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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for E2F2_E2F5
Z-value: 2.20
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Transcription factors associated with E2F2_E2F5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F2 | hg19_v2_chr1_-_23857698_23857733 | 0.70 | 2.0e-05 | Click! |
| E2F5 | hg19_v2_chr8_+_86121448_86121494 | -0.34 | 6.3e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F2_E2F5
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 34.2 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.8 | 33.0 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 3.6 | 21.4 | GO:0014038 | regulation of Schwann cell differentiation(GO:0014038) |
| 1.2 | 18.2 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 3.1 | 15.7 | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 5.1 | 15.2 | GO:0032877 | positive regulation of DNA endoreduplication(GO:0032877) |
| 0.6 | 14.6 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 2.2 | 13.5 | GO:0071163 | DNA replication preinitiation complex assembly(GO:0071163) |
| 0.1 | 13.5 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) |
| 4.2 | 12.6 | GO:0036333 | hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 49.5 | GO:0042555 | MCM complex(GO:0042555) |
| 4.3 | 21.4 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 0.0 | 15.7 | GO:0005667 | transcription factor complex(GO:0005667) |
| 2.9 | 14.6 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 3.5 | 14.0 | GO:0000811 | GINS complex(GO:0000811) |
| 0.7 | 12.6 | GO:0045120 | pronucleus(GO:0045120) |
| 0.0 | 12.3 | GO:0005874 | microtubule(GO:0005874) |
| 0.4 | 11.4 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 1.3 | 10.7 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 1.1 | 10.1 | GO:0031298 | replication fork protection complex(GO:0031298) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 29.1 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.1 | 22.1 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.9 | 21.4 | GO:0035173 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) histone kinase activity(GO:0035173) |
| 0.6 | 21.4 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.0 | 16.1 | GO:0015631 | tubulin binding(GO:0015631) |
| 2.9 | 14.6 | GO:0016728 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 1.0 | 14.0 | GO:0043138 | 3'-5' DNA helicase activity(GO:0043138) |
| 0.4 | 13.0 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.1 | 12.8 | GO:0035064 | methylated histone binding(GO:0035064) |
| 1.3 | 12.0 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 40.7 | PID E2F PATHWAY | E2F transcription factor network |
| 2.4 | 34.0 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.8 | 15.6 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.3 | 12.0 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.2 | 11.8 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.1 | 7.9 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.1 | 7.8 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 6.8 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 6.7 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.3 | 6.5 | PID FANCONI PATHWAY | Fanconi anemia pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 63.5 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 2.0 | 53.4 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 1.2 | 17.1 | REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX | Genes involved in Association of licensing factors with the pre-replicative complex |
| 0.6 | 13.6 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.2 | 13.4 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.6 | 11.9 | REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.7 | 9.5 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.5 | 9.0 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.2 | 7.1 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.3 | 6.5 | REACTOME FANCONI ANEMIA PATHWAY | Genes involved in Fanconi Anemia pathway |