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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for ATF4

Z-value: 1.18

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Transcription factors associated with ATF4

Gene Symbol Gene ID Gene Info
ATF4
ENSG00000128272.10 activating transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ATF4hg19_v2_chr22_+_39916558_399165790.666.3e-05Click!

Activity profile of ATF4 motif

Sorted Z-values of ATF4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_216300784 8.00 ENST00000421182.1
ENST00000432072.2
ENST00000323926.6
ENST00000336916.4
ENST00000357867.4
ENST00000359671.1
ENST00000346544.3
ENST00000345488.5
ENST00000357009.2
ENST00000446046.1
ENST00000356005.4
ENST00000443816.1
ENST00000426059.1
ENST00000354785.4
FN1
fibronectin 1
chr12_-_25102252 7.89 ENST00000261192.7
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr12_-_25101920 6.17 ENST00000539780.1
ENST00000546285.1
ENST00000342945.5
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr21_-_44495919 4.17 ENST00000398158.1
CBS
cystathionine-beta-synthase
chr21_-_44495964 3.75 ENST00000398168.1
ENST00000398165.3
CBS
cystathionine-beta-synthase
chr10_+_102106829 3.63 ENST00000370355.2
SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr15_+_41245160 3.53 ENST00000444189.2
ENST00000446533.3
CHAC1
ChaC, cation transport regulator homolog 1 (E. coli)
chr6_+_151187074 2.97 ENST00000367308.4
MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr12_+_57624119 2.85 ENST00000555773.1
ENST00000554975.1
ENST00000449049.3
ENST00000393827.4
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr14_-_100841670 2.64 ENST00000557297.1
ENST00000555813.1
ENST00000557135.1
ENST00000556698.1
ENST00000554509.1
ENST00000555410.1
WARS
tryptophanyl-tRNA synthetase
chr12_+_57624085 2.64 ENST00000553474.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr19_-_51014345 2.61 ENST00000391815.3
ENST00000594350.1
ENST00000601423.1
JOSD2
Josephin domain containing 2
chr16_+_46918235 2.42 ENST00000340124.4
GPT2
glutamic pyruvate transaminase (alanine aminotransferase) 2
chr12_+_57623477 2.40 ENST00000557487.1
ENST00000555634.1
ENST00000556689.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr12_+_57623869 2.39 ENST00000414700.3
ENST00000557703.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr11_+_62649158 2.35 ENST00000539891.1
ENST00000536981.1
SLC3A2
solute carrier family 3 (amino acid transporter heavy chain), member 2
chr14_+_24563510 2.20 ENST00000545054.2
ENST00000561286.1
ENST00000558096.1
PCK2
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr6_+_151187615 2.20 ENST00000441122.1
ENST00000423867.1
MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr3_-_48130707 2.05 ENST00000360240.6
ENST00000383737.4
MAP4
microtubule-associated protein 4
chr12_-_12674032 2.03 ENST00000298573.4
DUSP16
dual specificity phosphatase 16
chr7_-_50860565 2.02 ENST00000403097.1
GRB10
growth factor receptor-bound protein 10
chr19_-_51014460 1.96 ENST00000595669.1
JOSD2
Josephin domain containing 2
chr14_-_100841930 1.94 ENST00000555031.1
ENST00000553395.1
ENST00000553545.1
ENST00000344102.5
ENST00000556338.1
ENST00000392882.2
ENST00000553934.1
WARS
tryptophanyl-tRNA synthetase
chr22_+_50919944 1.92 ENST00000395738.2
ADM2
adrenomedullin 2
chr22_+_50919995 1.91 ENST00000362068.2
ENST00000395737.1
ADM2
adrenomedullin 2
chr14_+_24563262 1.86 ENST00000559250.1
ENST00000216780.4
ENST00000560736.1
ENST00000396973.4
ENST00000559837.1
PCK2
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr7_+_30634297 1.83 ENST00000389266.3
GARS
glycyl-tRNA synthetase
chr5_+_33440802 1.81 ENST00000502553.1
ENST00000514259.1
ENST00000265112.3
TARS
threonyl-tRNA synthetase
chr5_+_33441053 1.62 ENST00000541634.1
ENST00000455217.2
ENST00000414361.2
TARS
threonyl-tRNA synthetase
chr12_+_93963590 1.61 ENST00000340600.2
SOCS2
suppressor of cytokine signaling 2
chr9_+_80912059 1.58 ENST00000347159.2
ENST00000376588.3
PSAT1
phosphoserine aminotransferase 1
chr15_+_89182178 1.58 ENST00000559876.1
ISG20
interferon stimulated exonuclease gene 20kDa
chr15_+_40886199 1.54 ENST00000346991.5
ENST00000528975.1
ENST00000527044.1
CASC5
cancer susceptibility candidate 5
chr3_-_33686925 1.49 ENST00000485378.2
ENST00000313350.6
ENST00000487200.1
CLASP2
cytoplasmic linker associated protein 2
chr3_-_48130314 1.48 ENST00000439356.1
ENST00000395734.3
ENST00000426837.2
MAP4
microtubule-associated protein 4
chr12_-_57914275 1.45 ENST00000547303.1
ENST00000552740.1
ENST00000547526.1
ENST00000551116.1
ENST00000346473.3
DDIT3
DNA-damage-inducible transcript 3
chr11_-_3078616 1.45 ENST00000401769.3
ENST00000278224.9
ENST00000397114.3
ENST00000380525.4
CARS
cysteinyl-tRNA synthetase
chr17_-_79895097 1.32 ENST00000402252.2
ENST00000583564.1
ENST00000585244.1
ENST00000337943.5
ENST00000579698.1
PYCR1
pyrroline-5-carboxylate reductase 1
chr17_-_79895154 1.27 ENST00000405481.4
ENST00000585215.1
ENST00000577624.1
ENST00000403172.4
PYCR1
pyrroline-5-carboxylate reductase 1
chr19_+_49258775 1.27 ENST00000593756.1
FGF21
fibroblast growth factor 21
chr7_-_121944491 1.22 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
FEZF1
FEZ family zinc finger 1
chr4_-_21950356 1.20 ENST00000447367.2
ENST00000382152.2
KCNIP4
Kv channel interacting protein 4
chr19_-_51014588 1.15 ENST00000598418.1
JOSD2
Josephin domain containing 2
chr17_-_40829026 1.12 ENST00000412503.1
PLEKHH3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr4_+_77870856 1.09 ENST00000264893.6
ENST00000502584.1
ENST00000510641.1
SEPT11
septin 11
chr19_+_49259325 1.08 ENST00000222157.3
FGF21
fibroblast growth factor 21
chr12_-_117318788 1.07 ENST00000550505.1
HRK
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr17_-_40828969 1.06 ENST00000591022.1
ENST00000587627.1
ENST00000293349.6
PLEKHH3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr1_-_44497118 1.05 ENST00000537678.1
ENST00000466926.1
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr11_-_3078838 1.02 ENST00000397111.5
CARS
cysteinyl-tRNA synthetase
chr5_+_44809027 0.94 ENST00000507110.1
MRPS30
mitochondrial ribosomal protein S30
chr15_+_89182156 0.94 ENST00000379224.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr4_+_77870960 0.93 ENST00000505788.1
ENST00000510515.1
ENST00000504637.1
SEPT11
septin 11
chr15_+_89181974 0.92 ENST00000306072.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr3_-_99595037 0.87 ENST00000383694.2
FILIP1L
filamin A interacting protein 1-like
chr19_+_33865218 0.87 ENST00000585933.2
CEBPG
CCAAT/enhancer binding protein (C/EBP), gamma
chr7_-_99006443 0.86 ENST00000350498.3
PDAP1
PDGFA associated protein 1
chr12_-_10324716 0.86 ENST00000545927.1
ENST00000432556.2
ENST00000309539.3
ENST00000544577.1
OLR1
oxidized low density lipoprotein (lectin-like) receptor 1
chr12_-_46662772 0.84 ENST00000549049.1
ENST00000439706.1
ENST00000398637.5
SLC38A1
solute carrier family 38, member 1
chr9_+_36169380 0.82 ENST00000335119.2
CCIN
calicin
chr19_-_51192661 0.78 ENST00000391813.1
SHANK1
SH3 and multiple ankyrin repeat domains 1
chr21_-_31864275 0.77 ENST00000334063.4
KRTAP19-3
keratin associated protein 19-3
chr3_+_11314099 0.76 ENST00000446450.2
ENST00000354956.5
ENST00000354449.3
ENST00000419112.1
ATG7
autophagy related 7
chr1_-_44497024 0.75 ENST00000372306.3
ENST00000372310.3
ENST00000475075.2
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chrX_+_24072833 0.74 ENST00000253039.4
EIF2S3
eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
chr19_-_47288162 0.74 ENST00000594991.1
SLC1A5
solute carrier family 1 (neutral amino acid transporter), member 5
chrX_+_77359671 0.70 ENST00000373316.4
PGK1
phosphoglycerate kinase 1
chr9_-_95055956 0.69 ENST00000375629.3
ENST00000447699.2
ENST00000375643.3
ENST00000395554.3
IARS
isoleucyl-tRNA synthetase
chr7_-_48068671 0.69 ENST00000297325.4
SUN3
Sad1 and UNC84 domain containing 3
chr19_-_47287990 0.68 ENST00000593713.1
ENST00000598022.1
ENST00000434726.2
SLC1A5
solute carrier family 1 (neutral amino acid transporter), member 5
chr17_+_73089382 0.68 ENST00000538213.2
ENST00000584118.1
SLC16A5
solute carrier family 16 (monocarboxylate transporter), member 5
chr7_-_48068699 0.64 ENST00000412142.1
ENST00000395572.2
SUN3
Sad1 and UNC84 domain containing 3
chr3_-_99594948 0.64 ENST00000471562.1
ENST00000495625.2
FILIP1L
filamin A interacting protein 1-like
chr1_-_178840157 0.62 ENST00000367629.1
ENST00000234816.2
ANGPTL1
angiopoietin-like 1
chr1_-_204380919 0.61 ENST00000367188.4
PPP1R15B
protein phosphatase 1, regulatory subunit 15B
chr19_-_8809139 0.60 ENST00000324436.3
ACTL9
actin-like 9
chr5_+_167956121 0.60 ENST00000338333.4
FBLL1
fibrillarin-like 1
chr22_+_42229100 0.59 ENST00000361204.4
SREBF2
sterol regulatory element binding transcription factor 2
chr7_-_48068643 0.57 ENST00000453192.2
SUN3
Sad1 and UNC84 domain containing 3
chr3_-_33686743 0.57 ENST00000333778.6
ENST00000539981.1
CLASP2
cytoplasmic linker associated protein 2
chr15_+_40886439 0.56 ENST00000532056.1
ENST00000399668.2
CASC5
cancer susceptibility candidate 5
chr1_+_33283043 0.56 ENST00000373476.1
ENST00000373475.5
ENST00000529027.1
ENST00000398243.3
S100PBP
S100P binding protein
chr7_-_56101826 0.51 ENST00000421626.1
PSPH
phosphoserine phosphatase
chrX_+_77359726 0.47 ENST00000442431.1
PGK1
phosphoglycerate kinase 1
chr4_-_153457197 0.43 ENST00000281708.4
FBXW7
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr16_-_67694597 0.43 ENST00000393919.4
ENST00000219251.8
ACD
adrenocortical dysplasia homolog (mouse)
chr22_-_29457832 0.40 ENST00000216071.4
C22orf31
chromosome 22 open reading frame 31
chr1_+_162602244 0.39 ENST00000367922.3
ENST00000367921.3
DDR2
discoidin domain receptor tyrosine kinase 2
chr7_+_99006550 0.36 ENST00000222969.5
BUD31
BUD31 homolog (S. cerevisiae)
chr5_+_154135029 0.35 ENST00000518297.1
LARP1
La ribonucleoprotein domain family, member 1
chr1_-_220219775 0.35 ENST00000609181.1
EPRS
glutamyl-prolyl-tRNA synthetase
chr16_-_18908196 0.34 ENST00000565324.1
ENST00000561947.1
SMG1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr17_+_56315787 0.34 ENST00000262290.4
ENST00000421678.2
LPO
lactoperoxidase
chr11_-_8680383 0.31 ENST00000299550.6
TRIM66
tripartite motif containing 66
chr4_+_95128996 0.31 ENST00000457823.2
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr1_-_220220000 0.30 ENST00000366923.3
EPRS
glutamyl-prolyl-tRNA synthetase
chr4_+_95128748 0.30 ENST00000359052.4
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chrX_-_68385354 0.29 ENST00000361478.1
PJA1
praja ring finger 1, E3 ubiquitin protein ligase
chr7_-_115670792 0.26 ENST00000265440.7
ENST00000393485.1
TFEC
transcription factor EC
chrX_-_68385274 0.25 ENST00000374584.3
ENST00000590146.1
PJA1
praja ring finger 1, E3 ubiquitin protein ligase
chr9_+_100745615 0.25 ENST00000339399.4
ANP32B
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr1_+_241815577 0.25 ENST00000366552.2
ENST00000437684.2
WDR64
WD repeat domain 64
chr11_-_57092381 0.24 ENST00000358252.3
TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr12_+_56862301 0.24 ENST00000338146.5
SPRYD4
SPRY domain containing 4
chr10_+_50507181 0.24 ENST00000323868.4
C10orf71
chromosome 10 open reading frame 71
chr17_+_39846114 0.23 ENST00000586699.1
EIF1
eukaryotic translation initiation factor 1
chr1_+_52521928 0.23 ENST00000489308.2
BTF3L4
basic transcription factor 3-like 4
chr1_+_239882842 0.23 ENST00000448020.1
CHRM3
cholinergic receptor, muscarinic 3
chr7_-_115670804 0.22 ENST00000320239.7
TFEC
transcription factor EC
chr1_-_167883353 0.21 ENST00000545172.1
ADCY10
adenylate cyclase 10 (soluble)
chr12_-_92539614 0.21 ENST00000256015.3
BTG1
B-cell translocation gene 1, anti-proliferative
chr17_-_77813186 0.21 ENST00000448310.1
ENST00000269397.4
CBX4
chromobox homolog 4
chr10_+_50507232 0.20 ENST00000374144.3
C10orf71
chromosome 10 open reading frame 71
chr17_-_46703826 0.17 ENST00000550387.1
ENST00000311177.5
HOXB9
homeobox B9
chr19_-_49258606 0.17 ENST00000310160.3
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr7_-_93633658 0.13 ENST00000433727.1
BET1
Bet1 golgi vesicular membrane trafficking protein
chr22_-_43485381 0.12 ENST00000331018.7
ENST00000266254.7
ENST00000445824.1
TTLL1
tubulin tyrosine ligase-like family, member 1
chr7_-_93633684 0.12 ENST00000222547.3
ENST00000425626.1
BET1
Bet1 golgi vesicular membrane trafficking protein
chrX_-_133792480 0.10 ENST00000359237.4
PLAC1
placenta-specific 1
chr6_+_73076432 0.08 ENST00000414192.2
RIMS1
regulating synaptic membrane exocytosis 1
chrX_-_71792477 0.06 ENST00000421523.1
ENST00000415409.1
ENST00000373559.4
ENST00000373556.3
ENST00000373560.2
ENST00000373583.1
ENST00000429103.2
ENST00000373571.1
ENST00000373554.1
HDAC8
histone deacetylase 8
chr3_+_148415571 0.05 ENST00000497524.1
ENST00000349243.3
ENST00000542281.1
ENST00000418473.2
ENST00000404754.2
AGTR1
angiotensin II receptor, type 1
chr4_+_95129061 0.04 ENST00000354268.4
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr5_+_143584814 0.03 ENST00000507359.3
KCTD16
potassium channel tetramerization domain containing 16
chr17_-_76836729 0.01 ENST00000587783.1
ENST00000542802.3
ENST00000586531.1
ENST00000589424.1
ENST00000590546.2
USP36
ubiquitin specific peptidase 36
chr17_-_76836963 0.01 ENST00000312010.6
USP36
ubiquitin specific peptidase 36
chr16_-_70323422 0.01 ENST00000261772.8
AARS
alanyl-tRNA synthetase
chr8_-_11324273 0.01 ENST00000284486.4
FAM167A
family with sequence similarity 167, member A

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 8.0 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
2.6 7.9 GO:0006535 cysteine biosynthetic process from serine(GO:0006535)
2.3 14.1 GO:0009099 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
1.5 10.3 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
1.3 5.2 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
1.2 3.6 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.9 4.6 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.9 3.4 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
0.8 2.5 GO:0006423 cysteinyl-tRNA aminoacylation(GO:0006423)
0.7 3.4 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.6 2.4 GO:0042853 L-alanine metabolic process(GO:0042851) L-alanine catabolic process(GO:0042853)
0.6 1.8 GO:0061536 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.6 3.5 GO:0051012 microtubule sliding(GO:0051012)
0.5 4.1 GO:0006116 NADH oxidation(GO:0006116)
0.5 2.3 GO:0060356 leucine import(GO:0060356)
0.5 2.3 GO:1904640 response to methionine(GO:1904640)
0.5 1.8 GO:0015960 diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966)
0.4 2.0 GO:0045204 MAPK export from nucleus(GO:0045204)
0.4 2.6 GO:0055129 L-proline biosynthetic process(GO:0055129)
0.4 1.4 GO:1903803 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
0.3 1.5 GO:2000015 regulation of determination of dorsal identity(GO:2000015)
0.3 1.6 GO:0042816 vitamin B6 metabolic process(GO:0042816)
0.3 0.8 GO:0050894 determination of affect(GO:0050894)
0.3 0.8 GO:1902534 single-organism membrane invagination(GO:1902534)
0.2 0.7 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.2 0.7 GO:0006433 glutamyl-tRNA aminoacylation(GO:0006424) prolyl-tRNA aminoacylation(GO:0006433)
0.2 1.2 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 0.6 GO:0033967 box C/D snoRNA 3'-end processing(GO:0000494) box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963) histone glutamine methylation(GO:1990258)
0.2 2.4 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.2 3.5 GO:0006751 glutathione catabolic process(GO:0006751)
0.1 0.4 GO:0060380 regulation of single-stranded telomeric DNA binding(GO:0060380) positive regulation of single-stranded telomeric DNA binding(GO:0060381)
0.1 2.0 GO:0046325 negative regulation of glucose import(GO:0046325)
0.1 0.6 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.1 0.9 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.1 1.9 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.1 0.4 GO:1901355 response to rapamycin(GO:1901355)
0.1 0.4 GO:2000639 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.1 1.6 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.1 0.6 GO:1903898 negative regulation of PERK-mediated unfolded protein response(GO:1903898) negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912)
0.1 0.5 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.1 3.8 GO:0045776 negative regulation of blood pressure(GO:0045776)
0.0 1.1 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.6 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 1.2 GO:0031639 plasminogen activation(GO:0031639)
0.0 0.2 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.0 0.1 GO:0071922 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 0.1 GO:0090214 spongiotrophoblast layer developmental growth(GO:0090214)
0.0 0.2 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.8 GO:0001504 neurotransmitter uptake(GO:0001504)
0.0 0.5 GO:0030163 protein catabolic process(GO:0030163)
0.0 0.2 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.0 0.2 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.1 GO:0007288 sperm axoneme assembly(GO:0007288)
0.0 0.1 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.0 0.2 GO:0019317 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0 2.0 GO:0051291 protein heterooligomerization(GO:0051291)
0.0 4.7 GO:0016579 protein deubiquitination(GO:0016579)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 10.3 GO:0070552 BRISC complex(GO:0070552)
0.6 8.0 GO:0005577 fibrinogen complex(GO:0005577)
0.3 0.8 GO:0033150 cytoskeletal calyx(GO:0033150)
0.2 1.5 GO:0035976 AP1 complex(GO:0035976)
0.1 0.7 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1 0.6 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 2.1 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 0.6 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 1.9 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 0.7 GO:0097452 GAIT complex(GO:0097452)
0.1 0.4 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.8 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.2 GO:0032279 asymmetric synapse(GO:0032279)
0.0 3.4 GO:0015030 Cajal body(GO:0015030)
0.0 0.4 GO:0070187 telosome(GO:0070187)
0.0 0.4 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 4.3 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 15.7 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 2.0 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.9 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 0.6 GO:0035861 site of double-strand break(GO:0035861)
0.0 2.8 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.2 GO:0035102 PRC1 complex(GO:0035102)
0.0 3.5 GO:0005802 trans-Golgi network(GO:0005802)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 7.9 GO:0098809 cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809)
2.3 14.1 GO:0052656 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
1.5 10.3 GO:0008732 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
1.4 4.1 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
1.3 5.2 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
1.2 3.5 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
1.1 3.4 GO:0008859 exoribonuclease II activity(GO:0008859)
0.9 4.6 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.9 3.4 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
0.8 2.5 GO:0004817 cysteine-tRNA ligase activity(GO:0004817)
0.7 3.6 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.4 1.8 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.4 2.6 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.4 1.2 GO:0004618 phosphoglycerate kinase activity(GO:0004618)
0.3 1.6 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.3 0.8 GO:0031877 somatostatin receptor binding(GO:0031877)
0.2 0.7 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.2 0.7 GO:0004827 glutamate-tRNA ligase activity(GO:0004818) proline-tRNA ligase activity(GO:0004827)
0.2 1.4 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.2 0.6 GO:1990259 protein-glutamine N-methyltransferase activity(GO:0036009) histone-glutamine methyltransferase activity(GO:1990259)
0.2 4.0 GO:0008483 transaminase activity(GO:0008483)
0.1 2.3 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.1 0.8 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.1 8.0 GO:0016504 peptidase activator activity(GO:0016504)
0.1 2.0 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 1.8 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.1 1.5 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 0.5 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.1 2.1 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.4 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 1.9 GO:0043495 protein anchor(GO:0043495)
0.1 2.3 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 5.7 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 0.4 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.8 GO:0005283 sodium:amino acid symporter activity(GO:0005283)
0.0 0.2 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.6 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.9 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.2 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 1.3 GO:0005158 insulin receptor binding(GO:0005158)
0.0 3.7 GO:0005179 hormone activity(GO:0005179)
0.0 0.9 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.4 GO:0008494 translation activator activity(GO:0008494)
0.0 0.1 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.0 0.1 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.0 0.8 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 1.2 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 1.0 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.7 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 8.0 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 13.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.6 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 2.3 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.1 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 4.1 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.7 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 1.5 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.2 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.2 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 1.3 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.6 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.4 PID MYC PATHWAY C-MYC pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 14.1 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.3 12.3 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.2 8.0 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.2 7.1 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.2 7.9 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 2.0 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.1 1.8 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 1.5 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 4.6 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 5.2 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 3.4 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.6 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 3.8 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 2.1 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.4 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis