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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for CBFB

Z-value: 0.42

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Transcription factors associated with CBFB

Gene Symbol Gene ID Gene Info
ENSG00000067955.9 core-binding factor subunit beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
CBFBhg19_v2_chr16_+_67062996_670630190.271.5e-01Click!

Activity profile of CBFB motif

Sorted Z-values of CBFB motif

Promoter Log-likelihood Transcript Gene Gene Info
chr20_+_44637526 1.31 ENST00000372330.3
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr14_+_85996471 1.07 ENST00000330753.4
fibronectin leucine rich transmembrane protein 2
chr5_-_39203093 0.76 ENST00000515010.1
FYN binding protein
chr2_-_158300556 0.60 ENST00000264192.3
cytohesin 1 interacting protein
chr19_-_14049184 0.60 ENST00000339560.5
podocan-like 1
chr19_-_14048804 0.57 ENST00000254320.3
ENST00000586075.1
podocan-like 1
chr14_+_85996507 0.55 ENST00000554746.1
fibronectin leucine rich transmembrane protein 2
chr6_-_34524049 0.53 ENST00000374037.3
SAM pointed domain containing ETS transcription factor
chr20_+_62492566 0.49 ENST00000369916.3
abhydrolase domain containing 16B
chr6_-_34524093 0.46 ENST00000544425.1
SAM pointed domain containing ETS transcription factor
chr11_-_58343319 0.44 ENST00000395074.2
leupaxin
chr3_-_99569821 0.37 ENST00000487087.1
filamin A interacting protein 1-like
chr3_+_132843652 0.36 ENST00000508711.1
transmembrane protein 108
chr1_-_52499443 0.34 ENST00000371614.1
KTI12 homolog, chromatin associated (S. cerevisiae)
chr20_+_54987305 0.33 ENST00000371336.3
ENST00000434344.1
Cas scaffolding protein family member 4
chr11_-_66103867 0.32 ENST00000424433.2
Ras and Rab interactor 1
chr11_+_114310164 0.31 ENST00000544196.1
ENST00000539754.1
ENST00000539275.1
RNA exonuclease 2
chr20_+_54987168 0.30 ENST00000360314.3
Cas scaffolding protein family member 4
chr1_-_179112173 0.30 ENST00000408940.3
ENST00000504405.1
c-abl oncogene 2, non-receptor tyrosine kinase
chr8_-_60031762 0.29 ENST00000361421.1
thymocyte selection-associated high mobility group box
chr20_+_43343886 0.28 ENST00000190983.4
WNT1 inducible signaling pathway protein 2
chr11_+_114310102 0.26 ENST00000265881.5
RNA exonuclease 2
chr12_-_52585765 0.25 ENST00000313234.5
ENST00000394815.2
keratin 80
chr1_+_47264711 0.24 ENST00000371923.4
ENST00000271153.4
ENST00000371919.4
cytochrome P450, family 4, subfamily B, polypeptide 1
chr11_-_66104237 0.24 ENST00000530056.1
Ras and Rab interactor 1
chr11_+_114310237 0.23 ENST00000539119.1
RNA exonuclease 2
chrX_+_68048803 0.23 ENST00000204961.4
ephrin-B1
chr11_-_66103932 0.21 ENST00000311320.4
Ras and Rab interactor 1
chr17_-_39183452 0.21 ENST00000361883.5
keratin associated protein 1-5
chr22_+_42665742 0.20 ENST00000332965.3
ENST00000415205.1
ENST00000446578.1
Z83851.3
chr10_-_29811456 0.20 ENST00000535393.1
supervillin
chr15_-_64665911 0.20 ENST00000606793.1
ENST00000561349.1
ENST00000560278.1
Uncharacterized protein
chr12_-_54778471 0.20 ENST00000550120.1
ENST00000394313.2
ENST00000547210.1
zinc finger protein 385A
chrX_+_115567767 0.19 ENST00000371900.4
solute carrier family 6 (amino acid transporter), member 14
chr4_+_88896819 0.19 ENST00000237623.7
ENST00000395080.3
ENST00000508233.1
ENST00000360804.4
secreted phosphoprotein 1
chr14_+_22748980 0.19 ENST00000390465.2
T cell receptor alpha variable 38-2/delta variable 8
chr12_-_14849470 0.17 ENST00000261170.3
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr12_-_4754339 0.17 ENST00000228850.1
A kinase (PRKA) anchor protein 3
chr6_+_42847649 0.16 ENST00000424341.2
ENST00000602561.1
ribosomal protein L7-like 1
chr1_+_89246647 0.16 ENST00000544045.1
protein kinase N2
chr14_-_59950724 0.15 ENST00000481608.1
L-3-hydroxyproline dehydratase (trans-)
chr14_-_85996332 0.15 ENST00000380722.1
RP11-497E19.1
chr2_+_68592305 0.13 ENST00000234313.7
pleckstrin
chr5_+_131409476 0.12 ENST00000296871.2
colony stimulating factor 2 (granulocyte-macrophage)
chr14_-_35183886 0.12 ENST00000298159.6
cofilin 2 (muscle)
chr6_+_29068386 0.12 ENST00000377171.3
olfactory receptor, family 2, subfamily J, member 1 (gene/pseudogene)
chrX_-_49041242 0.11 ENST00000453382.1
ENST00000540849.1
ENST00000536904.1
ENST00000432913.1
prickle homolog 3 (Drosophila)
chr6_-_75912508 0.11 ENST00000416123.2
collagen, type XII, alpha 1
chrX_-_70838306 0.11 ENST00000373691.4
ENST00000373693.3
chemokine (C-X-C motif) receptor 3
chr4_+_71091786 0.10 ENST00000317987.5
follicular dendritic cell secreted protein
chr7_+_120628731 0.10 ENST00000310396.5
cadherin-like and PC-esterase domain containing 1
chr5_-_137878887 0.08 ENST00000507939.1
ENST00000572514.1
ENST00000499810.2
ENST00000360541.5
eukaryotic translation termination factor 1
chr3_+_156799587 0.08 ENST00000469196.1
RP11-6F2.5
chr12_-_53594227 0.07 ENST00000550743.2
integrin, beta 7
chr3_-_71834318 0.06 ENST00000353065.3
prokineticin 2
chr15_+_64386261 0.06 ENST00000560829.1
sorting nexin 1
chr1_+_196621002 0.06 ENST00000367429.4
ENST00000439155.2
complement factor H
chr4_+_74347400 0.05 ENST00000226355.3
afamin
chr1_+_39876151 0.05 ENST00000530275.1
KIAA0754
chr2_+_207024306 0.05 ENST00000236957.5
ENST00000392221.1
ENST00000392222.2
ENST00000445505.1
eukaryotic translation elongation factor 1 beta 2
chr11_+_18343800 0.05 ENST00000453096.2
general transcription factor IIH, polypeptide 1, 62kDa
chr9_+_15422702 0.05 ENST00000380821.3
ENST00000421710.1
small nuclear RNA activating complex, polypeptide 3, 50kDa
chr17_+_32582293 0.04 ENST00000580907.1
ENST00000225831.4
chemokine (C-C motif) ligand 2
chr6_+_30908747 0.04 ENST00000462446.1
ENST00000304311.2
diffuse panbronchiolitis critical region 1
chr6_+_27925019 0.04 ENST00000244623.1
olfactory receptor, family 2, subfamily B, member 6
chr14_+_72064945 0.03 ENST00000537413.1
signal-induced proliferation-associated 1 like 1
chr1_+_17634689 0.03 ENST00000375453.1
ENST00000375448.4
peptidyl arginine deiminase, type IV
chr15_+_73976545 0.03 ENST00000318443.5
ENST00000537340.2
ENST00000318424.5
CD276 molecule
chr13_-_28674693 0.02 ENST00000537084.1
ENST00000241453.7
ENST00000380982.4
fms-related tyrosine kinase 3
chr22_+_23222886 0.02 ENST00000390319.2
immunoglobulin lambda variable 3-1
chrX_-_153718988 0.02 ENST00000263512.4
ENST00000393587.4
ENST00000453912.1
solute carrier family 10, member 3
chr2_+_234826016 0.02 ENST00000324695.4
ENST00000433712.2
transient receptor potential cation channel, subfamily M, member 8
chr5_+_35856951 0.01 ENST00000303115.3
ENST00000343305.4
ENST00000506850.1
ENST00000511982.1
interleukin 7 receptor
chr8_+_104384616 0.01 ENST00000520337.1
collagen triple helix repeat containing 1
chr1_-_240775447 0.01 ENST00000318160.4
gremlin 2, DAN family BMP antagonist
chr12_-_55028664 0.01 ENST00000547511.1
ENST00000257867.4
lacritin
chr13_+_76210448 0.01 ENST00000377499.5
LIM domain 7
chr14_-_59951112 0.01 ENST00000247194.4
L-3-hydroxyproline dehydratase (trans-)
chr2_-_105030466 0.01 ENST00000449772.1
AC068535.3
chr11_-_84028180 0.00 ENST00000280241.8
discs, large homolog 2 (Drosophila)

Network of associatons between targets according to the STRING database.

First level regulatory network of CBFB

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.1 1.3 GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268)
0.1 1.0 GO:0060480 lung goblet cell differentiation(GO:0060480)
0.1 0.8 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.1 0.2 GO:2000863 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.1 0.4 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.0 0.2 GO:1902162 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.0 0.4 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0 0.2 GO:0018879 biphenyl metabolic process(GO:0018879)
0.0 0.1 GO:0045918 negative regulation of cytolysis(GO:0045918)
0.0 0.1 GO:0070560 protein secretion by platelet(GO:0070560)
0.0 0.1 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.0 0.8 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.2 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.0 GO:2000502 negative regulation of natural killer cell chemotaxis(GO:2000502)
0.0 1.2 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.8 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.0 0.2 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.2 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.1 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.0 0.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 1.3 GO:1904724 tertiary granule lumen(GO:1904724)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 GO:0045499 chemorepellent activity(GO:0045499)
0.1 0.2 GO:0036361 racemase and epimerase activity, acting on amino acids and derivatives(GO:0016855) racemase activity, acting on amino acids and derivatives(GO:0036361) amino-acid racemase activity(GO:0047661)
0.0 0.4 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.8 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.1 GO:0008431 vitamin E binding(GO:0008431)
0.0 0.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.1 GO:1990460 leptin receptor binding(GO:1990460)
0.0 1.3 GO:0005518 collagen binding(GO:0005518)
0.0 0.0 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.0 0.8 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 1.2 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.8 PID RAS PATHWAY Regulation of Ras family activation
0.0 1.0 PID AR TF PATHWAY Regulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.8 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions