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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for ESRRA_ESR2
Z-value: 1.66
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Transcription factors associated with ESRRA_ESR2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ESRRA | hg19_v2_chr11_+_64073022_64073056 | 0.46 | 1.1e-02 | Click! |
| ESR2 | hg19_v2_chr14_-_64761078_64761128 | -0.12 | 5.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_+_2880157 Show fit | 5.76 |
ENST00000382280.3
|
zymogen granule protein 16B |
|
| chr12_+_50355647 Show fit | 4.58 |
ENST00000293599.6
|
aquaporin 5 |
|
| chr4_-_16077741 Show fit | 4.56 |
ENST00000447510.2
ENST00000540805.1 ENST00000539194.1 |
prominin 1 |
|
| chr20_+_31870927 Show fit | 4.21 |
ENST00000253354.1
|
BPI fold containing family B, member 1 |
|
| chr16_+_2880369 Show fit | 4.19 |
ENST00000572863.1
|
zymogen granule protein 16B |
|
| chr16_+_2880254 Show fit | 4.13 |
ENST00000570670.1
|
zymogen granule protein 16B |
|
| chr6_-_32498046 Show fit | 4.05 |
ENST00000374975.3
|
major histocompatibility complex, class II, DR beta 5 |
|
| chr21_+_42688686 Show fit | 3.74 |
ENST00000398652.3
ENST00000398647.3 |
family with sequence similarity 3, member B |
|
| chr19_-_41388657 Show fit | 3.73 |
ENST00000301146.4
ENST00000291764.3 |
cytochrome P450, family 2, subfamily A, polypeptide 7 |
|
| chr16_+_2880296 Show fit | 3.71 |
ENST00000571723.1
|
zymogen granule protein 16B |
Network of associatons between targets according to the STRING database.
First level regulatory network of ESRRA_ESR2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 24.0 | GO:0001895 | retina homeostasis(GO:0001895) |
| 1.7 | 8.4 | GO:0002415 | immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415) |
| 0.1 | 8.4 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.1 | 7.5 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.4 | 7.1 | GO:0090361 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.1 | 6.8 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 0.1 | 6.6 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 5.5 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
| 1.3 | 5.1 | GO:0072139 | glomerular parietal epithelial cell differentiation(GO:0072139) |
| 0.0 | 5.1 | GO:0060333 | interferon-gamma-mediated signaling pathway(GO:0060333) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.8 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 13.1 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.5 | 11.4 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 10.8 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.1 | 10.8 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 10.4 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.2 | 7.9 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.2 | 5.8 | GO:0097381 | photoreceptor disc membrane(GO:0097381) |
| 0.2 | 5.7 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.1 | 5.1 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 13.3 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.0 | 11.5 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.5 | 10.4 | GO:0070330 | aromatase activity(GO:0070330) |
| 0.1 | 9.1 | GO:0015078 | hydrogen ion transmembrane transporter activity(GO:0015078) |
| 0.2 | 8.4 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.1 | 5.9 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 5.9 | GO:0019003 | GDP binding(GO:0019003) |
| 0.1 | 5.5 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.3 | 5.4 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.0 | 5.1 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 7.6 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 6.7 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 6.5 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 6.0 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 4.0 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.0 | 3.8 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 3.6 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 3.5 | PID FAS PATHWAY | FAS (CD95) signaling pathway |
| 0.1 | 3.3 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.1 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.5 | 10.5 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.3 | 7.9 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 6.5 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.3 | 6.2 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.2 | 6.2 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.1 | 6.2 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.1 | 5.5 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 5.3 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.3 | 4.9 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |