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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for E2F8

Z-value: 1.43

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Transcription factors associated with E2F8

Gene Symbol Gene ID Gene Info
ENSG00000129173.8 E2F transcription factor 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2F8hg19_v2_chr11_-_19263145_192631760.853.6e-09Click!

Activity profile of E2F8 motif

Sorted Z-values of E2F8 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_51845378 7.16 ENST00000335624.4
V-set and immunoglobulin domain containing 10 like
chr12_+_8975061 7.05 ENST00000299698.7
alpha-2-macroglobulin-like 1
chr9_-_123639304 6.04 ENST00000436309.1
PHD finger protein 19
chr20_+_42295745 5.68 ENST00000396863.4
ENST00000217026.4
v-myb avian myeloblastosis viral oncogene homolog-like 2
chr2_+_10262857 5.39 ENST00000304567.5
ribonucleotide reductase M2
chr22_+_19467261 5.18 ENST00000455750.1
ENST00000437685.2
ENST00000263201.1
ENST00000404724.3
cell division cycle 45
chr11_+_125495862 4.84 ENST00000428830.2
ENST00000544373.1
ENST00000527013.1
ENST00000526937.1
ENST00000534685.1
checkpoint kinase 1
chr9_-_123639445 4.59 ENST00000312189.6
PHD finger protein 19
chr22_+_35796108 4.48 ENST00000382011.5
ENST00000416905.1
minichromosome maintenance complex component 5
chr22_+_38071615 4.44 ENST00000215909.5
lectin, galactoside-binding, soluble, 1
chr22_+_35796056 4.28 ENST00000216122.4
minichromosome maintenance complex component 5
chr11_+_125496124 4.04 ENST00000533778.2
ENST00000534070.1
checkpoint kinase 1
chr9_-_123639600 3.92 ENST00000373896.3
PHD finger protein 19
chr14_-_55658252 3.57 ENST00000395425.2
discs, large (Drosophila) homolog-associated protein 5
chr2_-_136633940 3.52 ENST00000264156.2
minichromosome maintenance complex component 6
chr17_+_39975455 3.24 ENST00000455106.1
FK506 binding protein 10, 65 kDa
chr14_-_55658323 3.08 ENST00000554067.1
ENST00000247191.2
discs, large (Drosophila) homolog-associated protein 5
chr17_+_39975544 2.97 ENST00000544340.1
FK506 binding protein 10, 65 kDa
chr10_-_17659234 2.96 ENST00000466335.1
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr12_-_57146095 2.87 ENST00000550770.1
ENST00000338193.6
primase, DNA, polypeptide 1 (49kDa)
chr7_+_26331541 2.85 ENST00000416246.1
ENST00000338523.4
ENST00000412416.1
sorting nexin 10
chr16_+_11439286 2.79 ENST00000312499.5
ENST00000576027.1
RecQ mediated genome instability 2
chr11_-_19263145 2.75 ENST00000532666.1
ENST00000527884.1
E2F transcription factor 8
chr8_+_27632083 2.74 ENST00000519637.1
establishment of sister chromatid cohesion N-acetyltransferase 2
chr15_-_70390191 2.70 ENST00000559191.1
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chr3_+_127317066 2.50 ENST00000265056.7
minichromosome maintenance complex component 2
chr15_-_64673630 2.50 ENST00000558008.1
ENST00000559519.1
ENST00000380258.2
KIAA0101
chr4_-_174254823 2.48 ENST00000438704.2
high mobility group box 2
chr11_-_19262486 2.48 ENST00000250024.4
E2F transcription factor 8
chr7_-_56119238 2.42 ENST00000275605.3
ENST00000395471.3
phosphoserine phosphatase
chr7_-_21985656 2.42 ENST00000406877.3
cell division cycle associated 7-like
chr10_+_106028923 2.36 ENST00000338595.2
glutathione S-transferase omega 2
chr7_-_21985489 2.36 ENST00000356195.5
ENST00000447180.1
ENST00000373934.4
ENST00000457951.1
cell division cycle associated 7-like
chr1_-_26232522 2.24 ENST00000399728.1
stathmin 1
chr1_-_17307173 2.23 ENST00000438542.1
ENST00000375535.3
microfibrillar-associated protein 2
chr11_+_33061543 2.21 ENST00000432887.1
ENST00000528898.1
ENST00000531632.2
t-complex 11, testis-specific-like 1
chr7_-_56118981 2.18 ENST00000419984.2
ENST00000413218.1
ENST00000424596.1
phosphoserine phosphatase
chr12_+_107168342 2.03 ENST00000392837.4
RIC8 guanine nucleotide exchange factor B
chr11_+_35201826 1.89 ENST00000531873.1
CD44 molecule (Indian blood group)
chr1_-_150693318 1.88 ENST00000442853.1
ENST00000368995.4
ENST00000368993.2
ENST00000361824.2
ENST00000322343.7
HORMA domain containing 1
chr7_-_56119156 1.87 ENST00000421312.1
ENST00000416592.1
phosphoserine phosphatase
chr17_+_37894570 1.82 ENST00000394211.3
growth factor receptor-bound protein 7
chr10_-_17659357 1.81 ENST00000326961.6
ENST00000361271.3
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr12_+_123011776 1.81 ENST00000450485.2
ENST00000333479.7
kinetochore associated 1
chr12_+_107168418 1.80 ENST00000392839.2
ENST00000548914.1
ENST00000355478.2
ENST00000552619.1
ENST00000549643.1
RIC8 guanine nucleotide exchange factor B
chr9_+_79792410 1.80 ENST00000357409.5
vacuolar protein sorting 13 homolog A (S. cerevisiae)
chr14_-_67878917 1.79 ENST00000216446.4
pleckstrin 2
chr7_+_135242652 1.75 ENST00000285968.6
ENST00000440390.2
nucleoporin 205kDa
chr1_+_70876926 1.75 ENST00000370938.3
ENST00000346806.2
cystathionase (cystathionine gamma-lyase)
chr3_+_44803209 1.74 ENST00000326047.4
kinesin family member 15
chr11_+_126225789 1.69 ENST00000530591.1
ENST00000534083.1
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
chr8_-_131455835 1.65 ENST00000518721.1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr14_+_64854958 1.65 ENST00000555709.2
ENST00000554739.1
ENST00000554768.1
ENST00000216605.8
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
chr11_+_47236489 1.64 ENST00000256996.4
ENST00000378603.3
ENST00000378600.3
ENST00000378601.3
damage-specific DNA binding protein 2, 48kDa
chr17_-_59940830 1.61 ENST00000259008.2
BRCA1 interacting protein C-terminal helicase 1
chr8_-_92053212 1.61 ENST00000285419.3
transmembrane protein 55A
chr14_-_24898731 1.59 ENST00000267406.6
cerebellin 3 precursor
chr4_-_21699380 1.57 ENST00000382148.3
Kv channel interacting protein 4
chr14_-_100841670 1.57 ENST00000557297.1
ENST00000555813.1
ENST00000557135.1
ENST00000556698.1
ENST00000554509.1
ENST00000555410.1
tryptophanyl-tRNA synthetase
chrX_-_54522558 1.57 ENST00000375135.3
FYVE, RhoGEF and PH domain containing 1
chr8_+_27631903 1.55 ENST00000305188.8
establishment of sister chromatid cohesion N-acetyltransferase 2
chr10_+_115312766 1.54 ENST00000351270.3
hyaluronan binding protein 2
chr8_-_120868078 1.54 ENST00000313655.4
DNA replication and sister chromatid cohesion 1
chr18_+_21718924 1.53 ENST00000399496.3
calcium binding tyrosine-(Y)-phosphorylation regulated
chr12_-_8815215 1.49 ENST00000544889.1
ENST00000543369.1
microfibrillar associated protein 5
chr6_+_110299501 1.48 ENST00000414000.2
G protein-coupled receptor 6
chr18_+_21719018 1.46 ENST00000585037.1
ENST00000415309.2
ENST00000399481.2
ENST00000577705.1
ENST00000327201.6
calcium binding tyrosine-(Y)-phosphorylation regulated
chr21_+_39644305 1.45 ENST00000398930.1
potassium inwardly-rectifying channel, subfamily J, member 15
chr12_-_8815299 1.45 ENST00000535336.1
microfibrillar associated protein 5
chr8_+_27632047 1.41 ENST00000397418.2
establishment of sister chromatid cohesion N-acetyltransferase 2
chr15_-_64673665 1.37 ENST00000300035.4
KIAA0101
chr1_+_70876891 1.35 ENST00000411986.2
cystathionase (cystathionine gamma-lyase)
chr3_-_123168551 1.35 ENST00000462833.1
adenylate cyclase 5
chr15_-_89456630 1.34 ENST00000268150.8
milk fat globule-EGF factor 8 protein
chr12_+_56521840 1.30 ENST00000394048.5
extended synaptotagmin-like protein 1
chr18_-_12656715 1.30 ENST00000462226.1
ENST00000497844.2
ENST00000309836.5
ENST00000453447.2
spire-type actin nucleation factor 1
chr6_-_32157947 1.28 ENST00000375050.4
pre-B-cell leukemia homeobox 2
chr7_+_114562909 1.27 ENST00000423503.1
ENST00000427207.1
MyoD family inhibitor domain containing
chr15_+_44119159 1.25 ENST00000263795.6
ENST00000381246.2
ENST00000452115.1
WD repeat domain 76
chr1_+_150245099 1.25 ENST00000369099.3
chromosome 1 open reading frame 54
chr1_+_156024552 1.23 ENST00000368304.5
ENST00000368302.3
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
chr16_-_34740829 1.22 ENST00000562591.1
RP11-80F22.15
chr19_+_50887585 1.22 ENST00000440232.2
ENST00000601098.1
ENST00000599857.1
ENST00000593887.1
polymerase (DNA directed), delta 1, catalytic subunit
chr11_+_126225529 1.21 ENST00000227495.6
ENST00000444328.2
ENST00000356132.4
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
chr19_+_4402659 1.20 ENST00000301280.5
ENST00000585854.1
chromatin assembly factor 1, subunit A (p150)
chr15_-_70390213 1.20 ENST00000557997.1
ENST00000317509.8
ENST00000442299.2
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chr15_-_81616446 1.19 ENST00000302824.6
StAR-related lipid transfer (START) domain containing 5
chr1_-_52499443 1.17 ENST00000371614.1
KTI12 homolog, chromatin associated (S. cerevisiae)
chr9_-_138591341 1.17 ENST00000298466.5
ENST00000425225.1
spermatogenesis and oogenesis specific basic helix-loop-helix 1
chr2_-_24346218 1.15 ENST00000436622.1
ENST00000313213.4
profilin family, member 4
chr1_-_6453399 1.13 ENST00000608083.1
acyl-CoA thioesterase 7
chr2_-_215674374 1.12 ENST00000449967.2
ENST00000421162.1
ENST00000260947.4
BRCA1 associated RING domain 1
chr22_+_29999647 1.11 ENST00000334961.7
ENST00000353887.4
neurofibromin 2 (merlin)
chr3_+_197677047 1.10 ENST00000448864.1
ribosomal protein L35a
chr7_+_114562616 1.08 ENST00000448022.1
MyoD family inhibitor domain containing
chr1_+_33283043 1.08 ENST00000373476.1
ENST00000373475.5
ENST00000529027.1
ENST00000398243.3
S100P binding protein
chr19_-_33360647 1.08 ENST00000590341.1
ENST00000587772.1
ENST00000023064.4
solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
chr8_+_48873453 1.06 ENST00000523944.1
minichromosome maintenance complex component 4
chr15_-_89456593 1.03 ENST00000558029.1
ENST00000539437.1
ENST00000542878.1
ENST00000268151.7
ENST00000566497.1
milk fat globule-EGF factor 8 protein
chr1_+_156024525 1.02 ENST00000368305.4
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
chr19_-_17559376 1.02 ENST00000341130.5
transmembrane protein 221
chr13_+_32889605 1.01 ENST00000380152.3
ENST00000544455.1
ENST00000530893.2
breast cancer 2, early onset
chr6_+_70576457 1.00 ENST00000322773.4
collagen, type XIX, alpha 1
chr17_+_75401152 0.99 ENST00000585930.1
septin 9
chr7_+_100136811 0.99 ENST00000300176.4
ENST00000262935.4
ArfGAP with FG repeats 2
chr8_+_48873479 0.99 ENST00000262105.2
minichromosome maintenance complex component 4
chr4_-_130014705 0.98 ENST00000503401.1
sodium channel and clathrin linker 1
chr1_+_150245177 0.96 ENST00000369098.3
chromosome 1 open reading frame 54
chr19_-_49865639 0.94 ENST00000593945.1
ENST00000601519.1
ENST00000539846.1
ENST00000596757.1
ENST00000311227.2
TEA domain family member 2
chr19_-_49864746 0.94 ENST00000598810.1
TEA domain family member 2
chrX_+_131157290 0.94 ENST00000394334.2
Serine/threonine-protein kinase MST4
chr18_-_19994830 0.93 ENST00000525417.1
cutaneous T-cell lymphoma-associated antigen 1
chr9_-_37904084 0.92 ENST00000377716.2
ENST00000242275.6
solute carrier family 25, member 51
chrX_-_52736211 0.92 ENST00000336777.5
ENST00000337502.5
synovial sarcoma, X breakpoint 2
chr4_-_130014609 0.91 ENST00000511426.1
sodium channel and clathrin linker 1
chr1_-_43638168 0.91 ENST00000431635.2
EBNA1 binding protein 2
chrX_+_51927919 0.91 ENST00000416960.1
melanoma antigen family D, 4
chr12_-_16761007 0.90 ENST00000354662.1
ENST00000441439.2
LIM domain only 3 (rhombotin-like 2)
chr1_-_111682662 0.89 ENST00000286692.4
DNA-damage regulated autophagy modulator 2
chr2_-_70780572 0.87 ENST00000450929.1
transforming growth factor, alpha
chr3_+_122296443 0.87 ENST00000464300.2
poly (ADP-ribose) polymerase family, member 15
chr19_+_11546153 0.86 ENST00000591946.1
ENST00000252455.2
ENST00000412601.1
protein kinase C substrate 80K-H
chrX_+_131157322 0.85 ENST00000481105.1
ENST00000354719.6
ENST00000394335.2
Serine/threonine-protein kinase MST4
chr13_-_88463487 0.84 ENST00000606221.1
RP11-471M2.3
chr11_-_441964 0.83 ENST00000332826.6
anoctamin 9
chr17_+_16120512 0.82 ENST00000581006.1
ENST00000584797.1
ENST00000498772.2
ENST00000225609.5
ENST00000395844.4
ENST00000477745.1
phosphatidylinositol glycan anchor biosynthesis, class L
chr19_+_11546440 0.82 ENST00000589126.1
ENST00000588269.1
ENST00000587509.1
ENST00000592741.1
ENST00000593101.1
ENST00000587327.1
protein kinase C substrate 80K-H
chr12_+_56324933 0.82 ENST00000549629.1
ENST00000555218.1
diacylglycerol kinase, alpha 80kDa
chr1_+_205473720 0.80 ENST00000429964.2
ENST00000506784.1
ENST00000360066.2
cyclin-dependent kinase 18
chr14_+_24899141 0.79 ENST00000556842.1
ENST00000553935.1
KH and NYN domain containing
chr12_+_3069037 0.79 ENST00000397122.2
TEA domain family member 4
chr19_+_10765003 0.78 ENST00000407004.3
ENST00000589998.1
ENST00000589600.1
interleukin enhancer binding factor 3, 90kDa
chr22_+_40742497 0.77 ENST00000216194.7
adenylosuccinate lyase
chrX_-_40594755 0.77 ENST00000324817.1
mediator complex subunit 14
chrX_+_55026763 0.77 ENST00000374987.3
APEX nuclease (apurinic/apyrimidinic endonuclease) 2
chr2_-_130939115 0.77 ENST00000441135.1
ENST00000339679.7
ENST00000426662.2
ENST00000443958.2
ENST00000351288.6
ENST00000453750.1
ENST00000452225.2
sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
chr11_+_65029233 0.76 ENST00000265465.3
polymerase (DNA directed), alpha 2, accessory subunit
chr19_-_46146946 0.76 ENST00000536630.1
echinoderm microtubule associated protein like 2
chr13_-_19755975 0.76 ENST00000400113.3
tubulin, alpha 3c
chr22_+_20105259 0.76 ENST00000416427.1
ENST00000421656.1
ENST00000423859.1
ENST00000418705.2
RAN binding protein 1
chrX_-_119077695 0.75 ENST00000371410.3
NFKB activating protein
chr14_-_51135036 0.75 ENST00000324679.4
salvador homolog 1 (Drosophila)
chr1_-_159893507 0.75 ENST00000368096.1
transgelin 2
chr11_-_13484713 0.75 ENST00000526841.1
ENST00000529708.1
ENST00000278174.5
ENST00000528120.1
BTB (POZ) domain containing 10
chr20_+_31595406 0.72 ENST00000170150.3
BPI fold containing family B, member 2
chr19_-_47291843 0.72 ENST00000542575.2
solute carrier family 1 (neutral amino acid transporter), member 5
chr17_-_29151794 0.72 ENST00000324238.6
cytokine receptor-like factor 3
chr6_+_26251835 0.72 ENST00000356350.2
histone cluster 1, H2bh
chr9_-_131486367 0.71 ENST00000372663.4
ENST00000406904.2
ENST00000452105.1
ENST00000372672.2
ENST00000372667.5
zinc finger, DHHC-type containing 12
chr19_+_10764937 0.71 ENST00000449870.1
ENST00000318511.3
ENST00000420083.1
interleukin enhancer binding factor 3, 90kDa
chr22_+_40742512 0.70 ENST00000454266.2
ENST00000342312.6
adenylosuccinate lyase
chrX_-_119695279 0.70 ENST00000336592.6
cullin 4B
chr20_+_60174827 0.69 ENST00000543233.1
cadherin 4, type 1, R-cadherin (retinal)
chr8_-_81083731 0.69 ENST00000379096.5
tumor protein D52
chr4_+_15341442 0.69 ENST00000397700.2
ENST00000295297.4
C1q and tumor necrosis factor related protein 7
chrX_+_150866779 0.68 ENST00000370353.3
proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)
chr5_+_34757309 0.68 ENST00000397449.1
retinoic acid induced 14
chr8_+_128748466 0.68 ENST00000524013.1
ENST00000520751.1
v-myc avian myelocytomatosis viral oncogene homolog
chr4_-_174255400 0.68 ENST00000506267.1
high mobility group box 2
chr2_-_152589670 0.67 ENST00000604864.1
ENST00000603639.1
nebulin
chr4_-_57844989 0.67 ENST00000264230.4
nitric oxide associated 1
chr1_-_158656488 0.67 ENST00000368147.4
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr4_+_25314388 0.66 ENST00000302874.4
zinc finger, CCHC domain containing 4
chr2_-_177502659 0.66 ENST00000295549.4
long intergenic non-protein coding RNA 1116
chr3_-_57113314 0.65 ENST00000338458.4
ENST00000468727.1
Rho guanine nucleotide exchange factor (GEF) 3
chr4_-_130014729 0.65 ENST00000281142.5
ENST00000434680.1
sodium channel and clathrin linker 1
chr9_-_136039314 0.64 ENST00000372040.3
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
chr3_+_14058794 0.64 ENST00000424053.1
ENST00000528067.1
ENST00000429201.1
tetra-peptide repeat homeobox-like
chr12_+_57146233 0.63 ENST00000554643.1
ENST00000556650.1
ENST00000554150.1
ENST00000554155.1
hydroxysteroid (17-beta) dehydrogenase 6
chr22_-_29457832 0.62 ENST00000216071.4
chromosome 22 open reading frame 31
chr2_-_208994548 0.62 ENST00000282141.3
crystallin, gamma C
chr13_+_21277482 0.61 ENST00000304920.3
interleukin 17D
chr17_-_15165854 0.60 ENST00000395936.1
ENST00000395938.2
peripheral myelin protein 22
chr16_+_56691911 0.59 ENST00000568475.1
metallothionein 1F
chr12_-_71003568 0.59 ENST00000547715.1
ENST00000451516.2
ENST00000538708.1
ENST00000550857.1
ENST00000261266.5
protein tyrosine phosphatase, receptor type, B
chrX_+_135614293 0.59 ENST00000370634.3
vestigial like 1 (Drosophila)
chr17_-_39928106 0.59 ENST00000540235.1
junction plakoglobin
chr4_+_153701081 0.58 ENST00000451320.2
ENST00000429148.2
ENST00000353617.2
ENST00000405727.2
ENST00000356064.3
ADP-ribosylation factor interacting protein 1
chr5_+_66124590 0.58 ENST00000490016.2
ENST00000403666.1
ENST00000450827.1
microtubule associated serine/threonine kinase family member 4
chr14_+_105155925 0.58 ENST00000330634.7
ENST00000398337.4
ENST00000392634.4
inverted formin, FH2 and WH2 domain containing
chr2_+_130939235 0.58 ENST00000425361.1
ENST00000457492.1
mitotic spindle organizing protein 2B
chr10_-_131762105 0.57 ENST00000368648.3
ENST00000355311.5
early B-cell factor 3
chr12_+_56324756 0.57 ENST00000331886.5
ENST00000555090.1
diacylglycerol kinase, alpha 80kDa
chr15_-_34635314 0.55 ENST00000557912.1
ENST00000328848.4
NOP10 ribonucleoprotein
chr2_-_24583314 0.55 ENST00000443927.1
ENST00000406921.3
ENST00000412011.1
intersectin 2
chr2_+_132233664 0.55 ENST00000321253.6
tubulin, alpha 3d
chr5_-_119740532 0.55 ENST00000569928.1
RP11-574H6.1
chr4_-_4543700 0.55 ENST00000505286.1
ENST00000306200.2
syntaxin 18
chr22_+_20105012 0.54 ENST00000331821.3
ENST00000411892.1
RAN binding protein 1
chr11_+_134201911 0.54 ENST00000389881.3
galactosidase, beta 1-like 2
chr8_+_118532937 0.54 ENST00000297347.3
mediator complex subunit 30
chr15_-_40074996 0.54 ENST00000350221.3
fibrous sheath interacting protein 1
chr5_+_109025067 0.54 ENST00000261483.4
mannosidase, alpha, class 2A, member 1
chr10_+_70847852 0.53 ENST00000242465.3
serglycin
chr16_-_71264558 0.53 ENST00000448089.2
ENST00000393550.2
ENST00000448691.1
ENST00000393567.2
ENST00000321489.5
ENST00000539973.1
ENST00000288168.10
ENST00000545267.1
ENST00000541601.1
ENST00000538248.1
HYDIN, axonemal central pair apparatus protein
chr3_-_185542761 0.53 ENST00000457616.2
ENST00000346192.3
insulin-like growth factor 2 mRNA binding protein 2
chr3_-_125313934 0.52 ENST00000296220.5
oxysterol binding protein-like 11
chr6_-_41747595 0.52 ENST00000373018.3
fibroblast growth factor receptor substrate 3
chr11_+_73882144 0.52 ENST00000328257.8
protein phosphatase methylesterase 1
chr2_-_24583583 0.52 ENST00000355123.4
intersectin 2

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.2 GO:0000412 histone peptidyl-prolyl isomerization(GO:0000412)
1.7 5.2 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
1.7 5.2 GO:0031938 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) regulation of chromatin silencing at telomere(GO:0031938) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
1.5 8.9 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
1.2 14.5 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
1.2 7.2 GO:0034421 post-translational protein acetylation(GO:0034421)
1.1 6.6 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.9 4.4 GO:0002317 plasma cell differentiation(GO:0002317)
0.8 8.1 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.8 1.6 GO:0000706 meiotic DNA double-strand break processing(GO:0000706) double-strand break repair involved in meiotic recombination(GO:1990918)
0.8 3.1 GO:0018352 protein-pyridoxal-5-phosphate linkage(GO:0018352)
0.6 1.9 GO:0051598 meiotic DNA double-strand break formation(GO:0042138) meiotic recombination checkpoint(GO:0051598)
0.5 6.5 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.5 2.9 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.4 2.2 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.4 1.6 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.4 1.2 GO:0072186 metanephric cap development(GO:0072185) metanephric cap morphogenesis(GO:0072186) metanephric cap mesenchymal cell proliferation involved in metanephros development(GO:0090094)
0.3 1.6 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.3 1.5 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.3 3.2 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.3 1.1 GO:0036116 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.3 0.8 GO:0010360 negative regulation of anion channel activity(GO:0010360) negative regulation of chloride transport(GO:2001226)
0.3 1.7 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.2 2.2 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.2 1.9 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.2 2.4 GO:0090487 toxin catabolic process(GO:0009407) secondary metabolite catabolic process(GO:0090487)
0.2 5.4 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.2 1.2 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.2 0.8 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.2 1.3 GO:0040038 polar body extrusion after meiotic divisions(GO:0040038) formin-nucleated actin cable assembly(GO:0070649)
0.2 0.6 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.2 0.7 GO:0036229 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
0.2 1.1 GO:0015811 L-cystine transport(GO:0015811)
0.2 8.2 GO:0006270 DNA replication initiation(GO:0006270)
0.2 0.5 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.2 2.4 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.2 0.6 GO:0061358 negative regulation of Wnt protein secretion(GO:0061358)
0.2 1.6 GO:0014010 Schwann cell proliferation(GO:0014010)
0.2 0.5 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.2 2.3 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 1.6 GO:0006290 pyrimidine dimer repair(GO:0006290)
0.1 0.9 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.1 0.4 GO:0007412 axon target recognition(GO:0007412) regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
0.1 1.1 GO:0030259 lipid glycosylation(GO:0030259)
0.1 4.4 GO:0000732 strand displacement(GO:0000732)
0.1 0.7 GO:0007525 somatic muscle development(GO:0007525)
0.1 0.6 GO:0006710 androgen catabolic process(GO:0006710)
0.1 1.4 GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.1 1.2 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 0.6 GO:0002159 desmosome assembly(GO:0002159) endothelial cell-cell adhesion(GO:0071603)
0.1 0.5 GO:0019303 D-ribose catabolic process(GO:0019303)
0.1 0.5 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.1 0.3 GO:0060823 canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060823)
0.1 1.8 GO:0034063 stress granule assembly(GO:0034063)
0.1 2.2 GO:0030903 notochord development(GO:0030903)
0.1 3.0 GO:0048240 sperm capacitation(GO:0048240)
0.1 0.3 GO:2001191 gamma-delta T cell activation involved in immune response(GO:0002290) negative regulation of interferon-beta secretion(GO:0035548) regulation of gamma-delta T cell activation involved in immune response(GO:2001191) positive regulation of gamma-delta T cell activation involved in immune response(GO:2001193)
0.1 2.9 GO:0097503 sialylation(GO:0097503)
0.1 2.2 GO:0006491 N-glycan processing(GO:0006491)
0.1 0.3 GO:0018013 N-terminal protein amino acid methylation(GO:0006480) N-terminal peptidyl-alanine methylation(GO:0018011) N-terminal peptidyl-alanine trimethylation(GO:0018012) N-terminal peptidyl-glycine methylation(GO:0018013) N-terminal peptidyl-proline dimethylation(GO:0018016) peptidyl-alanine modification(GO:0018194) N-terminal peptidyl-proline methylation(GO:0035568) N-terminal peptidyl-serine methylation(GO:0035570) N-terminal peptidyl-serine dimethylation(GO:0035572) N-terminal peptidyl-serine trimethylation(GO:0035573)
0.1 1.7 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.1 0.3 GO:0000189 MAPK import into nucleus(GO:0000189)
0.1 2.4 GO:0071539 protein localization to centrosome(GO:0071539)
0.1 0.6 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.1 0.2 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.1 1.5 GO:0090520 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.1 0.7 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.1 3.9 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.1 0.2 GO:0036466 synaptic vesicle recycling via endosome(GO:0036466)
0.1 1.5 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.1 0.2 GO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140)
0.1 0.5 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.1 0.5 GO:0006102 isocitrate metabolic process(GO:0006102)
0.1 0.7 GO:0070914 UV-damage excision repair(GO:0070914)
0.1 0.8 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.1 1.2 GO:0070508 sterol import(GO:0035376) cholesterol import(GO:0070508)
0.1 1.8 GO:0006895 Golgi to endosome transport(GO:0006895)
0.1 0.4 GO:0033133 fructose 2,6-bisphosphate metabolic process(GO:0006003) positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.1 0.8 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 5.3 GO:0090307 mitotic spindle assembly(GO:0090307)
0.1 0.5 GO:0051026 chiasma assembly(GO:0051026)
0.1 1.4 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.1 2.2 GO:0060216 definitive hemopoiesis(GO:0060216)
0.1 0.9 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.1 2.3 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 2.2 GO:0007257 activation of JUN kinase activity(GO:0007257)
0.0 1.0 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.2 GO:0002774 Fc receptor mediated inhibitory signaling pathway(GO:0002774)
0.0 0.3 GO:0034197 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.0 0.4 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.8 GO:0006284 base-excision repair(GO:0006284)
0.0 0.8 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.0 0.6 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.0 1.3 GO:0009303 rRNA transcription(GO:0009303)
0.0 0.8 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 1.6 GO:0010107 potassium ion import(GO:0010107)
0.0 1.3 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 0.4 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.1 GO:1904640 response to methionine(GO:1904640)
0.0 0.3 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.1 GO:0021569 rhombomere 3 development(GO:0021569)
0.0 0.1 GO:0099640 axo-dendritic protein transport(GO:0099640)
0.0 0.5 GO:0035966 response to unfolded protein(GO:0006986) response to topologically incorrect protein(GO:0035966)
0.0 1.1 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.6 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.0 1.1 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.0 0.6 GO:0032060 bleb assembly(GO:0032060)
0.0 0.7 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.5 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.7 GO:0043457 regulation of cellular respiration(GO:0043457)
0.0 0.2 GO:2000286 regulation of endosome size(GO:0051036) receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.0 0.8 GO:0030851 granulocyte differentiation(GO:0030851)
0.0 0.3 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.5 GO:0009219 pyrimidine deoxyribonucleotide metabolic process(GO:0009219) pyrimidine deoxyribonucleotide catabolic process(GO:0009223)
0.0 0.7 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.1 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.0 0.3 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.0 3.8 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.0 0.5 GO:0039694 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.0 0.6 GO:0071294 cellular response to zinc ion(GO:0071294)
0.0 0.2 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.5 GO:0016180 snRNA processing(GO:0016180)
0.0 0.8 GO:0035329 hippo signaling(GO:0035329)
0.0 0.8 GO:0008214 protein demethylation(GO:0006482) protein dealkylation(GO:0008214)
0.0 0.1 GO:0006545 glycine biosynthetic process(GO:0006545) dihydrofolate metabolic process(GO:0046452)
0.0 1.7 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 1.7 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.0 1.3 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 6.0 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 1.5 GO:0046847 filopodium assembly(GO:0046847)
0.0 0.6 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.0 1.4 GO:0030521 androgen receptor signaling pathway(GO:0030521)
0.0 0.3 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.0 0.1 GO:0007341 penetration of zona pellucida(GO:0007341)
0.0 0.5 GO:0008283 cell proliferation(GO:0008283)
0.0 1.0 GO:0030574 collagen catabolic process(GO:0030574)
0.0 0.4 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.7 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 0.9 GO:0001541 ovarian follicle development(GO:0001541)
0.0 0.4 GO:2001222 regulation of neuron migration(GO:2001222)
0.0 0.7 GO:0032259 methylation(GO:0032259)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.7 GO:0031523 Myb complex(GO:0031523)
1.7 5.2 GO:0005656 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
1.1 5.4 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
1.1 16.8 GO:0042555 MCM complex(GO:0042555)
0.6 3.6 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.6 1.2 GO:0033186 CAF-1 complex(GO:0033186)
0.6 1.7 GO:0005873 plus-end kinesin complex(GO:0005873)
0.6 2.2 GO:1990423 RZZ complex(GO:1990423)
0.5 1.9 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.4 1.7 GO:0044611 nuclear pore inner ring(GO:0044611)
0.4 13.1 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.4 6.6 GO:0031616 spindle pole centrosome(GO:0031616)
0.4 2.9 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.3 5.7 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.3 1.2 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.3 2.3 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.3 1.1 GO:0031436 BRCA1-BARD1 complex(GO:0031436)
0.3 3.0 GO:0035686 sperm fibrous sheath(GO:0035686)
0.3 1.9 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.3 2.3 GO:0071986 Ragulator complex(GO:0071986)
0.2 5.2 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.2 0.5 GO:1990716 axonemal central apparatus(GO:1990716)
0.2 1.5 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.2 2.5 GO:0071439 clathrin complex(GO:0071439)
0.1 0.6 GO:1990246 uniplex complex(GO:1990246)
0.1 0.5 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.1 0.4 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 0.8 GO:0070847 core mediator complex(GO:0070847)
0.1 0.7 GO:0032437 cuticular plate(GO:0032437)
0.1 0.6 GO:0090661 box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.1 0.5 GO:0005797 Golgi medial cisterna(GO:0005797)
0.1 1.8 GO:0031045 dense core granule(GO:0031045)
0.1 0.7 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.1 8.6 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.1 0.6 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.1 0.6 GO:0000931 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.1 0.3 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.1 1.6 GO:0031527 filopodium membrane(GO:0031527)
0.1 1.3 GO:0044232 organelle membrane contact site(GO:0044232)
0.1 1.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 1.8 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.3 GO:0071256 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 1.4 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 1.0 GO:0031105 septin complex(GO:0031105)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.5 GO:0032039 integrator complex(GO:0032039)
0.0 15.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.3 GO:0016589 NURF complex(GO:0016589)
0.0 5.5 GO:0001650 fibrillar center(GO:0001650)
0.0 2.9 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.5 GO:0042588 zymogen granule(GO:0042588)
0.0 0.2 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.2 GO:0005683 U7 snRNP(GO:0005683)
0.0 0.9 GO:0016592 mediator complex(GO:0016592)
0.0 1.8 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.3 GO:0045179 apical cortex(GO:0045179)
0.0 0.2 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559)
0.0 0.5 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.2 GO:0000243 commitment complex(GO:0000243)
0.0 0.6 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.6 GO:0043218 compact myelin(GO:0043218)
0.0 0.1 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 1.1 GO:0031526 brush border membrane(GO:0031526)
0.0 2.3 GO:0000793 condensed chromosome(GO:0000793)
0.0 0.3 GO:0031143 pseudopodium(GO:0031143)
0.0 1.5 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 0.7 GO:0044815 nucleosome(GO:0000786) DNA packaging complex(GO:0044815)
0.0 0.8 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.7 GO:0002102 podosome(GO:0002102)
0.0 0.5 GO:0031201 SNARE complex(GO:0031201)
0.0 0.3 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.6 GO:0031901 early endosome membrane(GO:0031901)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 8.9 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
1.1 4.4 GO:0030395 lactose binding(GO:0030395)
1.1 6.5 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
1.1 5.4 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.9 15.1 GO:0003688 DNA replication origin binding(GO:0003688)
0.7 5.7 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.7 2.9 GO:0003896 DNA primase activity(GO:0003896)
0.6 3.2 GO:0044378 non-sequence-specific DNA binding, bending(GO:0044378)
0.6 2.9 GO:0047288 monosialoganglioside sialyltransferase activity(GO:0047288)
0.5 1.6 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.4 2.4 GO:0016672 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672) glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610)
0.3 1.6 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.3 3.1 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.3 0.8 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.2 1.0 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.2 1.6 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.2 6.2 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.2 1.7 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.2 1.5 GO:0016842 amidine-lyase activity(GO:0016842)
0.2 1.1 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.2 1.2 GO:0070087 chromo shadow domain binding(GO:0070087)
0.2 0.6 GO:0038047 beta-endorphin receptor activity(GO:0004979) morphine receptor activity(GO:0038047)
0.2 14.2 GO:0035064 methylated histone binding(GO:0035064)
0.1 2.4 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.1 0.7 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.1 2.4 GO:0030957 Tat protein binding(GO:0030957)
0.1 0.5 GO:0044715 8-oxo-dGDP phosphatase activity(GO:0044715)
0.1 3.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 6.1 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 1.5 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.1 0.5 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.1 1.1 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.1 1.7 GO:0042809 vitamin D receptor binding(GO:0042809)
0.1 1.2 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.1 2.9 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 1.6 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.3 GO:0017129 triglyceride binding(GO:0017129)
0.1 0.3 GO:0030107 HLA-A specific inhibitory MHC class I receptor activity(GO:0030107)
0.1 0.3 GO:0071885 N-terminal protein N-methyltransferase activity(GO:0071885)
0.1 1.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 0.3 GO:0004140 dephospho-CoA kinase activity(GO:0004140)
0.1 1.4 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 0.2 GO:0030627 pre-mRNA 5'-splice site binding(GO:0030627)
0.1 0.4 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.1 1.2 GO:0032052 bile acid binding(GO:0032052)
0.1 0.6 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.1 0.5 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1 0.6 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.1 1.8 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 0.8 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 1.7 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 0.6 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.1 7.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 0.3 GO:0016531 copper chaperone activity(GO:0016531)
0.1 0.5 GO:0004565 beta-galactosidase activity(GO:0004565)
0.0 0.5 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0 0.5 GO:0019103 pyrimidine nucleotide binding(GO:0019103)
0.0 0.2 GO:0032396 inhibitory MHC class I receptor activity(GO:0032396)
0.0 1.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.5 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 1.1 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 3.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.6 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.5 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.2 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.0 2.2 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.2 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.0 0.2 GO:0030620 U2 snRNA binding(GO:0030620)
0.0 1.8 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.3 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 1.2 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.0 0.1 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 1.0 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 3.4 GO:0032947 protein complex scaffold(GO:0032947)
0.0 1.1 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 5.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.7 GO:0070403 NAD+ binding(GO:0070403)
0.0 1.1 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.0 1.2 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.7 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.5 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 0.2 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.6 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 3.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.1 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 0.4 GO:0043274 phospholipase binding(GO:0043274)
0.0 0.6 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.1 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.9 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 4.5 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 0.1 GO:0002113 interleukin-33 binding(GO:0002113)
0.0 1.0 GO:0070888 E-box binding(GO:0070888)
0.0 2.0 GO:0003777 microtubule motor activity(GO:0003777)
0.0 2.7 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 1.1 GO:0000049 tRNA binding(GO:0000049)
0.0 0.4 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.9 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 1.5 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.3 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.8 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 1.1 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.1 GO:0051870 methotrexate binding(GO:0051870)
0.0 2.1 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.8 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 0.5 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.2 GO:0019789 SUMO transferase activity(GO:0019789)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 9.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 2.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 6.6 PID AURORA A PATHWAY Aurora A signaling
0.1 13.5 PID E2F PATHWAY E2F transcription factor network
0.1 1.6 PID FANCONI PATHWAY Fanconi anemia pathway
0.1 1.4 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 1.9 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 3.4 PID RAS PATHWAY Regulation of Ras family activation
0.1 1.7 PID ARF 3PATHWAY Arf1 pathway
0.1 5.2 PID NOTCH PATHWAY Notch signaling pathway
0.0 2.6 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 1.9 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 2.1 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 2.2 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 1.5 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 2.4 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 2.2 PID LKB1 PATHWAY LKB1 signaling events
0.0 3.6 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.6 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 7.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.0 PID BARD1 PATHWAY BARD1 signaling events
0.0 1.0 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.6 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.6 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 0.6 PID ATR PATHWAY ATR signaling pathway
0.0 0.5 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.8 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 22.0 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.4 9.1 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.3 4.9 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.3 5.7 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.2 5.5 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.2 6.5 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.2 3.2 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 1.9 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 1.7 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 1.4 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 3.1 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 1.5 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 5.1 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 2.7 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 1.8 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 4.0 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.3 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 1.7 REACTOME KINESINS Genes involved in Kinesins
0.0 1.6 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 1.7 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0 1.6 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.9 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.3 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 1.3 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.5 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 1.4 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.6 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 0.8 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 2.2 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 1.2 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.8 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.5 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.4 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 1.8 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.5 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 1.0 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.7 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.7 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.5 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.5 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.5 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.5 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.5 REACTOME FRS2 MEDIATED CASCADE Genes involved in FRS2-mediated cascade
0.0 1.1 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.3 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 1.0 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.2 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism