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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for DDIT3

Z-value: 0.38

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Transcription factors associated with DDIT3

Gene Symbol Gene ID Gene Info
DDIT3
ENSG00000175197.6 DNA damage inducible transcript 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DDIT3hg19_v2_chr12_-_57914275_579143040.479.1e-03Click!

Activity profile of DDIT3 motif

Sorted Z-values of DDIT3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_25102252 1.25 ENST00000261192.7
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr12_-_25101920 0.99 ENST00000539780.1
ENST00000546285.1
ENST00000342945.5
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr2_-_216300784 0.84 ENST00000421182.1
ENST00000432072.2
ENST00000323926.6
ENST00000336916.4
ENST00000357867.4
ENST00000359671.1
ENST00000346544.3
ENST00000345488.5
ENST00000357009.2
ENST00000446046.1
ENST00000356005.4
ENST00000443816.1
ENST00000426059.1
ENST00000354785.4
FN1
fibronectin 1
chr15_+_41245160 0.78 ENST00000444189.2
ENST00000446533.3
CHAC1
ChaC, cation transport regulator homolog 1 (E. coli)
chr19_-_35992780 0.77 ENST00000593342.1
ENST00000601650.1
ENST00000408915.2
DMKN
dermokine
chr9_+_80912059 0.72 ENST00000347159.2
ENST00000376588.3
PSAT1
phosphoserine aminotransferase 1
chr12_-_52867569 0.65 ENST00000252250.6
KRT6C
keratin 6C
chr2_-_208030647 0.54 ENST00000309446.6
KLF7
Kruppel-like factor 7 (ubiquitous)
chr14_+_21387508 0.49 ENST00000555624.1
RP11-84C10.2
RP11-84C10.2
chr1_+_150954493 0.46 ENST00000368947.4
ANXA9
annexin A9
chr8_-_11058847 0.39 ENST00000297303.4
ENST00000416569.2
XKR6
XK, Kell blood group complex subunit-related family, member 6
chr2_-_40680578 0.38 ENST00000455476.1
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr10_-_17659234 0.34 ENST00000466335.1
PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr6_+_151187074 0.32 ENST00000367308.4
MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr10_-_17659357 0.30 ENST00000326961.6
ENST00000361271.3
PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr22_-_27456361 0.30 ENST00000453934.1
CTA-992D9.6
CTA-992D9.6
chr17_-_47925379 0.27 ENST00000352793.2
ENST00000334568.4
ENST00000398154.1
ENST00000436235.1
ENST00000326219.5
TAC4
tachykinin 4 (hemokinin)
chr12_-_53074182 0.26 ENST00000252244.3
KRT1
keratin 1
chr1_-_67519782 0.25 ENST00000235345.5
SLC35D1
solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
chr11_+_62495997 0.23 ENST00000316461.4
TTC9C
tetratricopeptide repeat domain 9C
chr9_+_112542572 0.23 ENST00000374530.3
PALM2-AKAP2
PALM2-AKAP2 readthrough
chr5_-_178017355 0.22 ENST00000390654.3
COL23A1
collagen, type XXIII, alpha 1
chr1_+_111770278 0.20 ENST00000369748.4
CHI3L2
chitinase 3-like 2
chr19_+_49258775 0.20 ENST00000593756.1
FGF21
fibroblast growth factor 21
chr1_+_111770232 0.20 ENST00000369744.2
CHI3L2
chitinase 3-like 2
chr14_+_22265444 0.19 ENST00000390430.2
TRAV8-1
T cell receptor alpha variable 8-1
chr19_+_1450112 0.19 ENST00000590469.1
ENST00000233607.2
ENST00000238483.4
ENST00000590877.1
APC2
adenomatosis polyposis coli 2
chr14_+_32798547 0.18 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6
A kinase (PRKA) anchor protein 6
chr12_-_7899935 0.18 ENST00000543765.1
CLEC4C
C-type lectin domain family 4, member C
chr12_+_57857475 0.18 ENST00000528467.1
GLI1
GLI family zinc finger 1
chr14_+_32798462 0.17 ENST00000280979.4
AKAP6
A kinase (PRKA) anchor protein 6
chr3_+_12392971 0.17 ENST00000287820.6
PPARG
peroxisome proliferator-activated receptor gamma
chr13_-_24007815 0.17 ENST00000382298.3
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr6_-_48036363 0.17 ENST00000543600.1
ENST00000398738.2
ENST00000339488.4
PTCHD4
patched domain containing 4
chr3_+_157154578 0.17 ENST00000295927.3
PTX3
pentraxin 3, long
chr2_-_43453734 0.16 ENST00000282388.3
ZFP36L2
ZFP36 ring finger protein-like 2
chr2_-_101925055 0.16 ENST00000295317.3
RNF149
ring finger protein 149
chr17_-_46691990 0.15 ENST00000576562.1
HOXB8
homeobox B8
chr4_-_99578789 0.15 ENST00000511651.1
ENST00000505184.1
TSPAN5
tetraspanin 5
chr2_+_192141611 0.14 ENST00000392316.1
MYO1B
myosin IB
chr16_-_68269971 0.14 ENST00000565858.1
ESRP2
epithelial splicing regulatory protein 2
chr3_+_136676851 0.14 ENST00000309741.5
IL20RB
interleukin 20 receptor beta
chr11_+_34073269 0.13 ENST00000389645.3
CAPRIN1
cell cycle associated protein 1
chr5_-_54281407 0.13 ENST00000381403.4
ESM1
endothelial cell-specific molecule 1
chr17_+_4855053 0.13 ENST00000518175.1
ENO3
enolase 3 (beta, muscle)
chr14_+_62462541 0.13 ENST00000430451.2
SYT16
synaptotagmin XVI
chr9_+_110045537 0.13 ENST00000358015.3
RAD23B
RAD23 homolog B (S. cerevisiae)
chr8_-_93029865 0.12 ENST00000422361.2
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr15_+_85923856 0.12 ENST00000560302.1
ENST00000394518.2
ENST00000361243.2
ENST00000560256.1
AKAP13
A kinase (PRKA) anchor protein 13
chr1_-_161277210 0.12 ENST00000491222.2
MPZ
myelin protein zero
chr8_-_21669826 0.12 ENST00000517328.1
GFRA2
GDNF family receptor alpha 2
chr7_-_56101826 0.12 ENST00000421626.1
PSPH
phosphoserine phosphatase
chr9_-_95056010 0.12 ENST00000443024.2
IARS
isoleucyl-tRNA synthetase
chr11_+_62495541 0.12 ENST00000530625.1
ENST00000513247.2
TTC9C
tetratricopeptide repeat domain 9C
chr3_+_136676707 0.12 ENST00000329582.4
IL20RB
interleukin 20 receptor beta
chr19_-_6604094 0.11 ENST00000597430.2
CD70
CD70 molecule
chr9_-_95055956 0.11 ENST00000375629.3
ENST00000447699.2
ENST00000375643.3
ENST00000395554.3
IARS
isoleucyl-tRNA synthetase
chr10_-_92681033 0.10 ENST00000371697.3
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr19_+_33865218 0.10 ENST00000585933.2
CEBPG
CCAAT/enhancer binding protein (C/EBP), gamma
chr3_+_130569429 0.10 ENST00000505330.1
ENST00000504381.1
ENST00000507488.2
ENST00000393221.4
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chrX_-_40506766 0.10 ENST00000378421.1
ENST00000440784.2
ENST00000327877.5
ENST00000378426.1
ENST00000378418.2
CXorf38
chromosome X open reading frame 38
chr9_+_112542591 0.09 ENST00000483909.1
ENST00000314527.4
ENST00000413420.1
ENST00000302798.7
ENST00000555236.1
ENST00000510514.5
PALM2
PALM2-AKAP2
AKAP2
paralemmin 2
PALM2-AKAP2 readthrough
A kinase (PRKA) anchor protein 2
chr7_-_99006443 0.09 ENST00000350498.3
PDAP1
PDGFA associated protein 1
chr5_+_112074029 0.08 ENST00000512211.2
APC
adenomatous polyposis coli
chr20_+_54987305 0.08 ENST00000371336.3
ENST00000434344.1
CASS4
Cas scaffolding protein family member 4
chr17_-_30228678 0.08 ENST00000261708.4
UTP6
UTP6, small subunit (SSU) processome component, homolog (yeast)
chr2_+_227700652 0.08 ENST00000341329.3
ENST00000392062.2
ENST00000437454.1
ENST00000443477.1
ENST00000423616.1
ENST00000448992.1
RHBDD1
rhomboid domain containing 1
chr10_+_102756800 0.07 ENST00000370223.3
LZTS2
leucine zipper, putative tumor suppressor 2
chr20_+_24929866 0.07 ENST00000480798.1
ENST00000376835.2
CST7
cystatin F (leukocystatin)
chr17_+_4336955 0.07 ENST00000355530.2
SPNS3
spinster homolog 3 (Drosophila)
chr3_+_44840679 0.07 ENST00000425755.1
KIF15
kinesin family member 15
chr6_-_24489842 0.07 ENST00000230036.1
GPLD1
glycosylphosphatidylinositol specific phospholipase D1
chrX_-_133792480 0.07 ENST00000359237.4
PLAC1
placenta-specific 1
chr17_+_4337199 0.07 ENST00000333476.2
SPNS3
spinster homolog 3 (Drosophila)
chr19_+_10736183 0.07 ENST00000590857.1
ENST00000588688.1
ENST00000586078.1
SLC44A2
solute carrier family 44 (choline transporter), member 2
chr1_-_112032284 0.06 ENST00000414219.1
ADORA3
adenosine A3 receptor
chr11_-_104972158 0.06 ENST00000598974.1
ENST00000593315.1
ENST00000594519.1
ENST00000415981.2
ENST00000525374.1
ENST00000375707.1
CASP1
CARD16
CARD17
caspase 1, apoptosis-related cysteine peptidase
caspase recruitment domain family, member 16
caspase recruitment domain family, member 17
chr1_-_114447412 0.06 ENST00000369567.1
ENST00000369566.3
AP4B1
adaptor-related protein complex 4, beta 1 subunit
chr10_+_103986085 0.06 ENST00000370005.3
ELOVL3
ELOVL fatty acid elongase 3
chr1_-_114447683 0.06 ENST00000256658.4
ENST00000369564.1
AP4B1
adaptor-related protein complex 4, beta 1 subunit
chr11_-_8680383 0.06 ENST00000299550.6
TRIM66
tripartite motif containing 66
chr22_+_17956618 0.05 ENST00000262608.8
CECR2
cat eye syndrome chromosome region, candidate 2
chr16_-_70323422 0.05 ENST00000261772.8
AARS
alanyl-tRNA synthetase
chr4_+_111397216 0.05 ENST00000265162.5
ENPEP
glutamyl aminopeptidase (aminopeptidase A)
chr6_-_157744531 0.05 ENST00000400788.4
ENST00000367144.4
TMEM242
transmembrane protein 242
chr17_-_34257771 0.05 ENST00000394529.3
ENST00000293273.6
RDM1
RAD52 motif 1
chr17_-_77813186 0.05 ENST00000448310.1
ENST00000269397.4
CBX4
chromobox homolog 4
chr2_-_183106641 0.05 ENST00000346717.4
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr20_+_54987168 0.05 ENST00000360314.3
CASS4
Cas scaffolding protein family member 4
chr16_-_18908196 0.05 ENST00000565324.1
ENST00000561947.1
SMG1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr2_-_179672142 0.05 ENST00000342992.6
ENST00000360870.5
ENST00000460472.2
ENST00000589042.1
ENST00000591111.1
ENST00000342175.6
ENST00000359218.5
TTN
titin
chr9_-_77502636 0.04 ENST00000449912.2
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chr7_+_99006550 0.04 ENST00000222969.5
BUD31
BUD31 homolog (S. cerevisiae)
chr11_+_34073195 0.04 ENST00000341394.4
CAPRIN1
cell cycle associated protein 1
chr1_+_114447763 0.03 ENST00000369563.3
DCLRE1B
DNA cross-link repair 1B
chr2_-_63815628 0.03 ENST00000409562.3
WDPCP
WD repeat containing planar cell polarity effector
chr6_-_31864977 0.03 ENST00000395728.3
ENST00000375528.4
EHMT2
euchromatic histone-lysine N-methyltransferase 2
chr4_+_141178440 0.03 ENST00000394205.3
SCOC
short coiled-coil protein
chr17_-_34257731 0.03 ENST00000431884.2
ENST00000425909.3
ENST00000394528.3
ENST00000430160.2
RDM1
RAD52 motif 1
chr15_+_85923797 0.02 ENST00000559362.1
AKAP13
A kinase (PRKA) anchor protein 13
chr20_+_48807351 0.02 ENST00000303004.3
CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr1_-_20250110 0.02 ENST00000375116.3
PLA2G2E
phospholipase A2, group IIE
chr2_-_32390801 0.01 ENST00000608489.1
RP11-563N4.1
RP11-563N4.1
chr5_-_137878887 0.01 ENST00000507939.1
ENST00000572514.1
ENST00000499810.2
ENST00000360541.5
ETF1
eukaryotic translation termination factor 1
chr3_+_186330712 0.01 ENST00000411641.2
ENST00000273784.5
AHSG
alpha-2-HS-glycoprotein
chrX_-_138724677 0.01 ENST00000370573.4
ENST00000338585.6
ENST00000370576.4
MCF2
MCF.2 cell line derived transforming sequence
chr5_+_118812294 0.00 ENST00000509514.1
HSD17B4
hydroxysteroid (17-beta) dehydrogenase 4
chr12_-_12491608 0.00 ENST00000545735.1
MANSC1
MANSC domain containing 1
chr11_+_20044096 0.00 ENST00000533917.1
NAV2
neuron navigator 2

Network of associatons between targets according to the STRING database.

First level regulatory network of DDIT3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:0009098 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.3 0.8 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.1 0.8 GO:1903575 cornified envelope assembly(GO:1903575)
0.1 0.7 GO:0042816 vitamin B6 metabolic process(GO:0042816)
0.1 0.3 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.1 0.2 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.1 0.3 GO:0001808 negative regulation of type IV hypersensitivity(GO:0001808)
0.1 0.4 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.1 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0 0.2 GO:2000230 negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.0 0.3 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.0 0.2 GO:1904640 response to methionine(GO:1904640)
0.0 0.8 GO:0006751 glutathione catabolic process(GO:0006751)
0.0 0.3 GO:0046878 positive regulation of saliva secretion(GO:0046878)
0.0 0.4 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.0 0.2 GO:0021938 ventral midline development(GO:0007418) smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
0.0 0.4 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.2 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.0 0.3 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.1 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.0 0.2 GO:1904628 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.0 0.1 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.0 0.1 GO:0010982 regulation of high-density lipoprotein particle clearance(GO:0010982)
0.0 0.1 GO:0090214 spongiotrophoblast layer developmental growth(GO:0090214)
0.0 0.1 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.0 0.1 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.0 0.1 GO:1904885 beta-catenin destruction complex assembly(GO:1904885)
0.0 0.6 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.0 0.1 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.1 GO:2000254 regulation of male germ cell proliferation(GO:2000254)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.4 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.1 GO:0005873 plus-end kinesin complex(GO:0005873)
0.0 0.3 GO:0016342 catenin complex(GO:0016342)
0.0 0.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.2 GO:0070852 cell body fiber(GO:0070852)
0.0 0.1 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 0.2 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.9 GO:0045095 keratin filament(GO:0045095)
0.0 0.1 GO:0072558 NLRP1 inflammasome complex(GO:0072558) protease inhibitor complex(GO:0097179)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.3 0.8 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.1 0.3 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.1 0.2 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.1 0.4 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.1 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.0 0.3 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.1 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0 0.7 GO:0008483 transaminase activity(GO:0008483)
0.0 0.4 GO:0004568 chitinase activity(GO:0004568)
0.0 0.1 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.0 0.3 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 0.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.1 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.2 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.2 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.1 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.0 0.3 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.1 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.0 0.9 GO:0016504 peptidase activator activity(GO:0016504)
0.0 0.5 GO:0015464 acetylcholine receptor activity(GO:0015464)
0.0 0.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 2.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.8 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.8 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.4 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis