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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for DMBX1

Z-value: 0.27

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Transcription factors associated with DMBX1

Gene Symbol Gene ID Gene Info
ENSG00000197587.6 diencephalon/mesencephalon homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DMBX1hg19_v2_chr1_+_46972668_469726690.328.0e-02Click!

Activity profile of DMBX1 motif

Sorted Z-values of DMBX1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_38859996 0.82 ENST00000264651.2
keratin 24
chr3_+_188664988 0.75 ENST00000433971.1
tumor protein p63 regulated 1
chr10_+_118187379 0.66 ENST00000369230.3
pancreatic lipase-related protein 3
chr8_-_125577940 0.62 ENST00000519168.1
ENST00000395508.2
metastasis suppressor 1
chr2_-_70780572 0.41 ENST00000450929.1
transforming growth factor, alpha
chr18_+_29027696 0.41 ENST00000257189.4
desmoglein 3
chr19_-_51538118 0.36 ENST00000529888.1
kallikrein-related peptidase 12
chr19_-_51538148 0.36 ENST00000319590.4
ENST00000250351.4
kallikrein-related peptidase 12
chr2_-_70780770 0.33 ENST00000444975.1
ENST00000445399.1
ENST00000418333.2
transforming growth factor, alpha
chr6_+_130339710 0.29 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
l(3)mbt-like 3 (Drosophila)
chr3_-_137851220 0.29 ENST00000236709.3
alpha-1,4-N-acetylglucosaminyltransferase
chr9_-_21995249 0.27 ENST00000494262.1
cyclin-dependent kinase inhibitor 2A
chr9_-_21995300 0.26 ENST00000498628.2
cyclin-dependent kinase inhibitor 2A
chr15_+_93443419 0.25 ENST00000557381.1
ENST00000420239.2
chromodomain helicase DNA binding protein 2
chr7_+_1727755 0.23 ENST00000424383.2
extracellular leucine-rich repeat and fibronectin type III domain containing 1
chr3_-_16524357 0.22 ENST00000432519.1
raftlin, lipid raft linker 1
chr3_-_121468513 0.21 ENST00000494517.1
ENST00000393667.3
golgin B1
chr1_-_143913143 0.20 ENST00000400889.1
family with sequence similarity 72, member D
chr10_+_103986085 0.20 ENST00000370005.3
ELOVL fatty acid elongase 3
chr3_-_121468602 0.20 ENST00000340645.5
golgin B1
chr15_+_74165945 0.20 ENST00000535547.2
ENST00000300504.2
ENST00000562056.1
TBC1 domain family, member 21
chrX_-_32173579 0.19 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
dystrophin
chr1_+_206138457 0.19 ENST00000367128.3
ENST00000431655.2
family with sequence similarity 72, member A
chr3_-_10362725 0.19 ENST00000397109.3
ENST00000428626.1
ENST00000445064.1
ENST00000431352.1
ENST00000397117.1
ENST00000337354.4
ENST00000383801.2
ENST00000432213.1
ENST00000350697.3
SEC13 homolog (S. cerevisiae)
chr9_-_21994597 0.18 ENST00000579755.1
cyclin-dependent kinase inhibitor 2A
chr2_+_37571845 0.18 ENST00000537448.1
glutaminyl-peptide cyclotransferase
chr1_+_109756523 0.18 ENST00000234677.2
ENST00000369923.4
seryl-tRNA synthetase
chr1_+_120839005 0.18 ENST00000369390.3
ENST00000452190.1
family with sequence similarity 72, member B
chr12_+_53693812 0.17 ENST00000549488.1
chromosome 12 open reading frame 10
chr9_-_21994344 0.17 ENST00000530628.2
ENST00000361570.3
cyclin-dependent kinase inhibitor 2A
chr2_-_165812028 0.16 ENST00000303735.4
solute carrier family 38, member 11
chr15_+_63414760 0.15 ENST00000557972.1
lactamase, beta
chr19_+_36157715 0.15 ENST00000379013.2
ENST00000222275.2
uroplakin 1A
chr1_-_47655686 0.15 ENST00000294338.2
PDZK1 interacting protein 1
chr2_-_165811983 0.15 ENST00000409058.1
ENST00000409149.3
solute carrier family 38, member 11
chr6_-_111927062 0.15 ENST00000359831.4
TRAF3 interacting protein 2
chr6_-_26250835 0.14 ENST00000446824.2
histone cluster 1, H3f
chr18_-_35145728 0.13 ENST00000361795.5
ENST00000603232.1
CUGBP, Elav-like family member 4
chr12_+_115800817 0.13 ENST00000547948.1
HCG2038717; Uncharacterized protein
chr10_+_74451883 0.13 ENST00000373053.3
ENST00000357157.6
mitochondrial calcium uniporter
chr12_+_54718904 0.13 ENST00000262061.2
ENST00000549043.1
ENST00000552218.1
ENST00000553231.1
ENST00000552362.1
ENST00000455864.2
ENST00000416254.2
ENST00000549116.1
ENST00000551779.1
coatomer protein complex, subunit zeta 1
chr12_-_56321397 0.12 ENST00000557259.1
ENST00000549939.1
within bgcn homolog (Drosophila)
chr14_+_22265444 0.11 ENST00000390430.2
T cell receptor alpha variable 8-1
chr7_-_99774945 0.11 ENST00000292377.2
glypican 2
chr2_+_223725652 0.11 ENST00000357430.3
ENST00000392066.3
acyl-CoA synthetase long-chain family member 3
chr7_-_48068671 0.11 ENST00000297325.4
Sad1 and UNC84 domain containing 3
chr2_-_165811756 0.10 ENST00000409662.1
solute carrier family 38, member 11
chr15_+_63413990 0.10 ENST00000261893.4
lactamase, beta
chrX_+_72062802 0.10 ENST00000373533.1
DMRT-like family C1B
chr1_-_28384598 0.10 ENST00000373864.1
eyes absent homolog 3 (Drosophila)
chr12_+_7941989 0.10 ENST00000229307.4
Nanog homeobox
chr19_+_46001697 0.09 ENST00000451287.2
ENST00000324688.4
protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)
chrX_-_72097698 0.09 ENST00000373530.1
DMRT-like family C1
chr7_-_48068643 0.09 ENST00000453192.2
Sad1 and UNC84 domain containing 3
chr12_-_21487829 0.08 ENST00000445053.1
ENST00000452078.1
ENST00000458504.1
ENST00000422327.1
ENST00000421294.1
solute carrier organic anion transporter family, member 1A2
chr1_+_12851545 0.08 ENST00000332296.7
PRAME family member 1
chr12_-_118628350 0.08 ENST00000537952.1
ENST00000537822.1
TAO kinase 3
chr3_+_136649311 0.08 ENST00000469404.1
ENST00000467911.1
NCK adaptor protein 1
chr12_-_56321649 0.07 ENST00000454792.2
ENST00000408946.2
within bgcn homolog (Drosophila)
chr17_-_39324424 0.07 ENST00000391356.2
keratin associated protein 4-3
chr3_+_111393501 0.06 ENST00000393934.3
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr12_-_110937351 0.06 ENST00000552130.2
vacuolar protein sorting 29 homolog (S. cerevisiae)
chrX_+_72062617 0.05 ENST00000440247.1
DMRT-like family C1B
chr6_-_138893661 0.04 ENST00000427025.2
NHS-like 1
chr2_-_14541060 0.04 ENST00000418420.1
ENST00000417751.1
long intergenic non-protein coding RNA 276
chr20_+_34556488 0.04 ENST00000373973.3
ENST00000349339.1
ENST00000538900.1
cyclic nucleotide binding domain containing 2
chr10_-_101491828 0.03 ENST00000370483.5
ENST00000016171.5
cytochrome c oxidase assembly homolog 15 (yeast)
chr18_-_35145689 0.03 ENST00000591287.1
ENST00000601019.1
ENST00000601392.1
CUGBP, Elav-like family member 4
chr15_-_85201779 0.03 ENST00000360476.3
ENST00000394588.3
neuromedin B
chr16_-_20338748 0.03 ENST00000575582.1
ENST00000341642.5
ENST00000381362.4
ENST00000572347.1
ENST00000572478.1
ENST00000302555.5
glycoprotein 2 (zymogen granule membrane)
chr3_-_150920979 0.03 ENST00000309180.5
ENST00000480322.1
G protein-coupled receptor 171
chr3_-_196242233 0.02 ENST00000397537.2
single-pass membrane protein with coiled-coil domains 1
chrX_-_71792477 0.02 ENST00000421523.1
ENST00000415409.1
ENST00000373559.4
ENST00000373556.3
ENST00000373560.2
ENST00000373583.1
ENST00000429103.2
ENST00000373571.1
ENST00000373554.1
histone deacetylase 8
chr17_-_12921270 0.02 ENST00000578071.1
ENST00000426905.3
ENST00000395962.2
ENST00000583371.1
ENST00000338034.4
elaC ribonuclease Z 2
chr4_-_170679024 0.02 ENST00000393381.2
chromosome 4 open reading frame 27
chr18_-_35145593 0.02 ENST00000334919.5
ENST00000591282.1
ENST00000588597.1
CUGBP, Elav-like family member 4
chr17_-_48207157 0.01 ENST00000330175.4
ENST00000503131.1
sterile alpha motif domain containing 14
chr4_-_120225600 0.01 ENST00000399075.4
chromosome 4 open reading frame 3
chr20_+_59654146 0.01 ENST00000441660.1
RP5-827L5.1
chr18_-_70532906 0.01 ENST00000299430.2
ENST00000397929.1
neuropilin (NRP) and tolloid (TLL)-like 1
chr1_-_16563641 0.00 ENST00000375599.3
REM2 and RAB-like small GTPase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of DMBX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0030035 microspike assembly(GO:0030035)
0.1 0.9 GO:2000111 senescence-associated heterochromatin focus assembly(GO:0035986) positive regulation of macrophage apoptotic process(GO:2000111)
0.1 0.2 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.1 0.2 GO:0006434 seryl-tRNA aminoacylation(GO:0006434)
0.0 0.7 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 0.1 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.0 0.2 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.0 0.1 GO:1903676 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.0 0.3 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.2 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.2 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.0 0.2 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.1 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 1.9 GO:0070268 cornification(GO:0070268)
0.0 0.1 GO:0001714 endodermal cell fate specification(GO:0001714)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.1 GO:1990246 uniplex complex(GO:1990246)
0.0 0.2 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.2 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.1 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.0 0.4 GO:0030057 desmosome(GO:0030057)
0.0 0.2 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.1 0.2 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.0 0.9 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.2 GO:0042835 BRE binding(GO:0042835)
0.0 0.7 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.2 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.1 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 0.7 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.6 GO:0003785 actin monomer binding(GO:0003785)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.7 PID ERBB NETWORK PATHWAY ErbB receptor signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.9 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.3 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.1 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport