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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for DLX3_EVX1_MEOX1

Z-value: 0.51

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Transcription factors associated with DLX3_EVX1_MEOX1

Gene Symbol Gene ID Gene Info
DLX3
ENSG00000064195.7 distal-less homeobox 3
EVX1
ENSG00000106038.8 even-skipped homeobox 1
MEOX1
ENSG00000005102.8 mesenchyme homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MEOX1hg19_v2_chr17_-_41738931_41739040,
hg19_v2_chr17_-_41739283_41739322		0.203.0e-01Click!
EVX1hg19_v2_chr7_+_27282319_272823940.173.7e-01Click!
DLX3hg19_v2_chr17_-_48072574_480725970.115.8e-01Click!

Activity profile of DLX3_EVX1_MEOX1 motif

Sorted Z-values of DLX3_EVX1_MEOX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_151646800 1.82 ENST00000354675.6
AKAP12
A kinase (PRKA) anchor protein 12
chr3_+_111718173 1.73 ENST00000494932.1
TAGLN3
transgelin 3
chr4_+_169013666 1.43 ENST00000359299.3
ANXA10
annexin A10
chr3_+_111717600 1.15 ENST00000273368.4
TAGLN3
transgelin 3
chr3_+_111718036 1.13 ENST00000455401.2
TAGLN3
transgelin 3
chr3_+_111717511 1.09 ENST00000478951.1
ENST00000393917.2
TAGLN3
transgelin 3
chr12_-_89746173 0.76 ENST00000308385.6
DUSP6
dual specificity phosphatase 6
chr6_+_130339710 0.73 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr10_+_118187379 0.66 ENST00000369230.3
PNLIPRP3
pancreatic lipase-related protein 3
chr12_+_107712173 0.61 ENST00000280758.5
ENST00000420571.2
BTBD11
BTB (POZ) domain containing 11
chr15_-_64673630 0.55 ENST00000558008.1
ENST00000559519.1
ENST00000380258.2
KIAA0101
KIAA0101
chr12_+_15699286 0.54 ENST00000442921.2
ENST00000542557.1
ENST00000445537.2
ENST00000544244.1
PTPRO
protein tyrosine phosphatase, receptor type, O
chr17_-_57229155 0.52 ENST00000584089.1
SKA2
spindle and kinetochore associated complex subunit 2
chr3_-_141747950 0.51 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr6_-_32157947 0.48 ENST00000375050.4
PBX2
pre-B-cell leukemia homeobox 2
chr8_+_22424551 0.48 ENST00000523348.1
SORBS3
sorbin and SH3 domain containing 3
chr13_-_46716969 0.46 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr8_-_10512569 0.46 ENST00000382483.3
RP1L1
retinitis pigmentosa 1-like 1
chr18_-_44181442 0.45 ENST00000398722.4
LOXHD1
lipoxygenase homology domains 1
chr17_-_39140549 0.40 ENST00000377755.4
KRT40
keratin 40
chr20_+_60174827 0.38 ENST00000543233.1
CDH4
cadherin 4, type 1, R-cadherin (retinal)
chrX_-_21676442 0.38 ENST00000379499.2
KLHL34
kelch-like family member 34
chr3_-_74570291 0.37 ENST00000263665.6
CNTN3
contactin 3 (plasmacytoma associated)
chr15_-_64673665 0.36 ENST00000300035.4
KIAA0101
KIAA0101
chr14_-_37051798 0.36 ENST00000258829.5
NKX2-8
NK2 homeobox 8
chr3_+_185431080 0.34 ENST00000296270.1
C3orf65
chromosome 3 open reading frame 65
chr7_-_100860851 0.33 ENST00000223127.3
PLOD3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr1_+_202317815 0.33 ENST00000608999.1
ENST00000336894.4
ENST00000480184.1
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr2_-_216003127 0.32 ENST00000412081.1
ENST00000272895.7
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr3_-_195538760 0.30 ENST00000475231.1
MUC4
mucin 4, cell surface associated
chr3_-_123339343 0.30 ENST00000578202.1
MYLK
myosin light chain kinase
chr4_+_144354644 0.30 ENST00000512843.1
GAB1
GRB2-associated binding protein 1
chr12_+_81110684 0.29 ENST00000228644.3
MYF5
myogenic factor 5
chr17_-_33446735 0.29 ENST00000460118.2
ENST00000335858.7
RAD51D
RAD51 paralog D
chr11_-_107729887 0.29 ENST00000525815.1
SLC35F2
solute carrier family 35, member F2
chr15_-_55562479 0.29 ENST00000564609.1
RAB27A
RAB27A, member RAS oncogene family
chr17_+_62223320 0.29 ENST00000580828.1
ENST00000582965.1
SNORA76
small nucleolar RNA, H/ACA box 76
chr11_-_117748138 0.27 ENST00000527717.1
FXYD6
FXYD domain containing ion transport regulator 6
chr15_-_55563072 0.27 ENST00000567380.1
ENST00000565972.1
ENST00000569493.1
RAB27A
RAB27A, member RAS oncogene family
chr5_+_66300446 0.27 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr17_-_9694614 0.26 ENST00000330255.5
ENST00000571134.1
DHRS7C
dehydrogenase/reductase (SDR family) member 7C
chr1_+_28586006 0.26 ENST00000253063.3
SESN2
sestrin 2
chr1_+_107683644 0.25 ENST00000370067.1
NTNG1
netrin G1
chr3_-_33686925 0.25 ENST00000485378.2
ENST00000313350.6
ENST00000487200.1
CLASP2
cytoplasmic linker associated protein 2
chr3_-_195538728 0.25 ENST00000349607.4
ENST00000346145.4
MUC4
mucin 4, cell surface associated
chr14_+_56584414 0.24 ENST00000559044.1
PELI2
pellino E3 ubiquitin protein ligase family member 2
chr1_+_107683436 0.24 ENST00000370068.1
NTNG1
netrin G1
chr11_-_117747434 0.24 ENST00000529335.2
ENST00000530956.1
ENST00000260282.4
FXYD6
FXYD domain containing ion transport regulator 6
chr17_-_33446820 0.23 ENST00000592577.1
ENST00000590016.1
ENST00000345365.6
ENST00000360276.3
ENST00000357906.3
RAD51D
RAD51 paralog D
chr6_-_31107127 0.23 ENST00000259845.4
PSORS1C2
psoriasis susceptibility 1 candidate 2
chr14_-_57272366 0.23 ENST00000554788.1
ENST00000554845.1
ENST00000408990.3
OTX2
orthodenticle homeobox 2
chr20_+_3776371 0.23 ENST00000245960.5
CDC25B
cell division cycle 25B
chr11_-_117747607 0.23 ENST00000540359.1
ENST00000539526.1
FXYD6
FXYD domain containing ion transport regulator 6
chr12_-_53171128 0.22 ENST00000332411.2
KRT76
keratin 76
chr15_-_31393910 0.22 ENST00000397795.2
ENST00000256552.6
ENST00000559179.1
TRPM1
transient receptor potential cation channel, subfamily M, member 1
chr7_-_28220354 0.22 ENST00000283928.5
JAZF1
JAZF zinc finger 1
chr1_-_197115818 0.22 ENST00000367409.4
ENST00000294732.7
ASPM
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr2_-_31361543 0.22 ENST00000349752.5
GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr3_+_2933893 0.22 ENST00000397459.2
CNTN4
contactin 4
chr2_-_55647057 0.22 ENST00000436346.1
CCDC88A
coiled-coil domain containing 88A
chr18_+_55888767 0.21 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr2_-_203735484 0.21 ENST00000420558.1
ENST00000418208.1
ICA1L
islet cell autoantigen 1,69kDa-like
chr15_+_63188009 0.21 ENST00000557900.1
RP11-1069G10.2
RP11-1069G10.2
chr2_-_55646957 0.21 ENST00000263630.8
CCDC88A
coiled-coil domain containing 88A
chr5_+_31193847 0.21 ENST00000514738.1
ENST00000265071.2
CDH6
cadherin 6, type 2, K-cadherin (fetal kidney)
chr1_-_234667504 0.20 ENST00000421207.1
ENST00000435574.1
RP5-855F14.1
RP5-855F14.1
chr8_-_49833978 0.20 ENST00000020945.1
SNAI2
snail family zinc finger 2
chr4_-_109684120 0.20 ENST00000512646.1
ENST00000411864.2
ENST00000296486.3
ENST00000510706.1
ETNPPL
ethanolamine-phosphate phospho-lyase
chr10_-_99447024 0.20 ENST00000370626.3
AVPI1
arginine vasopressin-induced 1
chr6_+_34204642 0.19 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1
high mobility group AT-hook 1
chr1_+_68150744 0.19 ENST00000370986.4
ENST00000370985.3
GADD45A
growth arrest and DNA-damage-inducible, alpha
chr8_-_49834299 0.19 ENST00000396822.1
SNAI2
snail family zinc finger 2
chrX_+_43515467 0.19 ENST00000338702.3
ENST00000542639.1
MAOA
monoamine oxidase A
chr4_-_74486109 0.19 ENST00000395777.2
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr19_+_13049413 0.19 ENST00000316448.5
ENST00000588454.1
CALR
calreticulin
chr12_-_86650077 0.18 ENST00000552808.2
ENST00000547225.1
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr4_-_74486347 0.18 ENST00000342081.3
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr13_-_30881134 0.18 ENST00000380617.3
ENST00000441394.1
KATNAL1
katanin p60 subunit A-like 1
chr10_-_105845674 0.18 ENST00000353479.5
ENST00000369733.3
COL17A1
collagen, type XVII, alpha 1
chr3_+_159557637 0.18 ENST00000445224.2
SCHIP1
schwannomin interacting protein 1
chr17_-_39211463 0.18 ENST00000542910.1
ENST00000398477.1
KRTAP2-2
keratin associated protein 2-2
chr12_-_10978957 0.18 ENST00000240619.2
TAS2R10
taste receptor, type 2, member 10
chrX_+_105855160 0.18 ENST00000372544.2
ENST00000372548.4
CXorf57
chromosome X open reading frame 57
chr4_-_74486217 0.18 ENST00000335049.5
ENST00000307439.5
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chrX_-_18690210 0.17 ENST00000379984.3
RS1
retinoschisin 1
chr7_-_14029283 0.17 ENST00000433547.1
ENST00000405192.2
ETV1
ets variant 1
chr8_+_39792474 0.16 ENST00000502986.2
IDO2
indoleamine 2,3-dioxygenase 2
chr7_-_99716952 0.16 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr6_-_27880174 0.16 ENST00000303324.2
OR2B2
olfactory receptor, family 2, subfamily B, member 2
chr10_-_92681033 0.16 ENST00000371697.3
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr7_-_83824169 0.16 ENST00000265362.4
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr7_+_150811705 0.16 ENST00000335367.3
AGAP3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr6_+_47666275 0.16 ENST00000327753.3
ENST00000283303.2
GPR115
G protein-coupled receptor 115
chr14_+_32798547 0.16 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6
A kinase (PRKA) anchor protein 6
chrX_+_135730297 0.16 ENST00000370629.2
CD40LG
CD40 ligand
chr2_-_17981462 0.16 ENST00000402989.1
ENST00000428868.1
SMC6
structural maintenance of chromosomes 6
chr16_+_24741013 0.15 ENST00000315183.7
ENST00000395799.3
TNRC6A
trinucleotide repeat containing 6A
chr3_-_47934234 0.15 ENST00000420772.2
MAP4
microtubule-associated protein 4
chr7_-_25019760 0.15 ENST00000352860.1
ENST00000353930.1
ENST00000431825.2
ENST00000313367.2
OSBPL3
oxysterol binding protein-like 3
chr13_-_38172863 0.15 ENST00000541481.1
ENST00000379743.4
ENST00000379742.4
ENST00000379749.4
ENST00000541179.1
ENST00000379747.4
POSTN
periostin, osteoblast specific factor
chr19_+_15838834 0.15 ENST00000305899.3
OR10H2
olfactory receptor, family 10, subfamily H, member 2
chr3_-_47950745 0.15 ENST00000429422.1
MAP4
microtubule-associated protein 4
chr14_+_32798462 0.15 ENST00000280979.4
AKAP6
A kinase (PRKA) anchor protein 6
chr14_+_95027772 0.15 ENST00000555095.1
ENST00000298841.5
ENST00000554220.1
ENST00000553780.1
SERPINA4
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr11_-_121986923 0.15 ENST00000560104.1
BLID
BH3-like motif containing, cell death inducer
chr8_-_42234745 0.15 ENST00000220812.2
DKK4
dickkopf WNT signaling pathway inhibitor 4
chr7_-_14028488 0.15 ENST00000405358.4
ETV1
ets variant 1
chr22_-_41682172 0.14 ENST00000356244.3
RANGAP1
Ran GTPase activating protein 1
chr13_+_78315466 0.14 ENST00000314070.5
ENST00000462234.1
SLAIN1
SLAIN motif family, member 1
chr1_+_202317855 0.13 ENST00000356764.2
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr8_+_32579341 0.13 ENST00000519240.1
ENST00000539990.1
NRG1
neuregulin 1
chr2_+_27498289 0.13 ENST00000296097.3
ENST00000420191.1
DNAJC5G
DnaJ (Hsp40) homolog, subfamily C, member 5 gamma
chr9_+_124329336 0.13 ENST00000394340.3
ENST00000436835.1
ENST00000259371.2
DAB2IP
DAB2 interacting protein
chr5_+_126984710 0.13 ENST00000379445.3
CTXN3
cortexin 3
chr2_+_158114051 0.13 ENST00000259056.4
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr7_-_32338917 0.12 ENST00000396193.1
PDE1C
phosphodiesterase 1C, calmodulin-dependent 70kDa
chr1_+_230193521 0.12 ENST00000543760.1
GALNT2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)
chr21_+_31768348 0.12 ENST00000355459.2
KRTAP13-1
keratin associated protein 13-1
chr1_-_102312517 0.12 ENST00000338858.5
OLFM3
olfactomedin 3
chr4_-_139163491 0.12 ENST00000280612.5
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr9_-_28670283 0.12 ENST00000379992.2
LINGO2
leucine rich repeat and Ig domain containing 2
chr6_-_116833500 0.11 ENST00000356128.4
TRAPPC3L
trafficking protein particle complex 3-like
chr17_-_46716647 0.11 ENST00000608940.1
RP11-357H14.17
RP11-357H14.17
chrX_-_106243451 0.11 ENST00000355610.4
ENST00000535534.1
MORC4
MORC family CW-type zinc finger 4
chr5_+_115177178 0.11 ENST00000316788.7
AP3S1
adaptor-related protein complex 3, sigma 1 subunit
chrX_+_7137475 0.11 ENST00000217961.4
STS
steroid sulfatase (microsomal), isozyme S
chr4_-_8873531 0.10 ENST00000400677.3
HMX1
H6 family homeobox 1
chr7_-_81399411 0.10 ENST00000423064.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr3_-_151034734 0.10 ENST00000260843.4
GPR87
G protein-coupled receptor 87
chr7_-_99717463 0.10 ENST00000437822.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr5_-_141249154 0.10 ENST00000357517.5
ENST00000536585.1
PCDH1
protocadherin 1
chr4_-_39979576 0.10 ENST00000303538.8
ENST00000503396.1
PDS5A
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
chr3_-_178984759 0.10 ENST00000349697.2
ENST00000497599.1
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr20_-_50419055 0.10 ENST00000217086.4
SALL4
spalt-like transcription factor 4
chr15_+_26360970 0.09 ENST00000556159.1
ENST00000557523.1
LINC00929
long intergenic non-protein coding RNA 929
chr3_-_113897899 0.09 ENST00000383673.2
ENST00000295881.7
DRD3
dopamine receptor D3
chr2_-_209010874 0.09 ENST00000260988.4
CRYGB
crystallin, gamma B
chr8_-_101963482 0.09 ENST00000419477.2
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr21_-_35899113 0.09 ENST00000492600.1
ENST00000481448.1
ENST00000381132.2
RCAN1
regulator of calcineurin 1
chr14_-_51027838 0.09 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr14_-_36988882 0.09 ENST00000498187.2
NKX2-1
NK2 homeobox 1
chr10_-_23633720 0.09 ENST00000323327.4
C10orf67
chromosome 10 open reading frame 67
chr7_-_14029515 0.09 ENST00000430479.1
ENST00000405218.2
ENST00000343495.5
ETV1
ets variant 1
chr7_-_33102399 0.09 ENST00000242210.7
NT5C3A
5'-nucleotidase, cytosolic IIIA
chr3_+_44840679 0.09 ENST00000425755.1
KIF15
kinesin family member 15
chr10_+_118083919 0.08 ENST00000333254.3
CCDC172
coiled-coil domain containing 172
chr9_-_13165457 0.08 ENST00000542239.1
ENST00000538841.1
ENST00000433359.2
MPDZ
multiple PDZ domain protein
chr3_-_33686743 0.08 ENST00000333778.6
ENST00000539981.1
CLASP2
cytoplasmic linker associated protein 2
chr14_-_69261310 0.08 ENST00000336440.3
ZFP36L1
ZFP36 ring finger protein-like 1
chr3_+_35722424 0.08 ENST00000396481.2
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr15_+_89631647 0.08 ENST00000569550.1
ENST00000565066.1
ENST00000565973.1
ABHD2
abhydrolase domain containing 2
chr18_+_21572737 0.08 ENST00000304621.6
TTC39C
tetratricopeptide repeat domain 39C
chr7_-_33102338 0.08 ENST00000610140.1
NT5C3A
5'-nucleotidase, cytosolic IIIA
chr5_-_96478466 0.08 ENST00000274382.4
LIX1
Lix1 homolog (chicken)
chr1_-_201140673 0.08 ENST00000367333.2
TMEM9
transmembrane protein 9
chr12_-_86650045 0.08 ENST00000604798.1
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr18_+_32173276 0.08 ENST00000591816.1
ENST00000588125.1
ENST00000598334.1
ENST00000588684.1
ENST00000554864.3
ENST00000399121.5
ENST00000595022.1
ENST00000269190.7
ENST00000399097.3
DTNA
dystrobrevin, alpha
chr17_-_39306054 0.08 ENST00000343246.4
KRTAP4-5
keratin associated protein 4-5
chr14_+_70346125 0.08 ENST00000361956.3
ENST00000381280.4
SMOC1
SPARC related modular calcium binding 1
chr3_+_35722487 0.08 ENST00000441454.1
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr6_-_66417107 0.08 ENST00000370621.3
ENST00000370618.3
ENST00000503581.1
ENST00000393380.2
EYS
eyes shut homolog (Drosophila)
chr15_+_80351910 0.07 ENST00000261749.6
ENST00000561060.1
ZFAND6
zinc finger, AN1-type domain 6
chr20_+_18447771 0.07 ENST00000377603.4
POLR3F
polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
chr12_-_14849470 0.07 ENST00000261170.3
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr2_-_190927447 0.07 ENST00000260950.4
MSTN
myostatin
chr4_+_41614720 0.07 ENST00000509277.1
LIMCH1
LIM and calponin homology domains 1
chrX_-_72434628 0.07 ENST00000536638.1
ENST00000373517.3
NAP1L2
nucleosome assembly protein 1-like 2
chr1_-_243326612 0.07 ENST00000492145.1
ENST00000490813.1
ENST00000464936.1
CEP170
centrosomal protein 170kDa
chr3_-_57233966 0.07 ENST00000473921.1
ENST00000295934.3
HESX1
HESX homeobox 1
chr17_-_54893250 0.07 ENST00000397862.2
C17orf67
chromosome 17 open reading frame 67
chr3_-_123680246 0.07 ENST00000488653.2
CCDC14
coiled-coil domain containing 14
chr3_+_157828152 0.07 ENST00000476899.1
RSRC1
arginine/serine-rich coiled-coil 1
chr7_-_73038822 0.07 ENST00000414749.2
ENST00000429400.2
ENST00000434326.1
MLXIPL
MLX interacting protein-like
chr6_-_111927062 0.07 ENST00000359831.4
TRAF3IP2
TRAF3 interacting protein 2
chr18_-_33709268 0.07 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chr8_-_7243080 0.07 ENST00000400156.4
ZNF705G
zinc finger protein 705G
chr2_-_203735586 0.07 ENST00000454326.1
ENST00000432273.1
ENST00000450143.1
ENST00000411681.1
ICA1L
islet cell autoantigen 1,69kDa-like
chr17_-_39203519 0.06 ENST00000542137.1
ENST00000391419.3
KRTAP2-1
keratin associated protein 2-1
chr7_-_73038867 0.06 ENST00000313375.3
ENST00000354613.1
ENST00000395189.1
ENST00000453275.1
MLXIPL
MLX interacting protein-like
chr6_-_9977801 0.06 ENST00000316020.6
ENST00000491508.1
OFCC1
orofacial cleft 1 candidate 1
chr8_+_50824233 0.06 ENST00000522124.1
SNTG1
syntrophin, gamma 1
chr17_-_39677971 0.06 ENST00000393976.2
KRT15
keratin 15
chr4_-_119759795 0.06 ENST00000419654.2
SEC24D
SEC24 family member D
chr12_-_52995291 0.06 ENST00000293745.2
ENST00000354310.4
KRT72
keratin 72
chr7_+_154002189 0.06 ENST00000332007.3
DPP6
dipeptidyl-peptidase 6
chr12_-_52946923 0.06 ENST00000267119.5
KRT71
keratin 71
chr3_+_130569429 0.06 ENST00000505330.1
ENST00000504381.1
ENST00000507488.2
ENST00000393221.4
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr21_+_17792672 0.06 ENST00000602620.1
LINC00478
long intergenic non-protein coding RNA 478
chr12_+_28410128 0.06 ENST00000381259.1
ENST00000381256.1
CCDC91
coiled-coil domain containing 91
chr15_+_89164520 0.06 ENST00000332810.3
AEN
apoptosis enhancing nuclease
chr6_-_111927449 0.06 ENST00000368761.5
ENST00000392556.4
ENST00000340026.6
TRAF3IP2
TRAF3 interacting protein 2
chr20_+_42187608 0.06 ENST00000373100.1
SGK2
serum/glucocorticoid regulated kinase 2
chrX_-_77225135 0.06 ENST00000458128.1
PGAM4
phosphoglycerate mutase family member 4
chr19_-_7698599 0.06 ENST00000311069.5
PCP2
Purkinje cell protein 2
chr5_+_98109322 0.06 ENST00000513185.1
RGMB
repulsive guidance molecule family member b
chr1_+_62439037 0.06 ENST00000545929.1
INADL
InaD-like (Drosophila)
chr7_-_87342564 0.06 ENST00000265724.3
ENST00000416177.1
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr4_-_155533787 0.06 ENST00000407946.1
ENST00000405164.1
ENST00000336098.3
ENST00000393846.2
ENST00000404648.3
ENST00000443553.1
FGG
fibrinogen gamma chain
chr1_-_28384598 0.06 ENST00000373864.1
EYA3
eyes absent homolog 3 (Drosophila)
chr11_-_117747327 0.06 ENST00000584230.1
ENST00000527429.1
ENST00000584394.1
ENST00000532984.1
FXYD6
FXYD6-FXYD2
FXYD domain containing ion transport regulator 6
FXYD6-FXYD2 readthrough

Network of associatons between targets according to the STRING database.

First level regulatory network of DLX3_EVX1_MEOX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.2 0.5 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.1 0.4 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.1 1.7 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 0.3 GO:0046946 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.1 0.4 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.1 0.3 GO:0035627 ceramide transport(GO:0035627)
0.1 0.2 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.1 0.3 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.1 0.4 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.1 0.5 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.1 0.7 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 0.3 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.1 0.3 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.3 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880)
0.0 0.2 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 0.2 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.2 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.0 0.0 GO:0060259 positive regulation of behavior(GO:0048520) regulation of feeding behavior(GO:0060259) positive regulation of feeding behavior(GO:2000253)
0.0 0.2 GO:1903375 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375)
0.0 0.2 GO:0002501 peptide antigen assembly with MHC protein complex(GO:0002501)
0.0 0.1 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.0 0.2 GO:0032571 response to vitamin K(GO:0032571) bone regeneration(GO:1990523)
0.0 0.1 GO:0061107 seminal vesicle development(GO:0061107)
0.0 0.2 GO:2000543 positive regulation of gastrulation(GO:2000543)
0.0 0.5 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.1 GO:1904582 regulation of intracellular mRNA localization(GO:1904580) positive regulation of intracellular mRNA localization(GO:1904582)
0.0 0.1 GO:0043553 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 0.5 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.3 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.0 0.2 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.1 GO:1902725 negative regulation of satellite cell differentiation(GO:1902725)
0.0 0.1 GO:0050883 negative regulation of sodium:proton antiporter activity(GO:0032416) musculoskeletal movement, spinal reflex action(GO:0050883)
0.0 0.1 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.0 0.2 GO:0048733 sebaceous gland development(GO:0048733)
0.0 0.2 GO:0007144 female meiosis I(GO:0007144)
0.0 0.1 GO:0051799 negative regulation of hair follicle development(GO:0051799)
0.0 0.3 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.0 0.2 GO:0051013 microtubule severing(GO:0051013)
0.0 0.1 GO:0021840 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.0 0.1 GO:0044179 hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331)
0.0 0.1 GO:1902093 positive regulation of sperm motility(GO:1902093)
0.0 0.2 GO:0009642 response to light intensity(GO:0009642)
0.0 0.4 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.2 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.0 0.2 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.6 GO:0042461 photoreceptor cell development(GO:0042461)
0.0 0.1 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.0 0.2 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.0 0.0 GO:1903625 negative regulation of DNA catabolic process(GO:1903625)
0.0 0.1 GO:0021759 globus pallidus development(GO:0021759)
0.0 0.1 GO:0089700 protein kinase D signaling(GO:0089700)
0.0 0.5 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 0.2 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.6 GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.0 0.2 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.2 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.1 GO:0090324 negative regulation of oxidative phosphorylation(GO:0090324)
0.0 0.3 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.0 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.0 0.1 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.0 0.1 GO:0071442 positive regulation of histone H3-K14 acetylation(GO:0071442) regulation of stem cell division(GO:2000035)
0.0 1.1 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 0.1 GO:0030916 otic vesicle formation(GO:0030916)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0035841 new growing cell tip(GO:0035841)
0.1 0.5 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.1 GO:0036025 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
0.0 0.3 GO:0097209 epidermal lamellar body(GO:0097209)
0.0 0.1 GO:1990032 parallel fiber(GO:1990032)
0.0 0.1 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.5 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.2 GO:0035061 interchromatin granule(GO:0035061)
0.0 0.1 GO:0005873 plus-end kinesin complex(GO:0005873)
0.0 0.3 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.2 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.3 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.1 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.0 0.3 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.3 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.2 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.0 0.5 GO:0001891 phagocytic cup(GO:0001891)
0.0 5.0 GO:0043209 myelin sheath(GO:0043209)
0.0 0.2 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.3 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.2 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.3 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 0.3 GO:0033823 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.1 0.5 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
0.1 0.3 GO:0034040 lipid-transporting ATPase activity(GO:0034040)
0.1 0.2 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.1 0.2 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
0.1 0.2 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 0.2 GO:0005174 CD40 receptor binding(GO:0005174)
0.0 0.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.5 GO:0000150 recombinase activity(GO:0000150)
0.0 0.3 GO:0070728 leucine binding(GO:0070728)
0.0 0.2 GO:0008665 2'-phosphotransferase activity(GO:0008665)
0.0 0.3 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.2 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.7 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.2 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.2 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.4 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.2 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.5 GO:0017166 vinculin binding(GO:0017166)
0.0 0.3 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.1 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.0 0.5 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 5.4 GO:0051015 actin filament binding(GO:0051015)
0.0 0.3 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.3 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.1 GO:0030626 U12 snRNA binding(GO:0030626)
0.0 1.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 1.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.1 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.1 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0 0.1 GO:0032190 acrosin binding(GO:0032190)
0.0 0.1 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.2 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.4 GO:0031489 myosin V binding(GO:0031489)
0.0 0.1 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.2 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.0 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.0 0.1 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.0 0.2 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.0 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.3 GO:0004745 retinol dehydrogenase activity(GO:0004745)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.2 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.5 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.8 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.2 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.6 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.2 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.3 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.8 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.4 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.2 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.2 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.1 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)