ISMARA results: CEBPA

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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for CEBPA

Z-value: 1.04

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Transcription factors associated with CEBPA

Gene Symbol	Gene ID	Gene Info
CEBPA Ensembl NCBI GeneCards UniProt NextProt	ENSG00000245848.2	CCAAT enhancer binding protein alpha

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
CEBPA	hg19_v2_chr19_-_33793430_33793470	0.52	3.1e-03	Click!

Activity profile of CEBPA motif

Sorted Z-values of CEBPA motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr6_-_32557610 Show fit	5.23	ENST00000360004.5	HLA-DRB1 Ensembl NCBI GeneCards UniProt NextProt Show fit	major histocompatibility complex, class II, DR beta 1
chr12_+_69742121 Show fit	3.53	ENST00000261267.2 ENST00000549690.1 ENST00000548839.1	LYZ Ensembl NCBI GeneCards UniProt NextProt Show fit	lysozyme
chr12_-_71551652 Show fit	3.48	ENST00000546561.1	TSPAN8 Ensembl NCBI GeneCards UniProt NextProt Show fit	tetraspanin 8
chr13_+_96085847 Show fit	2.49	ENST00000376873.3	CLDN10 Ensembl NCBI GeneCards UniProt NextProt Show fit	claudin 10
chr12_-_71551868 Show fit	2.30	ENST00000247829.3	TSPAN8 Ensembl NCBI GeneCards UniProt NextProt Show fit	tetraspanin 8
chr11_+_27062860 Show fit	2.27	ENST00000528583.1	BBOX1 Ensembl NCBI GeneCards UniProt NextProt Show fit	butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr1_+_196621156 Show fit	2.14	ENST00000359637.2	CFH Ensembl NCBI GeneCards UniProt NextProt Show fit	complement factor H
chr16_+_82090028 Show fit	2.00	ENST00000568090.1	HSD17B2 Ensembl NCBI GeneCards UniProt NextProt Show fit	hydroxysteroid (17-beta) dehydrogenase 2
chr16_+_23765948 Show fit	1.99	ENST00000300113.2	CHP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	calcineurin-like EF-hand protein 2
chr5_-_121413974 Show fit	1.93	ENST00000231004.4	LOX Ensembl NCBI GeneCards UniProt NextProt Show fit	lysyl oxidase

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of CEBPA

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	6.6	GO:0002399	MHC class II protein complex assembly(GO:0002399)
0.1	6.4	GO:0015721	bile acid and bile salt transport(GO:0015721)
0.6	6.2	GO:0045329	carnitine biosynthetic process(GO:0045329)
0.2	4.6	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.2	3.4	GO:0016998	cell wall macromolecule catabolic process(GO:0016998)
0.0	3.3	GO:0010811	positive regulation of cell-substrate adhesion(GO:0010811)
0.1	2.4	GO:1902083	negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0	2.4	GO:0030195	negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.1	2.3	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.7	2.1	GO:0042270	protection from natural killer cell mediated cytotoxicity(GO:0042270)

Showing 1 to 10 of 179 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	7.3	GO:0042613	MHC class II protein complex(GO:0042613)
0.1	6.3	GO:0035580	specific granule lumen(GO:0035580)
0.0	5.1	GO:0072562	blood microparticle(GO:0072562)
0.0	4.8	GO:0035578	azurophil granule lumen(GO:0035578)
0.1	2.0	GO:0043203	axon hillock(GO:0043203)
0.0	1.8	GO:0005581	collagen trimer(GO:0005581)
0.0	1.8	GO:0005923	bicellular tight junction(GO:0005923)
0.1	1.7	GO:0005614	interstitial matrix(GO:0005614)
0.1	1.2	GO:0071682	endocytic vesicle lumen(GO:0071682)
0.0	1.2	GO:0070821	tertiary granule membrane(GO:0070821)

Showing 1 to 10 of 46 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	7.0	GO:0023026	MHC class II protein complex binding(GO:0023026)
1.6	6.2	GO:0008336	gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.3	6.0	GO:0015125	bile acid transmembrane transporter activity(GO:0015125)
0.0	5.3	GO:0005178	integrin binding(GO:0005178)
0.0	5.2	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	3.8	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.1	3.7	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.2	3.4	GO:0003796	lysozyme activity(GO:0003796)
0.1	3.1	GO:0001848	complement binding(GO:0001848)
0.7	2.8	GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)

Showing 1 to 10 of 109 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	5.1	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	4.4	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.0	4.2	PID CMYB PATHWAY	C-MYB transcription factor network
0.0	2.9	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0	2.4	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.1	2.3	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	1.9	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.1	1.4	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.0	1.4	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling

Showing 1 to 10 of 23 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	5.9	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.2	5.0	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.0	3.0	REACTOME AMYLOIDS	Genes involved in Amyloids
0.2	2.6	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.1	2.3	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.1	2.3	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.1	1.9	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.1	1.9	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.1	1.8	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.1	1.6	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins

Showing 1 to 10 of 36 entries

Results for CEBPA

Z-value: 1.04

Motif logo

Transcription factors associated with CEBPA

Activity-expression correlation:

Activity profile of CEBPA motif

Sorted Z-values of CEBPA motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of CEBPA

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: