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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for E2F2_E2F5

Z-value: 2.20

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Transcription factors associated with E2F2_E2F5

Gene Symbol Gene ID Gene Info
E2F2
ENSG00000007968.6 E2F transcription factor 2
E2F5
ENSG00000133740.6 E2F transcription factor 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2F2hg19_v2_chr1_-_23857698_238577330.702.0e-05Click!
E2F5hg19_v2_chr8_+_86121448_86121494-0.346.3e-02Click!

Activity profile of E2F2_E2F5 motif

Sorted Z-values of E2F2_E2F5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_10262857 13.56 ENST00000304567.5
RRM2
ribonucleotide reductase M2
chr10_+_62538089 11.35 ENST00000519078.2
ENST00000395284.3
ENST00000316629.4
CDK1
cyclin-dependent kinase 1
chr20_+_25388293 10.71 ENST00000262460.4
ENST00000429262.2
GINS1
GINS complex subunit 1 (Psf1 homolog)
chr2_-_136633940 10.49 ENST00000264156.2
MCM6
minichromosome maintenance complex component 6
chr2_+_174219548 10.40 ENST00000347703.3
ENST00000392567.2
ENST00000306721.3
ENST00000410101.3
ENST00000410019.3
CDCA7
cell division cycle associated 7
chr15_-_64673630 10.15 ENST00000558008.1
ENST00000559519.1
ENST00000380258.2
KIAA0101
KIAA0101
chr10_+_62538248 10.05 ENST00000448257.2
CDK1
cyclin-dependent kinase 1
chr8_-_124408652 9.54 ENST00000287394.5
ATAD2
ATPase family, AAA domain containing 2
chr9_-_99180597 9.20 ENST00000375256.4
ZNF367
zinc finger protein 367
chr1_+_212208919 8.97 ENST00000366991.4
ENST00000542077.1
DTL
denticleless E3 ubiquitin protein ligase homolog (Drosophila)
chr11_+_125495862 8.38 ENST00000428830.2
ENST00000544373.1
ENST00000527013.1
ENST00000526937.1
ENST00000534685.1
CHEK1
checkpoint kinase 1
chr3_+_127317066 8.24 ENST00000265056.7
MCM2
minichromosome maintenance complex component 2
chr22_+_35796108 8.14 ENST00000382011.5
ENST00000416905.1
MCM5
minichromosome maintenance complex component 5
chr22_+_35796056 7.90 ENST00000216122.4
MCM5
minichromosome maintenance complex component 5
chr4_+_154265784 7.90 ENST00000240488.3
MND1
meiotic nuclear divisions 1 homolog (S. cerevisiae)
chr15_-_64673665 7.34 ENST00000300035.4
KIAA0101
KIAA0101
chr14_-_50154921 7.21 ENST00000553805.2
ENST00000554396.1
ENST00000216367.5
ENST00000539565.2
POLE2
polymerase (DNA directed), epsilon 2, accessory subunit
chr6_+_24775641 7.20 ENST00000378054.2
ENST00000476555.1
GMNN
geminin, DNA replication inhibitor
chr1_-_26232522 7.06 ENST00000399728.1
STMN1
stathmin 1
chr11_-_118966167 6.70 ENST00000530167.1
H2AFX
H2A histone family, member X
chr1_-_26232951 6.48 ENST00000426559.2
ENST00000455785.2
STMN1
stathmin 1
chr11_-_19263145 6.43 ENST00000532666.1
ENST00000527884.1
E2F8
E2F transcription factor 8
chr7_-_148581251 6.41 ENST00000478654.1
ENST00000460911.1
ENST00000350995.2
EZH2
enhancer of zeste homolog 2 (Drosophila)
chr3_+_44803209 6.38 ENST00000326047.4
KIF15
kinesin family member 15
chr6_+_24775153 6.25 ENST00000356509.3
ENST00000230056.3
GMNN
geminin, DNA replication inhibitor
chr7_-_148581360 6.14 ENST00000320356.2
ENST00000541220.1
ENST00000483967.1
ENST00000536783.1
EZH2
enhancer of zeste homolog 2 (Drosophila)
chr7_-_99699538 5.99 ENST00000343023.6
ENST00000303887.5
MCM7
minichromosome maintenance complex component 7
chr16_-_3030407 5.49 ENST00000431515.2
ENST00000574385.1
ENST00000576268.1
ENST00000574730.1
ENST00000575632.1
ENST00000573944.1
ENST00000262300.8
PKMYT1
protein kinase, membrane associated tyrosine/threonine 1
chr10_+_96305535 5.18 ENST00000419900.1
ENST00000348459.5
ENST00000394045.1
ENST00000394044.1
ENST00000394036.1
HELLS
helicase, lymphoid-specific
chr7_-_158497431 5.17 ENST00000449727.2
ENST00000409339.3
ENST00000409423.1
ENST00000356309.3
NCAPG2
non-SMC condensin II complex, subunit G2
chr10_+_13203543 5.14 ENST00000378714.3
ENST00000479669.1
ENST00000484800.2
MCM10
minichromosome maintenance complex component 10
chr11_-_19262486 5.14 ENST00000250024.4
E2F8
E2F transcription factor 8
chr15_-_66649010 4.96 ENST00000367709.4
ENST00000261881.4
TIPIN
TIMELESS interacting protein
chr3_-_48229846 4.61 ENST00000302506.3
ENST00000351231.3
ENST00000437972.1
CDC25A
cell division cycle 25A
chr15_+_40987327 4.56 ENST00000423169.2
ENST00000267868.3
ENST00000557850.1
ENST00000532743.1
ENST00000382643.3
RAD51
RAD51 recombinase
chr9_-_35080013 4.49 ENST00000378643.3
FANCG
Fanconi anemia, complementation group G
chr15_+_32907691 4.24 ENST00000361627.3
ENST00000567348.1
ENST00000563864.1
ENST00000543522.1
ARHGAP11A
Rho GTPase activating protein 11A
chr7_+_94285637 3.98 ENST00000482108.1
ENST00000488574.1
PEG10
paternally expressed 10
chr16_-_3030283 3.98 ENST00000572619.1
ENST00000574415.1
ENST00000440027.2
ENST00000572059.1
PKMYT1
protein kinase, membrane associated tyrosine/threonine 1
chr19_-_10305752 3.97 ENST00000540357.1
ENST00000359526.4
ENST00000340748.4
DNMT1
DNA (cytosine-5-)-methyltransferase 1
chr1_-_23857698 3.95 ENST00000361729.2
E2F2
E2F transcription factor 2
chr9_-_123639304 3.77 ENST00000436309.1
PHF19
PHD finger protein 19
chr8_-_120868078 3.70 ENST00000313655.4
DSCC1
DNA replication and sister chromatid cohesion 1
chr12_-_77459306 3.61 ENST00000547316.1
ENST00000416496.2
ENST00000550669.1
ENST00000322886.7
E2F7
E2F transcription factor 7
chr5_-_79950371 3.44 ENST00000511032.1
ENST00000504396.1
ENST00000505337.1
DHFR
dihydrofolate reductase
chr2_-_235405679 3.34 ENST00000390645.2
ARL4C
ADP-ribosylation factor-like 4C
chr16_-_85722530 3.32 ENST00000253462.3
GINS2
GINS complex subunit 2 (Psf2 homolog)
chr7_-_94285402 3.29 ENST00000428696.2
ENST00000445866.2
SGCE
sarcoglycan, epsilon
chr7_-_94285472 3.28 ENST00000437425.2
ENST00000447873.1
ENST00000415788.2
SGCE
sarcoglycan, epsilon
chr7_-_94285511 3.17 ENST00000265735.7
SGCE
sarcoglycan, epsilon
chrX_+_24711997 3.15 ENST00000379068.3
ENST00000379059.3
POLA1
polymerase (DNA directed), alpha 1, catalytic subunit
chr5_+_36152179 3.15 ENST00000508514.1
ENST00000513151.1
ENST00000546211.1
SKP2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr9_-_123639445 3.03 ENST00000312189.6
PHF19
PHD finger protein 19
chr1_-_47779762 2.84 ENST00000371877.3
ENST00000360380.3
ENST00000337817.5
ENST00000447475.2
STIL
SCL/TAL1 interrupting locus
chr5_+_36152091 2.76 ENST00000274254.5
SKP2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr20_-_35724388 2.72 ENST00000344359.3
ENST00000373664.3
RBL1
retinoblastoma-like 1 (p107)
chrX_-_131623874 2.69 ENST00000436215.1
MBNL3
muscleblind-like splicing regulator 3
chrX_+_48554986 2.66 ENST00000376687.3
ENST00000453214.2
SUV39H1
suppressor of variegation 3-9 homolog 1 (Drosophila)
chr20_-_32274179 2.64 ENST00000343380.5
E2F1
E2F transcription factor 1
chr6_+_37137939 2.58 ENST00000373509.5
PIM1
pim-1 oncogene
chr22_+_42394780 2.57 ENST00000328823.9
WBP2NL
WBP2 N-terminal like
chr10_-_58120996 2.53 ENST00000361148.6
ENST00000395405.1
ENST00000373944.3
ZWINT
ZW10 interacting kinetochore protein
chr5_+_36152163 2.50 ENST00000274255.6
SKP2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr8_+_48873453 2.46 ENST00000523944.1
MCM4
minichromosome maintenance complex component 4
chr6_-_35656712 2.42 ENST00000357266.4
ENST00000542713.1
FKBP5
FK506 binding protein 5
chr11_+_62623544 2.42 ENST00000377890.2
ENST00000377891.2
ENST00000377889.2
SLC3A2
solute carrier family 3 (amino acid transporter heavy chain), member 2
chr8_+_48873479 2.41 ENST00000262105.2
MCM4
minichromosome maintenance complex component 4
chr11_+_62623512 2.40 ENST00000377892.1
SLC3A2
solute carrier family 3 (amino acid transporter heavy chain), member 2
chr4_-_174256276 2.39 ENST00000296503.5
HMGB2
high mobility group box 2
chr13_+_32889605 2.36 ENST00000380152.3
ENST00000544455.1
ENST00000530893.2
BRCA2
breast cancer 2, early onset
chr1_-_100598444 2.35 ENST00000535161.1
ENST00000287482.5
SASS6
spindle assembly 6 homolog (C. elegans)
chr6_-_144329531 2.34 ENST00000429150.1
ENST00000392309.1
ENST00000416623.1
ENST00000392307.1
PLAGL1
pleiomorphic adenoma gene-like 1
chr2_-_17935059 2.33 ENST00000448223.2
ENST00000381272.4
ENST00000351948.4
SMC6
structural maintenance of chromosomes 6
chr5_-_79950775 2.31 ENST00000439211.2
DHFR
dihydrofolate reductase
chr9_-_123639600 2.30 ENST00000373896.3
PHF19
PHD finger protein 19
chr11_+_62623621 2.28 ENST00000535296.1
SLC3A2
solute carrier family 3 (amino acid transporter heavy chain), member 2
chr17_+_74380683 2.25 ENST00000592299.1
ENST00000590959.1
ENST00000323374.4
SPHK1
sphingosine kinase 1
chr1_-_26233423 2.15 ENST00000357865.2
STMN1
stathmin 1
chr9_+_106856831 2.08 ENST00000303219.8
ENST00000374787.3
SMC2
structural maintenance of chromosomes 2
chr5_-_176738883 1.96 ENST00000513169.1
ENST00000423571.2
ENST00000502529.1
ENST00000427908.2
MXD3
MAX dimerization protein 3
chr11_+_64808368 1.83 ENST00000531072.1
ENST00000398846.1
SAC3D1
SAC3 domain containing 1
chr11_+_47236489 1.74 ENST00000256996.4
ENST00000378603.3
ENST00000378600.3
ENST00000378601.3
DDB2
damage-specific DNA binding protein 2, 48kDa
chr2_+_17935119 1.70 ENST00000317402.7
GEN1
GEN1 Holliday junction 5' flap endonuclease
chr1_-_54303934 1.65 ENST00000537333.1
NDC1
NDC1 transmembrane nucleoporin
chr22_+_20105012 1.64 ENST00000331821.3
ENST00000411892.1
RANBP1
RAN binding protein 1
chr15_-_70388943 1.62 ENST00000559048.1
ENST00000560939.1
ENST00000440567.3
ENST00000557907.1
ENST00000558379.1
ENST00000451782.2
ENST00000559929.1
TLE3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chr12_-_122238464 1.58 ENST00000546227.1
RHOF
ras homolog family member F (in filopodia)
chr3_+_10068095 1.52 ENST00000287647.3
ENST00000383807.1
ENST00000383806.1
ENST00000419585.1
FANCD2
Fanconi anemia, complementation group D2
chr2_+_48541776 1.51 ENST00000413569.1
ENST00000340553.3
FOXN2
forkhead box N2
chr10_-_25241499 1.47 ENST00000376378.1
ENST00000376376.3
ENST00000320152.6
PRTFDC1
phosphoribosyl transferase domain containing 1
chr20_+_5931497 1.47 ENST00000378886.2
ENST00000265187.4
MCM8
minichromosome maintenance complex component 8
chr13_+_114238997 1.46 ENST00000538138.1
ENST00000375370.5
TFDP1
transcription factor Dp-1
chr1_+_145209092 1.44 ENST00000362074.6
ENST00000344859.3
NOTCH2NL
notch 2 N-terminal like
chr11_+_64808675 1.43 ENST00000529996.1
SAC3D1
SAC3 domain containing 1
chr10_+_73724123 1.42 ENST00000373115.4
CHST3
carbohydrate (chondroitin 6) sulfotransferase 3
chr16_+_58426296 1.41 ENST00000426538.2
ENST00000328514.7
ENST00000318129.5
GINS3
GINS complex subunit 3 (Psf3 homolog)
chr22_+_20105259 1.40 ENST00000416427.1
ENST00000421656.1
ENST00000423859.1
ENST00000418705.2
RANBP1
RAN binding protein 1
chr2_+_17935383 1.38 ENST00000524465.1
ENST00000381254.2
ENST00000532257.1
GEN1
GEN1 Holliday junction 5' flap endonuclease
chr4_+_178230985 1.36 ENST00000264596.3
NEIL3
nei endonuclease VIII-like 3 (E. coli)
chr19_+_46144884 1.36 ENST00000593161.1
AC006132.1
chromosome 19 open reading frame 83
chr9_+_106856541 1.36 ENST00000286398.7
ENST00000440179.1
ENST00000374793.3
SMC2
structural maintenance of chromosomes 2
chr3_-_133380731 1.31 ENST00000260810.5
TOPBP1
topoisomerase (DNA) II binding protein 1
chr9_+_504674 1.28 ENST00000382297.2
KANK1
KN motif and ankyrin repeat domains 1
chr20_+_5931275 1.25 ENST00000378896.3
ENST00000378883.1
MCM8
minichromosome maintenance complex component 8
chr4_+_71859156 1.24 ENST00000286648.5
ENST00000504730.1
ENST00000504952.1
DCK
deoxycytidine kinase
chr8_-_125740514 1.23 ENST00000325064.5
ENST00000518547.1
MTSS1
metastasis suppressor 1
chrX_+_46696372 1.23 ENST00000218340.3
RP2
retinitis pigmentosa 2 (X-linked recessive)
chr12_-_133263893 1.23 ENST00000535270.1
ENST00000320574.5
POLE
polymerase (DNA directed), epsilon, catalytic subunit
chr19_+_50887585 1.21 ENST00000440232.2
ENST00000601098.1
ENST00000599857.1
ENST00000593887.1
POLD1
polymerase (DNA directed), delta 1, catalytic subunit
chr10_-_77161004 1.20 ENST00000418818.2
RP11-399K21.11
RP11-399K21.11
chr3_-_49893958 1.17 ENST00000482243.1
ENST00000331456.2
ENST00000469027.1
TRAIP
TRAF interacting protein
chr6_-_52149475 1.16 ENST00000419835.2
ENST00000229854.7
ENST00000596288.1
MCM3
minichromosome maintenance complex component 3
chr19_-_10679697 1.16 ENST00000335766.2
CDKN2D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chrX_-_106243451 1.16 ENST00000355610.4
ENST00000535534.1
MORC4
MORC family CW-type zinc finger 4
chr19_-_10679644 1.14 ENST00000393599.2
CDKN2D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr19_+_16187085 1.11 ENST00000300933.4
TPM4
tropomyosin 4
chr22_-_29137771 1.08 ENST00000439200.1
ENST00000405598.1
ENST00000398017.2
ENST00000425190.2
ENST00000348295.3
ENST00000382578.1
ENST00000382565.1
ENST00000382566.1
ENST00000382580.2
ENST00000328354.6
CHEK2
checkpoint kinase 2
chr11_+_4116054 1.07 ENST00000423050.2
RRM1
ribonucleotide reductase M1
chr12_+_57623477 1.02 ENST00000557487.1
ENST00000555634.1
ENST00000556689.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr11_-_74442430 1.02 ENST00000376332.3
CHRDL2
chordin-like 2
chr12_+_57623869 1.02 ENST00000414700.3
ENST00000557703.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr13_-_80915059 0.98 ENST00000377104.3
SPRY2
sprouty homolog 2 (Drosophila)
chr7_+_26241310 0.96 ENST00000396386.2
CBX3
chromobox homolog 3
chr14_+_64854958 0.95 ENST00000555709.2
ENST00000554739.1
ENST00000554768.1
ENST00000216605.8
MTHFD1
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
chr8_-_125740730 0.95 ENST00000354184.4
MTSS1
metastasis suppressor 1
chr2_+_27498289 0.93 ENST00000296097.3
ENST00000420191.1
DNAJC5G
DnaJ (Hsp40) homolog, subfamily C, member 5 gamma
chrX_+_100353153 0.92 ENST00000423383.1
ENST00000218507.5
ENST00000403304.2
ENST00000435570.1
CENPI
centromere protein I
chr4_-_130014729 0.92 ENST00000281142.5
ENST00000434680.1
SCLT1
sodium channel and clathrin linker 1
chr1_-_243418344 0.91 ENST00000366542.1
CEP170
centrosomal protein 170kDa
chr2_+_219433588 0.89 ENST00000295701.5
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr18_+_19192228 0.88 ENST00000300413.5
ENST00000579618.1
ENST00000582475.1
SNRPD1
small nuclear ribonucleoprotein D1 polypeptide 16kDa
chr14_+_21538517 0.88 ENST00000298693.3
ARHGEF40
Rho guanine nucleotide exchange factor (GEF) 40
chr7_+_26241325 0.87 ENST00000456948.1
ENST00000409747.1
CBX3
chromobox homolog 3
chr20_-_5100591 0.87 ENST00000379143.5
PCNA
proliferating cell nuclear antigen
chr2_-_27632390 0.87 ENST00000350803.4
ENST00000344034.4
PPM1G
protein phosphatase, Mg2+/Mn2+ dependent, 1G
chr20_-_60982330 0.85 ENST00000279101.5
CABLES2
Cdk5 and Abl enzyme substrate 2
chr4_-_39979576 0.83 ENST00000303538.8
ENST00000503396.1
PDS5A
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
chr1_-_243418621 0.83 ENST00000366544.1
ENST00000366543.1
CEP170
centrosomal protein 170kDa
chr1_-_180471947 0.83 ENST00000367595.3
ACBD6
acyl-CoA binding domain containing 6
chrX_+_21958674 0.81 ENST00000404933.2
SMS
spermine synthase
chr13_-_73301819 0.80 ENST00000377818.3
MZT1
mitotic spindle organizing protein 1
chr19_-_45909585 0.78 ENST00000593226.1
ENST00000418234.2
PPP1R13L
protein phosphatase 1, regulatory subunit 13 like
chr2_+_27498331 0.77 ENST00000402462.1
ENST00000404433.1
ENST00000406962.1
DNAJC5G
DnaJ (Hsp40) homolog, subfamily C, member 5 gamma
chrX_+_21958814 0.75 ENST00000379404.1
ENST00000415881.2
SMS
spermine synthase
chr14_+_75348592 0.69 ENST00000334220.4
DLST
dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
chr1_-_229694406 0.68 ENST00000344517.4
ABCB10
ATP-binding cassette, sub-family B (MDR/TAP), member 10
chr1_+_25598989 0.67 ENST00000454452.2
RHD
Rh blood group, D antigen
chr19_+_10764937 0.66 ENST00000449870.1
ENST00000318511.3
ENST00000420083.1
ILF3
interleukin enhancer binding factor 3, 90kDa
chr13_-_113242439 0.65 ENST00000375669.3
ENST00000261965.3
TUBGCP3
tubulin, gamma complex associated protein 3
chr2_-_38978492 0.65 ENST00000409276.1
ENST00000446327.2
ENST00000313117.6
SRSF7
serine/arginine-rich splicing factor 7
chr8_+_94929077 0.64 ENST00000297598.4
ENST00000520614.1
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr1_-_222885770 0.64 ENST00000355727.2
ENST00000340020.6
AIDA
axin interactor, dorsalization associated
chr12_-_58131931 0.63 ENST00000547588.1
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr12_-_12849073 0.62 ENST00000332427.2
ENST00000540796.1
GPR19
G protein-coupled receptor 19
chr8_+_94929168 0.62 ENST00000518107.1
ENST00000396200.3
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr10_-_77161650 0.62 ENST00000372524.4
ZNF503
zinc finger protein 503
chr10_-_77161533 0.61 ENST00000535216.1
ZNF503
zinc finger protein 503
chr4_-_130014705 0.61 ENST00000503401.1
SCLT1
sodium channel and clathrin linker 1
chr4_-_130014609 0.60 ENST00000511426.1
SCLT1
sodium channel and clathrin linker 1
chr19_+_2236509 0.58 ENST00000221494.5
SF3A2
splicing factor 3a, subunit 2, 66kDa
chr2_-_47168850 0.57 ENST00000409207.1
MCFD2
multiple coagulation factor deficiency 2
chrX_+_106871713 0.57 ENST00000372435.4
ENST00000372428.4
ENST00000372419.3
ENST00000543248.1
PRPS1
phosphoribosyl pyrophosphate synthetase 1
chr10_-_21786179 0.57 ENST00000377113.5
CASC10
cancer susceptibility candidate 10
chr6_+_35995552 0.56 ENST00000468133.1
MAPK14
mitogen-activated protein kinase 14
chr1_-_39325431 0.56 ENST00000373001.3
RRAGC
Ras-related GTP binding C
chr1_-_149982624 0.55 ENST00000417191.1
ENST00000369135.4
OTUD7B
OTU domain containing 7B
chr2_+_228337079 0.55 ENST00000409315.1
ENST00000373671.3
ENST00000409171.1
AGFG1
ArfGAP with FG repeats 1
chr1_+_36038971 0.54 ENST00000373235.3
TFAP2E
transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)
chr12_+_122326630 0.54 ENST00000541212.1
ENST00000340175.5
PSMD9
proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
chr1_+_25599018 0.53 ENST00000417538.2
ENST00000357542.4
ENST00000568195.1
ENST00000342055.5
ENST00000423810.2
RHD
Rh blood group, D antigen
chr9_-_98079965 0.51 ENST00000289081.3
FANCC
Fanconi anemia, complementation group C
chr5_+_75379224 0.50 ENST00000322285.7
SV2C
synaptic vesicle glycoprotein 2C
chr7_+_86781847 0.49 ENST00000432366.2
ENST00000423590.2
ENST00000394703.5
DMTF1
cyclin D binding myb-like transcription factor 1
chr6_+_31707725 0.49 ENST00000375755.3
ENST00000375742.3
ENST00000375750.3
ENST00000425703.1
ENST00000534153.4
ENST00000375703.3
ENST00000375740.3
MSH5
mutS homolog 5
chr7_+_86781677 0.48 ENST00000331242.7
ENST00000394702.3
ENST00000413276.2
ENST00000446796.2
ENST00000411766.2
ENST00000420131.1
ENST00000414630.2
ENST00000453049.1
ENST00000428819.1
ENST00000448598.1
ENST00000449088.3
ENST00000430405.3
DMTF1
cyclin D binding myb-like transcription factor 1
chr5_+_66254698 0.47 ENST00000405643.1
ENST00000407621.1
ENST00000432426.1
MAST4
microtubule associated serine/threonine kinase family member 4
chrX_+_131157290 0.47 ENST00000394334.2
MST4
Serine/threonine-protein kinase MST4
chr17_+_47296865 0.47 ENST00000573347.1
ABI3
ABI family, member 3
chrX_+_123095546 0.47 ENST00000371157.3
ENST00000371145.3
ENST00000371144.3
STAG2
stromal antigen 2
chr5_+_43120985 0.46 ENST00000515326.1
ZNF131
zinc finger protein 131
chr11_+_74303575 0.45 ENST00000263681.2
POLD3
polymerase (DNA-directed), delta 3, accessory subunit
chr16_+_29817399 0.45 ENST00000545521.1
MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chrX_-_152736013 0.44 ENST00000330912.2
ENST00000338525.2
ENST00000334497.2
ENST00000370232.1
ENST00000370212.3
ENST00000370211.4
TREX2
HAUS7
three prime repair exonuclease 2
HAUS augmin-like complex, subunit 7
chr5_+_93954039 0.44 ENST00000265140.5
ANKRD32
ankyrin repeat domain 32
chr19_-_1863567 0.44 ENST00000250916.4
KLF16
Kruppel-like factor 16
chr10_-_131762105 0.43 ENST00000368648.3
ENST00000355311.5
EBF3
early B-cell factor 3
chrX_+_131157322 0.42 ENST00000481105.1
ENST00000354719.6
ENST00000394335.2
MST4
Serine/threonine-protein kinase MST4
chr12_+_109535923 0.42 ENST00000336865.2
UNG
uracil-DNA glycosylase
chr6_+_35995531 0.41 ENST00000229794.4
MAPK14
mitogen-activated protein kinase 14
chr12_+_122326662 0.41 ENST00000261817.2
ENST00000538613.1
ENST00000542602.1
PSMD9
proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
chr6_+_27775899 0.40 ENST00000358739.3
HIST1H2AI
histone cluster 1, H2ai
chr1_+_151043070 0.40 ENST00000368918.3
ENST00000368917.1
GABPB2
GA binding protein transcription factor, beta subunit 2
chr14_+_21538429 0.40 ENST00000298694.4
ENST00000555038.1
ARHGEF40
Rho guanine nucleotide exchange factor (GEF) 40
chr17_-_17184605 0.40 ENST00000268717.5
COPS3
COP9 signalosome subunit 3
chr5_-_140998616 0.39 ENST00000389054.3
ENST00000398562.2
ENST00000389057.5
ENST00000398566.3
ENST00000398557.4
ENST00000253811.6
DIAPH1
diaphanous-related formin 1
chr22_+_35653445 0.38 ENST00000420166.1
ENST00000444518.2
ENST00000455359.1
ENST00000216106.5
HMGXB4
HMG box domain containing 4
chr3_+_10857885 0.36 ENST00000254488.2
ENST00000454147.1
SLC6A11
solute carrier family 6 (neurotransmitter transporter), member 11
chr8_+_94929110 0.36 ENST00000520728.1
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr5_+_133861790 0.35 ENST00000395003.1
PHF15
jade family PHD finger 2
chr12_+_81101277 0.35 ENST00000228641.3
MYF6
myogenic factor 6 (herculin)

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F2_E2F5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 15.2 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
4.2 12.6 GO:0036333 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
3.6 21.4 GO:0014038 regulation of Schwann cell differentiation(GO:0014038)
3.4 34.2 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
3.1 15.7 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
2.2 13.5 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
1.7 5.2 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
1.7 8.4 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
1.4 5.8 GO:0046452 dihydrofolate metabolic process(GO:0046452)
1.4 7.1 GO:0060356 leucine import(GO:0060356)
1.4 8.4 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
1.3 2.6 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
1.3 5.2 GO:0006272 leading strand elongation(GO:0006272)
1.2 18.2 GO:0001833 inner cell mass cell proliferation(GO:0001833)
1.0 3.1 GO:0071139 resolution of recombination intermediates(GO:0071139) resolution of mitotic recombination intermediates(GO:0071140)
1.0 4.0 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
1.0 9.5 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.8 3.3 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.8 4.0 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.8 33.0 GO:0006270 DNA replication initiation(GO:0006270)
0.7 2.2 GO:0046521 sphingoid catabolic process(GO:0046521)
0.7 5.0 GO:0048478 replication fork protection(GO:0048478)
0.7 7.6 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.6 2.6 GO:0007343 egg activation(GO:0007343)
0.6 3.7 GO:0034421 post-translational protein acetylation(GO:0034421)
0.6 14.6 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.5 1.6 GO:0070631 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.5 1.6 GO:0006597 spermine biosynthetic process(GO:0006597)
0.5 2.0 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
0.5 1.5 GO:1901069 guanosine-containing compound catabolic process(GO:1901069)
0.4 3.4 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.4 1.3 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.4 2.2 GO:0030035 microspike assembly(GO:0030035)
0.4 2.9 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.4 1.1 GO:1903926 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.4 2.8 GO:0033504 floor plate development(GO:0033504)
0.3 0.5 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.3 2.7 GO:0036123 histone H3-K9 dimethylation(GO:0036123)
0.3 1.3 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.2 1.2 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.2 1.0 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.2 2.6 GO:0070561 vitamin D receptor signaling pathway(GO:0070561) positive regulation of cell proliferation involved in heart morphogenesis(GO:2000138)
0.2 2.3 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.2 1.5 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.2 2.4 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.2 1.5 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.2 1.2 GO:0009157 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157)
0.2 1.2 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.2 1.0 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.2 2.3 GO:0048102 autophagic cell death(GO:0048102)
0.2 0.9 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.2 5.3 GO:0036297 interstrand cross-link repair(GO:0036297)
0.2 8.6 GO:0035825 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.2 0.7 GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
0.2 0.5 GO:0072186 metanephric cap development(GO:0072185) metanephric cap morphogenesis(GO:0072186) metanephric cap mesenchymal cell proliferation involved in metanephros development(GO:0090094)
0.2 1.5 GO:0051415 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.2 1.7 GO:0006290 pyrimidine dimer repair(GO:0006290)
0.1 0.6 GO:0046100 hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101)
0.1 0.3 GO:0000710 meiotic mismatch repair(GO:0000710)
0.1 1.2 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.1 2.2 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 6.1 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.1 0.5 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.1 6.1 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.1 1.7 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 0.8 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.1 1.4 GO:0006271 DNA strand elongation involved in DNA replication(GO:0006271)
0.1 13.5 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
0.1 0.3 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.1 0.3 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.1 2.2 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.1 2.4 GO:0007099 centriole replication(GO:0007099)
0.1 0.8 GO:0035372 protein localization to microtubule(GO:0035372)
0.1 6.4 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 1.4 GO:0007219 Notch signaling pathway(GO:0007219)
0.1 0.3 GO:0097476 spinal cord motor neuron migration(GO:0097476)
0.0 0.5 GO:0001675 acrosome assembly(GO:0001675)
0.0 1.7 GO:0006284 base-excision repair(GO:0006284)
0.0 0.2 GO:0070836 caveola assembly(GO:0070836)
0.0 0.3 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.8 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.0 1.2 GO:0015695 organic cation transport(GO:0015695)
0.0 1.5 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 1.9 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 1.6 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.5 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.0 0.3 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 2.7 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.0 1.0 GO:0031055 chromatin remodeling at centromere(GO:0031055)
0.0 0.2 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.0 0.3 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.0 1.5 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.0 0.4 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.0 0.5 GO:0033522 histone H2A ubiquitination(GO:0033522)
0.0 1.1 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.0 0.2 GO:0080009 mRNA methylation(GO:0080009)
0.0 0.6 GO:0043496 regulation of protein homodimerization activity(GO:0043496)
0.0 0.6 GO:1903432 regulation of TORC1 signaling(GO:1903432)
0.0 0.4 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.0 0.1 GO:0021986 epithalamus development(GO:0021538) habenula development(GO:0021986) sensory system development(GO:0048880)
0.0 0.3 GO:0000737 DNA catabolic process, endonucleolytic(GO:0000737) apoptotic DNA fragmentation(GO:0006309)
0.0 0.7 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 0.1 GO:0044791 modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
0.0 0.2 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.3 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.0 1.1 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 21.4 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
3.5 14.0 GO:0000811 GINS complex(GO:0000811)
3.1 49.5 GO:0042555 MCM complex(GO:0042555)
2.9 14.6 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
2.1 6.4 GO:0005873 plus-end kinesin complex(GO:0005873)
1.4 8.2 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
1.3 10.7 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
1.1 10.1 GO:0031298 replication fork protection complex(GO:0031298)
1.0 9.4 GO:0016012 sarcoglycan complex(GO:0016012)
0.9 2.6 GO:0035189 Rb-E2F complex(GO:0035189)
0.9 8.6 GO:0000796 condensin complex(GO:0000796)
0.7 12.6 GO:0045120 pronucleus(GO:0045120)
0.6 2.6 GO:0033011 perinuclear theca(GO:0033011)
0.5 1.6 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.5 2.7 GO:0033553 rDNA heterochromatin(GO:0033553)
0.5 3.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.5 5.0 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.5 8.0 GO:0001673 male germ cell nucleus(GO:0001673)
0.5 2.3 GO:0098536 deuterosome(GO:0098536)
0.5 2.3 GO:0035061 interchromatin granule(GO:0035061)
0.4 1.7 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.4 3.7 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.4 11.4 GO:0005721 pericentric heterochromatin(GO:0005721)
0.4 7.0 GO:0000800 lateral element(GO:0000800)
0.4 2.3 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.3 7.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.3 1.2 GO:1990075 periciliary membrane compartment(GO:1990075)
0.3 0.9 GO:0005663 DNA replication factor C complex(GO:0005663) PCNA-p21 complex(GO:0070557)
0.3 0.8 GO:0031021 interphase microtubule organizing center(GO:0031021)
0.3 2.0 GO:0070552 BRISC complex(GO:0070552)
0.1 0.6 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.1 0.6 GO:0008275 gamma-tubulin small complex(GO:0008275)
0.1 0.9 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.1 0.4 GO:0032301 MutSalpha complex(GO:0032301)
0.1 8.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 1.7 GO:0071439 clathrin complex(GO:0071439)
0.1 0.6 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1 6.8 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.1 0.5 GO:0033503 HULC complex(GO:0033503)
0.1 0.7 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.1 1.1 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.9 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.4 GO:0016589 NURF complex(GO:0016589)
0.0 0.2 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.0 6.4 GO:0000793 condensed chromosome(GO:0000793)
0.0 0.4 GO:0070652 HAUS complex(GO:0070652)
0.0 7.1 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 15.7 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.3 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.0 12.3 GO:0005874 microtubule(GO:0005874)
0.0 0.9 GO:0000776 kinetochore(GO:0000776)
0.0 4.2 GO:0005819 spindle(GO:0005819)
0.0 0.5 GO:0000775 chromosome, centromeric region(GO:0000775)
0.0 3.5 GO:0001726 ruffle(GO:0001726)
0.0 6.1 GO:0005813 centrosome(GO:0005813)
0.0 0.3 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.3 GO:0005719 nuclear euchromatin(GO:0005719)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 14.6 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
1.7 29.1 GO:0003688 DNA replication origin binding(GO:0003688)
1.4 8.4 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
1.3 12.0 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
1.0 14.0 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
1.0 5.8 GO:0051870 methotrexate binding(GO:0051870)
0.9 21.4 GO:0035173 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) histone kinase activity(GO:0035173)
0.7 2.7 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.7 4.0 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.6 21.4 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.6 8.3 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.5 2.4 GO:0044378 non-sequence-specific DNA binding, bending(GO:0044378)
0.5 2.4 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.4 7.1 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.4 0.9 GO:0030337 DNA polymerase processivity factor activity(GO:0030337)
0.4 1.2 GO:0004137 deoxycytidine kinase activity(GO:0004137)
0.4 2.2 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.4 13.0 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.3 1.0 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.3 3.1 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.3 2.0 GO:0008732 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.3 1.4 GO:0000405 bubble DNA binding(GO:0000405)
0.3 1.6 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.2 2.1 GO:1990226 histone methyltransferase binding(GO:1990226)
0.2 1.4 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.2 0.7 GO:0016748 succinyltransferase activity(GO:0016748)
0.2 2.6 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.1 12.8 GO:0035064 methylated histone binding(GO:0035064)
0.1 1.3 GO:0051525 NFAT protein binding(GO:0051525)
0.1 11.2 GO:0070491 repressing transcription factor binding(GO:0070491)
0.1 8.3 GO:0003684 damaged DNA binding(GO:0003684)
0.1 0.4 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.1 2.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 3.3 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 2.9 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 0.6 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.1 2.7 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 22.1 GO:0001047 core promoter binding(GO:0001047)
0.1 2.4 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 1.5 GO:0070182 DNA polymerase binding(GO:0070182)
0.1 0.4 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.1 8.4 GO:0042393 histone binding(GO:0042393)
0.1 7.8 GO:0004386 helicase activity(GO:0004386)
0.1 6.5 GO:0003777 microtubule motor activity(GO:0003777)
0.0 2.6 GO:0050699 WW domain binding(GO:0050699)
0.0 0.3 GO:0031386 protein tag(GO:0031386)
0.0 16.1 GO:0015631 tubulin binding(GO:0015631)
0.0 0.3 GO:0070888 E-box binding(GO:0070888)
0.0 2.2 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.5 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.3 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.0 1.1 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.9 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 1.2 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 4.7 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 9.8 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.3 GO:0003680 AT DNA binding(GO:0003680)
0.0 1.0 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.1 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.0 0.4 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.1 GO:0097158 pre-mRNA intronic pyrimidine-rich binding(GO:0097158)
0.0 1.5 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.0 0.1 GO:0031177 acyl binding(GO:0000035) phosphopantetheine binding(GO:0031177)
0.0 5.1 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.2 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.0 1.6 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 0.2 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 6.1 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.1 GO:0000150 recombinase activity(GO:0000150)
0.0 0.3 GO:0048038 quinone binding(GO:0048038)
0.0 0.1 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 1.2 GO:0030276 clathrin binding(GO:0030276)
0.0 1.1 GO:0008307 structural constituent of muscle(GO:0008307)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 34.0 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.8 15.6 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.3 40.7 PID E2F PATHWAY E2F transcription factor network
0.3 12.0 PID BARD1 PATHWAY BARD1 signaling events
0.3 6.5 PID FANCONI PATHWAY Fanconi anemia pathway
0.2 11.8 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.1 7.8 PID ATR PATHWAY ATR signaling pathway
0.1 2.6 PID IL5 PATHWAY IL5-mediated signaling events
0.1 7.9 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.1 6.7 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 2.8 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 2.2 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.1 5.2 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 6.8 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 3.4 PID AURORA B PATHWAY Aurora B signaling
0.0 2.2 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 2.4 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 1.0 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.0 PID FGF PATHWAY FGF signaling pathway
0.0 0.6 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.9 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.5 PID PLK1 PATHWAY PLK1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 63.5 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
2.0 53.4 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
1.2 17.1 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.7 9.5 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.6 13.6 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.6 11.9 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.5 9.0 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.3 1.7 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.3 6.5 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.2 13.4 REACTOME G1 PHASE Genes involved in G1 Phase
0.2 6.4 REACTOME KINESINS Genes involved in Kinesins
0.2 7.1 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.1 2.0 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 1.6 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 1.7 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.1 1.0 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.1 1.3 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.6 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 2.1 REACTOME RNA POL I TRANSCRIPTION Genes involved in RNA Polymerase I Transcription
0.1 2.2 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.2 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.6 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 1.4 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 2.5 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 1.0 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 1.1 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.7 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.9 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 1.2 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 1.6 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 4.8 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.8 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 1.1 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.4 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.7 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.9 REACTOME ORC1 REMOVAL FROM CHROMATIN Genes involved in Orc1 removal from chromatin
0.0 0.3 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.0 1.2 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.0 0.1 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis