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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for BHLHE40

Z-value: 0.79

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Transcription factors associated with BHLHE40

Gene Symbol Gene ID Gene Info
BHLHE40
ENSG00000134107.4 basic helix-loop-helix family member e40

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BHLHE40hg19_v2_chr3_+_5020801_50209520.542.3e-03Click!

Activity profile of BHLHE40 motif

Sorted Z-values of BHLHE40 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_25102252 4.12 ENST00000261192.7
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr19_+_35645618 3.92 ENST00000392218.2
ENST00000543307.1
ENST00000392219.2
ENST00000541435.2
ENST00000590686.1
ENST00000342879.3
ENST00000588699.1
FXYD5
FXYD domain containing ion transport regulator 5
chr12_-_25101920 3.34 ENST00000539780.1
ENST00000546285.1
ENST00000342945.5
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr19_+_35645817 3.21 ENST00000423817.3
FXYD5
FXYD domain containing ion transport regulator 5
chr12_+_66217911 2.06 ENST00000403681.2
HMGA2
high mobility group AT-hook 2
chr1_-_200589859 1.89 ENST00000367350.4
KIF14
kinesin family member 14
chr6_+_151561085 1.53 ENST00000402676.2
AKAP12
A kinase (PRKA) anchor protein 12
chr1_-_113498943 1.46 ENST00000369626.3
SLC16A1
solute carrier family 16 (monocarboxylate transporter), member 1
chr7_-_107642348 1.45 ENST00000393561.1
LAMB1
laminin, beta 1
chr8_+_32405728 1.42 ENST00000523079.1
ENST00000338921.4
ENST00000356819.4
ENST00000287845.5
ENST00000341377.5
NRG1
neuregulin 1
chr8_+_32405785 1.40 ENST00000287842.3
NRG1
neuregulin 1
chr4_-_159094194 1.39 ENST00000592057.1
ENST00000585682.1
ENST00000393807.5
FAM198B
family with sequence similarity 198, member B
chr8_+_99129513 1.31 ENST00000522319.1
ENST00000401707.2
POP1
processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
chr17_+_40811283 1.30 ENST00000251412.7
TUBG2
tubulin, gamma 2
chr11_+_60609537 1.22 ENST00000227520.5
CCDC86
coiled-coil domain containing 86
chr21_-_45079341 1.22 ENST00000443485.1
ENST00000291560.2
HSF2BP
heat shock transcription factor 2 binding protein
chr7_+_141463897 1.15 ENST00000247879.2
TAS2R3
taste receptor, type 2, member 3
chr19_-_55652290 1.12 ENST00000589745.1
TNNT1
troponin T type 1 (skeletal, slow)
chr2_-_47143160 1.11 ENST00000409800.1
ENST00000409218.1
MCFD2
multiple coagulation factor deficiency 2
chr2_-_47142884 1.10 ENST00000409105.1
ENST00000409973.1
ENST00000409913.1
ENST00000319466.4
MCFD2
multiple coagulation factor deficiency 2
chr9_+_706842 1.10 ENST00000382293.3
KANK1
KN motif and ankyrin repeat domains 1
chr17_+_2699697 1.09 ENST00000254695.8
ENST00000366401.4
ENST00000542807.1
RAP1GAP2
RAP1 GTPase activating protein 2
chr1_-_43638168 1.07 ENST00000431635.2
EBNA1BP2
EBNA1 binding protein 2
chr7_-_73133959 1.05 ENST00000395155.3
ENST00000395154.3
ENST00000222812.3
ENST00000395156.3
STX1A
syntaxin 1A (brain)
chr1_+_119957554 0.98 ENST00000543831.1
ENST00000433745.1
ENST00000369416.3
HSD3B2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
chr1_-_231376836 0.97 ENST00000451322.1
C1orf131
chromosome 1 open reading frame 131
chr22_-_30987837 0.91 ENST00000335214.6
PES1
pescadillo ribosomal biogenesis factor 1
chr1_+_35247859 0.86 ENST00000373362.3
GJB3
gap junction protein, beta 3, 31kDa
chr5_+_89770664 0.84 ENST00000503973.1
ENST00000399107.1
POLR3G
polymerase (RNA) III (DNA directed) polypeptide G (32kD)
chr5_+_89770696 0.81 ENST00000504930.1
ENST00000514483.1
POLR3G
polymerase (RNA) III (DNA directed) polypeptide G (32kD)
chr4_-_57301748 0.81 ENST00000264220.2
PPAT
phosphoribosyl pyrophosphate amidotransferase
chr19_-_16045665 0.77 ENST00000248041.8
CYP4F11
cytochrome P450, family 4, subfamily F, polypeptide 11
chr19_-_16045619 0.77 ENST00000402119.4
CYP4F11
cytochrome P450, family 4, subfamily F, polypeptide 11
chrX_-_128977781 0.76 ENST00000357166.6
ZDHHC9
zinc finger, DHHC-type containing 9
chr5_-_101834617 0.76 ENST00000513675.1
ENST00000379807.3
SLCO6A1
solute carrier organic anion transporter family, member 6A1
chrX_+_43515467 0.75 ENST00000338702.3
ENST00000542639.1
MAOA
monoamine oxidase A
chr4_+_57301896 0.75 ENST00000514888.1
ENST00000264221.2
ENST00000505164.1
PAICS
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr5_-_101834712 0.75 ENST00000506729.1
ENST00000389019.3
ENST00000379810.1
SLCO6A1
solute carrier organic anion transporter family, member 6A1
chr8_+_22857048 0.74 ENST00000251822.6
RHOBTB2
Rho-related BTB domain containing 2
chr19_-_45909585 0.74 ENST00000593226.1
ENST00000418234.2
PPP1R13L
protein phosphatase 1, regulatory subunit 13 like
chr4_+_57302297 0.70 ENST00000399688.3
ENST00000512576.1
PAICS
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr5_-_145214893 0.70 ENST00000394450.2
PRELID2
PRELI domain containing 2
chr16_-_56701933 0.69 ENST00000568675.1
ENST00000569500.1
ENST00000444837.2
ENST00000379811.3
MT1G
metallothionein 1G
chr3_+_111578640 0.68 ENST00000393925.3
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr12_-_48298785 0.68 ENST00000550325.1
ENST00000546653.1
ENST00000549336.1
ENST00000535672.1
ENST00000229022.3
ENST00000548664.1
VDR
vitamin D (1,25- dihydroxyvitamin D3) receptor
chr1_+_173793777 0.66 ENST00000239457.5
DARS2
aspartyl-tRNA synthetase 2, mitochondrial
chr7_+_2671568 0.66 ENST00000258796.7
TTYH3
tweety family member 3
chr7_-_229557 0.65 ENST00000514988.1
AC145676.2
Uncharacterized protein
chr1_-_43637915 0.64 ENST00000236051.2
EBNA1BP2
EBNA1 binding protein 2
chr7_+_28725585 0.63 ENST00000396298.2
CREB5
cAMP responsive element binding protein 5
chr5_+_36152179 0.62 ENST00000508514.1
ENST00000513151.1
ENST00000546211.1
SKP2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr5_+_36152091 0.62 ENST00000274254.5
SKP2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr14_-_102026643 0.62 ENST00000555882.1
ENST00000554441.1
ENST00000553729.1
ENST00000557109.1
ENST00000557532.1
ENST00000554694.1
ENST00000554735.1
ENST00000555174.1
ENST00000557661.1
DIO3OS
DIO3 opposite strand/antisense RNA (head to head)
chr7_+_147830776 0.60 ENST00000538075.1
CNTNAP2
contactin associated protein-like 2
chr22_-_30987849 0.58 ENST00000402284.3
ENST00000354694.7
PES1
pescadillo ribosomal biogenesis factor 1
chr16_+_29911666 0.58 ENST00000563177.1
ENST00000483405.1
ASPHD1
aspartate beta-hydroxylase domain containing 1
chr21_+_38071430 0.56 ENST00000290399.6
SIM2
single-minded family bHLH transcription factor 2
chr2_+_201676908 0.55 ENST00000409226.1
ENST00000452790.2
BZW1
basic leucine zipper and W2 domains 1
chr3_+_99536663 0.55 ENST00000421999.2
ENST00000463526.1
CMSS1
cms1 ribosomal small subunit homolog (yeast)
chr6_+_70576457 0.53 ENST00000322773.4
COL19A1
collagen, type XIX, alpha 1
chr9_-_139258235 0.53 ENST00000371738.3
DNLZ
DNL-type zinc finger
chrX_-_128977364 0.53 ENST00000371064.3
ZDHHC9
zinc finger, DHHC-type containing 9
chr2_-_10588630 0.51 ENST00000234111.4
ODC1
ornithine decarboxylase 1
chr6_-_151773232 0.49 ENST00000444024.1
ENST00000367303.4
RMND1
required for meiotic nuclear division 1 homolog (S. cerevisiae)
chr16_+_29911864 0.49 ENST00000308748.5
ASPHD1
aspartate beta-hydroxylase domain containing 1
chr5_+_149737202 0.49 ENST00000451292.1
ENST00000377797.3
ENST00000445265.2
ENST00000323668.7
ENST00000439160.2
ENST00000394269.3
ENST00000427724.2
ENST00000504761.2
ENST00000513346.1
ENST00000515516.1
TCOF1
Treacher Collins-Franceschetti syndrome 1
chr17_+_72199721 0.48 ENST00000439590.2
ENST00000311111.6
ENST00000584577.1
ENST00000534490.1
ENST00000528433.2
ENST00000533498.1
RPL38
ribosomal protein L38
chr7_-_151574191 0.48 ENST00000287878.4
PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr5_+_36152163 0.47 ENST00000274255.6
SKP2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr1_-_165325939 0.46 ENST00000342310.3
LMX1A
LIM homeobox transcription factor 1, alpha
chr17_-_72772462 0.45 ENST00000582870.1
ENST00000581136.1
ENST00000357814.3
ENST00000579218.1
ENST00000583476.1
ENST00000580301.1
ENST00000583757.1
ENST00000582524.1
NAT9
N-acetyltransferase 9 (GCN5-related, putative)
chr1_-_171621815 0.45 ENST00000037502.6
MYOC
myocilin, trabecular meshwork inducible glucocorticoid response
chr4_-_85418103 0.44 ENST00000515820.2
NKX6-1
NK6 homeobox 1
chr14_+_93389425 0.44 ENST00000216492.5
ENST00000334654.4
CHGA
chromogranin A (parathyroid secretory protein 1)
chr8_-_134584152 0.43 ENST00000521180.1
ENST00000517668.1
ENST00000319914.5
ST3GAL1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr12_-_6677422 0.43 ENST00000382421.3
ENST00000545200.1
ENST00000399466.2
ENST00000536124.1
ENST00000540228.1
ENST00000542867.1
ENST00000545492.1
ENST00000322166.5
ENST00000545915.1
NOP2
NOP2 nucleolar protein
chr19_-_45953983 0.43 ENST00000592083.1
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr21_+_27107672 0.42 ENST00000400075.3
GABPA
GA binding protein transcription factor, alpha subunit 60kDa
chr7_-_37024665 0.42 ENST00000396040.2
ELMO1
engulfment and cell motility 1
chr5_-_145214848 0.41 ENST00000505416.1
ENST00000334744.4
ENST00000358004.2
ENST00000511435.1
PRELID2
PRELI domain containing 2
chr9_-_123691047 0.41 ENST00000373887.3
TRAF1
TNF receptor-associated factor 1
chr3_-_98312548 0.39 ENST00000264193.2
CPOX
coproporphyrinogen oxidase
chr19_-_52133588 0.38 ENST00000570106.2
SIGLEC5
sialic acid binding Ig-like lectin 5
chr2_-_10587897 0.38 ENST00000405333.1
ENST00000443218.1
ODC1
ornithine decarboxylase 1
chr8_-_134584092 0.37 ENST00000522652.1
ST3GAL1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr3_+_133293278 0.37 ENST00000508481.1
ENST00000420115.2
ENST00000504867.1
ENST00000507408.1
ENST00000511392.1
ENST00000515421.1
CDV3
CDV3 homolog (mouse)
chr17_-_53046058 0.36 ENST00000571584.1
ENST00000299335.3
COX11
cytochrome c oxidase assembly homolog 11 (yeast)
chr4_-_100009856 0.36 ENST00000296412.8
ADH5
alcohol dehydrogenase 5 (class III), chi polypeptide
chr1_-_47407111 0.35 ENST00000371904.4
CYP4A11
cytochrome P450, family 4, subfamily A, polypeptide 11
chr14_-_45722605 0.34 ENST00000310806.4
MIS18BP1
MIS18 binding protein 1
chr1_+_203830703 0.34 ENST00000414487.2
SNRPE
small nuclear ribonucleoprotein polypeptide E
chr9_-_139258159 0.33 ENST00000371739.3
DNLZ
DNL-type zinc finger
chr14_+_71648152 0.33 ENST00000561794.1
RP6-91H8.2
RP6-91H8.2
chr8_-_48872686 0.33 ENST00000314191.2
ENST00000338368.3
PRKDC
protein kinase, DNA-activated, catalytic polypeptide
chr1_+_44445549 0.33 ENST00000356836.6
B4GALT2
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
chr4_+_188916918 0.30 ENST00000509524.1
ENST00000326866.4
ZFP42
ZFP42 zinc finger protein
chr12_-_58165870 0.30 ENST00000257848.7
METTL1
methyltransferase like 1
chr19_+_7660716 0.29 ENST00000160298.4
ENST00000446248.2
CAMSAP3
calmodulin regulated spectrin-associated protein family, member 3
chr22_-_50523760 0.29 ENST00000395876.2
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr4_+_119200215 0.29 ENST00000602573.1
SNHG8
small nucleolar RNA host gene 8 (non-protein coding)
chr1_+_43637996 0.29 ENST00000528956.1
ENST00000529956.1
WDR65
WD repeat domain 65
chr5_+_161274685 0.28 ENST00000428797.2
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr1_+_12079517 0.27 ENST00000235332.4
ENST00000436478.2
MIIP
migration and invasion inhibitory protein
chr1_-_231376867 0.27 ENST00000366649.2
ENST00000318906.2
ENST00000366651.3
C1orf131
chromosome 1 open reading frame 131
chr15_+_58724184 0.26 ENST00000433326.2
LIPC
lipase, hepatic
chr11_-_65626753 0.25 ENST00000526975.1
ENST00000531413.1
CFL1
cofilin 1 (non-muscle)
chr13_-_99630233 0.24 ENST00000376460.1
ENST00000442173.1
DOCK9
dedicator of cytokinesis 9
chr8_-_99129338 0.24 ENST00000520507.1
HRSP12
heat-responsive protein 12
chr1_+_207070775 0.24 ENST00000391929.3
ENST00000294984.2
ENST00000367093.3
IL24
interleukin 24
chr8_+_125985531 0.23 ENST00000319286.5
ZNF572
zinc finger protein 572
chr1_+_231376941 0.23 ENST00000436239.1
ENST00000366647.4
ENST00000366646.3
ENST00000416000.1
GNPAT
glyceronephosphate O-acyltransferase
chr6_+_144164455 0.23 ENST00000367576.5
LTV1
LTV1 homolog (S. cerevisiae)
chr17_-_8066843 0.23 ENST00000404970.3
VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr17_+_72772621 0.22 ENST00000335464.5
ENST00000417024.2
ENST00000578764.1
ENST00000582773.1
ENST00000582330.1
TMEM104
transmembrane protein 104
chr9_-_95640218 0.22 ENST00000395506.3
ENST00000375495.3
ENST00000332591.6
ZNF484
zinc finger protein 484
chr19_+_56154913 0.22 ENST00000270451.5
ENST00000588537.1
ZNF581
zinc finger protein 581
chr2_-_136743039 0.21 ENST00000537273.1
DARS
aspartyl-tRNA synthetase
chrX_+_129040122 0.20 ENST00000394422.3
ENST00000371051.5
UTP14A
UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
chr22_+_48885272 0.20 ENST00000402357.1
FAM19A5
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
chr14_+_73393040 0.20 ENST00000358377.2
ENST00000353777.3
ENST00000394234.2
ENST00000509153.1
ENST00000555042.1
DCAF4
DDB1 and CUL4 associated factor 4
chr2_-_136743169 0.20 ENST00000264161.4
DARS
aspartyl-tRNA synthetase
chr3_+_111578583 0.19 ENST00000478922.1
ENST00000477695.1
PHLDB2
pleckstrin homology-like domain, family B, member 2
chrX_+_129040094 0.18 ENST00000425117.2
UTP14A
UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
chr10_-_35379524 0.18 ENST00000374751.3
ENST00000374742.1
ENST00000602371.1
CUL2
cullin 2
chrX_+_66764375 0.18 ENST00000374690.3
AR
androgen receptor
chr1_+_20465805 0.17 ENST00000375102.3
PLA2G2F
phospholipase A2, group IIF
chrX_+_55101495 0.17 ENST00000374974.3
ENST00000374971.1
PAGE2B
P antigen family, member 2B
chr5_+_94982435 0.17 ENST00000511684.1
ENST00000380005.4
RFESD
Rieske (Fe-S) domain containing
chr8_-_99129384 0.16 ENST00000521560.1
ENST00000254878.3
HRSP12
heat-responsive protein 12
chr6_-_5261141 0.16 ENST00000330636.4
ENST00000500576.2
LYRM4
LYR motif containing 4
chr4_+_41983713 0.15 ENST00000333141.5
DCAF4L1
DDB1 and CUL4 associated factor 4-like 1
chr9_-_100881466 0.15 ENST00000341469.2
ENST00000342043.3
ENST00000375098.3
TRIM14
tripartite motif containing 14
chr11_+_6624970 0.15 ENST00000420936.2
ENST00000528995.1
ILK
integrin-linked kinase
chr13_-_38172863 0.14 ENST00000541481.1
ENST00000379743.4
ENST00000379742.4
ENST00000379749.4
ENST00000541179.1
ENST00000379747.4
POSTN
periostin, osteoblast specific factor
chr15_-_35088340 0.14 ENST00000290378.4
ACTC1
actin, alpha, cardiac muscle 1
chr22_-_50964558 0.14 ENST00000535425.1
ENST00000439934.1
SCO2
SCO2 cytochrome c oxidase assembly protein
chr13_+_50656307 0.14 ENST00000378180.4
DLEU1
deleted in lymphocytic leukemia 1 (non-protein coding)
chr2_+_74153953 0.13 ENST00000264093.4
ENST00000348222.1
DGUOK
deoxyguanosine kinase
chr17_+_15635561 0.13 ENST00000584301.1
ENST00000580596.1
ENST00000464963.1
ENST00000437605.2
ENST00000579428.1
TBC1D26
TBC1 domain family, member 26
chr5_-_71616043 0.13 ENST00000508863.2
ENST00000522095.1
ENST00000513900.1
ENST00000515404.1
ENST00000457646.4
ENST00000261413.5
MRPS27
mitochondrial ribosomal protein S27
chr2_+_103236004 0.12 ENST00000233969.2
SLC9A2
solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
chr4_+_47487285 0.12 ENST00000273859.3
ENST00000504445.1
ATP10D
ATPase, class V, type 10D
chrX_+_23685563 0.12 ENST00000379341.4
PRDX4
peroxiredoxin 4
chr4_+_119199904 0.12 ENST00000602483.1
ENST00000602819.1
SNHG8
small nucleolar RNA host gene 8 (non-protein coding)
chr1_+_48688357 0.12 ENST00000533824.1
ENST00000438567.2
ENST00000236495.5
ENST00000420136.2
SLC5A9
solute carrier family 5 (sodium/sugar cotransporter), member 9
chr11_-_65626797 0.11 ENST00000525451.2
CFL1
cofilin 1 (non-muscle)
chr11_+_6624955 0.11 ENST00000299421.4
ENST00000537806.1
ILK
integrin-linked kinase
chr1_+_213123976 0.11 ENST00000366965.2
ENST00000366967.2
VASH2
vasohibin 2
chr11_+_6625046 0.11 ENST00000396751.2
ILK
integrin-linked kinase
chr9_+_130565147 0.10 ENST00000373247.2
ENST00000373245.1
ENST00000393706.2
ENST00000373228.1
FPGS
folylpolyglutamate synthase
chr1_+_201708992 0.10 ENST00000367295.1
NAV1
neuron navigator 1
chr6_+_13615554 0.09 ENST00000451315.2
NOL7
nucleolar protein 7, 27kDa
chr6_-_36842784 0.09 ENST00000373699.5
PPIL1
peptidylprolyl isomerase (cyclophilin)-like 1
chr2_-_112642267 0.09 ENST00000341068.3
ANAPC1
anaphase promoting complex subunit 1
chr19_-_3786253 0.09 ENST00000585778.1
MATK
megakaryocyte-associated tyrosine kinase
chr10_+_101491968 0.08 ENST00000370476.5
ENST00000370472.4
CUTC
cutC copper transporter
chr21_-_30391636 0.08 ENST00000493196.1
RWDD2B
RWD domain containing 2B
chr6_-_5260963 0.07 ENST00000464010.1
ENST00000468929.1
ENST00000480566.1
LYRM4
LYR motif containing 4
chr2_+_207630081 0.07 ENST00000236980.6
ENST00000418289.1
ENST00000402774.3
ENST00000403094.3
FASTKD2
FAST kinase domains 2
chr17_-_13505219 0.07 ENST00000284110.1
HS3ST3A1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
chr2_-_27545921 0.07 ENST00000402310.1
ENST00000405983.1
ENST00000403262.2
ENST00000428910.1
ENST00000402722.1
ENST00000399052.4
ENST00000380044.1
ENST00000405076.1
MPV17
MpV17 mitochondrial inner membrane protein
chr22_-_37505449 0.06 ENST00000406725.1
TMPRSS6
transmembrane protease, serine 6
chr17_+_74733744 0.06 ENST00000586689.1
ENST00000587661.1
ENST00000593181.1
ENST00000336509.4
ENST00000355954.3
MFSD11
major facilitator superfamily domain containing 11
chr12_+_93861282 0.06 ENST00000552217.1
ENST00000393128.4
ENST00000547098.1
MRPL42
mitochondrial ribosomal protein L42
chr6_+_36410762 0.06 ENST00000483557.1
ENST00000498267.1
ENST00000544295.1
ENST00000449081.2
ENST00000536244.1
ENST00000460983.1
KCTD20
potassium channel tetramerization domain containing 20
chr10_-_6019552 0.06 ENST00000379977.3
ENST00000397251.3
ENST00000397248.2
IL15RA
interleukin 15 receptor, alpha
chr5_+_172571445 0.06 ENST00000231668.9
ENST00000351486.5
ENST00000352523.6
ENST00000393770.4
BNIP1
BCL2/adenovirus E1B 19kDa interacting protein 1
chr4_+_119199864 0.05 ENST00000602414.1
ENST00000602520.1
SNHG8
small nucleolar RNA host gene 8 (non-protein coding)
chr12_+_93861264 0.04 ENST00000549982.1
ENST00000361630.2
MRPL42
mitochondrial ribosomal protein L42
chr16_+_4897632 0.04 ENST00000262376.6
UBN1
ubinuclein 1
chr12_+_54674482 0.03 ENST00000547708.1
ENST00000340913.6
ENST00000551702.1
ENST00000330752.8
ENST00000547276.1
HNRNPA1
heterogeneous nuclear ribonucleoprotein A1
chr1_+_213123915 0.03 ENST00000366968.4
ENST00000490792.1
VASH2
vasohibin 2
chrX_+_23685653 0.02 ENST00000379331.3
PRDX4
peroxiredoxin 4
chr5_-_137090028 0.02 ENST00000314940.4
HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr20_-_35374456 0.02 ENST00000373803.2
ENST00000359675.2
ENST00000540765.1
ENST00000349004.1
NDRG3
NDRG family member 3
chr2_+_74154032 0.01 ENST00000356837.6
DGUOK
deoxyguanosine kinase
chr15_+_68924327 0.01 ENST00000543950.1
CORO2B
coronin, actin binding protein, 2B
chr1_-_112046289 0.00 ENST00000241356.4
ADORA3
adenosine A3 receptor
chr17_-_10600818 0.00 ENST00000577427.1
ENST00000255390.5
SCO1
SCO1 cytochrome c oxidase assembly protein

Network of associatons between targets according to the STRING database.

