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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for EN1_ESX1_GBX1

Z-value: 0.64

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Transcription factors associated with EN1_ESX1_GBX1

Gene Symbol Gene ID Gene Info
EN1
ENSG00000163064.6 engrailed homeobox 1
ESX1
ENSG00000123576.5 ESX homeobox 1
GBX1
ENSG00000164900.4 gastrulation brain homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GBX1hg19_v2_chr7_-_150864635_150864785-0.202.9e-01Click!
ESX1hg19_v2_chrX_-_103499602_103499617-0.106.0e-01Click!
EN1hg19_v2_chr2_-_119605253_119605264-0.048.2e-01Click!

Activity profile of EN1_ESX1_GBX1 motif

Sorted Z-values of EN1_ESX1_GBX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_169013666 1.97 ENST00000359299.3
ANXA10
annexin A10
chr5_+_31193847 1.63 ENST00000514738.1
ENST00000265071.2
CDH6
cadherin 6, type 2, K-cadherin (fetal kidney)
chr17_+_59489112 1.51 ENST00000335108.2
C17orf82
chromosome 17 open reading frame 82
chr12_-_28122980 1.45 ENST00000395868.3
ENST00000534890.1
PTHLH
parathyroid hormone-like hormone
chr16_-_55866997 1.35 ENST00000360526.3
ENST00000361503.4
CES1
carboxylesterase 1
chr5_+_135394840 1.28 ENST00000503087.1
TGFBI
transforming growth factor, beta-induced, 68kDa
chr2_+_158114051 1.17 ENST00000259056.4
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr12_-_10978957 1.15 ENST00000240619.2
TAS2R10
taste receptor, type 2, member 10
chr12_-_28123206 1.13 ENST00000542963.1
ENST00000535992.1
PTHLH
parathyroid hormone-like hormone
chr20_+_3776371 1.12 ENST00000245960.5
CDC25B
cell division cycle 25B
chr12_-_89746173 1.07 ENST00000308385.6
DUSP6
dual specificity phosphatase 6
chr3_-_74570291 1.02 ENST00000263665.6
CNTN3
contactin 3 (plasmacytoma associated)
chr3_+_111718173 1.00 ENST00000494932.1
TAGLN3
transgelin 3
chr5_+_52776228 0.97 ENST00000256759.3
FST
follistatin
chr1_+_209878182 0.97 ENST00000367027.3
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr6_+_130339710 0.96 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr11_-_121986923 0.88 ENST00000560104.1
BLID
BH3-like motif containing, cell death inducer
chr17_-_39211463 0.80 ENST00000542910.1
ENST00000398477.1
KRTAP2-2
keratin associated protein 2-2
chr18_-_31803169 0.77 ENST00000590712.1
NOL4
nucleolar protein 4
chr12_+_107712173 0.74 ENST00000280758.5
ENST00000420571.2
BTBD11
BTB (POZ) domain containing 11
chrX_-_153602991 0.73 ENST00000369850.3
ENST00000422373.1
FLNA
filamin A, alpha
chr5_+_52776449 0.72 ENST00000396947.3
FST
follistatin
chr4_-_57547870 0.72 ENST00000381260.3
ENST00000420433.1
ENST00000554144.1
ENST00000557328.1
HOPX
HOP homeobox
chr2_-_208031943 0.71 ENST00000421199.1
ENST00000457962.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr4_-_57547454 0.71 ENST00000556376.2
HOPX
HOP homeobox
chr3_+_121774202 0.70 ENST00000469710.1
ENST00000493101.1
ENST00000330540.2
ENST00000264468.5
CD86
CD86 molecule
chr2_+_171034646 0.69 ENST00000409044.3
ENST00000408978.4
MYO3B
myosin IIIB
chr3_+_111718036 0.69 ENST00000455401.2
TAGLN3
transgelin 3
chr5_+_150639360 0.68 ENST00000523004.1
GM2A
GM2 ganglioside activator
chr3_+_111717600 0.66 ENST00000273368.4
TAGLN3
transgelin 3
chr12_-_10022735 0.65 ENST00000228438.2
CLEC2B
C-type lectin domain family 2, member B
chr3_+_111717511 0.64 ENST00000478951.1
ENST00000393917.2
TAGLN3
transgelin 3
chr6_+_26199737 0.62 ENST00000359985.1
HIST1H2BF
histone cluster 1, H2bf
chrX_+_7137475 0.61 ENST00000217961.4
STS
steroid sulfatase (microsomal), isozyme S
chr6_-_32157947 0.60 ENST00000375050.4
PBX2
pre-B-cell leukemia homeobox 2
chr17_+_62223320 0.59 ENST00000580828.1
ENST00000582965.1
SNORA76
small nucleolar RNA, H/ACA box 76
chr19_-_59084647 0.58 ENST00000594234.1
ENST00000596039.1
MZF1
myeloid zinc finger 1
chr1_-_17304771 0.58 ENST00000375534.3
MFAP2
microfibrillar-associated protein 2
chr3_-_178984759 0.56 ENST00000349697.2
ENST00000497599.1
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr8_+_22424551 0.55 ENST00000523348.1
SORBS3
sorbin and SH3 domain containing 3
chr4_-_143227088 0.55 ENST00000511838.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr8_+_50824233 0.53 ENST00000522124.1
SNTG1
syntrophin, gamma 1
chr12_+_1099675 0.53 ENST00000545318.2
ERC1
ELKS/RAB6-interacting/CAST family member 1
chr3_-_195538760 0.51 ENST00000475231.1
MUC4
mucin 4, cell surface associated
chr17_+_42785976 0.50 ENST00000393547.2
ENST00000398338.3
DBF4B
DBF4 homolog B (S. cerevisiae)
chr1_-_201140673 0.50 ENST00000367333.2
TMEM9
transmembrane protein 9
chr16_+_50300427 0.49 ENST00000394697.2
ENST00000566433.2
ENST00000538642.1
ADCY7
adenylate cyclase 7
chr7_-_107642348 0.49 ENST00000393561.1
LAMB1
laminin, beta 1
chrX_+_99839799 0.48 ENST00000373031.4
TNMD
tenomodulin
chr6_+_34204642 0.48 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1
high mobility group AT-hook 1
chr11_+_33061543 0.48 ENST00000432887.1
ENST00000528898.1
ENST00000531632.2
TCP11L1
t-complex 11, testis-specific-like 1
chr7_-_100860851 0.46 ENST00000223127.3
PLOD3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr11_+_75526212 0.45 ENST00000356136.3
UVRAG
UV radiation resistance associated
chr19_+_7030589 0.45 ENST00000329753.5
MBD3L5
methyl-CpG binding domain protein 3-like 5
chr19_-_7040190 0.45 ENST00000381394.4
MBD3L4
methyl-CpG binding domain protein 3-like 4
chr10_-_49813090 0.44 ENST00000249601.4
ARHGAP22
Rho GTPase activating protein 22
chr4_-_39979576 0.44 ENST00000303538.8
ENST00000503396.1
PDS5A
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
chrX_+_107288197 0.44 ENST00000415430.3
VSIG1
V-set and immunoglobulin domain containing 1
chr16_-_46655538 0.43 ENST00000303383.3
SHCBP1
SHC SH2-domain binding protein 1
chr11_-_124190184 0.43 ENST00000357438.2
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr19_-_51522955 0.42 ENST00000358789.3
KLK10
kallikrein-related peptidase 10
chr17_-_46716647 0.41 ENST00000608940.1
RP11-357H14.17
RP11-357H14.17
chr17_-_57229155 0.41 ENST00000584089.1
SKA2
spindle and kinetochore associated complex subunit 2
chr3_+_130569429 0.41 ENST00000505330.1
ENST00000504381.1
ENST00000507488.2
ENST00000393221.4
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr15_+_94899183 0.40 ENST00000557742.1
MCTP2
multiple C2 domains, transmembrane 2
chr14_+_56584414 0.40 ENST00000559044.1
PELI2
pellino E3 ubiquitin protein ligase family member 2
chr19_+_48949030 0.40 ENST00000253237.5
GRWD1
glutamate-rich WD repeat containing 1
chr18_-_31803435 0.39 ENST00000589544.1
ENST00000269185.4
ENST00000261592.5
NOL4
nucleolar protein 4
chr7_-_25019760 0.39 ENST00000352860.1
ENST00000353930.1
ENST00000431825.2
ENST00000313367.2
OSBPL3
oxysterol binding protein-like 3
chr13_-_36050819 0.39 ENST00000379919.4
MAB21L1
mab-21-like 1 (C. elegans)
chrX_+_107288239 0.39 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chr1_-_78444738 0.38 ENST00000436586.2
ENST00000370768.2
FUBP1
far upstream element (FUSE) binding protein 1
chr18_+_59000815 0.38 ENST00000262717.4
CDH20
cadherin 20, type 2
chr8_-_135522425 0.38 ENST00000521673.1
ZFAT
zinc finger and AT hook domain containing
chrX_+_135730297 0.38 ENST00000370629.2
CD40LG
CD40 ligand
chr2_-_163008903 0.37 ENST00000418842.2
ENST00000375497.3
GCG
glucagon
chr15_-_42264702 0.37 ENST00000220325.4
EHD4
EH-domain containing 4
chr2_-_238322770 0.37 ENST00000472056.1
COL6A3
collagen, type VI, alpha 3
chr2_-_238322800 0.36 ENST00000392004.3
ENST00000433762.1
ENST00000347401.3
ENST00000353578.4
ENST00000346358.4
ENST00000392003.2
COL6A3
collagen, type VI, alpha 3
chr3_-_141747950 0.36 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr2_-_238323007 0.36 ENST00000295550.4
COL6A3
collagen, type VI, alpha 3
chr12_-_10007448 0.35 ENST00000538152.1
CLEC2B
C-type lectin domain family 2, member B
chr12_+_28410128 0.35 ENST00000381259.1
ENST00000381256.1
CCDC91
coiled-coil domain containing 91
chr12_-_53171128 0.35 ENST00000332411.2
KRT76
keratin 76
chrX_+_100805496 0.34 ENST00000372829.3
ARMCX1
armadillo repeat containing, X-linked 1
chr15_+_89164520 0.34 ENST00000332810.3
AEN
apoptosis enhancing nuclease
chr14_+_22309368 0.34 ENST00000390433.1
TRAV12-1
T cell receptor alpha variable 12-1
chr17_-_64225508 0.34 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr15_-_55562479 0.34 ENST00000564609.1
RAB27A
RAB27A, member RAS oncogene family
chr19_+_45973120 0.33 ENST00000592811.1
ENST00000586615.1
FOSB
FBJ murine osteosarcoma viral oncogene homolog B
chr7_+_77428066 0.33 ENST00000422959.2
ENST00000307305.8
ENST00000424760.1
PHTF2
putative homeodomain transcription factor 2
chr18_+_34124507 0.33 ENST00000591635.1
FHOD3
formin homology 2 domain containing 3
chr22_-_32766972 0.33 ENST00000382084.4
ENST00000382086.2
RFPL3S
RFPL3 antisense
chr10_+_6779326 0.33 ENST00000417112.1
RP11-554I8.2
RP11-554I8.2
chr20_+_43538692 0.33 ENST00000217074.4
ENST00000255136.3
PABPC1L
poly(A) binding protein, cytoplasmic 1-like
chr18_-_44181442 0.32 ENST00000398722.4
LOXHD1
lipoxygenase homology domains 1
chr1_-_78444776 0.32 ENST00000370767.1
ENST00000421641.1
FUBP1
far upstream element (FUSE) binding protein 1
chr4_+_71200681 0.32 ENST00000273936.5
CABS1
calcium-binding protein, spermatid-specific 1
chr20_+_43538756 0.31 ENST00000537323.1
ENST00000217073.2
PABPC1L
poly(A) binding protein, cytoplasmic 1-like
chr19_+_41869894 0.31 ENST00000413014.2
TMEM91
transmembrane protein 91
chr21_+_31768348 0.31 ENST00000355459.2
KRTAP13-1
keratin associated protein 13-1
chr3_-_195538728 0.31 ENST00000349607.4
ENST00000346145.4
MUC4
mucin 4, cell surface associated
chr1_+_62439037 0.31 ENST00000545929.1
INADL
InaD-like (Drosophila)
chr2_-_188419078 0.30 ENST00000437725.1
ENST00000409676.1
ENST00000339091.4
ENST00000420747.1
TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr14_+_74815116 0.30 ENST00000256362.4
VRTN
vertebrae development associated
chr5_+_115177178 0.30 ENST00000316788.7
AP3S1
adaptor-related protein complex 3, sigma 1 subunit
chr5_+_140529630 0.30 ENST00000543635.1
PCDHB6
protocadherin beta 6
chr7_-_92777606 0.30 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
SAMD9L
sterile alpha motif domain containing 9-like
chr14_-_106494587 0.30 ENST00000390597.2
IGHV2-5
immunoglobulin heavy variable 2-5
chr15_+_63188009 0.30 ENST00000557900.1
RP11-1069G10.2
RP11-1069G10.2
chr18_+_29027696 0.30 ENST00000257189.4
DSG3
desmoglein 3
chr20_-_56286479 0.30 ENST00000265626.4
PMEPA1
prostate transmembrane protein, androgen induced 1
chr17_-_9694614 0.30 ENST00000330255.5
ENST00000571134.1
DHRS7C
dehydrogenase/reductase (SDR family) member 7C
chr3_+_152879985 0.30 ENST00000323534.2
RAP2B
RAP2B, member of RAS oncogene family
chr4_-_143226979 0.30 ENST00000514525.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr11_-_71823266 0.29 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
ANAPC15
anaphase promoting complex subunit 15
chr14_-_55658323 0.29 ENST00000554067.1
ENST00000247191.2
DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr6_-_26199471 0.29 ENST00000341023.1
HIST1H2AD
histone cluster 1, H2ad
chr20_-_50722183 0.29 ENST00000371523.4
ZFP64
ZFP64 zinc finger protein
chr19_+_34287751 0.29 ENST00000590771.1
ENST00000589786.1
ENST00000284006.6
ENST00000588881.1
KCTD15
potassium channel tetramerization domain containing 15
chr1_+_244515930 0.29 ENST00000366537.1
ENST00000308105.4
C1orf100
chromosome 1 open reading frame 100
chr13_-_30881134 0.28 ENST00000380617.3
ENST00000441394.1
KATNAL1
katanin p60 subunit A-like 1
chr12_+_122688090 0.28 ENST00000324189.4
ENST00000546192.1
B3GNT4
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
chr22_+_46476192 0.28 ENST00000443490.1
FLJ27365
hsa-mir-4763
chr8_+_98881268 0.28 ENST00000254898.5
ENST00000524308.1
ENST00000522025.2
MATN2
matrilin 2
chr6_-_111927062 0.28 ENST00000359831.4
TRAF3IP2
TRAF3 interacting protein 2
chr8_-_101661887 0.28 ENST00000311812.2
SNX31
sorting nexin 31
chr5_-_82969405 0.28 ENST00000510978.1
HAPLN1
hyaluronan and proteoglycan link protein 1
chr1_-_197115818 0.28 ENST00000367409.4
ENST00000294732.7
ASPM
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr3_-_151034734 0.28 ENST00000260843.4
GPR87
G protein-coupled receptor 87
chr6_-_32145861 0.28 ENST00000336984.6
AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1
chr9_+_12693336 0.27 ENST00000381137.2
ENST00000388918.5
TYRP1
tyrosinase-related protein 1
chr1_+_10290822 0.27 ENST00000377083.1
KIF1B
kinesin family member 1B
chr10_-_135379132 0.27 ENST00000343131.5
SYCE1
synaptonemal complex central element protein 1
chr1_-_67266939 0.27 ENST00000304526.2
INSL5
insulin-like 5
chr8_-_42234745 0.27 ENST00000220812.2
DKK4
dickkopf WNT signaling pathway inhibitor 4
chr19_+_3762703 0.26 ENST00000589174.1
MRPL54
mitochondrial ribosomal protein L54
chr12_+_26348246 0.26 ENST00000422622.2
SSPN
sarcospan
chr6_-_26199499 0.26 ENST00000377831.5
HIST1H3D
histone cluster 1, H3d
chr22_-_32767017 0.26 ENST00000400234.1
RFPL3S
RFPL3 antisense
chr2_+_89184868 0.26 ENST00000390243.2
IGKV4-1
immunoglobulin kappa variable 4-1
chr1_-_143913143 0.26 ENST00000400889.1
FAM72D
family with sequence similarity 72, member D
chr6_+_151186554 0.26 ENST00000367321.3
ENST00000367307.4
MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr15_-_55563072 0.26 ENST00000567380.1
ENST00000565972.1
ENST00000569493.1
RAB27A
RAB27A, member RAS oncogene family
chr14_+_29236269 0.26 ENST00000313071.4
FOXG1
forkhead box G1
chr1_+_206138457 0.26 ENST00000367128.3
ENST00000431655.2
FAM72A
family with sequence similarity 72, member A
chr10_-_56560939 0.25 ENST00000373955.1
PCDH15
protocadherin-related 15
chr1_-_118472171 0.25 ENST00000369442.3
GDAP2
ganglioside induced differentiation associated protein 2
chr4_+_70796784 0.25 ENST00000246891.4
ENST00000444405.3
CSN1S1
casein alpha s1
chr11_-_117748138 0.25 ENST00000527717.1
FXYD6
FXYD domain containing ion transport regulator 6
chr6_+_43968306 0.25 ENST00000442114.2
ENST00000336600.5
ENST00000439969.2
C6orf223
chromosome 6 open reading frame 223
chr10_-_50970322 0.25 ENST00000374103.4
OGDHL
oxoglutarate dehydrogenase-like
chr4_+_88754113 0.25 ENST00000560249.1
ENST00000540395.1
ENST00000511670.1
ENST00000361056.3
MEPE
matrix extracellular phosphoglycoprotein
chr10_+_5005598 0.25 ENST00000442997.1
AKR1C1
aldo-keto reductase family 1, member C1
chr14_+_32798462 0.24 ENST00000280979.4
AKAP6
A kinase (PRKA) anchor protein 6
chr1_+_120839005 0.24 ENST00000369390.3
ENST00000452190.1
FAM72B
family with sequence similarity 72, member B
chr16_-_20702578 0.24 ENST00000307493.4
ENST00000219151.4
ACSM1
acyl-CoA synthetase medium-chain family member 1
chr3_-_187009798 0.24 ENST00000337774.5
MASP1
mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
chr4_-_8873531 0.24 ENST00000400677.3
HMX1
H6 family homeobox 1
chr14_-_55658252 0.24 ENST00000395425.2
DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr6_-_22297730 0.24 ENST00000306482.1
PRL
prolactin
chr9_-_131486367 0.24 ENST00000372663.4
ENST00000406904.2
ENST00000452105.1
ENST00000372672.2
ENST00000372667.5
ZDHHC12
zinc finger, DHHC-type containing 12
chr1_+_202317815 0.24 ENST00000608999.1
ENST00000336894.4
ENST00000480184.1
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr9_-_107690420 0.24 ENST00000423487.2
ENST00000374733.1
ENST00000374736.3
ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr7_-_77427676 0.24 ENST00000257663.3
TMEM60
transmembrane protein 60
chr8_+_98900132 0.23 ENST00000520016.1
MATN2
matrilin 2
chr14_-_95236551 0.23 ENST00000238558.3
GSC
goosecoid homeobox
chr19_-_47137942 0.23 ENST00000300873.4
GNG8
guanine nucleotide binding protein (G protein), gamma 8
chr14_+_32798547 0.23 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6
A kinase (PRKA) anchor protein 6
chr6_-_111927449 0.23 ENST00000368761.5
ENST00000392556.4
ENST00000340026.6
TRAF3IP2
TRAF3 interacting protein 2
chr12_-_10955226 0.23 ENST00000240687.2
TAS2R7
taste receptor, type 2, member 7
chr11_-_117747607 0.23 ENST00000540359.1
ENST00000539526.1
FXYD6
FXYD domain containing ion transport regulator 6
chr8_+_42873548 0.23 ENST00000533338.1
ENST00000534420.1
HOOK3
RP11-598P20.5
hook microtubule-tethering protein 3
Uncharacterized protein
chr1_+_225600404 0.23 ENST00000366845.2
AC092811.1
AC092811.1
chr11_-_117747434 0.22 ENST00000529335.2
ENST00000530956.1
ENST00000260282.4
FXYD6
FXYD domain containing ion transport regulator 6
chr11_-_36310958 0.22 ENST00000532705.1
ENST00000263401.5
ENST00000452374.2
COMMD9
COMM domain containing 9
chr6_+_153552455 0.22 ENST00000392385.2
AL590867.1
Uncharacterized protein; cDNA FLJ59044, highly similar to LINE-1 reverse transcriptase homolog
chr17_+_7905912 0.22 ENST00000254854.4
GUCY2D
guanylate cyclase 2D, membrane (retina-specific)
chr5_-_9630463 0.22 ENST00000382492.2
TAS2R1
taste receptor, type 2, member 1
chr12_-_52828147 0.21 ENST00000252245.5
KRT75
keratin 75
chr11_-_71823715 0.21 ENST00000545944.1
ENST00000502597.2
ANAPC15
anaphase promoting complex subunit 15
chr10_-_50970382 0.21 ENST00000419399.1
ENST00000432695.1
OGDHL
oxoglutarate dehydrogenase-like
chr10_-_48416849 0.21 ENST00000249598.1
GDF2
growth differentiation factor 2
chr14_-_36988882 0.21 ENST00000498187.2
NKX2-1
NK2 homeobox 1
chr8_+_32579341 0.21 ENST00000519240.1
ENST00000539990.1
NRG1
neuregulin 1
chr15_+_58430567 0.21 ENST00000536493.1
AQP9
aquaporin 9
chr12_-_22063787 0.21 ENST00000544039.1
ABCC9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr8_-_7243080 0.21 ENST00000400156.4
ZNF705G
zinc finger protein 705G
chr14_+_22748980 0.20 ENST00000390465.2
TRAV38-2DV8
T cell receptor alpha variable 38-2/delta variable 8
chr2_+_143635067 0.20 ENST00000264170.4
KYNU
kynureninase
chr9_+_125133315 0.20 ENST00000223423.4
ENST00000362012.2
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr4_+_88754069 0.20 ENST00000395102.4
ENST00000497649.2
MEPE
matrix extracellular phosphoglycoprotein
chr14_+_68086515 0.20 ENST00000261783.3
ARG2
arginase 2
chr19_-_7968427 0.20 ENST00000539278.1
AC010336.1
Uncharacterized protein
chr3_-_33686925 0.20 ENST00000485378.2
ENST00000313350.6
ENST00000487200.1
CLASP2
cytoplasmic linker associated protein 2
chr7_+_100136811 0.20 ENST00000300176.4
ENST00000262935.4
AGFG2
ArfGAP with FG repeats 2
chr18_+_55888767 0.20 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr7_+_77428149 0.20 ENST00000415251.2
ENST00000275575.7
PHTF2
putative homeodomain transcription factor 2
chr19_+_39421556 0.19 ENST00000407800.2
ENST00000402029.3
MRPS12
mitochondrial ribosomal protein S12
chr3_+_130569592 0.19 ENST00000533801.2
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1

Network of associatons between targets according to the STRING database.

First level regulatory network of EN1_ESX1_GBX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 0.5 GO:0035992 tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.4 1.1 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.3 1.3 GO:0090119 vesicle-mediated cholesterol transport(GO:0090119)
0.2 0.7 GO:0002644 negative regulation of tolerance induction(GO:0002644) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.2 1.6 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.2 0.5 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.1 0.5 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.1 0.7 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.1 1.1 GO:0007144 female meiosis I(GO:0007144)
0.1 0.6 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.1 0.5 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.1 0.4 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.1 0.3 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.1 0.5 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.1 0.5 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.1 0.6 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.1 0.2 GO:0018874 benzoate metabolic process(GO:0018874)
0.1 0.5 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.1 1.6 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.1 1.0 GO:0048583 regulation of response to stimulus(GO:0048583)
0.1 0.7 GO:0006689 ganglioside catabolic process(GO:0006689)
0.1 0.5 GO:0051684 maintenance of Golgi location(GO:0051684)
0.1 1.0 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 2.3 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.1 0.3 GO:0030311 poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.1 0.2 GO:0014034 neural crest cell fate commitment(GO:0014034)
0.1 0.3 GO:1904647 response to rotenone(GO:1904647)
0.1 0.2 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.1 0.4 GO:0008063 Toll signaling pathway(GO:0008063)
0.1 0.3 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.1 0.2 GO:2001027 negative regulation of endothelial cell chemotaxis(GO:2001027)
0.1 0.3 GO:0015722 canalicular bile acid transport(GO:0015722)
0.1 0.2 GO:0090107 aminophospholipid transport(GO:0015917) regulation of high-density lipoprotein particle assembly(GO:0090107)
0.1 0.2 GO:1903625 negative regulation of DNA catabolic process(GO:1903625)
0.1 0.2 GO:0070781 arginine biosynthetic process via ornithine(GO:0042450) response to biotin(GO:0070781)
0.1 1.5 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.1 0.2 GO:0003162 atrioventricular node development(GO:0003162)
0.0 0.1 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.0 0.5 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
0.0 0.2 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.0 0.1 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.0 1.8 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 1.0 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.6 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.1 GO:0097187 dentinogenesis(GO:0097187) regulation of sodium-dependent phosphate transport(GO:2000118)
0.0 0.9 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.3 GO:0071395 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.0 0.3 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.2 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 0.2 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.0 0.3 GO:0051799 negative regulation of hair follicle development(GO:0051799)
0.0 0.1 GO:2000646 positive regulation of receptor catabolic process(GO:2000646)
0.0 0.3 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.0 0.9 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.0 0.3 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.3 GO:0048733 sebaceous gland development(GO:0048733)
0.0 0.4 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.2 GO:0060301 vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040)
0.0 0.2 GO:0019236 response to pheromone(GO:0019236)
0.0 0.1 GO:0006114 glycerol biosynthetic process(GO:0006114)
0.0 0.4 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.0 0.3 GO:0051013 microtubule severing(GO:0051013)
0.0 0.1 GO:0060748 tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.0 0.1 GO:0003335 corneocyte development(GO:0003335)
0.0 0.2 GO:0021840 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.0 0.1 GO:1901228 positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation(GO:0003257) negative regulation of beta-amyloid clearance(GO:1900222) positive regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901228)
0.0 0.1 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.0 0.4 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.1 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.0 0.6 GO:0005513 detection of calcium ion(GO:0005513)
0.0 1.0 GO:0048305 immunoglobulin secretion(GO:0048305)
0.0 0.1 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.1 GO:0030070 insulin processing(GO:0030070)
0.0 0.3 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.1 GO:0021524 visceral motor neuron differentiation(GO:0021524)
0.0 0.1 GO:0006434 seryl-tRNA aminoacylation(GO:0006434)
0.0 0.5 GO:0071361 cellular response to ethanol(GO:0071361)
0.0 0.3 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.2 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.0 0.6 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.0 0.2 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.3 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.3 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.3 GO:0002934 desmosome organization(GO:0002934)
0.0 0.0 GO:0003218 cardiac left ventricle formation(GO:0003218)
0.0 0.1 GO:0045872 positive regulation of rhodopsin gene expression(GO:0045872)
0.0 0.2 GO:0045905 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0 0.2 GO:0090649 response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
0.0 0.4 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880)
0.0 0.1 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.0 0.1 GO:0032571 response to vitamin K(GO:0032571)
0.0 0.1 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.0 0.2 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.2 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0 0.0 GO:0006789 bilirubin conjugation(GO:0006789)
0.0 0.3 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.2 GO:0000050 urea cycle(GO:0000050)
0.0 0.1 GO:0042816 vitamin B6 metabolic process(GO:0042816)
0.0 0.5 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.1 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.0 0.2 GO:0021759 globus pallidus development(GO:0021759)
0.0 0.2 GO:0043543 protein acylation(GO:0043543)
0.0 0.2 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.4 GO:0060712 spongiotrophoblast layer development(GO:0060712)
0.0 0.1 GO:1901994 meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.0 0.1 GO:1903961 positive regulation of anion transmembrane transport(GO:1903961)
0.0 0.1 GO:0097338 response to clozapine(GO:0097338)
0.0 0.1 GO:0014057 positive regulation of acetylcholine secretion, neurotransmission(GO:0014057)
0.0 0.1 GO:1900005 positive regulation of serine-type endopeptidase activity(GO:1900005) negative regulation of sperm motility(GO:1901318) positive regulation of serine-type peptidase activity(GO:1902573)
0.0 0.3 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.0 0.3 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.0 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.0 0.3 GO:0032196 transposition(GO:0032196)
0.0 0.5 GO:0006706 steroid catabolic process(GO:0006706)
0.0 0.1 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.0 0.4 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 0.3 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.2 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.0 0.1 GO:0048241 epinephrine transport(GO:0048241)
0.0 0.1 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.1 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.0 0.3 GO:0006183 GTP biosynthetic process(GO:0006183)
0.0 0.0 GO:0030997 regulation of centriole-centriole cohesion(GO:0030997)
0.0 0.0 GO:0009946 proximal/distal axis specification(GO:0009946)
0.0 0.1 GO:0036166 phenotypic switching(GO:0036166) regulation of phenotypic switching(GO:1900239)
0.0 0.1 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.0 0.2 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.0 0.0 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.0 0.1 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.0 0.2 GO:0009642 response to light intensity(GO:0009642)
0.0 0.0 GO:1901419 regulation of response to alcohol(GO:1901419)
0.0 0.1 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.3 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.0 0.3 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.0 0.1 GO:0006172 ADP biosynthetic process(GO:0006172)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.2 GO:0044804 nucleophagy(GO:0044804)
0.0 0.3 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.0 0.5 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 0.2 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.3 GO:0051412 response to corticosterone(GO:0051412)
0.0 0.1 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.0 0.8 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.0 0.9 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 0.2 GO:0098828 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0 0.0 GO:0045726 positive regulation of integrin biosynthetic process(GO:0045726)
0.0 0.4 GO:0006907 pinocytosis(GO:0006907)
0.0 0.2 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.0 0.2 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 1.1 GO:0030574 collagen catabolic process(GO:0030574)
0.0 0.5 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.1 GO:0055089 fatty acid homeostasis(GO:0055089)
0.0 0.0 GO:2000537 regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.0 0.1 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.1 GO:0042670 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.1 GO:2000504 positive regulation of blood vessel remodeling(GO:2000504)
0.0 0.2 GO:0042693 muscle cell fate commitment(GO:0042693)
0.0 0.1 GO:1903543 positive regulation of exosomal secretion(GO:1903543)
0.0 0.4 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.0 0.1 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.0 0.1 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 1.1 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 0.2 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 1.1 GO:0002062 chondrocyte differentiation(GO:0002062)
0.0 0.0 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.0 0.2 GO:0046069 cGMP catabolic process(GO:0046069)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0031523 Myb complex(GO:0031523)
0.2 0.7 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.2 0.5 GO:0005607 laminin-2 complex(GO:0005607)
0.1 1.2 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 0.6 GO:0016013 syntrophin complex(GO:0016013)
0.1 0.2 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.1 0.3 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.8 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.1 GO:0033565 ESCRT-0 complex(GO:0033565)
0.0 0.3 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.5 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.6 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.2 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.7 GO:0030897 HOPS complex(GO:0030897)
0.0 0.5 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.5 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.1 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.0 0.3 GO:0000801 central element(GO:0000801)
0.0 0.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.2 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.4 GO:0070652 HAUS complex(GO:0070652)
0.0 0.8 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.1 GO:0036338 viral envelope(GO:0019031) viral membrane(GO:0036338)
0.0 0.3 GO:0097443 sorting endosome(GO:0097443)
0.0 0.1 GO:0044301 climbing fiber(GO:0044301)
0.0 0.4 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.1 GO:1990075 periciliary membrane compartment(GO:1990075)
0.0 0.2 GO:0014802 terminal cisterna(GO:0014802)
0.0 0.6 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.1 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.1 GO:0071547 piP-body(GO:0071547)
0.0 0.1 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.3 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.1 GO:0097452 GAIT complex(GO:0097452)
0.0 0.7 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.1 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.5 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 0.2 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.4 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.3 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.1 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.0 0.2 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.2 GO:0016600 flotillin complex(GO:0016600)
0.0 0.1 GO:0097433 dense body(GO:0097433)
0.0 0.0 GO:1990037 Lewy body core(GO:1990037)
0.0 0.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.0 GO:0000811 GINS complex(GO:0000811)
0.0 0.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.2 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.0 3.0 GO:0043209 myelin sheath(GO:0043209)
0.0 0.1 GO:1990246 uniplex complex(GO:1990246)
0.0 0.0 GO:0033186 CAF-1 complex(GO:0033186)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.3 1.3 GO:0047374 methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.2 0.6 GO:0005174 CD40 receptor binding(GO:0005174)
0.2 0.7 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.2 0.5 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.1 0.8 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.1 0.8 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
0.1 1.7 GO:0048185 activin binding(GO:0048185)
0.1 2.6 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 0.2 GO:0005148 prolactin receptor binding(GO:0005148)
0.1 0.2 GO:0090556 apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.1 1.7 GO:0033038 bitter taste receptor activity(GO:0033038)
0.1 0.3 GO:0004803 transposase activity(GO:0004803)
0.1 0.3 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.1 0.7 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.1 0.4 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.1 0.3 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.1 0.2 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.1 0.5 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1 0.3 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.1 0.1 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.1 1.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.2 GO:0047023 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006) androsterone dehydrogenase activity(GO:0047023) indanol dehydrogenase activity(GO:0047718)
0.1 0.2 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.1 0.3 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 0.2 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.3 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 1.1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.2 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0 0.1 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0 0.1 GO:0016608 growth hormone-releasing hormone activity(GO:0016608)
0.0 0.5 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.2 GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0 0.7 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.5 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.1 GO:0000994 RNA polymerase III core binding(GO:0000994)
0.0 0.1 GO:0043398 HLH domain binding(GO:0043398)
0.0 0.8 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 2.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.2 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.2 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.3 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.2 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.1 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.0 0.2 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.3 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.4 GO:0005549 odorant binding(GO:0005549)
0.0 0.1 GO:1901375 acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
0.0 0.6 GO:0017166 vinculin binding(GO:0017166)
0.0 0.1 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 0.6 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 0.4 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.1 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.9 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.1 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.1 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.1 GO:0003883 CTP synthase activity(GO:0003883)
0.0 0.4 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.5 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 0.6 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.1 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.0 0.5 GO:0031489 myosin V binding(GO:0031489)
0.0 0.6 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 1.0 GO:0015026 coreceptor activity(GO:0015026)
0.0 1.3 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.1 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 0.0 GO:0004087 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.0 0.1 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.0 0.2 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.2 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.1 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.0 0.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.4 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 0.1 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.0 0.2 GO:0042301 phosphate ion binding(GO:0042301)
0.0 0.2 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 0.0 GO:0018636 phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086)
0.0 0.1 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.1 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 0.2 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.2 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.2 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.2 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.2 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.3 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.1 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.0 1.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.1 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.0 0.3 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.1 GO:0015288 porin activity(GO:0015288)
0.0 0.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.0 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 0.2 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.1 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 0.1 GO:0004995 tachykinin receptor activity(GO:0004995)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 1.3 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 1.9 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.8 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 1.6 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 1.7 PID BMP PATHWAY BMP receptor signaling
0.0 1.0 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.5 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.9 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.0 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.8 PID AURORA A PATHWAY Aurora A signaling
0.0 0.7 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.1 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.3 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.4 PID CONE PATHWAY Visual signal transduction: Cones

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.1 0.5 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.8 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 1.1 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 1.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.6 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.5 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 3.3 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.4 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.7 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.4 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 3.2 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.3 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.3 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.8 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 1.5 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.3 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.5 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.3 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.2 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.7 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.7 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.2 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.3 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.2 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.2 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.2 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.4 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.7 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.1 REACTOME OPSINS Genes involved in Opsins