ISMARA results: CUX2

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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for CUX2

Z-value: 1.17

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Transcription factors associated with CUX2

Gene Symbol	Gene ID	Gene Info
CUX2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000111249.9	cut like homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
CUX2	hg19_v2_chr12_+_111471828_111471975	0.01	9.7e-01	Click!

Activity profile of CUX2 motif

Sorted Z-values of CUX2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_+_100354442 Show fit	3.94	ENST00000475887.1	GPR128 Ensembl NCBI GeneCards UniProt NextProt Show fit	G protein-coupled receptor 128
chr7_-_23510086 Show fit	2.73	ENST00000258729.3	IGF2BP3 Ensembl NCBI GeneCards UniProt NextProt Show fit	insulin-like growth factor 2 mRNA binding protein 3
chr1_-_109618566 Show fit	2.68	ENST00000338366.5	TAF13 Ensembl NCBI GeneCards UniProt NextProt Show fit	TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
chr2_-_216257849 Show fit	2.61	ENST00000456923.1	FN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	fibronectin 1
chr22_+_38071615 Show fit	1.95	ENST00000215909.5	LGALS1 Ensembl NCBI GeneCards UniProt NextProt Show fit	lectin, galactoside-binding, soluble, 1
chr7_+_80231466 Show fit	1.76	ENST00000309881.7 ENST00000534394.1	CD36 Ensembl NCBI GeneCards UniProt NextProt Show fit	CD36 molecule (thrombospondin receptor)
chr19_-_22379753 Show fit	1.69	ENST00000397121.2	ZNF676 Ensembl NCBI GeneCards UniProt NextProt Show fit	zinc finger protein 676
chr9_+_35673853 Show fit	1.63	ENST00000378357.4	CA9 Ensembl NCBI GeneCards UniProt NextProt Show fit	carbonic anhydrase IX
chr9_+_105757590 Show fit	1.61	ENST00000374798.3 ENST00000487798.1	CYLC2 Ensembl NCBI GeneCards UniProt NextProt Show fit	cylicin, basic protein of sperm head cytoskeleton 2
chr8_-_62559366 Show fit	1.59	ENST00000522919.1	ASPH Ensembl NCBI GeneCards UniProt NextProt Show fit	aspartate beta-hydroxylase

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of CUX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.8	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0	2.9	GO:0042035	regulation of cytokine biosynthetic process(GO:0042035)
0.1	2.8	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.9	2.6	GO:0052047	interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.2	2.5	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1	2.5	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0	2.5	GO:0009301	snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.7	2.0	GO:0071789	spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.4	1.9	GO:0002317	plasma cell differentiation(GO:0002317)
0.4	1.8	GO:0042264	peptidyl-aspartic acid hydroxylation(GO:0042264)

Showing 1 to 10 of 186 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.6	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.2	2.9	GO:0005577	fibrinogen complex(GO:0005577)
0.0	2.9	GO:0043679	axon terminus(GO:0043679)
0.1	2.8	GO:0005669	transcription factor TFIID complex(GO:0005669)
0.1	2.6	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.7	2.0	GO:0070762	nuclear pore transmembrane ring(GO:0070762)
0.0	2.0	GO:0005901	caveola(GO:0005901)
0.2	1.8	GO:0032541	cortical endoplasmic reticulum(GO:0032541)
0.1	1.8	GO:0001891	phagocytic cup(GO:0001891)
0.0	1.7	GO:0009295	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)

Showing 1 to 10 of 66 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.5	GO:0004984	olfactory receptor activity(GO:0004984)
0.1	3.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	2.6	GO:0016504	peptidase activator activity(GO:0016504)
0.5	2.5	GO:0050473	arachidonate 15-lipoxygenase activity(GO:0050473)
0.2	2.5	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.1	2.3	GO:0015020	glucuronosyltransferase activity(GO:0015020)
0.1	2.2	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.1	2.0	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.5	1.9	GO:0030395	lactose binding(GO:0030395)
0.6	1.8	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)

Showing 1 to 10 of 127 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.7	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.1	2.6	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	2.0	PID EPHB FWD PATHWAY	EPHB forward signaling
0.0	1.8	PID RAS PATHWAY	Regulation of Ras family activation
0.0	1.6	PID PDGFRB PATHWAY	PDGFR-beta signaling pathway
0.0	1.3	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	1.2	PID IL27 PATHWAY	IL27-mediated signaling events
0.0	1.2	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.0	1.1	PID S1P S1P1 PATHWAY	S1P1 pathway
0.0	1.1	ST G ALPHA I PATHWAY	G alpha i Pathway

Showing 1 to 10 of 23 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.3	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.0	3.3	REACTOME DIABETES PATHWAYS	Genes involved in Diabetes pathways
0.1	2.9	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	2.5	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	2.5	REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING	Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0	2.3	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.1	2.2	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.1	2.1	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.0	1.8	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.0	1.8	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends

Showing 1 to 10 of 44 entries

Results for CUX2

Z-value: 1.17

Motif logo

Transcription factors associated with CUX2

Activity-expression correlation:

Activity profile of CUX2 motif

Sorted Z-values of CUX2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of CUX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: