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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for BBX

Z-value: 0.55

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Transcription factors associated with BBX

Gene Symbol Gene ID Gene Info
BBX
ENSG00000114439.14 BBX high mobility group box domain containing

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BBXhg19_v2_chr3_+_107241783_1072418500.374.4e-02Click!

Activity profile of BBX motif

Sorted Z-values of BBX motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_228735763 3.09 ENST00000373666.2
DAW1
dynein assembly factor with WDR repeat domains 1
chr7_-_16921601 2.69 ENST00000402239.3
ENST00000310398.2
ENST00000414935.1
AGR3
anterior gradient 3
chr20_-_7921090 2.25 ENST00000378789.3
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr11_+_60467047 1.74 ENST00000300226.2
MS4A8
membrane-spanning 4-domains, subfamily A, member 8
chr1_-_161337662 1.67 ENST00000367974.1
C1orf192
chromosome 1 open reading frame 192
chr4_-_123542224 0.84 ENST00000264497.3
IL21
interleukin 21
chr1_-_216978709 0.81 ENST00000360012.3
ESRRG
estrogen-related receptor gamma
chr2_-_62081148 0.78 ENST00000404929.1
FAM161A
family with sequence similarity 161, member A
chr2_-_62081254 0.77 ENST00000405894.3
FAM161A
family with sequence similarity 161, member A
chr8_-_28347737 0.68 ENST00000517673.1
ENST00000518734.1
ENST00000346498.2
ENST00000380254.2
FBXO16
F-box protein 16
chr2_-_120124258 0.68 ENST00000409877.1
ENST00000409523.1
ENST00000409466.2
ENST00000414534.1
C2orf76
chromosome 2 open reading frame 76
chr7_-_130080977 0.67 ENST00000223208.5
CEP41
centrosomal protein 41kDa
chr2_+_179149636 0.66 ENST00000409631.1
OSBPL6
oxysterol binding protein-like 6
chr17_-_16256718 0.62 ENST00000476243.1
ENST00000299736.4
CENPV
centromere protein V
chr1_-_28527152 0.57 ENST00000321830.5
AL353354.1
Uncharacterized protein
chr13_+_77522632 0.54 ENST00000377462.1
IRG1
immunoresponsive 1 homolog (mouse)
chr11_+_58390132 0.52 ENST00000361987.4
CNTF
ciliary neurotrophic factor
chr9_-_13175823 0.50 ENST00000545857.1
MPDZ
multiple PDZ domain protein
chr6_-_25874440 0.50 ENST00000361703.6
ENST00000397060.4
SLC17A3
solute carrier family 17 (organic anion transporter), member 3
chr3_+_94657118 0.49 ENST00000466089.1
ENST00000470465.1
LINC00879
long intergenic non-protein coding RNA 879
chr19_+_9361606 0.46 ENST00000456448.1
OR7E24
olfactory receptor, family 7, subfamily E, member 24
chr6_+_31895254 0.44 ENST00000299367.5
ENST00000442278.2
C2
complement component 2
chr3_+_94657086 0.42 ENST00000463200.1
LINC00879
long intergenic non-protein coding RNA 879
chr10_+_115674530 0.41 ENST00000451472.1
AL162407.1
CDNA FLJ20147 fis, clone COL07954; HCG1781466; Uncharacterized protein
chr17_+_40950900 0.39 ENST00000588527.1
CNTD1
cyclin N-terminal domain containing 1
chrX_+_78426469 0.38 ENST00000276077.1
GPR174
G protein-coupled receptor 174
chr11_+_61717336 0.37 ENST00000378042.3
BEST1
bestrophin 1
chr12_-_39734783 0.35 ENST00000552961.1
KIF21A
kinesin family member 21A
chr11_+_61717279 0.34 ENST00000378043.4
BEST1
bestrophin 1
chrX_-_102531717 0.32 ENST00000372680.1
TCEAL5
transcription elongation factor A (SII)-like 5
chr2_+_102928009 0.30 ENST00000404917.2
ENST00000447231.1
IL1RL1
interleukin 1 receptor-like 1
chr3_-_112218205 0.30 ENST00000383680.4
BTLA
B and T lymphocyte associated
chr4_-_159644507 0.24 ENST00000307720.3
PPID
peptidylprolyl isomerase D
chr4_+_129349188 0.23 ENST00000511497.1
RP11-420A23.1
RP11-420A23.1
chr16_-_28374829 0.23 ENST00000532254.1
NPIPB6
nuclear pore complex interacting protein family, member B6
chr17_+_66255310 0.22 ENST00000448504.2
ARSG
arylsulfatase G
chr1_-_206785789 0.22 ENST00000437518.1
ENST00000367114.3
EIF2D
eukaryotic translation initiation factor 2D
chr6_-_29343068 0.21 ENST00000396806.3
OR12D3
olfactory receptor, family 12, subfamily D, member 3
chr21_+_31768348 0.21 ENST00000355459.2
KRTAP13-1
keratin associated protein 13-1
chr20_-_30310656 0.20 ENST00000376055.4
BCL2L1
BCL2-like 1
chr9_-_95166841 0.19 ENST00000262551.4
OGN
osteoglycin
chr19_+_6887571 0.19 ENST00000250572.8
ENST00000381407.5
ENST00000312053.4
ENST00000450315.3
ENST00000381404.4
EMR1
egf-like module containing, mucin-like, hormone receptor-like 1
chr6_-_133084580 0.19 ENST00000525270.1
ENST00000530536.1
ENST00000524919.1
VNN2
vanin 2
chr5_+_161494521 0.19 ENST00000356592.3
GABRG2
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr4_-_987164 0.19 ENST00000398520.2
SLC26A1
solute carrier family 26 (anion exchanger), member 1
chr9_-_95166884 0.19 ENST00000375561.5
OGN
osteoglycin
chr4_-_104021009 0.19 ENST00000509245.1
ENST00000296424.4
BDH2
3-hydroxybutyrate dehydrogenase, type 2
chr14_+_57671888 0.18 ENST00000391612.1
AL391152.1
AL391152.1
chr11_+_22689648 0.18 ENST00000278187.3
GAS2
growth arrest-specific 2
chr6_-_49712123 0.18 ENST00000263045.4
CRISP3
cysteine-rich secretory protein 3
chr3_+_111260856 0.17 ENST00000352690.4
CD96
CD96 molecule
chr15_+_65823092 0.17 ENST00000566074.1
PTPLAD1
protein tyrosine phosphatase-like A domain containing 1
chr20_-_30310693 0.17 ENST00000307677.4
ENST00000420653.1
BCL2L1
BCL2-like 1
chr1_-_153123345 0.16 ENST00000368748.4
SPRR2G
small proline-rich protein 2G
chr1_+_229440129 0.15 ENST00000366688.3
SPHAR
S-phase response (cyclin related)
chr5_+_140079919 0.15 ENST00000274712.3
ZMAT2
zinc finger, matrin-type 2
chrX_-_19817869 0.15 ENST00000379698.4
SH3KBP1
SH3-domain kinase binding protein 1
chr13_+_33160553 0.14 ENST00000315596.10
PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr14_+_22458631 0.13 ENST00000390444.1
TRAV16
T cell receptor alpha variable 16
chr3_-_112218378 0.13 ENST00000334529.5
BTLA
B and T lymphocyte associated
chr5_+_125758813 0.13 ENST00000285689.3
ENST00000515200.1
GRAMD3
GRAM domain containing 3
chr10_+_111765562 0.12 ENST00000360162.3
ADD3
adducin 3 (gamma)
chr7_-_16872932 0.12 ENST00000419572.2
ENST00000412973.1
AGR2
anterior gradient 2
chr10_-_94003003 0.12 ENST00000412050.4
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr15_+_49715293 0.12 ENST00000267843.4
ENST00000560270.1
FGF7
fibroblast growth factor 7
chr15_+_54305101 0.11 ENST00000260323.11
ENST00000545554.1
ENST00000537900.1
UNC13C
unc-13 homolog C (C. elegans)
chr4_-_186697044 0.11 ENST00000437304.2
SORBS2
sorbin and SH3 domain containing 2
chr16_+_28763108 0.11 ENST00000357796.3
ENST00000550983.1
NPIPB9
nuclear pore complex interacting protein family, member B9
chr4_-_186696425 0.10 ENST00000430503.1
ENST00000319454.6
ENST00000450341.1
SORBS2
sorbin and SH3 domain containing 2
chr21_+_19617140 0.10 ENST00000299295.2
ENST00000338326.3
CHODL
chondrolectin
chr3_+_148583043 0.10 ENST00000296046.3
CPA3
carboxypeptidase A3 (mast cell)
chr6_+_54173227 0.10 ENST00000259782.4
ENST00000370864.3
TINAG
tubulointerstitial nephritis antigen
chr14_+_22337014 0.09 ENST00000390436.2
TRAV13-1
T cell receptor alpha variable 13-1
chr20_-_30310336 0.09 ENST00000434194.1
ENST00000376062.2
BCL2L1
BCL2-like 1
chr18_+_29769978 0.08 ENST00000269202.6
ENST00000581447.1
MEP1B
meprin A, beta
chr8_-_108510224 0.07 ENST00000517746.1
ENST00000297450.3
ANGPT1
angiopoietin 1
chr18_-_21017817 0.06 ENST00000542162.1
ENST00000383233.3
ENST00000582336.1
ENST00000450466.2
ENST00000578520.1
ENST00000399707.1
TMEM241
transmembrane protein 241
chr9_+_35161998 0.06 ENST00000396787.1
ENST00000378495.3
ENST00000378496.4
UNC13B
unc-13 homolog B (C. elegans)
chr12_-_100656134 0.06 ENST00000548313.1
DEPDC4
DEP domain containing 4
chr14_+_22771851 0.05 ENST00000390466.1
TRAV39
T cell receptor alpha variable 39
chr11_+_18154059 0.05 ENST00000531264.1
MRGPRX3
MAS-related GPR, member X3
chr1_-_59043166 0.05 ENST00000371225.2
TACSTD2
tumor-associated calcium signal transducer 2
chrX_+_54834004 0.05 ENST00000375068.1
MAGED2
melanoma antigen family D, 2
chr9_-_5833027 0.04 ENST00000339450.5
ERMP1
endoplasmic reticulum metallopeptidase 1
chr10_+_24497704 0.04 ENST00000376456.4
ENST00000458595.1
KIAA1217
KIAA1217
chr14_+_75230011 0.03 ENST00000552421.1
ENST00000325680.7
ENST00000238571.3
YLPM1
YLP motif containing 1
chr4_-_113558014 0.03 ENST00000503172.1
ENST00000505019.1
ENST00000309071.5
C4orf21
chromosome 4 open reading frame 21
chr3_+_122399444 0.03 ENST00000474629.2
PARP14
poly (ADP-ribose) polymerase family, member 14
chr2_+_63816295 0.03 ENST00000539945.1
ENST00000544381.1
MDH1
malate dehydrogenase 1, NAD (soluble)
chr19_+_47421933 0.03 ENST00000404338.3
ARHGAP35
Rho GTPase activating protein 35
chr3_-_168865522 0.02 ENST00000464456.1
MECOM
MDS1 and EVI1 complex locus
chr11_+_118443098 0.02 ENST00000392859.3
ENST00000359415.4
ENST00000534182.2
ENST00000264028.4
ARCN1
archain 1
chr9_-_116837249 0.01 ENST00000466610.2
AMBP
alpha-1-microglobulin/bikunin precursor
chr15_+_54901540 0.01 ENST00000539562.2
UNC13C
unc-13 homolog C (C. elegans)
chr2_+_102927962 0.01 ENST00000233954.1
ENST00000393393.3
ENST00000410040.1
IL1RL1
IL18R1
interleukin 1 receptor-like 1
interleukin 18 receptor 1

Network of associatons between targets according to the STRING database.

First level regulatory network of BBX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.3 GO:0009441 glycolate metabolic process(GO:0009441)
0.2 0.6 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.1 0.5 GO:0046668 regulation of retinal cell programmed cell death(GO:0046668)
0.1 0.7 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 0.8 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.1 0.5 GO:0060154 cellular process regulating host cell cycle in response to virus(GO:0060154)
0.1 0.7 GO:0030321 transepithelial chloride transport(GO:0030321)
0.1 0.3 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.0 0.2 GO:0071492 cellular response to UV-A(GO:0071492)
0.0 0.5 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.1 GO:0002728 negative regulation of natural killer cell cytokine production(GO:0002728)
0.0 0.1 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.0 0.4 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.0 0.1 GO:0060437 lung growth(GO:0060437)
0.0 0.2 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.0 3.1 GO:0007368 determination of left/right symmetry(GO:0007368)
0.0 0.2 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.2 GO:0015939 pantothenate metabolic process(GO:0015939)
0.0 0.1 GO:1903899 lung goblet cell differentiation(GO:0060480) positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.0 0.1 GO:0036079 GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
0.0 0.1 GO:0050428 purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.0 0.2 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.0 0.6 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.0 0.8 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.2 GO:0071420 cellular response to histamine(GO:0071420)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 0.2 GO:0044305 calyx of Held(GO:0044305)
0.0 2.3 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 1.5 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.5 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.6 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.5 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.0 0.6 GO:0051233 spindle midzone(GO:0051233)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.1 0.8 GO:0050682 AF-2 domain binding(GO:0050682)
0.1 2.7 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.8 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.1 0.3 GO:0002113 interleukin-33 binding(GO:0002113)
0.1 0.5 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 0.6 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.1 0.2 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
0.1 0.5 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.5 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.2 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.7 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.2 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.0 0.4 GO:0045125 bioactive lipid receptor activity(GO:0045125)
0.0 0.1 GO:0005457 GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)
0.0 0.2 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.6 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.2 GO:0004065 arylsulfatase activity(GO:0004065)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.0 0.5 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.2 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.4 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis