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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for ELK4_ETV5_ELK1_ELK3_ELF4
Z-value: 2.23
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Transcription factors associated with ELK4_ETV5_ELK1_ELK3_ELF4
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000158711.9 | ETS transcription factor ELK4 | |
| ENSG00000244405.3 | ETS variant transcription factor 5 | |
| ENSG00000126767.13 | ETS transcription factor ELK1 | |
| ENSG00000111145.3 | ETS transcription factor ELK3 | |
| ENSG00000102034.12 | E74 like ETS transcription factor 4 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ELK3 | hg19_v2_chr12_+_96588143_96588185 | -0.73 | 4.3e-06 | Click! |
| ETV5 | hg19_v2_chr3_-_185826855_185826911 | -0.59 | 6.0e-04 | Click! |
| ELF4 | hg19_v2_chrX_-_129244454_129244488, hg19_v2_chrX_-_129244655_129244697 | -0.57 | 9.0e-04 | Click! |
| ELK4 | hg19_v2_chr1_-_205601064_205601090 | 0.24 | 2.0e-01 | Click! |
| ELK1 | hg19_v2_chrX_-_47509887_47509990 | -0.20 | 2.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_+_80574854 Show fit | 29.56 |
ENST00000305904.6
ENST00000568035.1 |
dynein, light chain, roadblock-type 2 |
|
| chr3_-_47324079 Show fit | 23.40 |
ENST00000352910.4
|
kinesin family member 9 |
|
| chr3_-_47324242 Show fit | 23.18 |
ENST00000456548.1
ENST00000432493.1 ENST00000335044.2 ENST00000444589.2 |
kinesin family member 9 |
|
| chr3_-_47324008 Show fit | 23.03 |
ENST00000425853.1
|
kinesin family member 9 |
|
| chr17_+_45908974 Show fit | 20.78 |
ENST00000269025.4
|
leucine rich repeat containing 46 |
|
| chr17_-_19281203 Show fit | 20.60 |
ENST00000487415.2
|
B9 protein domain 1 |
|
| chr15_+_71184931 Show fit | 17.96 |
ENST00000560369.1
ENST00000260382.5 |
leucine rich repeat containing 49 |
|
| chr3_-_47324060 Show fit | 16.50 |
ENST00000452770.2
|
kinesin family member 9 |
|
| chr15_+_71185148 Show fit | 15.61 |
ENST00000443425.2
ENST00000560755.1 |
leucine rich repeat containing 49 |
|
| chr12_-_58329819 Show fit | 14.92 |
ENST00000551421.1
|
RP11-620J15.3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ELK4_ETV5_ELK1_ELK3_ELF4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 94.3 | GO:0042073 | intraciliary transport(GO:0042073) |
| 2.0 | 76.9 | GO:0071801 | regulation of podosome assembly(GO:0071801) |
| 9.1 | 36.4 | GO:0072139 | glomerular parietal epithelial cell differentiation(GO:0072139) |
| 1.4 | 29.8 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 0.9 | 29.6 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.8 | 28.8 | GO:0003341 | cilium movement(GO:0003341) |
| 0.4 | 28.8 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 1.4 | 28.4 | GO:0042424 | catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424) |
| 0.3 | 22.2 | GO:0042733 | embryonic digit morphogenesis(GO:0042733) |
| 0.1 | 21.9 | GO:0060271 | cilium morphogenesis(GO:0060271) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 58.0 | GO:0002102 | podosome(GO:0002102) |
| 1.7 | 49.9 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 3.9 | 43.1 | GO:0036157 | outer dynein arm(GO:0036157) |
| 2.2 | 41.1 | GO:0036038 | MKS complex(GO:0036038) |
| 0.3 | 40.6 | GO:0005874 | microtubule(GO:0005874) |
| 0.2 | 31.6 | GO:0031514 | motile cilium(GO:0031514) |
| 0.3 | 31.0 | GO:0036064 | ciliary basal body(GO:0036064) |
| 1.4 | 28.8 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.3 | 24.3 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 1.3 | 24.1 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 148.0 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.7 | 55.3 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 43.7 | GO:0003677 | DNA binding(GO:0003677) |
| 1.2 | 33.0 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 3.0 | 26.8 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 0.3 | 25.8 | GO:0016279 | protein-lysine N-methyltransferase activity(GO:0016279) |
| 0.4 | 25.1 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.4 | 25.1 | GO:0042805 | actinin binding(GO:0042805) |
| 0.8 | 22.1 | GO:0000030 | mannosyltransferase activity(GO:0000030) |
| 2.3 | 20.8 | GO:0008158 | hedgehog receptor activity(GO:0008158) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 15.9 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.3 | 15.5 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 15.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 10.0 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.1 | 7.4 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.3 | 6.4 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 6.3 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 6.0 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.1 | 5.5 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 5.1 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 89.0 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 1.4 | 54.1 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.4 | 31.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 1.1 | 25.6 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.3 | 20.1 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.5 | 14.8 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.5 | 13.5 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.4 | 13.4 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.4 | 11.5 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 11.4 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |