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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for BRCA1

Z-value: 0.41

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Transcription factors associated with BRCA1

Gene Symbol Gene ID Gene Info
BRCA1
ENSG00000012048.15 BRCA1 DNA repair associated

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BRCA1hg19_v2_chr17_-_41277317_41277348-0.328.0e-02Click!

Activity profile of BRCA1 motif

Sorted Z-values of BRCA1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_55888186 2.18 ENST00000291934.3
TMEM190
transmembrane protein 190
chr20_+_9049682 1.88 ENST00000334005.3
ENST00000378473.3
PLCB4
phospholipase C, beta 4
chr20_+_31749574 1.18 ENST00000253362.2
BPIFA2
BPI fold containing family A, member 2
chr7_-_6010263 0.90 ENST00000455618.2
ENST00000405415.1
ENST00000404406.1
ENST00000542644.1
RSPH10B
radial spoke head 10 homolog B (Chlamydomonas)
chr8_+_37553261 0.87 ENST00000331569.4
ZNF703
zinc finger protein 703
chr6_+_16129308 0.85 ENST00000356840.3
ENST00000349606.4
MYLIP
myosin regulatory light chain interacting protein
chr5_+_140186647 0.85 ENST00000512229.2
ENST00000356878.4
ENST00000530339.1
PCDHA4
protocadherin alpha 4
chr17_-_42019836 0.84 ENST00000225992.3
PPY
pancreatic polypeptide
chr1_-_160232312 0.79 ENST00000440682.1
DCAF8
DDB1 and CUL4 associated factor 8
chr1_-_227505289 0.66 ENST00000366765.3
CDC42BPA
CDC42 binding protein kinase alpha (DMPK-like)
chr20_+_52105495 0.62 ENST00000439873.2
AL354993.1
Cell growth-inhibiting protein 7; HCG1784586; Uncharacterized protein
chr9_-_124976154 0.51 ENST00000482062.1
LHX6
LIM homeobox 6
chr11_-_119234876 0.49 ENST00000525735.1
USP2
ubiquitin specific peptidase 2
chr6_+_12717892 0.46 ENST00000379350.1
PHACTR1
phosphatase and actin regulator 1
chrX_-_10851762 0.42 ENST00000380785.1
ENST00000380787.1
MID1
midline 1 (Opitz/BBB syndrome)
chr5_+_139027877 0.41 ENST00000302517.3
CXXC5
CXXC finger protein 5
chr10_-_61900762 0.39 ENST00000355288.2
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr17_-_27230035 0.39 ENST00000378895.4
ENST00000394901.3
DHRS13
dehydrogenase/reductase (SDR family) member 13
chr3_+_184056614 0.36 ENST00000453072.1
FAM131A
family with sequence similarity 131, member A
chr3_-_27410847 0.36 ENST00000429845.2
ENST00000341435.5
ENST00000435750.1
NEK10
NIMA-related kinase 10
chr10_-_69597810 0.36 ENST00000483798.2
DNAJC12
DnaJ (Hsp40) homolog, subfamily C, member 12
chr8_-_72459885 0.35 ENST00000523987.1
RP11-1102P16.1
Uncharacterized protein
chr1_-_217250231 0.35 ENST00000493748.1
ENST00000463665.1
ESRRG
estrogen-related receptor gamma
chr7_-_121944491 0.35 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
FEZF1
FEZ family zinc finger 1
chr12_-_49449107 0.34 ENST00000301067.7
KMT2D
lysine (K)-specific methyltransferase 2D
chr12_-_122879969 0.32 ENST00000540304.1
CLIP1
CAP-GLY domain containing linker protein 1
chr1_-_160232291 0.31 ENST00000368074.1
ENST00000447377.1
DCAF8
DDB1 and CUL4 associated factor 8
chr17_-_56296580 0.30 ENST00000313863.6
ENST00000546108.1
ENST00000337050.7
ENST00000393119.2
MKS1
Meckel syndrome, type 1
chr1_-_160232197 0.29 ENST00000419626.1
ENST00000610139.1
ENST00000475733.1
ENST00000407642.2
ENST00000368073.3
ENST00000326837.2
DCAF8
DDB1 and CUL4 associated factor 8
chr5_+_145583107 0.28 ENST00000506502.1
RBM27
RNA binding motif protein 27
chr1_-_170043709 0.25 ENST00000367767.1
ENST00000361580.2
ENST00000538366.1
KIFAP3
kinesin-associated protein 3
chr13_-_99910673 0.25 ENST00000397473.2
ENST00000397470.2
GPR18
G protein-coupled receptor 18
chr7_+_99717230 0.24 ENST00000262932.3
CNPY4
canopy FGF signaling regulator 4
chr5_+_145583156 0.24 ENST00000265271.5
RBM27
RNA binding motif protein 27
chr17_-_8702667 0.23 ENST00000329805.4
MFSD6L
major facilitator superfamily domain containing 6-like
chr18_-_49557 0.23 ENST00000308911.6
RP11-683L23.1
Tubulin beta-8 chain-like protein LOC260334
chr1_+_159141397 0.23 ENST00000368124.4
ENST00000368125.4
ENST00000416746.1
CADM3
cell adhesion molecule 3
chr12_+_510742 0.22 ENST00000239830.4
CCDC77
coiled-coil domain containing 77
chr12_+_510795 0.22 ENST00000412006.2
CCDC77
coiled-coil domain containing 77
chr14_-_75179774 0.22 ENST00000555249.1
ENST00000556202.1
ENST00000356357.4
ENST00000338772.5
AREL1
AC007956.1
apoptosis resistant E3 ubiquitin protein ligase 1
Full-length cDNA 5-PRIME end of clone CS0CAP004YO05 of Thymus of Homo sapiens (human); Uncharacterized protein
chr4_+_619347 0.21 ENST00000255622.6
PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta
chrX_+_10124977 0.21 ENST00000380833.4
CLCN4
chloride channel, voltage-sensitive 4
chr10_+_93683519 0.21 ENST00000265990.6
BTAF1
BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa
chrX_-_46187069 0.20 ENST00000446884.1
RP1-30G7.2
RP1-30G7.2
chr11_-_27722021 0.20 ENST00000356660.4
ENST00000418212.1
ENST00000533246.1
BDNF
brain-derived neurotrophic factor
chr2_-_152118352 0.19 ENST00000331426.5
RBM43
RNA binding motif protein 43
chr11_+_47291645 0.19 ENST00000395336.3
ENST00000402192.2
MADD
MAP-kinase activating death domain
chr17_-_60142609 0.19 ENST00000397786.2
MED13
mediator complex subunit 13
chr4_-_140005443 0.18 ENST00000510408.1
ENST00000420916.2
ENST00000358635.3
ELF2
E74-like factor 2 (ets domain transcription factor)
chr10_+_102295616 0.18 ENST00000299163.6
HIF1AN
hypoxia inducible factor 1, alpha subunit inhibitor
chr8_-_116681221 0.18 ENST00000395715.3
TRPS1
trichorhinophalangeal syndrome I
chr13_+_103046954 0.17 ENST00000606448.1
FGF14-AS2
FGF14 antisense RNA 2
chr5_+_140079919 0.17 ENST00000274712.3
ZMAT2
zinc finger, matrin-type 2
chr6_+_33172407 0.17 ENST00000374662.3
HSD17B8
hydroxysteroid (17-beta) dehydrogenase 8
chr13_-_50018140 0.16 ENST00000410043.1
ENST00000347776.5
CAB39L
calcium binding protein 39-like
chr2_-_158182410 0.16 ENST00000419116.2
ENST00000410096.1
ERMN
ermin, ERM-like protein
chr4_+_619386 0.16 ENST00000496514.1
PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta
chr20_-_48530230 0.16 ENST00000422556.1
SPATA2
spermatogenesis associated 2
chrX_+_49644470 0.16 ENST00000508866.2
USP27X
ubiquitin specific peptidase 27, X-linked
chr13_+_30002846 0.15 ENST00000542829.1
MTUS2
microtubule associated tumor suppressor candidate 2
chr11_-_110583912 0.15 ENST00000533353.1
ENST00000527598.1
ARHGAP20
Rho GTPase activating protein 20
chr2_-_25194476 0.15 ENST00000534855.1
DNAJC27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr17_+_21730180 0.15 ENST00000584398.1
UBBP4
ubiquitin B pseudogene 4
chr11_+_47291193 0.15 ENST00000428807.1
ENST00000402799.1
ENST00000406482.1
ENST00000349238.3
ENST00000311027.5
ENST00000407859.3
ENST00000395344.3
ENST00000444117.1
MADD
MAP-kinase activating death domain
chr2_-_179914760 0.14 ENST00000420890.2
ENST00000409284.1
ENST00000443758.1
ENST00000446116.1
CCDC141
coiled-coil domain containing 141
chr5_+_139493665 0.13 ENST00000331327.3
PURA
purine-rich element binding protein A
chr16_-_790887 0.13 ENST00000540986.1
NARFL
nuclear prelamin A recognition factor-like
chr16_-_790982 0.13 ENST00000301694.5
ENST00000251588.2
NARFL
nuclear prelamin A recognition factor-like
chr6_+_123100620 0.12 ENST00000368444.3
FABP7
fatty acid binding protein 7, brain
chr1_-_232598163 0.12 ENST00000308942.4
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr1_+_161736072 0.11 ENST00000367942.3
ATF6
activating transcription factor 6
chr19_-_37663332 0.10 ENST00000392157.2
ZNF585A
zinc finger protein 585A
chr17_-_7082861 0.10 ENST00000269299.3
ASGR1
asialoglycoprotein receptor 1
chr7_+_73868439 0.09 ENST00000424337.2
GTF2IRD1
GTF2I repeat domain containing 1
chr10_+_104404644 0.08 ENST00000462202.2
TRIM8
tripartite motif containing 8
chr10_-_69597828 0.08 ENST00000339758.7
DNAJC12
DnaJ (Hsp40) homolog, subfamily C, member 12
chr10_+_92631709 0.07 ENST00000413330.1
ENST00000277882.3
RPP30
ribonuclease P/MRP 30kDa subunit
chr12_+_122880045 0.07 ENST00000539034.1
ENST00000535976.1
RP11-450K4.1
RP11-450K4.1
chr5_-_68665296 0.07 ENST00000512152.1
ENST00000503245.1
ENST00000512561.1
ENST00000380822.4
TAF9
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
chr13_+_27825706 0.07 ENST00000272274.4
ENST00000319826.4
ENST00000326092.4
RPL21
ribosomal protein L21
chr14_-_60097524 0.07 ENST00000342503.4
RTN1
reticulon 1
chr18_-_23671139 0.06 ENST00000579061.1
ENST00000542420.2
SS18
synovial sarcoma translocation, chromosome 18
chr10_-_102289611 0.06 ENST00000299166.4
ENST00000370320.4
ENST00000531258.1
ENST00000370322.1
ENST00000535773.1
NDUFB8
SEC31B
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
SEC31 homolog B (S. cerevisiae)
chr14_-_60097297 0.06 ENST00000395090.1
RTN1
reticulon 1
chr21_+_46066331 0.05 ENST00000334670.8
KRTAP10-11
keratin associated protein 10-11
chr9_+_35792151 0.05 ENST00000342694.2
NPR2
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr19_-_37663572 0.04 ENST00000588354.1
ENST00000292841.5
ENST00000355533.2
ENST00000356958.4
ZNF585A
zinc finger protein 585A
chr1_+_160147176 0.04 ENST00000470705.1
ATP1A4
ATPase, Na+/K+ transporting, alpha 4 polypeptide
chr4_+_185570767 0.03 ENST00000314970.6
ENST00000515774.1
ENST00000503752.1
PRIMPOL
primase and polymerase (DNA-directed)
chr3_+_185303962 0.03 ENST00000296257.5
SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chrX_-_77150911 0.03 ENST00000373336.3
MAGT1
magnesium transporter 1
chr8_-_16859690 0.02 ENST00000180166.5
FGF20
fibroblast growth factor 20
chr6_-_137314371 0.01 ENST00000432330.1
ENST00000418699.1
RP11-55K22.5
RP11-55K22.5
chr4_-_48782259 0.01 ENST00000507711.1
ENST00000358350.4
ENST00000537810.1
ENST00000264319.7
FRYL
FRY-like
chr18_+_55888767 0.01 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr13_+_30002741 0.01 ENST00000380808.2
MTUS2
microtubule associated tumor suppressor candidate 2
chrX_-_77150985 0.01 ENST00000358075.6
MAGT1
magnesium transporter 1
chr1_+_10271674 0.00 ENST00000377086.1
KIF1B
kinesin family member 1B

Network of associatons between targets according to the STRING database.

First level regulatory network of BRCA1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0032803 regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803)
0.1 0.4 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 0.2 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
0.1 0.2 GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
0.1 0.3 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.1 0.9 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.1 0.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 0.3 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.0 0.2 GO:0001555 oocyte growth(GO:0001555)
0.0 0.2 GO:0061009 common bile duct development(GO:0061009)
0.0 0.5 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 0.2 GO:0061428 peptidyl-aspartic acid hydroxylation(GO:0042264) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.0 0.5 GO:0045475 locomotor rhythm(GO:0045475)
0.0 0.2 GO:0045204 MAPK export from nucleus(GO:0045204)
0.0 0.4 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.8 GO:0032098 regulation of appetite(GO:0032098)
0.0 0.2 GO:0042492 gamma-delta T cell differentiation(GO:0042492)
0.0 0.1 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.0 0.3 GO:0032364 oxygen homeostasis(GO:0032364)
0.0 0.1 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 1.9 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.0 0.2 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.0 0.1 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.0 GO:1900194 negative regulation of oocyte maturation(GO:1900194)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:0002079 inner acrosomal membrane(GO:0002079)
0.1 0.2 GO:1990075 kinesin II complex(GO:0016939) periciliary membrane compartment(GO:1990075)
0.0 0.3 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.3 GO:0097361 CIA complex(GO:0097361)
0.0 1.9 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 1.4 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.2 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.4 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.2 GO:0033269 internode region of axon(GO:0033269)
0.0 0.3 GO:0036038 MKS complex(GO:0036038)
0.0 0.4 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.1 GO:0000172 ribonuclease MRP complex(GO:0000172)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.1 0.4 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 1.9 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.2 GO:0070404 NADH binding(GO:0070404)
0.0 2.2 GO:0043621 protein self-association(GO:0043621)
0.0 0.8 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 1.0 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 0.2 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.4 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 0.1 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.0 0.2 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.2 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.2 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.9 ST G ALPHA I PATHWAY G alpha i Pathway
0.0 0.4 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.9 REACTOME PLC BETA MEDIATED EVENTS Genes involved in PLC beta mediated events
0.0 0.4 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins