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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for EN2_GBX2_LBX2

Z-value: 0.45

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Transcription factors associated with EN2_GBX2_LBX2

Gene Symbol Gene ID Gene Info
EN2
ENSG00000164778.4 engrailed homeobox 2
GBX2
ENSG00000168505.6 gastrulation brain homeobox 2
LBX2
ENSG00000179528.11 ladybird homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
EN2hg19_v2_chr7_+_155250824_1552508240.144.6e-01Click!
GBX2hg19_v2_chr2_-_237076992_2370770120.125.4e-01Click!

Activity profile of EN2_GBX2_LBX2 motif

Sorted Z-values of EN2_GBX2_LBX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_39203519 2.27 ENST00000542137.1
ENST00000391419.3
KRTAP2-1
keratin associated protein 2-1
chr1_+_171227069 1.30 ENST00000354841.4
FMO1
flavin containing monooxygenase 1
chr1_+_40713573 1.28 ENST00000372766.3
TMCO2
transmembrane and coiled-coil domains 2
chr4_-_138453606 1.11 ENST00000412923.2
ENST00000344876.4
ENST00000507846.1
ENST00000510305.1
PCDH18
protocadherin 18
chr6_-_26199471 0.84 ENST00000341023.1
HIST1H2AD
histone cluster 1, H2ad
chr16_+_53133070 0.83 ENST00000565832.1
CHD9
chromodomain helicase DNA binding protein 9
chr8_-_10512569 0.76 ENST00000382483.3
RP1L1
retinitis pigmentosa 1-like 1
chr12_+_7013897 0.72 ENST00000007969.8
ENST00000323702.5
LRRC23
leucine rich repeat containing 23
chr12_+_7014064 0.71 ENST00000443597.2
LRRC23
leucine rich repeat containing 23
chr6_-_26199499 0.68 ENST00000377831.5
HIST1H3D
histone cluster 1, H3d
chr5_-_35938674 0.58 ENST00000397366.1
ENST00000513623.1
ENST00000514524.1
ENST00000397367.2
CAPSL
calcyphosine-like
chr2_-_73460334 0.56 ENST00000258083.2
PRADC1
protease-associated domain containing 1
chr4_-_105416039 0.51 ENST00000394767.2
CXXC4
CXXC finger protein 4
chr17_-_39211463 0.49 ENST00000542910.1
ENST00000398477.1
KRTAP2-2
keratin associated protein 2-2
chr9_+_1050331 0.49 ENST00000382255.3
ENST00000382251.3
ENST00000412350.2
DMRT2
doublesex and mab-3 related transcription factor 2
chr11_-_40315640 0.46 ENST00000278198.2
LRRC4C
leucine rich repeat containing 4C
chr14_+_32798462 0.41 ENST00000280979.4
AKAP6
A kinase (PRKA) anchor protein 6
chr19_-_7698599 0.37 ENST00000311069.5
PCP2
Purkinje cell protein 2
chr20_-_18447667 0.37 ENST00000262547.5
ENST00000329494.5
ENST00000357236.4
DZANK1
double zinc ribbon and ankyrin repeat domains 1
chr9_+_12693336 0.37 ENST00000381137.2
ENST00000388918.5
TYRP1
tyrosinase-related protein 1
chr14_+_32798547 0.35 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6
A kinase (PRKA) anchor protein 6
chr6_+_26199737 0.34 ENST00000359985.1
HIST1H2BF
histone cluster 1, H2bf
chr7_-_122339162 0.33 ENST00000340112.2
RNF133
ring finger protein 133
chr17_+_59489112 0.32 ENST00000335108.2
C17orf82
chromosome 17 open reading frame 82
chr12_-_52828147 0.31 ENST00000252245.5
KRT75
keratin 75
chr3_-_141747950 0.29 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr11_-_124190184 0.27 ENST00000357438.2
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr13_-_36788718 0.26 ENST00000317764.6
ENST00000379881.3
SOHLH2
spermatogenesis and oogenesis specific basic helix-loop-helix 2
chr15_+_76629064 0.25 ENST00000290759.4
ISL2
ISL LIM homeobox 2
chr7_-_137028534 0.24 ENST00000348225.2
PTN
pleiotrophin
chrX_-_21676442 0.23 ENST00000379499.2
KLHL34
kelch-like family member 34
chr15_-_37393406 0.22 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
MEIS2
Meis homeobox 2
chr16_-_29910853 0.22 ENST00000308713.5
SEZ6L2
seizure related 6 homolog (mouse)-like 2
chr3_+_111718036 0.21 ENST00000455401.2
TAGLN3
transgelin 3
chr7_-_137028498 0.21 ENST00000393083.2
PTN
pleiotrophin
chr5_+_53751445 0.21 ENST00000302005.1
HSPB3
heat shock 27kDa protein 3
chr3_+_111717600 0.20 ENST00000273368.4
TAGLN3
transgelin 3
chr11_-_118023490 0.20 ENST00000324727.4
SCN4B
sodium channel, voltage-gated, type IV, beta subunit
chr1_+_118472343 0.19 ENST00000369441.3
ENST00000349139.5
WDR3
WD repeat domain 3
chr21_+_31768348 0.19 ENST00000355459.2
KRTAP13-1
keratin associated protein 13-1
chr1_+_153190053 0.18 ENST00000368744.3
PRR9
proline rich 9
chr19_-_14064114 0.17 ENST00000585607.1
ENST00000538517.2
ENST00000587458.1
ENST00000538371.2
PODNL1
podocan-like 1
chr1_-_152131703 0.17 ENST00000316073.3
RPTN
repetin
chr6_+_39760129 0.16 ENST00000274867.4
DAAM2
dishevelled associated activator of morphogenesis 2
chr19_+_51728316 0.16 ENST00000436584.2
ENST00000421133.2
ENST00000391796.3
ENST00000262262.4
CD33
CD33 molecule
chr1_-_118472216 0.16 ENST00000369443.5
GDAP2
ganglioside induced differentiation associated protein 2
chr1_+_214161272 0.15 ENST00000498508.2
ENST00000366958.4
PROX1
prospero homeobox 1
chr4_-_138453559 0.15 ENST00000511115.1
PCDH18
protocadherin 18
chrX_-_46187069 0.15 ENST00000446884.1
RP1-30G7.2
RP1-30G7.2
chr12_-_10955226 0.15 ENST00000240687.2
TAS2R7
taste receptor, type 2, member 7
chrM_+_12331 0.15 ENST00000361567.2
MT-ND5
mitochondrially encoded NADH dehydrogenase 5
chr15_+_58430368 0.15 ENST00000558772.1
ENST00000219919.4
AQP9
aquaporin 9
chr15_+_58430567 0.15 ENST00000536493.1
AQP9
aquaporin 9
chr3_+_111717511 0.14 ENST00000478951.1
ENST00000393917.2
TAGLN3
transgelin 3
chr7_-_25268104 0.14 ENST00000222674.2
NPVF
neuropeptide VF precursor
chr1_+_179923873 0.14 ENST00000367607.3
ENST00000491495.2
CEP350
centrosomal protein 350kDa
chr4_+_89206076 0.14 ENST00000500009.2
RP11-10L7.1
RP11-10L7.1
chr8_+_50824233 0.14 ENST00000522124.1
SNTG1
syntrophin, gamma 1
chr11_-_124981475 0.14 ENST00000532156.1
ENST00000532407.1
ENST00000279968.4
ENST00000527766.1
ENST00000529583.1
ENST00000524373.1
ENST00000527271.1
ENST00000526175.1
ENST00000529609.1
ENST00000533273.1
ENST00000531909.1
ENST00000529530.1
TMEM218
transmembrane protein 218
chr19_-_7697857 0.14 ENST00000598935.1
PCP2
Purkinje cell protein 2
chrX_+_95939711 0.13 ENST00000373049.4
ENST00000324765.8
DIAPH2
diaphanous-related formin 2
chr1_+_42846443 0.13 ENST00000410070.2
ENST00000431473.3
RIMKLA
ribosomal modification protein rimK-like family member A
chr5_+_125758813 0.12 ENST00000285689.3
ENST00000515200.1
GRAMD3
GRAM domain containing 3
chr5_-_95297534 0.12 ENST00000513343.1
ENST00000431061.2
ELL2
elongation factor, RNA polymerase II, 2
chr12_+_7014126 0.12 ENST00000415834.1
ENST00000436789.1
LRRC23
leucine rich repeat containing 23
chr4_-_69111401 0.12 ENST00000332644.5
TMPRSS11B
transmembrane protease, serine 11B
chr5_+_125758865 0.11 ENST00000542322.1
ENST00000544396.1
GRAMD3
GRAM domain containing 3
chr2_+_47630255 0.11 ENST00000406134.1
MSH2
mutS homolog 2
chr12_-_101604185 0.11 ENST00000536262.2
SLC5A8
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
chr7_-_92777606 0.11 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
SAMD9L
sterile alpha motif domain containing 9-like
chr2_-_224467093 0.11 ENST00000305409.2
SCG2
secretogranin II
chr2_+_47630108 0.11 ENST00000233146.2
ENST00000454849.1
ENST00000543555.1
MSH2
mutS homolog 2
chr6_-_139613269 0.11 ENST00000358430.3
TXLNB
taxilin beta
chr6_-_76203345 0.11 ENST00000393004.2
FILIP1
filamin A interacting protein 1
chr14_+_22739823 0.10 ENST00000390464.2
TRAV38-1
T cell receptor alpha variable 38-1
chr8_+_38831683 0.10 ENST00000302495.4
HTRA4
HtrA serine peptidase 4
chr5_-_147286065 0.10 ENST00000318315.4
ENST00000515291.1
C5orf46
chromosome 5 open reading frame 46
chrX_+_95939638 0.09 ENST00000373061.3
ENST00000373054.4
ENST00000355827.4
DIAPH2
diaphanous-related formin 2
chr20_+_18447771 0.09 ENST00000377603.4
POLR3F
polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
chr2_+_65216462 0.08 ENST00000234256.3
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr6_+_135502501 0.08 ENST00000527615.1
ENST00000420123.2
ENST00000525369.1
ENST00000528774.1
ENST00000534121.1
ENST00000534044.1
ENST00000533624.1
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr1_+_62901968 0.08 ENST00000452143.1
ENST00000442679.1
ENST00000371146.1
USP1
ubiquitin specific peptidase 1
chr15_-_31393910 0.08 ENST00000397795.2
ENST00000256552.6
ENST00000559179.1
TRPM1
transient receptor potential cation channel, subfamily M, member 1
chr1_-_23670817 0.08 ENST00000478691.1
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr7_+_138145076 0.08 ENST00000343526.4
TRIM24
tripartite motif containing 24
chr18_-_33709268 0.08 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chr17_-_39306054 0.08 ENST00000343246.4
KRTAP4-5
keratin associated protein 4-5
chr22_+_41777927 0.08 ENST00000266304.4
TEF
thyrotrophic embryonic factor
chrX_-_18690210 0.08 ENST00000379984.3
RS1
retinoschisin 1
chr1_-_117664317 0.08 ENST00000256649.4
ENST00000369464.3
ENST00000485032.1
TRIM45
tripartite motif containing 45
chr6_-_76203454 0.07 ENST00000237172.7
FILIP1
filamin A interacting protein 1
chr5_+_148737562 0.07 ENST00000274569.4
PCYOX1L
prenylcysteine oxidase 1 like
chr6_-_49681235 0.07 ENST00000339139.4
CRISP2
cysteine-rich secretory protein 2
chr1_-_17766198 0.07 ENST00000375436.4
RCC2
regulator of chromosome condensation 2
chr3_+_167453493 0.07 ENST00000295777.5
ENST00000472747.2
SERPINI1
serpin peptidase inhibitor, clade I (neuroserpin), member 1
chr6_+_130339710 0.07 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr19_-_51522955 0.07 ENST00000358789.3
KLK10
kallikrein-related peptidase 10
chr4_-_54232144 0.07 ENST00000388940.4
ENST00000503450.1
ENST00000401642.3
SCFD2
sec1 family domain containing 2
chr17_-_9929581 0.07 ENST00000437099.2
ENST00000396115.2
GAS7
growth arrest-specific 7
chr19_-_7968427 0.07 ENST00000539278.1
AC010336.1
Uncharacterized protein
chr14_-_82000140 0.07 ENST00000555824.1
ENST00000557372.1
ENST00000336735.4
SEL1L
sel-1 suppressor of lin-12-like (C. elegans)
chr1_+_152943122 0.06 ENST00000328051.2
SPRR4
small proline-rich protein 4
chr16_+_103816 0.06 ENST00000383018.3
ENST00000417493.1
SNRNP25
small nuclear ribonucleoprotein 25kDa (U11/U12)
chrM_+_9207 0.06 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr20_+_18488137 0.05 ENST00000450074.1
ENST00000262544.2
ENST00000336714.3
ENST00000377475.3
SEC23B
Sec23 homolog B (S. cerevisiae)
chrX_-_53461288 0.05 ENST00000375298.4
ENST00000375304.5
HSD17B10
hydroxysteroid (17-beta) dehydrogenase 10
chr11_-_71823266 0.05 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
ANAPC15
anaphase promoting complex subunit 15
chr3_+_35722487 0.05 ENST00000441454.1
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr2_+_105654441 0.05 ENST00000258455.3
MRPS9
mitochondrial ribosomal protein S9
chr1_+_101003687 0.05 ENST00000315033.4
GPR88
G protein-coupled receptor 88
chr18_+_32173276 0.05 ENST00000591816.1
ENST00000588125.1
ENST00000598334.1
ENST00000588684.1
ENST00000554864.3
ENST00000399121.5
ENST00000595022.1
ENST00000269190.7
ENST00000399097.3
DTNA
dystrobrevin, alpha
chr1_-_23670752 0.05 ENST00000302271.6
ENST00000426846.2
ENST00000427764.2
ENST00000606561.1
ENST00000374616.3
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr1_-_232651312 0.05 ENST00000262861.4
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr1_-_2461684 0.05 ENST00000378453.3
HES5
hes family bHLH transcription factor 5
chr1_+_210501589 0.05 ENST00000413764.2
ENST00000541565.1
HHAT
hedgehog acyltransferase
chr9_+_80912059 0.05 ENST00000347159.2
ENST00000376588.3
PSAT1
phosphoserine aminotransferase 1
chr19_-_41870026 0.05 ENST00000243578.3
B9D2
B9 protein domain 2
chr1_-_23670813 0.05 ENST00000374612.1
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr19_-_40931891 0.05 ENST00000357949.4
SERTAD1
SERTA domain containing 1
chrX_+_135730297 0.05 ENST00000370629.2
CD40LG
CD40 ligand
chr3_-_195538760 0.05 ENST00000475231.1
MUC4
mucin 4, cell surface associated
chrX_-_53461305 0.04 ENST00000168216.6
HSD17B10
hydroxysteroid (17-beta) dehydrogenase 10
chr11_-_71823796 0.04 ENST00000545680.1
ENST00000543587.1
ENST00000538393.1
ENST00000535234.1
ENST00000227618.4
ENST00000535503.1
ANAPC15
anaphase promoting complex subunit 15
chr14_-_51027838 0.04 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr2_-_157189180 0.04 ENST00000539077.1
ENST00000424077.1
ENST00000426264.1
ENST00000339562.4
ENST00000421709.1
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr21_-_43816052 0.04 ENST00000398405.1
TMPRSS3
transmembrane protease, serine 3
chr2_-_242089677 0.04 ENST00000405260.1
PASK
PAS domain containing serine/threonine kinase
chr1_-_157746909 0.04 ENST00000392274.3
ENST00000361516.3
ENST00000368181.4
FCRL2
Fc receptor-like 2
chr3_-_157221380 0.04 ENST00000468233.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr7_-_73038867 0.04 ENST00000313375.3
ENST00000354613.1
ENST00000395189.1
ENST00000453275.1
MLXIPL
MLX interacting protein-like
chr7_-_73038822 0.04 ENST00000414749.2
ENST00000429400.2
ENST00000434326.1
MLXIPL
MLX interacting protein-like
chr19_-_10121144 0.04 ENST00000264828.3
COL5A3
collagen, type V, alpha 3
chr6_-_161695042 0.04 ENST00000366908.5
ENST00000366911.5
ENST00000366905.3
AGPAT4
1-acylglycerol-3-phosphate O-acyltransferase 4
chr11_-_71823715 0.04 ENST00000545944.1
ENST00000502597.2
ANAPC15
anaphase promoting complex subunit 15
chr16_+_69345243 0.04 ENST00000254950.11
VPS4A
vacuolar protein sorting 4 homolog A (S. cerevisiae)
chr4_+_144354644 0.04 ENST00000512843.1
GAB1
GRB2-associated binding protein 1
chr16_+_53164833 0.04 ENST00000564845.1
CHD9
chromodomain helicase DNA binding protein 9
chr2_-_77749474 0.04 ENST00000409093.1
ENST00000409088.3
LRRTM4
leucine rich repeat transmembrane neuronal 4
chr6_-_31107127 0.03 ENST00000259845.4
PSORS1C2
psoriasis susceptibility 1 candidate 2
chr14_-_104181771 0.03 ENST00000554913.1
ENST00000554974.1
ENST00000553361.1
ENST00000555055.1
ENST00000555964.1
ENST00000556682.1
ENST00000445556.1
ENST00000553332.1
ENST00000352127.7
XRCC3
X-ray repair complementing defective repair in Chinese hamster cells 3
chr15_+_40733387 0.03 ENST00000416165.1
BAHD1
bromo adjacent homology domain containing 1
chr5_+_141303373 0.03 ENST00000432126.2
ENST00000194118.4
KIAA0141
KIAA0141
chr2_-_227050079 0.03 ENST00000423838.1
AC068138.1
AC068138.1
chr19_+_45394477 0.03 ENST00000252487.5
ENST00000405636.2
ENST00000592434.1
ENST00000426677.2
ENST00000589649.1
TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr12_-_14849470 0.03 ENST00000261170.3
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr3_-_195538728 0.03 ENST00000349607.4
ENST00000346145.4
MUC4
mucin 4, cell surface associated
chr19_-_19302931 0.03 ENST00000444486.3
ENST00000514819.3
ENST00000585679.1
ENST00000162023.5
MEF2BNB-MEF2B
MEF2BNB
MEF2B
MEF2BNB-MEF2B readthrough
MEF2B neighbor
myocyte enhancer factor 2B
chr22_+_39916558 0.03 ENST00000337304.2
ENST00000396680.1
ATF4
activating transcription factor 4
chr6_-_161695074 0.03 ENST00000457520.2
ENST00000366906.5
ENST00000320285.4
AGPAT4
1-acylglycerol-3-phosphate O-acyltransferase 4
chr10_-_99205607 0.03 ENST00000477692.2
ENST00000485122.2
ENST00000370886.5
ENST00000370885.4
ENST00000370902.3
ENST00000370884.5
EXOSC1
exosome component 1
chr6_+_111408698 0.03 ENST00000368851.5
SLC16A10
solute carrier family 16 (aromatic amino acid transporter), member 10
chr17_-_74163159 0.03 ENST00000591615.1
RNF157
ring finger protein 157
chr14_-_78083112 0.03 ENST00000216484.2
SPTLC2
serine palmitoyltransferase, long chain base subunit 2
chr18_+_55888767 0.03 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr6_+_31783291 0.02 ENST00000375651.5
ENST00000608703.1
ENST00000458062.2
HSPA1A
heat shock 70kDa protein 1A
chr6_-_72130472 0.02 ENST00000426635.2
LINC00472
long intergenic non-protein coding RNA 472
chr9_-_136933134 0.02 ENST00000303407.7
BRD3
bromodomain containing 3
chr3_+_133292759 0.02 ENST00000431519.2
CDV3
CDV3 homolog (mouse)
chr11_+_57435219 0.02 ENST00000527985.1
ENST00000287169.3
ZDHHC5
zinc finger, DHHC-type containing 5
chr12_+_52695617 0.02 ENST00000293525.5
KRT86
keratin 86
chr17_-_10017864 0.02 ENST00000323816.4
GAS7
growth arrest-specific 7
chr11_-_33913708 0.02 ENST00000257818.2
LMO2
LIM domain only 2 (rhombotin-like 1)
chr14_+_96000930 0.02 ENST00000331334.4
GLRX5
glutaredoxin 5
chr11_-_31531121 0.01 ENST00000532287.1
ENST00000526776.1
ENST00000534812.1
ENST00000529749.1
ENST00000278200.1
ENST00000530023.1
ENST00000533642.1
IMMP1L
IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr19_+_11485333 0.01 ENST00000312423.2
SWSAP1
SWIM-type zinc finger 7 associated protein 1
chr6_-_26032288 0.01 ENST00000244661.2
HIST1H3B
histone cluster 1, H3b
chr3_+_111718173 0.01 ENST00000494932.1
TAGLN3
transgelin 3
chr4_-_26492076 0.01 ENST00000295589.3
CCKAR
cholecystokinin A receptor
chr3_-_112360116 0.01 ENST00000206423.3
ENST00000439685.2
CCDC80
coiled-coil domain containing 80
chr12_-_16759711 0.01 ENST00000447609.1
LMO3
LIM domain only 3 (rhombotin-like 2)
chr4_-_143226979 0.01 ENST00000514525.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr20_-_50418947 0.01 ENST00000371539.3
SALL4
spalt-like transcription factor 4
chr6_-_31088214 0.01 ENST00000376288.2
CDSN
corneodesmosin
chrX_+_154444643 0.01 ENST00000286428.5
VBP1
von Hippel-Lindau binding protein 1
chr2_+_86668464 0.01 ENST00000409064.1
KDM3A
lysine (K)-specific demethylase 3A
chr6_+_140175987 0.01 ENST00000414038.1
ENST00000431609.1
RP5-899B16.1
RP5-899B16.1
chr6_-_31782813 0.01 ENST00000375654.4
HSPA1L
heat shock 70kDa protein 1-like
chr17_-_47045949 0.01 ENST00000357424.2
GIP
gastric inhibitory polypeptide
chr5_-_10761206 0.01 ENST00000432074.2
ENST00000230895.6
DAP
death-associated protein
chr2_+_196313239 0.01 ENST00000413290.1
AC064834.1
AC064834.1
chr8_+_24298531 0.01 ENST00000175238.6
ADAM7
ADAM metallopeptidase domain 7
chr19_+_48949030 0.01 ENST00000253237.5
GRWD1
glutamate-rich WD repeat containing 1
chr1_+_160160283 0.01 ENST00000368079.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr8_+_24298597 0.01 ENST00000380789.1
ADAM7
ADAM metallopeptidase domain 7
chr10_-_50970382 0.01 ENST00000419399.1
ENST00000432695.1
OGDHL
oxoglutarate dehydrogenase-like
chr8_+_9413410 0.01 ENST00000520408.1
ENST00000310430.6
ENST00000522110.1
TNKS
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr1_+_160160346 0.00 ENST00000368078.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chrX_-_70326455 0.00 ENST00000374251.5
CXorf65
chromosome X open reading frame 65
chr4_-_74486109 0.00 ENST00000395777.2
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr9_+_2159850 0.00 ENST00000416751.1
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr7_-_130080977 0.00 ENST00000223208.5
CEP41
centrosomal protein 41kDa
chr18_-_33702078 0.00 ENST00000586829.1
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chr1_+_145507587 0.00 ENST00000330165.8
ENST00000369307.3
RBM8A
RNA binding motif protein 8A
chr2_-_61697862 0.00 ENST00000398571.2
USP34
ubiquitin specific peptidase 34
chr7_-_83278322 0.00 ENST00000307792.3
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr2_+_135596180 0.00 ENST00000283054.4
ENST00000392928.1
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr2_+_135596106 0.00 ENST00000356140.5
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr11_+_75526212 0.00 ENST00000356136.3
UVRAG
UV radiation resistance associated
chr6_-_99873145 0.00 ENST00000369239.5
ENST00000438806.1
PNISR
PNN-interacting serine/arginine-rich protein

Network of associatons between targets according to the STRING database.

First level regulatory network of EN2_GBX2_LBX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0070995 NADPH oxidation(GO:0070995)
0.2 0.5 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.1 0.8 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.1 0.5 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.1 0.2 GO:0021524 visceral motor neuron differentiation(GO:0021524)
0.1 0.5 GO:0061055 myotome development(GO:0061055)
0.1 0.3 GO:0015722 canalicular bile acid transport(GO:0015722)
0.1 0.2 GO:0061114 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.0 0.2 GO:0010520 regulation of reciprocal meiotic recombination(GO:0010520)
0.0 0.4 GO:0048023 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.0 0.1 GO:1904897 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.0 0.1 GO:0070901 mitochondrial tRNA methylation(GO:0070901)
0.0 0.1 GO:0030327 prenylated protein catabolic process(GO:0030327)
0.0 0.1 GO:2000974 auditory receptor cell fate determination(GO:0042668) negative regulation of pro-B cell differentiation(GO:2000974)
0.0 0.0 GO:0021986 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.0 0.7 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 0.1 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
0.0 0.1 GO:0015808 L-alanine transport(GO:0015808) L-cystine transport(GO:0015811)
0.0 0.1 GO:0061743 motor learning(GO:0061743)
0.0 2.4 GO:0031424 keratinization(GO:0031424)
0.0 0.1 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.1 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0 0.0 GO:0071140 resolution of recombination intermediates(GO:0071139) resolution of mitotic recombination intermediates(GO:0071140)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0032302 MutSbeta complex(GO:0032302)
0.1 0.8 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.2 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 0.1 GO:0035841 new growing cell tip(GO:0035841)
0.0 2.1 GO:0045095 keratin filament(GO:0045095)
0.0 0.1 GO:0030678 mitochondrial ribonuclease P complex(GO:0030678)
0.0 0.1 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.8 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.1 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.0 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.8 GO:0000786 nucleosome(GO:0000786)
0.0 0.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 0.5 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.1 0.3 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.1 0.2 GO:0000406 heteroduplex DNA loop binding(GO:0000404) double-strand/single-strand DNA junction binding(GO:0000406) dinucleotide repeat insertion binding(GO:0032181)
0.0 0.8 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.2 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 0.2 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.3 GO:0005549 odorant binding(GO:0005549)
0.0 0.0 GO:0005174 CD40 receptor binding(GO:0005174)
0.0 0.1 GO:0022858 L-alanine transmembrane transporter activity(GO:0015180) L-cystine transmembrane transporter activity(GO:0015184) alanine transmembrane transporter activity(GO:0022858)
0.0 0.0 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0 0.1 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.7 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.3 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 1.3 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds