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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for DMC1

Z-value: 0.51

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Transcription factors associated with DMC1

Gene Symbol Gene ID Gene Info
DMC1
ENSG00000100206.5 DNA meiotic recombinase 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DMC1hg19_v2_chr22_-_38966172_38966291-0.374.5e-02Click!

Activity profile of DMC1 motif

Sorted Z-values of DMC1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_94727048 3.85 ENST00000283357.5
FAM81B
family with sequence similarity 81, member B
chr7_+_6793740 2.54 ENST00000403107.1
ENST00000404077.1
ENST00000435395.1
ENST00000418406.1
RSPH10B2
radial spoke head 10 homolog B2 (Chlamydomonas)
chr7_-_6010263 2.53 ENST00000455618.2
ENST00000405415.1
ENST00000404406.1
ENST00000542644.1
RSPH10B
radial spoke head 10 homolog B (Chlamydomonas)
chr4_+_15471489 2.00 ENST00000424120.1
ENST00000413206.1
ENST00000438599.2
ENST00000511544.1
ENST00000512702.1
ENST00000507954.1
ENST00000515124.1
ENST00000503292.1
ENST00000503658.1
CC2D2A
coiled-coil and C2 domain containing 2A
chr21_-_46348694 1.75 ENST00000355153.4
ENST00000397850.2
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr2_+_120187465 1.22 ENST00000409826.1
ENST00000417645.1
TMEM37
transmembrane protein 37
chr10_-_62332357 1.02 ENST00000503366.1
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr11_+_101785727 1.00 ENST00000263468.8
KIAA1377
KIAA1377
chr10_+_74870206 0.90 ENST00000357321.4
ENST00000349051.5
NUDT13
nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr10_+_74870253 0.81 ENST00000544879.1
ENST00000537969.1
ENST00000372997.3
NUDT13
nudix (nucleoside diphosphate linked moiety X)-type motif 13
chrX_+_105855160 0.74 ENST00000372544.2
ENST00000372548.4
CXorf57
chromosome X open reading frame 57
chr1_+_166958346 0.73 ENST00000367872.4
MAEL
maelstrom spermatogenic transposon silencer
chr11_+_71238313 0.72 ENST00000398536.4
KRTAP5-7
keratin associated protein 5-7
chr12_-_9268707 0.67 ENST00000318602.7
A2M
alpha-2-macroglobulin
chr1_+_166958497 0.63 ENST00000367870.2
MAEL
maelstrom spermatogenic transposon silencer
chr2_+_233497931 0.58 ENST00000264059.3
EFHD1
EF-hand domain family, member D1
chr20_-_21378666 0.47 ENST00000351817.4
NKX2-4
NK2 homeobox 4
chr20_+_11008408 0.47 ENST00000378252.1
C20orf187
chromosome 20 open reading frame 187
chr14_+_74318611 0.45 ENST00000555976.1
ENST00000267568.4
PTGR2
prostaglandin reductase 2
chr14_+_74318513 0.45 ENST00000555228.1
ENST00000555661.1
PTGR2
prostaglandin reductase 2
chr2_-_18741882 0.44 ENST00000381249.3
RDH14
retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
chr14_-_21492113 0.41 ENST00000554094.1
NDRG2
NDRG family member 2
chr14_-_21492251 0.37 ENST00000554398.1
NDRG2
NDRG family member 2
chr3_-_108672742 0.36 ENST00000261047.3
GUCA1C
guanylate cyclase activator 1C
chr3_-_108672609 0.35 ENST00000393963.3
ENST00000471108.1
GUCA1C
guanylate cyclase activator 1C
chrX_+_65382433 0.34 ENST00000374727.3
HEPH
hephaestin
chr14_-_21491477 0.34 ENST00000298684.5
ENST00000557169.1
ENST00000553563.1
NDRG2
NDRG family member 2
chr17_+_77018896 0.34 ENST00000578229.1
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr17_+_77019030 0.29 ENST00000580454.1
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr4_+_106473768 0.29 ENST00000265154.2
ENST00000420470.2
ARHGEF38
Rho guanine nucleotide exchange factor (GEF) 38
chr5_-_135231516 0.27 ENST00000274520.1
IL9
interleukin 9
chr1_-_182642017 0.22 ENST00000367557.4
ENST00000258302.4
RGS8
regulator of G-protein signaling 8
chr10_-_74856608 0.21 ENST00000307116.2
ENST00000373008.2
ENST00000412021.2
ENST00000394890.2
ENST00000263556.3
ENST00000440381.1
P4HA1
prolyl 4-hydroxylase, alpha polypeptide I
chr16_-_30122717 0.21 ENST00000566613.1
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr9_-_34729457 0.20 ENST00000378788.3
FAM205A
family with sequence similarity 205, member A
chr6_+_80129989 0.19 ENST00000429444.1
RP1-232L24.3
RP1-232L24.3
chrX_-_134305322 0.18 ENST00000276241.6
ENST00000344129.2
CXorf48
cancer/testis antigen 55
chrX_+_65382381 0.18 ENST00000519389.1
HEPH
hephaestin
chr1_-_47131521 0.18 ENST00000542495.1
ENST00000532925.1
ATPAF1
ATP synthase mitochondrial F1 complex assembly factor 1
chr6_-_31670723 0.17 ENST00000440843.2
ENST00000375842.4
ABHD16A
abhydrolase domain containing 16A
chr15_-_49103235 0.17 ENST00000380950.2
CEP152
centrosomal protein 152kDa
chr10_-_98031265 0.16 ENST00000224337.5
ENST00000371176.2
BLNK
B-cell linker
chr10_-_98031310 0.14 ENST00000427367.2
ENST00000413476.2
BLNK
B-cell linker
chr11_-_73720122 0.14 ENST00000426995.2
UCP3
uncoupling protein 3 (mitochondrial, proton carrier)
chr10_+_17851362 0.13 ENST00000331429.2
ENST00000457317.1
MRC1L1
cDNA FLJ56855, highly similar to Macrophage mannose receptor 1
chr11_+_71846748 0.12 ENST00000445078.2
FOLR3
folate receptor 3 (gamma)
chr17_-_60142609 0.11 ENST00000397786.2
MED13
mediator complex subunit 13
chr1_+_18958008 0.11 ENST00000420770.2
ENST00000400661.3
PAX7
paired box 7
chr12_-_71031220 0.11 ENST00000334414.6
PTPRB
protein tyrosine phosphatase, receptor type, B
chr6_-_62996066 0.10 ENST00000281156.4
KHDRBS2
KH domain containing, RNA binding, signal transduction associated 2
chr2_-_163008903 0.10 ENST00000418842.2
ENST00000375497.3
GCG
glucagon
chr11_+_71846764 0.10 ENST00000456237.1
ENST00000442948.2
ENST00000546166.1
FOLR3
folate receptor 3 (gamma)
chr12_-_53901266 0.09 ENST00000609999.1
ENST00000267017.3
NPFF
neuropeptide FF-amide peptide precursor
chr10_+_62538248 0.07 ENST00000448257.2
CDK1
cyclin-dependent kinase 1
chr17_+_4846101 0.07 ENST00000576965.1
RNF167
ring finger protein 167
chr19_+_44617511 0.06 ENST00000262894.6
ENST00000588926.1
ENST00000592780.1
ZNF225
zinc finger protein 225
chr2_+_219246746 0.06 ENST00000233202.6
SLC11A1
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
chr5_-_157603408 0.05 ENST00000522769.1
CTC-436K13.5
CTC-436K13.5
chr12_-_71031185 0.04 ENST00000548122.1
ENST00000551525.1
ENST00000550358.1
PTPRB
protein tyrosine phosphatase, receptor type, B
chr10_+_62538089 0.04 ENST00000519078.2
ENST00000395284.3
ENST00000316629.4
CDK1
cyclin-dependent kinase 1
chr1_-_11863571 0.04 ENST00000376583.3
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr19_-_3600549 0.04 ENST00000589966.1
TBXA2R
thromboxane A2 receptor
chr7_+_47694842 0.03 ENST00000408988.2
C7orf65
chromosome 7 open reading frame 65
chr21_-_35281399 0.03 ENST00000418933.1
ATP5O
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
chr19_-_42947121 0.02 ENST00000601181.1
CXCL17
chemokine (C-X-C motif) ligand 17
chr3_+_9944492 0.02 ENST00000383814.3
ENST00000454190.2
ENST00000454992.1
IL17RE
interleukin 17 receptor E
chr8_-_101734907 0.02 ENST00000318607.5
ENST00000521865.1
ENST00000520804.1
ENST00000522720.1
ENST00000521067.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr20_+_2796948 0.02 ENST00000361033.1
ENST00000380585.1
TMEM239
transmembrane protein 239
chr5_+_55149356 0.02 ENST00000490985.1
ENST00000354961.4
IL31RA
interleukin 31 receptor A
chr3_+_9944303 0.01 ENST00000421412.1
ENST00000295980.3
IL17RE
interleukin 17 receptor E
chr10_-_135187193 0.00 ENST00000368547.3
ECHS1
enoyl CoA hydratase, short chain, 1, mitochondrial
chr16_+_2255710 0.00 ENST00000397124.1
ENST00000565250.1
MLST8
MTOR associated protein, LST8 homolog (S. cerevisiae)

Network of associatons between targets according to the STRING database.

First level regulatory network of DMC1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.0 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.3 1.0 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 0.6 GO:2000860 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.1 1.1 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.1 1.4 GO:0034587 piRNA metabolic process(GO:0034587)
0.1 1.4 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.1 0.7 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 0.7 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.2 GO:0046462 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.0 0.2 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.0 1.7 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.0 0.1 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.0 0.2 GO:0098535 de novo centriole assembly(GO:0098535)
0.0 0.1 GO:0070253 somatostatin secretion(GO:0070253)
0.0 0.1 GO:0014038 regulation of Schwann cell differentiation(GO:0014038)
0.0 0.2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.2 GO:0015884 folic acid transport(GO:0015884)
0.0 0.1 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.0 0.0 GO:0038193 thromboxane A2 signaling pathway(GO:0038193)
0.0 0.0 GO:0055073 cadmium ion homeostasis(GO:0055073) divalent metal ion export(GO:0070839)
0.0 0.6 GO:0006692 prostanoid metabolic process(GO:0006692) prostaglandin metabolic process(GO:0006693)
0.0 0.2 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0030849 autosome(GO:0030849)
0.2 1.4 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
0.1 2.0 GO:0036038 MKS complex(GO:0036038)
0.1 0.2 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0 1.0 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.2 GO:0098536 deuterosome(GO:0098536)
0.0 0.1 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.0 0.7 GO:0097381 photoreceptor disc membrane(GO:0097381)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0019959 interleukin-8 binding(GO:0019959)
0.1 1.4 GO:0030369 ICAM-3 receptor activity(GO:0030369)
0.1 0.9 GO:0047522 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.1 0.7 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.1 0.5 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.4 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.2 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.0 1.0 GO:0030507 spectrin binding(GO:0030507)
0.0 0.1 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.0 0.3 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.0 GO:0004960 thromboxane receptor activity(GO:0004960) thromboxane A2 receptor activity(GO:0004961)
0.0 0.0 GO:0051139 metal ion:proton antiporter activity(GO:0051139)
0.0 0.2 GO:0005542 folic acid binding(GO:0005542)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 0.7 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.3 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 1.0 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.6 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 1.4 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell