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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for E2F7_E2F1
Z-value: 3.02
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Transcription factors associated with E2F7_E2F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F7 | hg19_v2_chr12_-_77459306_77459365 | 0.71 | 1.0e-05 | Click! |
| E2F1 | hg19_v2_chr20_-_32274179_32274213 | 0.47 | 9.5e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F7_E2F1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.8 | 34.0 | GO:0033567 | DNA replication, Okazaki fragment processing(GO:0033567) |
| 0.8 | 33.3 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 3.8 | 30.7 | GO:0000727 | double-strand break repair via break-induced replication(GO:0000727) |
| 2.9 | 29.4 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 7.0 | 21.0 | GO:1904772 | hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772) |
| 0.8 | 20.1 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 6.2 | 18.7 | GO:0032877 | positive regulation of DNA endoreduplication(GO:0032877) |
| 0.5 | 16.4 | GO:0031116 | positive regulation of microtubule polymerization(GO:0031116) |
| 4.0 | 16.1 | GO:0046125 | thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125) |
| 1.9 | 15.3 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 42.4 | GO:0042555 | MCM complex(GO:0042555) |
| 2.7 | 26.7 | GO:0000796 | condensin complex(GO:0000796) |
| 0.4 | 26.5 | GO:0005876 | spindle microtubule(GO:0005876) |
| 1.5 | 24.3 | GO:0045120 | pronucleus(GO:0045120) |
| 0.2 | 22.7 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.3 | 21.6 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 21.4 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.2 | 20.7 | GO:0000793 | condensed chromosome(GO:0000793) |
| 3.9 | 19.3 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 0.0 | 15.2 | GO:0005759 | mitochondrial matrix(GO:0005759) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 37.3 | GO:0003910 | DNA ligase (ATP) activity(GO:0003910) |
| 0.7 | 34.5 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 2.5 | 22.3 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
| 1.2 | 20.2 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 1.4 | 19.6 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
| 0.2 | 19.4 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 3.9 | 19.3 | GO:0004748 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.1 | 16.2 | GO:0008017 | microtubule binding(GO:0008017) |
| 5.4 | 16.1 | GO:0004797 | thymidine kinase activity(GO:0004797) |
| 2.3 | 13.9 | GO:0043515 | kinetochore binding(GO:0043515) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 97.5 | PID E2F PATHWAY | E2F transcription factor network |
| 0.6 | 35.1 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.3 | 21.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 1.4 | 19.7 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.1 | 12.7 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 11.8 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.2 | 9.6 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 8.8 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 7.3 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.6 | 5.0 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 58.8 | REACTOME LAGGING STRAND SYNTHESIS | Genes involved in Lagging Strand Synthesis |
| 3.1 | 56.0 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 1.9 | 45.0 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.3 | 35.1 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 1.2 | 21.6 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 1.3 | 20.7 | REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 1.1 | 20.5 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.5 | 19.6 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.2 | 14.5 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.8 | 12.6 | REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS | Genes involved in Activation of ATR in response to replication stress |