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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for CEBPB
Z-value: 1.46
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Transcription factors associated with CEBPB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CEBPB | hg19_v2_chr20_+_48807351_48807384 | -0.16 | 3.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CEBPB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 21.9 | GO:0045717 | negative regulation of fatty acid biosynthetic process(GO:0045717) |
| 2.0 | 13.8 | GO:0019264 | glycine biosynthetic process from serine(GO:0019264) |
| 1.9 | 11.2 | GO:0009098 | branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099) |
| 2.6 | 7.7 | GO:0006535 | cysteine biosynthetic process from serine(GO:0006535) |
| 0.8 | 7.6 | GO:2000660 | negative regulation of interleukin-1-mediated signaling pathway(GO:2000660) |
| 0.2 | 7.3 | GO:0032461 | positive regulation of protein oligomerization(GO:0032461) |
| 0.2 | 7.0 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 1.5 | 6.1 | GO:0009257 | 10-formyltetrahydrofolate biosynthetic process(GO:0009257) |
| 2.0 | 5.9 | GO:0052047 | interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) |
| 0.2 | 5.7 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 13.8 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.0 | 10.2 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 9.3 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.5 | 6.9 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 6.9 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.1 | 6.8 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 4.2 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 3.9 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 3.8 | GO:0001726 | ruffle(GO:0001726) |
| 1.2 | 3.7 | GO:0005900 | oncostatin-M receptor complex(GO:0005900) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 21.9 | GO:0055106 | ubiquitin-protein transferase regulator activity(GO:0055106) |
| 2.0 | 13.8 | GO:0004372 | glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 2.4 | 12.0 | GO:0005294 | neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294) |
| 1.9 | 11.2 | GO:0052654 | branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656) |
| 2.6 | 7.7 | GO:0070025 | cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809) |
| 2.5 | 7.6 | GO:0005150 | interleukin-1, Type I receptor binding(GO:0005150) |
| 0.3 | 7.0 | GO:0051400 | BH domain binding(GO:0051400) |
| 1.5 | 6.1 | GO:0004329 | formate-tetrahydrofolate ligase activity(GO:0004329) |
| 0.1 | 5.9 | GO:0016504 | peptidase activator activity(GO:0016504) |
| 0.0 | 5.5 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.2 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 8.0 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 7.6 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.1 | 7.0 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.2 | 5.9 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 4.9 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 3.1 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.1 | 2.9 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.1 | 2.7 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.0 | 2.3 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 21.9 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.4 | 19.5 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.4 | 11.2 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.3 | 11.0 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.2 | 7.6 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 7.6 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.2 | 5.6 | REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |
| 0.0 | 5.2 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.2 | 5.1 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.2 | 3.7 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |