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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for ESR1
Z-value: 1.09
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Transcription factors associated with ESR1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ESR1 | hg19_v2_chr6_+_152130240_152130274 | -0.21 | 2.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ESR1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 14.4 | GO:0006068 | ethanol catabolic process(GO:0006068) |
| 0.1 | 7.5 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 0.1 | 6.0 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.1 | 5.6 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 1.4 | 5.5 | GO:0097089 | methyl-branched fatty acid metabolic process(GO:0097089) |
| 0.5 | 5.4 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
| 0.0 | 5.4 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.1 | 5.0 | GO:0015949 | nucleobase-containing small molecule interconversion(GO:0015949) |
| 0.3 | 4.2 | GO:0021694 | cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702) |
| 0.3 | 4.1 | GO:0070327 | thyroid hormone transport(GO:0070327) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.6 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.2 | 8.3 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 7.6 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.2 | 7.0 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.0 | 6.8 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.6 | 6.2 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.1 | 6.0 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 5.5 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 3.8 | GO:0031228 | intrinsic component of Golgi membrane(GO:0031228) |
| 0.0 | 3.7 | GO:0035580 | specific granule lumen(GO:0035580) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 9.7 | GO:0047894 | flavonol 3-sulfotransferase activity(GO:0047894) |
| 0.4 | 7.8 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.1 | 6.0 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 1.3 | 5.4 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
| 0.3 | 5.4 | GO:0008320 | protein transmembrane transporter activity(GO:0008320) |
| 0.4 | 4.1 | GO:0031013 | troponin I binding(GO:0031013) |
| 0.2 | 3.9 | GO:0015643 | toxic substance binding(GO:0015643) |
| 1.0 | 3.8 | GO:0016639 | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639) |
| 0.0 | 3.6 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.3 | 3.5 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.4 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 3.8 | PID FAS PATHWAY | FAS (CD95) signaling pathway |
| 0.0 | 3.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 3.0 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 2.8 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 2.7 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 2.6 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 2.4 | ST GA13 PATHWAY | G alpha 13 Pathway |
| 0.1 | 1.9 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 1.2 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 13.3 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 6.3 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 5.9 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.4 | 4.8 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.1 | 3.4 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.1 | 3.1 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.1 | 3.0 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 3.0 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.1 | 2.9 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.2 | 2.7 | REACTOME PROSTANOID LIGAND RECEPTORS | Genes involved in Prostanoid ligand receptors |