First level regulatory network of BHLHE40

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 7.1 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
1.2 7.5 GO:0009098 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.5 2.1 GO:0035978 mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685)
0.5 1.5 GO:0051780 mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780)
0.4 3.3 GO:0038129 ERBB3 signaling pathway(GO:0038129)
0.4 1.5 GO:0042377 menaquinone catabolic process(GO:0042361) vitamin K catabolic process(GO:0042377)
0.4 1.9 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
0.4 1.1 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.4 1.4 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.3 1.7 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.3 1.1 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.2 0.7 GO:1904747 apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.2 2.3 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.2 0.9 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.2 0.7 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.2 0.6 GO:0071109 superior temporal gyrus development(GO:0071109)
0.2 1.3 GO:0016078 tRNA catabolic process(GO:0016078)
0.1 0.4 GO:0002071 glandular epithelial cell maturation(GO:0002071) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913) type B pancreatic cell maturation(GO:0072560)
0.1 0.4 GO:0061110 dense core granule biogenesis(GO:0061110) positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of dense core granule biogenesis(GO:2000705)
0.1 1.5 GO:0007000 nucleolus organization(GO:0007000)
0.1 0.4 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.1 1.3 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 1.1 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.1 0.4 GO:0046294 formaldehyde catabolic process(GO:0046294)
0.1 0.3 GO:0003095 pressure natriuresis(GO:0003095)
0.1 1.5 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 0.4 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.1 1.0 GO:0008212 mineralocorticoid biosynthetic process(GO:0006705) mineralocorticoid metabolic process(GO:0008212)
0.1 0.4 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.1 0.4 GO:0033132 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.1 0.2 GO:0060748 lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599) tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.1 0.9 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 0.8 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.1 0.4 GO:0070475 rRNA base methylation(GO:0070475)
0.1 0.4 GO:2000782 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.0 0.3 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.5 GO:0048318 axial mesoderm development(GO:0048318)
0.0 0.8 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.3 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)
0.0 0.2 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0 0.5 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.0 1.7 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.9 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.7 GO:0042117 monocyte activation(GO:0042117)
0.0 0.4 GO:0051597 response to methylmercury(GO:0051597)
0.0 0.1 GO:0046122 purine deoxyribonucleoside metabolic process(GO:0046122)
0.0 1.3 GO:0007020 microtubule nucleation(GO:0007020)
0.0 0.1 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.0 0.5 GO:0042048 olfactory behavior(GO:0042048)
0.0 1.5 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.5 GO:0014029 neural crest formation(GO:0014029)
0.0 0.7 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.0 1.1 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.1 GO:0032571 response to vitamin K(GO:0032571) bone regeneration(GO:1990523)
0.0 0.1 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.0 0.2 GO:1903593 regulation of histamine secretion by mast cell(GO:1903593)
0.0 1.9 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.2 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.1 GO:0090131 mesenchyme migration(GO:0090131)
0.0 0.5 GO:0006853 carnitine shuttle(GO:0006853)
0.0 1.8 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.0 0.3 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.0 0.3 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.3 GO:0071420 cellular response to histamine(GO:0071420)
0.0 1.2 GO:0015914 phospholipid transport(GO:0015914)
0.0 0.4 GO:0032288 myelin assembly(GO:0032288)
0.0 0.3 GO:0018146 keratan sulfate biosynthetic process(GO:0018146)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0005607 laminin-2 complex(GO:0005607)
0.3 1.3 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.2 1.5 GO:0070545 PeBoW complex(GO:0070545)
0.2 1.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.2 2.1 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 1.0 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.1 3.4 GO:0030673 axolemma(GO:0030673)
0.1 0.4 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.1 1.7 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 1.7 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 0.3 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.1 0.9 GO:0045180 basal cortex(GO:0045180)
0.0 1.1 GO:0005861 troponin complex(GO:0005861)
0.0 1.9 GO:0051233 spindle midzone(GO:0051233)
0.0 1.3 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.3 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.0 0.3 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.0 0.2 GO:0030891 VCB complex(GO:0030891)
0.0 0.9 GO:0005922 connexon complex(GO:0005922)
0.0 0.2 GO:0034448 EGO complex(GO:0034448)
0.0 0.3 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.0 0.1 GO:0042643 actomyosin, actin portion(GO:0042643)
0.0 2.2 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.4 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.4 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 1.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.3 GO:0005915 zonula adherens(GO:0005915)
0.0 0.5 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.4 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 1.3 GO:0031228 intrinsic component of Golgi membrane(GO:0031228)
0.0 0.5 GO:0030686 90S preribosome(GO:0030686)
0.0 0.8 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.4 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.1 GO:0043194 axon initial segment(GO:0043194)
0.0 1.1 GO:0032580 Golgi cisterna membrane(GO:0032580)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 7.5 GO:0052656 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.5 2.1 GO:0035501 MH1 domain binding(GO:0035501)
0.5 1.5 GO:0015130 mevalonate transmembrane transporter activity(GO:0015130)
0.3 1.0 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.3 2.8 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.2 1.1 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.2 1.1 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.1 0.7 GO:0038181 vitamin D binding(GO:0005499) bile acid receptor activity(GO:0038181) vitamin D response element binding(GO:0070644)
0.1 0.3 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.1 7.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 0.4 GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383)
0.1 0.8 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 1.5 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 1.1 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.1 0.3 GO:0018685 alkane 1-monooxygenase activity(GO:0018685)
0.1 1.3 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 0.3 GO:0004461 lactose synthase activity(GO:0004461)
0.1 1.1 GO:0031014 troponin T binding(GO:0031014)
0.1 0.4 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.1 0.8 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1 1.1 GO:0033038 bitter taste receptor activity(GO:0033038)
0.1 1.9 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 1.6 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.5 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.5 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.0 0.9 GO:0005243 gap junction channel activity(GO:0005243)
0.0 1.3 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.4 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.0 1.5 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.3 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.4 GO:0032027 myosin light chain binding(GO:0032027)
0.0 1.5 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.3 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 0.2 GO:0004882 androgen receptor activity(GO:0004882)
0.0 1.7 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 0.4 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.0 0.4 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.1 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.0 0.7 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.2 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.0 0.3 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.0 0.3 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 2.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.8 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.9 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.1 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.1 GO:0004645 phosphorylase activity(GO:0004645)
0.0 0.3 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.4 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.1 GO:0015386 potassium:proton antiporter activity(GO:0015386)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.8 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 1.7 PID MYC PATHWAY C-MYC pathway
0.1 1.4 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 8.3 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.6 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.7 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.4 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.3 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 7.5 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 2.3 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 2.0 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1 2.8 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 1.5 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 1.3 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 1.0 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 2.5 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.9 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.9 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.8 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 1.7 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 1.1 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.5 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.3 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.6 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.4 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 0.4 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.1 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.4 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.4 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.4 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 1.4 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.3 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.4 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA