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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for BRCA1

Z-value: 0.41

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Transcription factors associated with BRCA1

Gene Symbol Gene ID Gene Info
ENSG00000012048.15 BRCA1 DNA repair associated

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BRCA1hg19_v2_chr17_-_41277317_41277348-0.328.0e-02Click!

Activity profile of BRCA1 motif

Sorted Z-values of BRCA1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_55888186 2.18 ENST00000291934.3
transmembrane protein 190
chr20_+_9049682 1.88 ENST00000334005.3
ENST00000378473.3
phospholipase C, beta 4
chr20_+_31749574 1.18 ENST00000253362.2
BPI fold containing family A, member 2
chr7_-_6010263 0.90 ENST00000455618.2
ENST00000405415.1
ENST00000404406.1
ENST00000542644.1
radial spoke head 10 homolog B (Chlamydomonas)
chr8_+_37553261 0.87 ENST00000331569.4
zinc finger protein 703
chr6_+_16129308 0.85 ENST00000356840.3
ENST00000349606.4
myosin regulatory light chain interacting protein
chr5_+_140186647 0.85 ENST00000512229.2
ENST00000356878.4
ENST00000530339.1
protocadherin alpha 4
chr17_-_42019836 0.84 ENST00000225992.3
pancreatic polypeptide
chr1_-_160232312 0.79 ENST00000440682.1
DDB1 and CUL4 associated factor 8
chr1_-_227505289 0.66 ENST00000366765.3
CDC42 binding protein kinase alpha (DMPK-like)
chr20_+_52105495 0.62 ENST00000439873.2
Cell growth-inhibiting protein 7; HCG1784586; Uncharacterized protein
chr9_-_124976154 0.51 ENST00000482062.1
LIM homeobox 6
chr11_-_119234876 0.49 ENST00000525735.1
ubiquitin specific peptidase 2
chr6_+_12717892 0.46 ENST00000379350.1
phosphatase and actin regulator 1
chrX_-_10851762 0.42 ENST00000380785.1
ENST00000380787.1
midline 1 (Opitz/BBB syndrome)
chr5_+_139027877 0.41 ENST00000302517.3
CXXC finger protein 5
chr10_-_61900762 0.39 ENST00000355288.2
ankyrin 3, node of Ranvier (ankyrin G)
chr17_-_27230035 0.39 ENST00000378895.4
ENST00000394901.3
dehydrogenase/reductase (SDR family) member 13
chr3_+_184056614 0.36 ENST00000453072.1
family with sequence similarity 131, member A
chr3_-_27410847 0.36 ENST00000429845.2
ENST00000341435.5
ENST00000435750.1
NIMA-related kinase 10
chr10_-_69597810 0.36 ENST00000483798.2
DnaJ (Hsp40) homolog, subfamily C, member 12
chr8_-_72459885 0.35 ENST00000523987.1
Uncharacterized protein
chr1_-_217250231 0.35 ENST00000493748.1
ENST00000463665.1
estrogen-related receptor gamma
chr7_-_121944491 0.35 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
FEZ family zinc finger 1
chr12_-_49449107 0.34 ENST00000301067.7
lysine (K)-specific methyltransferase 2D
chr12_-_122879969 0.32 ENST00000540304.1
CAP-GLY domain containing linker protein 1
chr1_-_160232291 0.31 ENST00000368074.1
ENST00000447377.1
DDB1 and CUL4 associated factor 8
chr17_-_56296580 0.30 ENST00000313863.6
ENST00000546108.1
ENST00000337050.7
ENST00000393119.2
Meckel syndrome, type 1
chr1_-_160232197 0.29 ENST00000419626.1
ENST00000610139.1
ENST00000475733.1
ENST00000407642.2
ENST00000368073.3
ENST00000326837.2
DDB1 and CUL4 associated factor 8
chr5_+_145583107 0.28 ENST00000506502.1
RNA binding motif protein 27
chr1_-_170043709 0.25 ENST00000367767.1
ENST00000361580.2
ENST00000538366.1
kinesin-associated protein 3
chr13_-_99910673 0.25 ENST00000397473.2
ENST00000397470.2
G protein-coupled receptor 18
chr7_+_99717230 0.24 ENST00000262932.3
canopy FGF signaling regulator 4
chr5_+_145583156 0.24 ENST00000265271.5
RNA binding motif protein 27
chr17_-_8702667 0.23 ENST00000329805.4
major facilitator superfamily domain containing 6-like
chr18_-_49557 0.23 ENST00000308911.6
Tubulin beta-8 chain-like protein LOC260334
chr1_+_159141397 0.23 ENST00000368124.4
ENST00000368125.4
ENST00000416746.1
cell adhesion molecule 3
chr12_+_510742 0.22 ENST00000239830.4
coiled-coil domain containing 77
chr12_+_510795 0.22 ENST00000412006.2
coiled-coil domain containing 77
chr14_-_75179774 0.22 ENST00000555249.1
ENST00000556202.1
ENST00000356357.4
ENST00000338772.5
apoptosis resistant E3 ubiquitin protein ligase 1
Full-length cDNA 5-PRIME end of clone CS0CAP004YO05 of Thymus of Homo sapiens (human); Uncharacterized protein
chr4_+_619347 0.21 ENST00000255622.6
phosphodiesterase 6B, cGMP-specific, rod, beta
chrX_+_10124977 0.21 ENST00000380833.4
chloride channel, voltage-sensitive 4
chr10_+_93683519 0.21 ENST00000265990.6
BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa
chrX_-_46187069 0.20 ENST00000446884.1
RP1-30G7.2
chr11_-_27722021 0.20 ENST00000356660.4
ENST00000418212.1
ENST00000533246.1
brain-derived neurotrophic factor
chr2_-_152118352 0.19 ENST00000331426.5
RNA binding motif protein 43
chr11_+_47291645 0.19 ENST00000395336.3
ENST00000402192.2
MAP-kinase activating death domain
chr17_-_60142609 0.19 ENST00000397786.2
mediator complex subunit 13
chr4_-_140005443 0.18 ENST00000510408.1
ENST00000420916.2
ENST00000358635.3
E74-like factor 2 (ets domain transcription factor)
chr10_+_102295616 0.18 ENST00000299163.6
hypoxia inducible factor 1, alpha subunit inhibitor
chr8_-_116681221 0.18 ENST00000395715.3
trichorhinophalangeal syndrome I
chr13_+_103046954 0.17 ENST00000606448.1
FGF14 antisense RNA 2
chr5_+_140079919 0.17 ENST00000274712.3
zinc finger, matrin-type 2
chr6_+_33172407 0.17 ENST00000374662.3
hydroxysteroid (17-beta) dehydrogenase 8
chr13_-_50018140 0.16 ENST00000410043.1
ENST00000347776.5
calcium binding protein 39-like
chr2_-_158182410 0.16 ENST00000419116.2
ENST00000410096.1
ermin, ERM-like protein
chr4_+_619386 0.16 ENST00000496514.1
phosphodiesterase 6B, cGMP-specific, rod, beta
chr20_-_48530230 0.16 ENST00000422556.1
spermatogenesis associated 2
chrX_+_49644470 0.16 ENST00000508866.2
ubiquitin specific peptidase 27, X-linked
chr13_+_30002846 0.15 ENST00000542829.1
microtubule associated tumor suppressor candidate 2
chr11_-_110583912 0.15 ENST00000533353.1
ENST00000527598.1
Rho GTPase activating protein 20
chr2_-_25194476 0.15 ENST00000534855.1
DnaJ (Hsp40) homolog, subfamily C, member 27
chr17_+_21730180 0.15 ENST00000584398.1
ubiquitin B pseudogene 4
chr11_+_47291193 0.15 ENST00000428807.1
ENST00000402799.1
ENST00000406482.1
ENST00000349238.3
ENST00000311027.5
ENST00000407859.3
ENST00000395344.3
ENST00000444117.1
MAP-kinase activating death domain
chr2_-_179914760 0.14 ENST00000420890.2
ENST00000409284.1
ENST00000443758.1
ENST00000446116.1
coiled-coil domain containing 141
chr5_+_139493665 0.13 ENST00000331327.3
purine-rich element binding protein A
chr16_-_790887 0.13 ENST00000540986.1
nuclear prelamin A recognition factor-like
chr16_-_790982 0.13 ENST00000301694.5
ENST00000251588.2
nuclear prelamin A recognition factor-like
chr6_+_123100620 0.12 ENST00000368444.3
fatty acid binding protein 7, brain
chr1_-_232598163 0.12 ENST00000308942.4
signal-induced proliferation-associated 1 like 2
chr1_+_161736072 0.11 ENST00000367942.3
activating transcription factor 6
chr19_-_37663332 0.10 ENST00000392157.2
zinc finger protein 585A
chr17_-_7082861 0.10 ENST00000269299.3
asialoglycoprotein receptor 1
chr7_+_73868439 0.09 ENST00000424337.2
GTF2I repeat domain containing 1
chr10_+_104404644 0.08 ENST00000462202.2
tripartite motif containing 8
chr10_-_69597828 0.08 ENST00000339758.7
DnaJ (Hsp40) homolog, subfamily C, member 12
chr10_+_92631709 0.07 ENST00000413330.1
ENST00000277882.3
ribonuclease P/MRP 30kDa subunit
chr12_+_122880045 0.07 ENST00000539034.1
ENST00000535976.1
RP11-450K4.1
chr5_-_68665296 0.07 ENST00000512152.1
ENST00000503245.1
ENST00000512561.1
ENST00000380822.4
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
chr13_+_27825706 0.07 ENST00000272274.4
ENST00000319826.4
ENST00000326092.4
ribosomal protein L21
chr14_-_60097524 0.07 ENST00000342503.4
reticulon 1
chr18_-_23671139 0.06 ENST00000579061.1
ENST00000542420.2
synovial sarcoma translocation, chromosome 18
chr10_-_102289611 0.06 ENST00000299166.4
ENST00000370320.4
ENST00000531258.1
ENST00000370322.1
ENST00000535773.1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
SEC31 homolog B (S. cerevisiae)
chr14_-_60097297 0.06 ENST00000395090.1
reticulon 1
chr21_+_46066331 0.05 ENST00000334670.8
keratin associated protein 10-11
chr9_+_35792151 0.05 ENST00000342694.2
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr19_-_37663572 0.04 ENST00000588354.1
ENST00000292841.5
ENST00000355533.2
ENST00000356958.4
zinc finger protein 585A
chr1_+_160147176 0.04 ENST00000470705.1
ATPase, Na+/K+ transporting, alpha 4 polypeptide
chr4_+_185570767 0.03 ENST00000314970.6
ENST00000515774.1
ENST00000503752.1
primase and polymerase (DNA-directed)
chr3_+_185303962 0.03 ENST00000296257.5
SUMO1/sentrin/SMT3 specific peptidase 2
chrX_-_77150911 0.03 ENST00000373336.3
magnesium transporter 1
chr8_-_16859690 0.02 ENST00000180166.5
fibroblast growth factor 20
chr6_-_137314371 0.01 ENST00000432330.1
ENST00000418699.1
RP11-55K22.5
chr4_-_48782259 0.01 ENST00000507711.1
ENST00000358350.4
ENST00000537810.1
ENST00000264319.7
FRY-like
chr18_+_55888767 0.01 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr13_+_30002741 0.01 ENST00000380808.2
microtubule associated tumor suppressor candidate 2
chrX_-_77150985 0.01 ENST00000358075.6
magnesium transporter 1
chr1_+_10271674 0.00 ENST00000377086.1
kinesin family member 1B

Network of associatons between targets according to the STRING database.

First level regulatory network of BRCA1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0032803 regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803)
0.1 0.4 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 0.2 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
0.1 0.2 GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
0.1 0.3 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.1 0.9 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.1 0.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 0.3 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.0 0.2 GO:0001555 oocyte growth(GO:0001555)
0.0 0.2 GO:0061009 common bile duct development(GO:0061009)
0.0 0.5 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 0.2 GO:0061428 peptidyl-aspartic acid hydroxylation(GO:0042264) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.0 0.5 GO:0045475 locomotor rhythm(GO:0045475)
0.0 0.2 GO:0045204 MAPK export from nucleus(GO:0045204)
0.0 0.4 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.8 GO:0032098 regulation of appetite(GO:0032098)
0.0 0.2 GO:0042492 gamma-delta T cell differentiation(GO:0042492)
0.0 0.1 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.0 0.3 GO:0032364 oxygen homeostasis(GO:0032364)
0.0 0.1 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 1.9 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.0 0.2 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.0 0.1 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.0 GO:1900194 negative regulation of oocyte maturation(GO:1900194)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:0002079 inner acrosomal membrane(GO:0002079)
0.1 0.2 GO:1990075 kinesin II complex(GO:0016939) periciliary membrane compartment(GO:1990075)
0.0 0.3 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.3 GO:0097361 CIA complex(GO:0097361)
0.0 1.9 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 1.4 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.2 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.4 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.2 GO:0033269 internode region of axon(GO:0033269)
0.0 0.3 GO:0036038 MKS complex(GO:0036038)
0.0 0.4 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.1 GO:0000172 ribonuclease MRP complex(GO:0000172)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.1 0.4 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 1.9 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.2 GO:0070404 NADH binding(GO:0070404)
0.0 2.2 GO:0043621 protein self-association(GO:0043621)
0.0 0.8 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 1.0 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 0.2 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.4 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 0.1 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.0 0.2 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.2 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.2 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.9 ST G ALPHA I PATHWAY G alpha i Pathway
0.0 0.4 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.9 REACTOME PLC BETA MEDIATED EVENTS Genes involved in PLC beta mediated events
0.0 0.4 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins