Project
Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for CLOCK
Z-value: 1.03
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Transcription factors associated with CLOCK
Network of associatons between targets according to the STRING database.
First level regulatory network of CLOCK
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 7.1 | GO:0031536 | positive regulation of exit from mitosis(GO:0031536) |
| 0.5 | 6.8 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.1 | 6.3 | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771) |
| 1.0 | 6.0 | GO:0009098 | branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099) |
| 0.5 | 5.6 | GO:0015691 | cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574) |
| 0.4 | 5.3 | GO:0070257 | positive regulation of mucus secretion(GO:0070257) |
| 0.7 | 4.6 | GO:0019264 | glycine biosynthetic process from serine(GO:0019264) |
| 0.4 | 4.3 | GO:0061087 | positive regulation of histone H3-K27 methylation(GO:0061087) |
| 0.7 | 3.9 | GO:0060528 | secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528) |
| 0.8 | 3.8 | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.1 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.0 | 6.8 | GO:0005813 | centrosome(GO:0005813) |
| 0.8 | 6.5 | GO:0098560 | cytoplasmic side of late endosome membrane(GO:0098560) |
| 0.6 | 4.6 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.0 | 4.4 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.1 | 4.0 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.2 | 3.7 | GO:0034709 | methylosome(GO:0034709) |
| 0.3 | 3.5 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 3.3 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 0.1 | 3.2 | GO:0031011 | Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 6.8 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.1 | 6.8 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.1 | 6.1 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 1.0 | 6.0 | GO:0004084 | branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656) |
| 0.1 | 5.2 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.7 | 4.6 | GO:0004372 | glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 0.1 | 4.2 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.2 | 3.7 | GO:0016274 | arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274) |
| 0.1 | 3.7 | GO:0016504 | peptidase activator activity(GO:0016504) |
| 0.1 | 3.6 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.5 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.3 | 6.5 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 4.6 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.2 | 4.2 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 3.6 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 3.3 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 2.0 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 1.8 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 1.7 | ST STAT3 PATHWAY | STAT3 Pathway |
| 0.1 | 1.7 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.1 | REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.2 | 5.8 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.2 | 5.6 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.1 | 5.1 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.1 | 4.6 | REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |
| 0.0 | 4.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 3.6 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 0.2 | 3.5 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.2 | 3.1 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.1 | 2.8 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |