GO:0000050) |
| 0.1 | 3.7 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.2 | 3.0 | GO:0051382 | kinetochore assembly(GO:0051382) |
| 0.2 | 3.0 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.1 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.0 | 9.9 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 9.3 | GO:0009986 | cell surface(GO:0009986) |
| 0.1 | 8.4 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.3 | 5.4 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
| 0.1 | 3.9 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.3 | 3.8 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 3.8 | GO:0005769 | early endosome(GO:0005769) |
| 1.2 | 3.6 | GO:0097124 | cyclin A2-CDK2 complex(GO:0097124) |
| 0.0 | 3.5 | GO:0060076 | excitatory synapse(GO:0060076) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 9.5 | GO:0004305 | ethanolamine kinase activity(GO:0004305) |
| 0.2 | 9.3 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.9 | 4.7 | GO:0010521 | telomerase inhibitor activity(GO:0010521) |
| 0.0 | 4.1 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.0 | 4.0 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 0.2 | 3.7 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.1 | 3.7 | GO:0097472 | cyclin-dependent protein kinase activity(GO:0097472) |
| 0.1 | 3.7 | GO:0016504 | peptidase activator activity(GO:0016504) |
| 0.1 | 3.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.3 | 3.2 | GO:0019237 | centromeric DNA binding(GO:0019237) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.1 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 7.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 6.0 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 4.8 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.2 | 4.6 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.2 | 4.6 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 4.0 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 3.8 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.1 | 3.4 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 2.4 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 9.8 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.2 | 6.1 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 5.8 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.2 | 4.6 | REACTOME HYALURONAN METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.1 | 4.6 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.1 | 4.1 | REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |
| 0.1 | 3.8 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.1 | 3.0 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.1 | 3.0 | REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS | Genes involved in Activation of ATR in response to replication stress |
| 0.1 | 2.9 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |