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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for CDC5L
Z-value: 1.06
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Transcription factors associated with CDC5L
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CDC5L | hg19_v2_chr6_+_44355257_44355315 | 0.11 | 5.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_16921601 Show fit | 7.82 |
ENST00000402239.3
ENST00000310398.2 ENST00000414935.1 |
anterior gradient 3 |
|
| chr6_-_32557610 Show fit | 6.77 |
ENST00000360004.5
|
major histocompatibility complex, class II, DR beta 1 |
|
| chr16_+_80574854 Show fit | 5.13 |
ENST00000305904.6
ENST00000568035.1 |
dynein, light chain, roadblock-type 2 |
|
| chr6_-_32498046 Show fit | 4.50 |
ENST00000374975.3
|
major histocompatibility complex, class II, DR beta 5 |
|
| chr1_+_38022572 Show fit | 4.49 |
ENST00000541606.1
|
dynein, axonemal, light intermediate chain 1 |
|
| chr5_+_94727048 Show fit | 4.08 |
ENST00000283357.5
|
family with sequence similarity 81, member B |
|
| chr5_-_35938674 Show fit | 3.73 |
ENST00000397366.1
ENST00000513623.1 ENST00000514524.1 ENST00000397367.2 |
calcyphosine-like |
|
| chr1_+_38022513 Show fit | 3.68 |
ENST00000296218.7
|
dynein, axonemal, light intermediate chain 1 |
|
| chr6_+_131958436 Show fit | 3.56 |
ENST00000357639.3
ENST00000543135.1 ENST00000427148.2 ENST00000358229.5 |
ectonucleotide pyrophosphatase/phosphodiesterase 3 |
|
| chr4_-_100356844 Show fit | 3.43 |
ENST00000437033.2
|
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide |
Network of associatons between targets according to the STRING database.
First level regulatory network of CDC5L
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.7 | GO:0060333 | interferon-gamma-mediated signaling pathway(GO:0060333) |
| 0.2 | 10.5 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.0 | 7.7 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 1.4 | 6.8 | GO:0002399 | MHC class II protein complex assembly(GO:0002399) |
| 2.2 | 6.5 | GO:0010430 | fatty acid omega-oxidation(GO:0010430) |
| 0.1 | 5.9 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 1.2 | 3.6 | GO:0030505 | inorganic diphosphate transport(GO:0030505) |
| 0.0 | 3.4 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 0.0 | 3.3 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.0 | 3.2 | GO:0030032 | lamellipodium assembly(GO:0030032) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 17.0 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 10.2 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 8.4 | GO:0030286 | dynein complex(GO:0030286) |
| 0.5 | 5.1 | GO:0036157 | outer dynein arm(GO:0036157) |
| 0.0 | 5.0 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.2 | 3.6 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.0 | 3.2 | GO:0005930 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.3 | 2.4 | GO:0036021 | endolysosome lumen(GO:0036021) |
| 0.0 | 2.4 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 2.1 | GO:0005813 | centrosome(GO:0005813) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 11.3 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.5 | 10.5 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.4 | 8.3 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 1.6 | 6.5 | GO:0004031 | aldehyde oxidase activity(GO:0004031) |
| 0.4 | 5.7 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.2 | 5.4 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.2 | 5.3 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 0.7 | 3.6 | GO:0035529 | NADH pyrophosphatase activity(GO:0035529) |
| 0.1 | 3.6 | GO:0043394 | proteoglycan binding(GO:0043394) |
| 0.0 | 2.9 | GO:0033613 | activating transcription factor binding(GO:0033613) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.4 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 3.1 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.1 | 2.5 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 1.9 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 1.5 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 0.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.8 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 0.8 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.8 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 0.6 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 16.7 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.4 | 6.8 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.5 | 6.5 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.5 | 4.8 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.1 | 3.3 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.1 | 2.7 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.2 | 2.4 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.0 | 2.3 | REACTOME IRON UPTAKE AND TRANSPORT | Genes involved in Iron uptake and transport |
| 0.1 | 2.2 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 2.2 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |