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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for BHLHE22_BHLHA15_BHLHE23

Z-value: 0.69

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Transcription factors associated with BHLHE22_BHLHA15_BHLHE23

Gene Symbol Gene ID Gene Info
BHLHE22
ENSG00000180828.1 basic helix-loop-helix family member e22
BHLHA15
ENSG00000180535.3 basic helix-loop-helix family member a15
BHLHE23
ENSG00000125533.4 basic helix-loop-helix family member e23

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BHLHE22hg19_v2_chr8_+_65492756_65492814-0.115.6e-01Click!

Activity profile of BHLHE22_BHLHA15_BHLHE23 motif

Sorted Z-values of BHLHE22_BHLHA15_BHLHE23 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_163148161 3.89 ENST00000337019.3
ENST00000366889.2
PACRG
PARK2 co-regulated
chr1_+_95975672 3.82 ENST00000440116.2
ENST00000456933.1
RP11-286B14.1
RP11-286B14.1
chr1_+_104293028 3.62 ENST00000370079.3
AMY1C
amylase, alpha 1C (salivary)
chr15_-_65503801 2.98 ENST00000261883.4
CILP
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr1_+_244214577 2.83 ENST00000358704.4
ZBTB18
zinc finger and BTB domain containing 18
chr5_-_111312622 2.11 ENST00000395634.3
NREP
neuronal regeneration related protein
chr3_-_121379739 2.09 ENST00000428394.2
ENST00000314583.3
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr15_-_98417780 2.06 ENST00000503874.3
LINC00923
long intergenic non-protein coding RNA 923
chr1_+_47489240 1.93 ENST00000371901.3
CYP4X1
cytochrome P450, family 4, subfamily X, polypeptide 1
chr6_+_135502501 1.64 ENST00000527615.1
ENST00000420123.2
ENST00000525369.1
ENST00000528774.1
ENST00000534121.1
ENST00000534044.1
ENST00000533624.1
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr3_-_114477962 1.47 ENST00000471418.1
ZBTB20
zinc finger and BTB domain containing 20
chr19_+_56368803 1.45 ENST00000587891.1
NLRP4
NLR family, pyrin domain containing 4
chr3_-_114477787 1.37 ENST00000464560.1
ZBTB20
zinc finger and BTB domain containing 20
chr7_-_99573677 1.32 ENST00000292401.4
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr16_-_69385681 1.31 ENST00000288025.3
TMED6
transmembrane emp24 protein transport domain containing 6
chr1_+_61330931 1.16 ENST00000371191.1
NFIA
nuclear factor I/A
chr9_-_130635741 0.99 ENST00000223836.10
AK1
adenylate kinase 1
chr2_+_186603355 0.92 ENST00000343098.5
FSIP2
fibrous sheath interacting protein 2
chr14_-_107283278 0.89 ENST00000390639.2
IGHV7-81
immunoglobulin heavy variable 7-81 (non-functional)
chr4_+_160188889 0.82 ENST00000264431.4
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr4_-_70505358 0.81 ENST00000457664.2
ENST00000604629.1
ENST00000604021.1
UGT2A2
UDP glucuronosyltransferase 2 family, polypeptide A2
chr11_+_120107344 0.70 ENST00000260264.4
POU2F3
POU class 2 homeobox 3
chr7_-_55930443 0.70 ENST00000388975.3
SEPT14
septin 14
chr7_-_38403077 0.70 ENST00000426402.2
TRGV2
T cell receptor gamma variable 2
chr3_-_197300194 0.68 ENST00000358186.2
ENST00000431056.1
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr5_-_114632307 0.66 ENST00000506442.1
ENST00000379611.5
CCDC112
coiled-coil domain containing 112
chr8_+_67976593 0.55 ENST00000262210.5
ENST00000412460.1
CSPP1
centrosome and spindle pole associated protein 1
chr15_+_65843130 0.51 ENST00000569894.1
PTPLAD1
protein tyrosine phosphatase-like A domain containing 1
chr6_-_119031228 0.51 ENST00000392500.3
ENST00000368488.5
ENST00000434604.1
CEP85L
centrosomal protein 85kDa-like
chr4_-_74088800 0.49 ENST00000509867.2
ANKRD17
ankyrin repeat domain 17
chr12_-_91573132 0.47 ENST00000550563.1
ENST00000546370.1
DCN
decorin
chr3_+_112930306 0.47 ENST00000495514.1
BOC
BOC cell adhesion associated, oncogene regulated
chr1_-_152131703 0.47 ENST00000316073.3
RPTN
repetin
chr19_-_37019562 0.43 ENST00000523638.1
ZNF260
zinc finger protein 260
chr16_-_4896205 0.41 ENST00000589389.1
GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr13_+_28813645 0.40 ENST00000282391.5
PAN3
PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr18_-_52989525 0.39 ENST00000457482.3
TCF4
transcription factor 4
chr3_-_131753830 0.38 ENST00000429747.1
CPNE4
copine IV
chr6_+_97010424 0.37 ENST00000541107.1
ENST00000450218.1
ENST00000326771.2
FHL5
four and a half LIM domains 5
chr20_-_34117447 0.37 ENST00000246199.2
ENST00000424444.1
ENST00000374345.4
ENST00000444723.1
C20orf173
chromosome 20 open reading frame 173
chr10_-_48416849 0.35 ENST00000249598.1
GDF2
growth differentiation factor 2
chr7_-_92855762 0.35 ENST00000453812.2
ENST00000394468.2
HEPACAM2
HEPACAM family member 2
chrX_+_105855160 0.34 ENST00000372544.2
ENST00000372548.4
CXorf57
chromosome X open reading frame 57
chr4_-_87028478 0.33 ENST00000515400.1
ENST00000395157.3
MAPK10
mitogen-activated protein kinase 10
chr11_-_44972418 0.33 ENST00000525680.1
ENST00000528290.1
ENST00000530035.1
TP53I11
tumor protein p53 inducible protein 11
chr21_-_36421401 0.33 ENST00000486278.2
RUNX1
runt-related transcription factor 1
chr9_+_18474098 0.33 ENST00000327883.7
ENST00000431052.2
ENST00000380570.4
ADAMTSL1
ADAMTS-like 1
chr1_-_186344802 0.31 ENST00000451586.1
TPR
translocated promoter region, nuclear basket protein
chr1_+_186344883 0.30 ENST00000367470.3
C1orf27
chromosome 1 open reading frame 27
chr19_+_18208603 0.30 ENST00000262811.6
MAST3
microtubule associated serine/threonine kinase 3
chr15_-_55700522 0.29 ENST00000564092.1
ENST00000310958.6
CCPG1
cell cycle progression 1
chrX_-_13835147 0.29 ENST00000493677.1
ENST00000355135.2
GPM6B
glycoprotein M6B
chr11_-_44972476 0.28 ENST00000527685.1
ENST00000308212.5
TP53I11
tumor protein p53 inducible protein 11
chr8_-_38239732 0.27 ENST00000534155.1
ENST00000433384.2
ENST00000317025.8
ENST00000316985.3
WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chr19_-_54876558 0.27 ENST00000391742.2
ENST00000434277.2
LAIR1
leukocyte-associated immunoglobulin-like receptor 1
chrX_-_13835461 0.25 ENST00000316715.4
ENST00000356942.5
GPM6B
glycoprotein M6B
chr9_+_2158485 0.25 ENST00000417599.1
ENST00000382185.1
ENST00000382183.1
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr3_+_112930387 0.25 ENST00000485230.1
BOC
BOC cell adhesion associated, oncogene regulated
chr8_-_23315190 0.25 ENST00000356206.6
ENST00000358689.4
ENST00000417069.2
ENTPD4
ectonucleoside triphosphate diphosphohydrolase 4
chr1_-_217250231 0.24 ENST00000493748.1
ENST00000463665.1
ESRRG
estrogen-related receptor gamma
chr9_+_2158443 0.24 ENST00000302401.3
ENST00000324954.5
ENST00000423555.1
ENST00000382186.1
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr13_+_49551020 0.24 ENST00000541916.1
FNDC3A
fibronectin type III domain containing 3A
chr1_+_186344945 0.23 ENST00000419367.3
ENST00000287859.6
C1orf27
chromosome 1 open reading frame 27
chr4_+_25915896 0.23 ENST00000514384.1
SMIM20
small integral membrane protein 20
chr4_+_154178520 0.22 ENST00000433687.1
TRIM2
tripartite motif containing 2
chr1_+_159272111 0.21 ENST00000368114.1
FCER1A
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
chr15_-_55700457 0.21 ENST00000442196.3
ENST00000563171.1
ENST00000425574.3
CCPG1
cell cycle progression 1
chr16_-_52640834 0.20 ENST00000510238.3
CASC16
cancer susceptibility candidate 16 (non-protein coding)
chr14_+_27342334 0.20 ENST00000548170.1
ENST00000552926.1
RP11-384J4.1
RP11-384J4.1
chr2_-_32490859 0.19 ENST00000404025.2
NLRC4
NLR family, CARD domain containing 4
chr2_-_32490801 0.19 ENST00000360906.5
ENST00000342905.6
NLRC4
NLR family, CARD domain containing 4
chr3_+_62304648 0.19 ENST00000462069.1
ENST00000232519.5
ENST00000465142.1
C3orf14
chromosome 3 open reading frame 14
chr5_+_173316341 0.19 ENST00000520867.1
ENST00000334035.5
CPEB4
cytoplasmic polyadenylation element binding protein 4
chr4_-_100575781 0.18 ENST00000511828.1
RP11-766F14.2
Protein LOC285556
chr10_+_51565188 0.16 ENST00000430396.2
ENST00000374087.4
ENST00000414907.2
NCOA4
nuclear receptor coactivator 4
chr9_+_108424738 0.16 ENST00000334077.3
TAL2
T-cell acute lymphocytic leukemia 2
chr7_+_107531580 0.15 ENST00000537148.1
ENST00000440410.1
ENST00000437604.2
DLD
dihydrolipoamide dehydrogenase
chr1_-_205091115 0.15 ENST00000264515.6
ENST00000367164.1
RBBP5
retinoblastoma binding protein 5
chr10_+_51565108 0.15 ENST00000438493.1
ENST00000452682.1
NCOA4
nuclear receptor coactivator 4
chr3_+_113251143 0.14 ENST00000264852.4
ENST00000393830.3
SIDT1
SID1 transmembrane family, member 1
chr1_+_12524965 0.14 ENST00000471923.1
VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr5_+_135496675 0.14 ENST00000507637.1
SMAD5
SMAD family member 5
chr3_+_46924829 0.13 ENST00000313049.5
PTH1R
parathyroid hormone 1 receptor
chr6_+_30539153 0.13 ENST00000326195.8
ENST00000376545.3
ENST00000396515.4
ENST00000441867.1
ENST00000468958.1
ABCF1
ATP-binding cassette, sub-family F (GCN20), member 1
chr10_-_69597810 0.13 ENST00000483798.2
DNAJC12
DnaJ (Hsp40) homolog, subfamily C, member 12
chr10_+_17794251 0.13 ENST00000377495.1
ENST00000338221.5
TMEM236
transmembrane protein 236
chr11_-_62359027 0.13 ENST00000494385.1
ENST00000308436.7
TUT1
terminal uridylyl transferase 1, U6 snRNA-specific
chr14_+_69865401 0.13 ENST00000556605.1
ENST00000336643.5
ENST00000031146.4
SLC39A9
solute carrier family 39, member 9
chr10_-_94257512 0.12 ENST00000371581.5
IDE
insulin-degrading enzyme
chrX_-_19817869 0.11 ENST00000379698.4
SH3KBP1
SH3-domain kinase binding protein 1
chrX_-_129402857 0.11 ENST00000447817.1
ENST00000370978.4
ZNF280C
zinc finger protein 280C
chr14_-_51297837 0.10 ENST00000245441.5
ENST00000389868.3
ENST00000382041.3
ENST00000324330.9
ENST00000453196.1
ENST00000453401.2
NIN
ninein (GSK3B interacting protein)
chr9_+_12775011 0.10 ENST00000319264.3
LURAP1L
leucine rich adaptor protein 1-like
chr2_-_183387430 0.10 ENST00000410103.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr3_-_108672742 0.09 ENST00000261047.3
GUCA1C
guanylate cyclase activator 1C
chr5_+_156607829 0.09 ENST00000422843.3
ITK
IL2-inducible T-cell kinase
chr1_-_44818599 0.08 ENST00000537474.1
ERI3
ERI1 exoribonuclease family member 3
chr3_-_18480260 0.08 ENST00000454909.2
SATB1
SATB homeobox 1
chr12_+_50794730 0.08 ENST00000523389.1
ENST00000518561.1
ENST00000347328.5
ENST00000550260.1
LARP4
La ribonucleoprotein domain family, member 4
chr9_+_125796806 0.07 ENST00000373642.1
GPR21
G protein-coupled receptor 21
chr1_-_168464875 0.07 ENST00000422253.1
RP5-968D22.3
RP5-968D22.3
chr7_+_116502605 0.07 ENST00000458284.2
ENST00000490693.1
CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr2_-_228582709 0.07 ENST00000541617.1
ENST00000409456.2
ENST00000409287.1
ENST00000258403.3
SLC19A3
solute carrier family 19 (thiamine transporter), member 3
chr2_-_183387283 0.07 ENST00000435564.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr8_+_67782984 0.06 ENST00000396592.3
ENST00000422365.2
ENST00000492775.1
MCMDC2
minichromosome maintenance domain containing 2
chr14_-_69864993 0.06 ENST00000555373.1
ERH
enhancer of rudimentary homolog (Drosophila)
chr12_-_75723805 0.06 ENST00000409799.1
ENST00000409445.3
CAPS2
calcyphosine 2
chr12_-_40013553 0.05 ENST00000308666.3
ABCD2
ATP-binding cassette, sub-family D (ALD), member 2
chr1_+_180897269 0.05 ENST00000367587.1
KIAA1614
KIAA1614
chr15_-_55700216 0.05 ENST00000569205.1
CCPG1
cell cycle progression 1
chr12_-_91573316 0.05 ENST00000393155.1
DCN
decorin
chr6_-_169364429 0.04 ENST00000444586.1
RP3-495K2.3
RP3-495K2.3
chr3_+_137728842 0.04 ENST00000183605.5
CLDN18
claudin 18
chr4_-_141075330 0.04 ENST00000509479.2
MAML3
mastermind-like 3 (Drosophila)
chr12_-_108714412 0.04 ENST00000412676.1
ENST00000550573.1
CMKLR1
chemokine-like receptor 1
chr6_+_73076432 0.03 ENST00000414192.2
RIMS1
regulating synaptic membrane exocytosis 1
chr1_-_99470368 0.03 ENST00000263177.4
LPPR5
Lipid phosphate phosphatase-related protein type 5
chr7_-_97881429 0.03 ENST00000420697.1
ENST00000379795.3
ENST00000415086.1
ENST00000542604.1
ENST00000447648.2
TECPR1
tectonin beta-propeller repeat containing 1
chr2_+_181845843 0.03 ENST00000602710.1
UBE2E3
ubiquitin-conjugating enzyme E2E 3
chr3_-_150264272 0.03 ENST00000491660.1
ENST00000487153.1
ENST00000239944.2
SERP1
stress-associated endoplasmic reticulum protein 1
chr10_-_15902449 0.03 ENST00000277632.3
FAM188A
family with sequence similarity 188, member A
chr15_+_85144217 0.03 ENST00000540936.1
ENST00000448803.2
ENST00000546275.1
ENST00000546148.1
ENST00000442073.3
ENST00000334141.3
ENST00000358472.3
ENST00000502939.2
ENST00000379358.3
ENST00000327179.6
ZSCAN2
zinc finger and SCAN domain containing 2
chr3_-_108672609 0.02 ENST00000393963.3
ENST00000471108.1
GUCA1C
guanylate cyclase activator 1C
chr11_-_107582775 0.02 ENST00000305991.2
SLN
sarcolipin
chr8_-_67976509 0.01 ENST00000518747.1
COPS5
COP9 signalosome subunit 5
chr5_+_175299743 0.01 ENST00000502265.1
CPLX2
complexin 2
chr2_+_234637754 0.01 ENST00000482026.1
ENST00000609767.1
UGT1A3
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A3
UDP glucuronosyltransferase 1 family, polypeptide A8
chr1_-_99470558 0.01 ENST00000370188.3
LPPR5
Lipid phosphate phosphatase-related protein type 5
chr7_+_148287657 0.01 ENST00000307003.2
C7orf33
chromosome 7 open reading frame 33
chr7_+_116502527 0.01 ENST00000361183.3
CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr7_-_112758665 0.01 ENST00000397764.3
LINC00998
long intergenic non-protein coding RNA 998
chr19_-_52227221 0.01 ENST00000222115.1
ENST00000540069.2
HAS1
hyaluronan synthase 1
chrX_+_107334895 0.01 ENST00000372232.3
ENST00000345734.3
ENST00000372254.3
ATG4A
autophagy related 4A, cysteine peptidase
chr17_+_39846114 0.00 ENST00000586699.1
EIF1
eukaryotic translation initiation factor 1

Network of associatons between targets according to the STRING database.

First level regulatory network of BHLHE22_BHLHA15_BHLHE23

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:1904899 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.3 0.8 GO:0048022 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.3 3.0 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.2 2.4 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 0.7 GO:0046952 ketone body catabolic process(GO:0046952)
0.1 0.5 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.1 0.5 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.1 0.3 GO:0045799 mRNA export from nucleus in response to heat stress(GO:0031990) negative regulation of nucleobase-containing compound transport(GO:0032240) positive regulation of chromatin assembly or disassembly(GO:0045799) negative regulation of RNA export from nucleus(GO:0046832)
0.1 0.2 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.1 0.2 GO:0001812 positive regulation of type I hypersensitivity(GO:0001812)
0.1 0.1 GO:1990918 double-strand break repair involved in meiotic recombination(GO:1990918)
0.1 0.5 GO:0051581 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.1 2.8 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.3 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 1.1 GO:0072189 ureter development(GO:0072189)
0.0 0.4 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.1 GO:1901143 insulin catabolic process(GO:1901143)
0.0 0.4 GO:0070269 pyroptosis(GO:0070269)
0.0 0.7 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.0 0.1 GO:0009106 lipoate metabolic process(GO:0009106)
0.0 1.3 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 4.6 GO:0007286 spermatid development(GO:0007286)
0.0 0.4 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 0.7 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.0 0.1 GO:0001880 Mullerian duct regression(GO:0001880)
0.0 0.1 GO:0033227 dsRNA transport(GO:0033227)
0.0 0.3 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.0 0.4 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 1.0 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.0 0.1 GO:0071934 thiamine transmembrane transport(GO:0071934)
0.0 0.2 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 2.8 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.0 0.9 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.2 GO:0043523 regulation of neuron apoptotic process(GO:0043523)
0.0 0.4 GO:0097503 sialylation(GO:0097503)
0.0 0.6 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.1 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0 1.4 GO:0032479 regulation of type I interferon production(GO:0032479)
0.0 0.2 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.9 GO:0097225 sperm midpiece(GO:0097225)
0.1 0.4 GO:0031251 PAN complex(GO:0031251)
0.1 0.2 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.0 0.1 GO:0043159 acrosomal matrix(GO:0043159)
0.0 0.4 GO:0072557 IPAF inflammasome complex(GO:0072557)
0.0 1.9 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.4 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.7 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.5 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.3 GO:0044754 autolysosome(GO:0044754)
0.0 0.5 GO:0071564 npBAF complex(GO:0071564)
0.0 0.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.3 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.7 GO:0098576 lumenal side of membrane(GO:0098576)
0.0 0.1 GO:0044666 MLL3/4 complex(GO:0044666)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.0 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.2 0.7 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
0.2 0.8 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.1 1.6 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 0.4 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.1 3.9 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 1.9 GO:0070330 aromatase activity(GO:0070330)
0.1 0.4 GO:0047288 monosialoganglioside sialyltransferase activity(GO:0047288)
0.1 1.3 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.1 1.0 GO:0004017 adenylate kinase activity(GO:0004017)
0.1 0.3 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.2 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.0 0.2 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.1 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.4 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.1 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
0.0 0.2 GO:0019863 immunoglobulin receptor activity(GO:0019763) IgE binding(GO:0019863)
0.0 0.1 GO:0022884 macromolecule transmembrane transporter activity(GO:0022884)
0.0 0.1 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.0 0.1 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.0 0.4 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.1 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.0 0.1 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.9 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.1 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.1 GO:0043559 insulin binding(GO:0043559)
0.0 2.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 2.1 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.3 GO:0043495 protein anchor(GO:0043495)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.7 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.6 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 1.2 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.6 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 1.0 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.3 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 1.1 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.4 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.4 REACTOME INFLAMMASOMES Genes involved in Inflammasomes