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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for DBP
Z-value: 0.63
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Transcription factors associated with DBP
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| DBP | hg19_v2_chr19_-_49137762_49137783 | -0.17 | 3.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_112564797 Show fit | 1.77 |
ENST00000398214.1
ENST00000448932.1 |
CD200 receptor 1-like |
|
| chr4_-_23891693 Show fit | 1.54 |
ENST00000264867.2
|
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
|
| chr1_+_104293028 Show fit | 1.41 |
ENST00000370079.3
|
amylase, alpha 1C (salivary) |
|
| chr8_+_99076750 Show fit | 1.22 |
ENST00000545282.1
|
chromosome 8 open reading frame 47 |
|
| chr15_+_71228826 Show fit | 1.21 |
ENST00000558456.1
ENST00000560158.2 ENST00000558808.1 ENST00000559806.1 ENST00000559069.1 |
leucine rich repeat containing 49 |
|
| chr1_+_104159999 Show fit | 1.20 |
ENST00000414303.2
ENST00000423678.1 |
amylase, alpha 2A (pancreatic) |
|
| chr10_+_115511213 Show fit | 1.18 |
ENST00000361048.1
|
pleckstrin homology domain containing, family S member 1 |
|
| chr8_+_99076509 Show fit | 1.13 |
ENST00000318528.3
|
chromosome 8 open reading frame 47 |
|
| chr1_+_61547405 Show fit | 1.13 |
ENST00000371189.4
|
nuclear factor I/A |
|
| chr9_-_89562104 Show fit | 1.06 |
ENST00000298743.7
|
growth arrest-specific 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of DBP
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.1 | GO:0072189 | ureter development(GO:0072189) |
| 0.5 | 1.5 | GO:1901860 | positive regulation of mitochondrial DNA metabolic process(GO:1901860) |
| 0.2 | 1.2 | GO:0044245 | polysaccharide digestion(GO:0044245) |
| 0.0 | 1.2 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.1 | 1.1 | GO:0060628 | regulation of ER to Golgi vesicle-mediated transport(GO:0060628) |
| 0.2 | 1.0 | GO:0060024 | rhythmic synaptic transmission(GO:0060024) |
| 0.1 | 1.0 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.3 | 0.8 | GO:0021919 | BMP signaling pathway involved in spinal cord dorsal/ventral patterning(GO:0021919) |
| 0.0 | 0.8 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.2 | 0.7 | GO:0052047 | interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.8 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.0 | 1.7 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 1.1 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.1 | 0.7 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 0.6 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.0 | 0.6 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.0 | 0.5 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
| 0.0 | 0.5 | GO:0030130 | clathrin coat of trans-Golgi network vesicle(GO:0030130) |
| 0.0 | 0.5 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.1 | 0.4 | GO:0031673 | H zone(GO:0031673) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 1.5 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.0 | 1.4 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.0 | 1.4 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.3 | 1.2 | GO:0016160 | amylase activity(GO:0016160) |
| 0.1 | 0.8 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.0 | 0.7 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 0.7 | GO:0016504 | peptidase activator activity(GO:0016504) |
| 0.0 | 0.6 | GO:0022851 | GABA-gated chloride ion channel activity(GO:0022851) |
| 0.0 | 0.6 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.7 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 1.5 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 1.4 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 0.8 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 0.7 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 0.5 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.0 | 0.4 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.0 | 0.3 | ST GA12 PATHWAY | G alpha 12 Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.6 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.0 | 1.5 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 0.9 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.0 | 0.7 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 0.6 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.0 | 0.6 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 0.5 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.4 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.0 | 0.3 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 0.3 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |