ISMARA results: BHLHE22_BHLHA15

Project

Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

Navigation

Downloads

Results for BHLHE22_BHLHA15_BHLHE23

Z-value: 0.69

Motif logo

Transcription factors associated with BHLHE22_BHLHA15_BHLHE23

Gene Symbol	Gene ID	Gene Info
BHLHE22 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000180828.1	basic helix-loop-helix family member e22
BHLHA15 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000180535.3	basic helix-loop-helix family member a15
BHLHE23 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000125533.4	basic helix-loop-helix family member e23

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
BHLHE22	hg19_v2_chr8_+_65492756_65492814	-0.11	5.6e-01	Click!

Activity profile of BHLHE22_BHLHA15_BHLHE23 motif

Sorted Z-values of BHLHE22_BHLHA15_BHLHE23 motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr6_+_163148161 Show fit	3.89	ENST00000337019.3 ENST00000366889.2	PACRG Ensembl NCBI GeneCards UniProt NextProt Show fit	PARK2 co-regulated
chr1_+_95975672 Show fit	3.82	ENST00000440116.2 ENST00000456933.1	RP11-286B14.1 Ensembl NCBI GeneCards UniProt NextProt Show fit	RP11-286B14.1
chr1_+_104293028 Show fit	3.62	ENST00000370079.3	AMY1C Ensembl NCBI GeneCards UniProt NextProt Show fit	amylase, alpha 1C (salivary)
chr15_-_65503801 Show fit	2.98	ENST00000261883.4	CILP Ensembl NCBI GeneCards UniProt NextProt Show fit	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr1_+_244214577 Show fit	2.83	ENST00000358704.4	ZBTB18 Ensembl NCBI GeneCards UniProt NextProt Show fit	zinc finger and BTB domain containing 18
chr5_-_111312622 Show fit	2.11	ENST00000395634.3	NREP Ensembl NCBI GeneCards UniProt NextProt Show fit	neuronal regeneration related protein
chr3_-_121379739 Show fit	2.09	ENST00000428394.2 ENST00000314583.3	HCLS1 Ensembl NCBI GeneCards UniProt NextProt Show fit	hematopoietic cell-specific Lyn substrate 1
chr15_-_98417780 Show fit	2.06	ENST00000503874.3	LINC00923 Ensembl NCBI GeneCards UniProt NextProt Show fit	long intergenic non-protein coding RNA 923
chr1_+_47489240 Show fit	1.93	ENST00000371901.3	CYP4X1 Ensembl NCBI GeneCards UniProt NextProt Show fit	cytochrome P450, family 4, subfamily X, polypeptide 1
chr6_+_135502501 Show fit	1.64	ENST00000527615.1 ENST00000420123.2 ENST00000525369.1 ENST00000528774.1 ENST00000534121.1 ENST00000534044.1 ENST00000533624.1	MYB Ensembl NCBI GeneCards UniProt NextProt Show fit	v-myb avian myeloblastosis viral oncogene homolog

Showing 1 to 10 of 134 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of BHLHE22_BHLHA15_BHLHE23

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.6	GO:0007286	spermatid development(GO:0007286)
0.3	3.0	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1	2.8	GO:0032728	positive regulation of interferon-beta production(GO:0032728)
0.0	2.8	GO:0007519	skeletal muscle tissue development(GO:0007519)
0.2	2.4	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.5	1.6	GO:1904899	regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.0	1.4	GO:0032479	regulation of type I interferon production(GO:0032479)
0.0	1.3	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0	1.1	GO:0072189	ureter development(GO:0072189)
0.0	1.0	GO:0015949	nucleobase-containing small molecule interconversion(GO:0015949)

Showing 1 to 10 of 39 entries

Gene overrepresentation in cellular_component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.9	GO:0097225	sperm midpiece(GO:0097225)
0.0	1.9	GO:0045171	intercellular bridge(GO:0045171)
0.0	0.9	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.0	0.7	GO:0044295	axonal growth cone(GO:0044295)
0.0	0.7	GO:0098576	lumenal side of membrane(GO:0098576)
0.0	0.5	GO:0098857	membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0	0.5	GO:0071564	npBAF complex(GO:0071564)
0.1	0.4	GO:0031251	PAN complex(GO:0031251)
0.0	0.4	GO:0072557	IPAF inflammasome complex(GO:0072557)
0.0	0.4	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)

Showing 1 to 10 of 15 entries

Gene overrepresentation in molecular_function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.9	GO:0043014	alpha-tubulin binding(GO:0043014)
0.4	3.0	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.0	2.8	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0	2.1	GO:0001085	RNA polymerase II transcription factor binding(GO:0001085)
0.1	1.9	GO:0070330	aromatase activity(GO:0070330)
0.1	1.6	GO:0001135	transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1	1.3	GO:0008320	protein transmembrane transporter activity(GO:0008320)
0.1	1.0	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	0.9	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.2	0.8	GO:0031697	beta-1 adrenergic receptor binding(GO:0031697)

Showing 1 to 10 of 29 entries

Gene overrepresentation in C2:CP category:

Search:

Show entries

Total log-likelihood	Term	Description
1.6	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
1.6	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
1.2	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.7	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.6	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks

Showing 1 to 5 of 5 entries

Gene overrepresentation in C2:CP:REACTOME category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	3.6	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate
0.0	1.1	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	1.0	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	0.4	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.0	0.4	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.0	0.3	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors

Showing 1 to 6 of 6 entries

Results for BHLHE22_BHLHA15_BHLHE23

Z-value: 0.69

Motif logo

Transcription factors associated with BHLHE22_BHLHA15_BHLHE23

Activity-expression correlation:

Activity profile of BHLHE22_BHLHA15_BHLHE23 motif

Sorted Z-values of BHLHE22_BHLHA15_BHLHE23 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of BHLHE22_BHLHA15_BHLHE23

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: