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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for DRGX_PROP1
Z-value: 0.88
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Transcription factors associated with DRGX_PROP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PROP1 | hg19_v2_chr5_-_177423243_177423243 | -0.59 | 6.4e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_+_31823792 Show fit | 13.34 |
ENST00000375413.4
ENST00000354297.4 ENST00000375422.2 |
BPI fold containing family A, member 1 |
|
| chr13_+_50589390 Show fit | 6.20 |
ENST00000360473.4
ENST00000312942.1 |
potassium channel regulator |
|
| chr4_-_100356291 Show fit | 5.18 |
ENST00000476959.1
ENST00000482593.1 |
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide |
|
| chr4_-_100356551 Show fit | 5.18 |
ENST00000209665.4
|
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide |
|
| chr9_-_34397800 Show fit | 4.70 |
ENST00000297623.2
|
chromosome 9 open reading frame 24 |
|
| chrX_+_35937843 Show fit | 3.91 |
ENST00000297866.5
|
chromosome X open reading frame 22 |
|
| chr14_+_75536280 Show fit | 3.66 |
ENST00000238686.8
|
zinc finger, C2HC-type containing 1C |
|
| chr6_+_88117683 Show fit | 3.35 |
ENST00000369562.4
|
UPF0704 protein C6orf165 |
|
| chr5_-_160279207 Show fit | 3.10 |
ENST00000327245.5
|
ATPase, class V, type 10B |
|
| chr7_+_90338712 Show fit | 2.99 |
ENST00000265741.3
ENST00000406263.1 |
cyclin-dependent kinase 14 |
Network of associatons between targets according to the STRING database.
First level regulatory network of DRGX_PROP1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 13.3 | GO:0044407 | biofilm formation(GO:0042710) single-species biofilm formation(GO:0044010) single-species biofilm formation in or on host organism(GO:0044407) regulation of single-species biofilm formation(GO:1900190) negative regulation of single-species biofilm formation(GO:1900191) regulation of single-species biofilm formation in or on host organism(GO:1900228) negative regulation of single-species biofilm formation in or on host organism(GO:1900229) |
| 3.5 | 10.4 | GO:0010430 | fatty acid omega-oxidation(GO:0010430) |
| 0.5 | 8.5 | GO:1902260 | negative regulation of delayed rectifier potassium channel activity(GO:1902260) |
| 0.1 | 3.4 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.0 | 3.3 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.1 | 3.1 | GO:0045332 | phospholipid translocation(GO:0045332) |
| 0.0 | 3.0 | GO:1904668 | positive regulation of ubiquitin protein ligase activity(GO:1904668) |
| 0.2 | 2.9 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
| 0.7 | 2.7 | GO:0007181 | transforming growth factor beta receptor complex assembly(GO:0007181) |
| 0.1 | 2.7 | GO:0045494 | photoreceptor cell maintenance(GO:0045494) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.6 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 3.2 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.6 | 3.0 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 0.0 | 2.9 | GO:0005901 | caveola(GO:0005901) |
| 0.1 | 2.8 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.0 | 2.8 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.7 | 2.7 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
| 0.0 | 2.2 | GO:0036126 | sperm flagellum(GO:0036126) |
| 0.0 | 2.1 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 2.0 | GO:0042613 | MHC class II protein complex(GO:0042613) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.6 | GO:0008289 | lipid binding(GO:0008289) |
| 2.6 | 10.4 | GO:0004031 | aldehyde oxidase activity(GO:0004031) |
| 0.3 | 3.6 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.2 | 3.4 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.1 | 3.1 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.4 | 3.0 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 0.1 | 3.0 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.1 | 2.9 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.2 | 2.7 | GO:0005114 | type II transforming growth factor beta receptor binding(GO:0005114) |
| 0.7 | 2.2 | GO:0004937 | alpha1-adrenergic receptor activity(GO:0004937) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 3.6 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 2.8 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.0 | 2.6 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 2.4 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.1 | 2.0 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.0 | 2.0 | PID TXA2PATHWAY | Thromboxane A2 receptor signaling |
| 0.0 | 1.4 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 0.9 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.0 | 0.8 | PID BMP PATHWAY | BMP receptor signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 10.4 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.1 | 4.7 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 4.5 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.1 | 4.2 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 2.6 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 2.2 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.0 | 2.0 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.0 | 2.0 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.1 | 1.4 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 1.4 | REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM | Genes involved in Chondroitin sulfate/dermatan sulfate metabolism |