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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for BARHL1
Z-value: 2.45
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Transcription factors associated with BARHL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BARHL1 | hg19_v2_chr9_+_135457530_135457572 | -0.51 | 4.2e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_19988462 Show fit | 19.45 |
ENST00000344838.4
|
EF-hand domain family, member B |
|
| chr12_-_71551868 Show fit | 17.57 |
ENST00000247829.3
|
tetraspanin 8 |
|
| chr12_-_71551652 Show fit | 17.25 |
ENST00000546561.1
|
tetraspanin 8 |
|
| chr2_+_228735763 Show fit | 15.21 |
ENST00000373666.2
|
dynein assembly factor with WDR repeat domains 1 |
|
| chr2_+_228736321 Show fit | 14.12 |
ENST00000309931.2
|
dynein assembly factor with WDR repeat domains 1 |
|
| chr3_-_197686847 Show fit | 12.58 |
ENST00000265239.6
|
IQ motif containing G |
|
| chr5_+_121465207 Show fit | 12.16 |
ENST00000296600.4
|
zinc finger protein 474 |
|
| chr15_-_56757329 Show fit | 11.94 |
ENST00000260453.3
|
meiosis-specific nuclear structural 1 |
|
| chr9_-_138391692 Show fit | 10.45 |
ENST00000429260.2
|
chromosome 9 open reading frame 116 |
|
| chr12_+_7013897 Show fit | 10.42 |
ENST00000007969.8
ENST00000323702.5 |
leucine rich repeat containing 23 |
Network of associatons between targets according to the STRING database.
First level regulatory network of BARHL1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 38.6 | GO:0007368 | determination of left/right symmetry(GO:0007368) |
| 1.3 | 27.5 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 1.1 | 25.4 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 0.3 | 23.7 | GO:1900047 | negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047) |
| 2.9 | 20.4 | GO:1904491 | protein localization to ciliary transition zone(GO:1904491) |
| 1.9 | 18.8 | GO:0007288 | sperm axoneme assembly(GO:0007288) |
| 0.8 | 16.7 | GO:0070986 | left/right axis specification(GO:0070986) |
| 0.1 | 16.5 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 1.4 | 15.1 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
| 0.2 | 13.6 | GO:0016266 | O-glycan processing(GO:0016266) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 37.6 | GO:0036038 | MKS complex(GO:0036038) |
| 0.3 | 29.9 | GO:0097014 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.0 | 27.1 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 1.2 | 25.7 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 2.7 | 18.8 | GO:0002177 | manchette(GO:0002177) |
| 0.0 | 17.4 | GO:0005929 | cilium(GO:0005929) |
| 1.4 | 15.0 | GO:0036157 | outer dynein arm(GO:0036157) |
| 0.3 | 13.6 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.7 | 11.0 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.0 | 10.4 | GO:0019867 | outer membrane(GO:0019867) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 36.1 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 32.0 | GO:0005509 | calcium ion binding(GO:0005509) |
| 1.4 | 28.7 | GO:0008391 | arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392) |
| 0.3 | 20.2 | GO:0030544 | Hsp70 protein binding(GO:0030544) |
| 3.9 | 15.7 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
| 0.7 | 13.4 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.9 | 13.1 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.2 | 13.1 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.6 | 12.7 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.6 | 11.5 | GO:0005344 | oxygen transporter activity(GO:0005344) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 10.0 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 6.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 6.1 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 4.6 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 4.5 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 4.3 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 4.1 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.1 | 3.1 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.0 | 3.1 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 26.3 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 17.3 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.9 | 16.7 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.7 | 16.4 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 1.1 | 15.7 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 1.7 | 15.4 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.3 | 13.2 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.3 | 9.2 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 7.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 5.4 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |