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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for BACH1_NFE2_NFE2L2
Z-value: 0.66
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Transcription factors associated with BACH1_NFE2_NFE2L2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000156273.11 | BTB domain and CNC homolog 1 | |
| ENSG00000123405.9 | nuclear factor, erythroid 2 | |
| ENSG00000116044.11 | nuclear factor, erythroid 2 like 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BACH1 | hg19_v2_chr21_+_30671690_30671762, hg19_v2_chr21_+_30671189_30671207 | -0.38 | 4.0e-02 | Click! |
| NFE2L2 | hg19_v2_chr2_-_178129551_178129572 | 0.25 | 1.7e-01 | Click! |
| NFE2 | hg19_v2_chr12_-_54694807_54694905, hg19_v2_chr12_-_54689532_54689551, hg19_v2_chr12_-_54694758_54694805 | -0.04 | 8.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of BACH1_NFE2_NFE2L2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | GO:0098869 | cellular oxidant detoxification(GO:0098869) |
| 0.0 | 1.4 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.0 | 1.3 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.1 | 1.1 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.1 | 0.9 | GO:0002191 | cap-dependent translational initiation(GO:0002191) |
| 0.3 | 0.8 | GO:0031938 | pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) regulation of chromatin silencing at telomere(GO:0031938) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299) |
| 0.1 | 0.7 | GO:0071461 | cellular response to redox state(GO:0071461) |
| 0.1 | 0.7 | GO:1902037 | negative regulation of hematopoietic stem cell differentiation(GO:1902037) |
| 0.0 | 0.7 | GO:0015695 | organic cation transport(GO:0015695) |
| 0.0 | 0.7 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 1.2 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.1 | 0.9 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.0 | 0.9 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.0 | 0.9 | GO:0000502 | proteasome complex(GO:0000502) |
| 0.3 | 0.8 | GO:0036387 | nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387) |
| 0.0 | 0.7 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 0.6 | GO:0097513 | myosin II filament(GO:0097513) |
| 0.0 | 0.6 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.0 | 0.6 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | GO:0004791 | thioredoxin-disulfide reductase activity(GO:0004791) |
| 0.0 | 0.9 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.1 | 0.8 | GO:0019534 | toxin transporter activity(GO:0019534) |
| 0.0 | 0.8 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.0 | 0.8 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.1 | 0.7 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.0 | 0.7 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.2 | 0.6 | GO:0004852 | uroporphyrinogen-III synthase activity(GO:0004852) |
| 0.2 | 0.5 | GO:0004362 | glutathione-disulfide reductase activity(GO:0004362) |
| 0.2 | 0.5 | GO:0008192 | RNA guanylyltransferase activity(GO:0008192) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.5 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.0 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.0 | 1.0 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 1.0 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 0.9 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.0 | 0.9 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 0.8 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.0 | 0.8 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 0.6 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 0.6 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 0.6 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |