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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for DLX5

Z-value: 0.81

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Transcription factors associated with DLX5

Gene Symbol Gene ID Gene Info
DLX5
ENSG00000105880.4 distal-less homeobox 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DLX5hg19_v2_chr7_-_96654133_966544090.222.4e-01Click!

Activity profile of DLX5 motif

Sorted Z-values of DLX5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_7013897 5.74 ENST00000007969.8
ENST00000323702.5
LRRC23
leucine rich repeat containing 23
chr12_+_7014064 5.73 ENST00000443597.2
LRRC23
leucine rich repeat containing 23
chr2_+_228736321 5.09 ENST00000309931.2
DAW1
dynein assembly factor with WDR repeat domains 1
chr2_+_228735763 4.99 ENST00000373666.2
DAW1
dynein assembly factor with WDR repeat domains 1
chr13_+_36050881 4.99 ENST00000537702.1
NBEA
neurobeachin
chr12_+_7014126 4.45 ENST00000415834.1
ENST00000436789.1
LRRC23
leucine rich repeat containing 23
chr2_+_228736335 4.08 ENST00000440997.1
ENST00000545118.1
DAW1
dynein assembly factor with WDR repeat domains 1
chr11_-_26593779 2.82 ENST00000529533.1
MUC15
mucin 15, cell surface associated
chr16_+_53133070 2.37 ENST00000565832.1
CHD9
chromodomain helicase DNA binding protein 9
chr5_-_160279207 2.32 ENST00000327245.5
ATP10B
ATPase, class V, type 10B
chr3_+_186560462 2.06 ENST00000412955.2
ADIPOQ
adiponectin, C1Q and collagen domain containing
chr3_+_186560476 2.06 ENST00000320741.2
ENST00000444204.2
ADIPOQ
adiponectin, C1Q and collagen domain containing
chr4_+_77356248 1.98 ENST00000296043.6
SHROOM3
shroom family member 3
chr11_-_26593649 1.80 ENST00000455601.2
MUC15
mucin 15, cell surface associated
chr11_-_26593677 1.74 ENST00000527569.1
MUC15
mucin 15, cell surface associated
chr12_-_10151773 1.72 ENST00000298527.6
ENST00000348658.4
CLEC1B
C-type lectin domain family 1, member B
chr8_-_10512569 1.62 ENST00000382483.3
RP1L1
retinitis pigmentosa 1-like 1
chr20_+_58571419 1.54 ENST00000244049.3
ENST00000350849.6
ENST00000456106.1
CDH26
cadherin 26
chr11_-_33913708 1.50 ENST00000257818.2
LMO2
LIM domain only 2 (rhombotin-like 1)
chr4_-_105416039 1.49 ENST00000394767.2
CXXC4
CXXC finger protein 4
chr1_+_61547405 1.48 ENST00000371189.4
NFIA
nuclear factor I/A
chr5_-_42811986 1.42 ENST00000511224.1
ENST00000507920.1
ENST00000510965.1
SEPP1
selenoprotein P, plasma, 1
chr4_-_138453559 1.32 ENST00000511115.1
PCDH18
protocadherin 18
chr5_-_42812143 1.26 ENST00000514985.1
SEPP1
selenoprotein P, plasma, 1
chr1_+_61547894 1.16 ENST00000403491.3
NFIA
nuclear factor I/A
chr15_+_89631381 1.05 ENST00000352732.5
ABHD2
abhydrolase domain containing 2
chr1_-_23670817 0.92 ENST00000478691.1
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr3_-_105587879 0.92 ENST00000264122.4
ENST00000403724.1
ENST00000405772.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr5_-_20575959 0.89 ENST00000507958.1
CDH18
cadherin 18, type 2
chr11_+_818902 0.87 ENST00000336615.4
PNPLA2
patatin-like phospholipase domain containing 2
chr3_+_2933893 0.86 ENST00000397459.2
CNTN4
contactin 4
chr7_+_70597109 0.85 ENST00000333538.5
WBSCR17
Williams-Beuren syndrome chromosome region 17
chr4_-_66536196 0.81 ENST00000511294.1
EPHA5
EPH receptor A5
chr7_+_99717230 0.79 ENST00000262932.3
CNPY4
canopy FGF signaling regulator 4
chr6_-_78173490 0.78 ENST00000369947.2
HTR1B
5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
chr14_+_22739823 0.75 ENST00000390464.2
TRAV38-1
T cell receptor alpha variable 38-1
chr3_-_186288097 0.71 ENST00000446782.1
TBCCD1
TBCC domain containing 1
chr7_-_86849883 0.70 ENST00000433078.1
TMEM243
transmembrane protein 243, mitochondrial
chr12_+_52695617 0.68 ENST00000293525.5
KRT86
keratin 86
chr1_-_150669500 0.65 ENST00000271732.3
GOLPH3L
golgi phosphoprotein 3-like
chr1_-_23670813 0.58 ENST00000374612.1
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr1_+_101003687 0.58 ENST00000315033.4
GPR88
G protein-coupled receptor 88
chr1_-_23670752 0.57 ENST00000302271.6
ENST00000426846.2
ENST00000427764.2
ENST00000606561.1
ENST00000374616.3
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr15_+_41913690 0.53 ENST00000563576.1
MGA
MGA, MAX dimerization protein
chr2_+_169757750 0.52 ENST00000375363.3
ENST00000429379.2
ENST00000421979.1
G6PC2
glucose-6-phosphatase, catalytic, 2
chr2_+_95963052 0.51 ENST00000295225.5
KCNIP3
Kv channel interacting protein 3, calsenilin
chr1_+_160160283 0.51 ENST00000368079.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr1_+_160160346 0.47 ENST00000368078.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr21_-_32253874 0.45 ENST00000332378.4
KRTAP11-1
keratin associated protein 11-1
chr19_-_36606181 0.44 ENST00000221859.4
POLR2I
polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
chr5_-_58571935 0.43 ENST00000503258.1
PDE4D
phosphodiesterase 4D, cAMP-specific
chr4_-_66536057 0.41 ENST00000273854.3
EPHA5
EPH receptor A5
chr14_-_95236551 0.29 ENST00000238558.3
GSC
goosecoid homeobox
chr14_-_68283291 0.27 ENST00000555452.1
ENST00000347230.4
ZFYVE26
zinc finger, FYVE domain containing 26
chr3_-_105588231 0.26 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chrX_-_16887963 0.25 ENST00000380084.4
RBBP7
retinoblastoma binding protein 7
chr12_+_54378923 0.25 ENST00000303460.4
HOXC10
homeobox C10
chr18_-_33709268 0.23 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chr17_-_47785504 0.23 ENST00000514907.1
ENST00000503334.1
ENST00000508520.1
SLC35B1
solute carrier family 35, member B1
chr14_+_96000930 0.22 ENST00000331334.4
GLRX5
glutaredoxin 5
chr7_-_99717463 0.21 ENST00000437822.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr1_-_150669604 0.21 ENST00000427665.1
ENST00000540514.1
GOLPH3L
golgi phosphoprotein 3-like
chr19_+_6372444 0.20 ENST00000245812.3
ALKBH7
alkB, alkylation repair homolog 7 (E. coli)
chr5_+_63802109 0.20 ENST00000334025.2
RGS7BP
regulator of G-protein signaling 7 binding protein
chr2_-_183387430 0.19 ENST00000410103.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr3_+_186288454 0.18 ENST00000265028.3
DNAJB11
DnaJ (Hsp40) homolog, subfamily B, member 11
chr10_-_56561022 0.17 ENST00000373965.2
ENST00000414778.1
ENST00000395438.1
ENST00000409834.1
ENST00000395445.1
ENST00000395446.1
ENST00000395442.1
ENST00000395440.1
ENST00000395432.2
ENST00000361849.3
ENST00000395433.1
ENST00000320301.6
ENST00000395430.1
ENST00000437009.1
PCDH15
protocadherin-related 15
chr2_+_30369859 0.17 ENST00000402003.3
YPEL5
yippee-like 5 (Drosophila)
chr12_-_57039739 0.17 ENST00000552959.1
ENST00000551020.1
ENST00000553007.2
ENST00000552919.1
ENST00000552104.1
ENST00000262030.3
ATP5B
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr17_-_39341594 0.16 ENST00000398472.1
KRTAP4-1
keratin associated protein 4-1
chr1_+_202317855 0.16 ENST00000356764.2
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr17_+_42264556 0.16 ENST00000319511.6
ENST00000589785.1
ENST00000592825.1
ENST00000589184.1
TMUB2
transmembrane and ubiquitin-like domain containing 2
chr7_-_7575477 0.13 ENST00000399429.3
COL28A1
collagen, type XXVIII, alpha 1
chr2_+_30369807 0.12 ENST00000379520.3
ENST00000379519.3
ENST00000261353.4
YPEL5
yippee-like 5 (Drosophila)
chr4_+_66536248 0.12 ENST00000514260.1
ENST00000507117.1
RP11-807H7.1
RP11-807H7.1
chrX_+_150565653 0.11 ENST00000330374.6
VMA21
VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
chr19_+_54641444 0.11 ENST00000221232.5
ENST00000358389.3
CNOT3
CCR4-NOT transcription complex, subunit 3
chr17_-_39324424 0.10 ENST00000391356.2
KRTAP4-3
keratin associated protein 4-3
chr13_-_36788718 0.10 ENST00000317764.6
ENST00000379881.3
SOHLH2
spermatogenesis and oogenesis specific basic helix-loop-helix 2
chr6_-_27860956 0.09 ENST00000359611.2
HIST1H2AM
histone cluster 1, H2am
chr1_+_202317815 0.08 ENST00000608999.1
ENST00000336894.4
ENST00000480184.1
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr6_-_33160231 0.08 ENST00000395194.1
ENST00000457788.1
ENST00000341947.2
ENST00000357486.1
ENST00000374714.1
ENST00000374713.1
ENST00000395197.1
ENST00000374712.1
ENST00000361917.1
ENST00000374708.4
COL11A2
collagen, type XI, alpha 2
chr19_-_19302931 0.06 ENST00000444486.3
ENST00000514819.3
ENST00000585679.1
ENST00000162023.5
MEF2BNB-MEF2B
MEF2BNB
MEF2B
MEF2BNB-MEF2B readthrough
MEF2B neighbor
myocyte enhancer factor 2B
chr15_+_89631647 0.06 ENST00000569550.1
ENST00000565066.1
ENST00000565973.1
ABHD2
abhydrolase domain containing 2
chr11_+_118398178 0.05 ENST00000302783.4
ENST00000539546.1
TTC36
tetratricopeptide repeat domain 36
chr11_+_76092353 0.04 ENST00000530460.1
ENST00000321844.4
RP11-111M22.2
Homo sapiens putative uncharacterized protein FLJ37770-like (LOC100506127), mRNA.
chr2_-_183387283 0.04 ENST00000435564.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr11_+_73498898 0.04 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
MRPL48
mitochondrial ribosomal protein L48
chr3_+_158519654 0.01 ENST00000415822.2
ENST00000392813.4
ENST00000264266.8
MFSD1
major facilitator superfamily domain containing 1
chr8_+_92261516 0.01 ENST00000276609.3
ENST00000309536.2
SLC26A7
solute carrier family 26 (anion exchanger), member 7

Network of associatons between targets according to the STRING database.

First level regulatory network of DLX5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.1 GO:0097018 renal albumin absorption(GO:0097018) regulation of renal albumin absorption(GO:2000532) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.2 1.5 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.2 0.8 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.1 0.6 GO:0061743 motor learning(GO:0061743)
0.1 2.0 GO:0045176 apical protein localization(GO:0045176)
0.1 0.7 GO:0051684 maintenance of Golgi location(GO:0051684)
0.1 2.6 GO:0072189 ureter development(GO:0072189)
0.1 0.3 GO:0014034 neural crest cell fate commitment(GO:0014034)
0.1 14.2 GO:0007368 determination of left/right symmetry(GO:0007368)
0.1 1.0 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 6.4 GO:0016266 O-glycan processing(GO:0016266)
0.1 2.3 GO:0045332 phospholipid translocation(GO:0045332)
0.1 0.9 GO:0048194 Golgi vesicle budding(GO:0048194)
0.1 0.2 GO:0015785 UDP-galactose transport(GO:0015785) UDP-galactose transmembrane transport(GO:0072334)
0.1 0.9 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898) acylglycerol acyl-chain remodeling(GO:0036155)
0.1 1.5 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.1 1.2 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.1 2.1 GO:0061157 mRNA destabilization(GO:0061157)
0.1 1.7 GO:0030220 platelet formation(GO:0030220) platelet morphogenesis(GO:0036344)
0.1 1.2 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.1 0.3 GO:0010286 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.0 0.4 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 1.7 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 0.2 GO:1902445 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445)
0.0 1.1 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.9 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.0 0.3 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.0 0.2 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.2 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0 0.1 GO:0060023 soft palate development(GO:0060023)
0.0 3.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.5 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.0 0.2 GO:0071578 zinc II ion transmembrane import(GO:0071578)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0014802 terminal cisterna(GO:0014802)
0.1 1.1 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 6.4 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.7 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 4.3 GO:0005581 collagen trimer(GO:0005581)
0.0 1.6 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.3 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0 0.2 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0 14.2 GO:0005929 cilium(GO:0005929)
0.0 5.6 GO:0005802 trans-Golgi network(GO:0005802)
0.0 2.6 GO:0043679 axon terminus(GO:0043679)
0.0 0.7 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 1.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.4 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.1 GO:0030015 CCR4-NOT core complex(GO:0030015)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.1 GO:0033691 sialic acid binding(GO:0033691)
0.1 0.5 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.1 1.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 0.9 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.1 2.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 0.2 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.1 0.8 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.1 1.1 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.8 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.2 GO:0043532 angiostatin binding(GO:0043532)
0.0 1.5 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.9 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.4 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 1.1 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.2 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 1.5 GO:0030165 PDZ domain binding(GO:0030165)
0.0 2.4 GO:0004386 helicase activity(GO:0004386)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 8.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.5 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 2.6 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.2 PID CD40 PATHWAY CD40/CD40L signaling
0.0 4.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.4 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 0.8 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 2.3 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 4.1 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.9 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.8 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.3 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.4 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 2.1 REACTOME MRNA SPLICING Genes involved in mRNA Splicing