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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for ESRRB_ESRRG
Z-value: 0.89
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Transcription factors associated with ESRRB_ESRRG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ESRRB | hg19_v2_chr14_+_76776957_76777061 | -0.21 | 2.7e-01 | Click! |
| ESRRG | hg19_v2_chr1_-_216896780_216896800 | 0.08 | 6.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_+_58179582 Show fit | 3.09 |
ENST00000371015.1
ENST00000395639.4 |
phosphatase and actin regulator 3 |
|
| chr20_+_58152524 Show fit | 1.86 |
ENST00000359926.3
|
phosphatase and actin regulator 3 |
|
| chr9_-_39239171 Show fit | 1.80 |
ENST00000358144.2
|
contactin associated protein-like 3 |
|
| chr11_+_66624527 Show fit | 1.62 |
ENST00000393952.3
|
leucine rich repeat and fibronectin type III domain containing 4 |
|
| chr10_+_81107271 Show fit | 1.58 |
ENST00000448165.1
|
peptidylprolyl isomerase F |
|
| chr2_+_120189422 Show fit | 1.52 |
ENST00000306406.4
|
transmembrane protein 37 |
|
| chr1_-_207119738 Show fit | 1.41 |
ENST00000356495.4
|
polymeric immunoglobulin receptor |
|
| chr6_-_97345689 Show fit | 1.37 |
ENST00000316149.7
|
NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 |
|
| chr22_-_24110063 Show fit | 1.12 |
ENST00000520222.1
ENST00000401675.3 |
coiled-coil-helix-coiled-coil-helix domain containing 10 |
|
| chr10_+_81107216 Show fit | 1.05 |
ENST00000394579.3
ENST00000225174.3 |
peptidylprolyl isomerase F |
Network of associatons between targets according to the STRING database.
First level regulatory network of ESRRB_ESRRG
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.8 | GO:0032981 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.1 | 3.5 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 0.6 | 2.8 | GO:0002415 | immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415) |
| 0.9 | 2.6 | GO:2000276 | negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276) |
| 0.0 | 2.5 | GO:0008037 | cell recognition(GO:0008037) |
| 0.0 | 1.9 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.0 | 1.6 | GO:0006099 | tricarboxylic acid cycle(GO:0006099) |
| 0.0 | 1.5 | GO:0006754 | ATP biosynthetic process(GO:0006754) |
| 0.1 | 1.3 | GO:0090361 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.0 | 1.3 | GO:0016266 | O-glycan processing(GO:0016266) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.0 | GO:0005753 | mitochondrial proton-transporting ATP synthase complex(GO:0005753) |
| 0.0 | 4.8 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 2.8 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 2.0 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 1.8 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 1.8 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 1.4 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.1 | 1.3 | GO:0045239 | tricarboxylic acid cycle enzyme complex(GO:0045239) |
| 0.0 | 1.2 | GO:0031305 | intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305) |
| 0.2 | 1.1 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.0 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.2 | 2.5 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 0.1 | 2.4 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.0 | 2.2 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 2.2 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.1 | 2.1 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.0 | 2.1 | GO:0019003 | GDP binding(GO:0019003) |
| 0.1 | 1.7 | GO:0015266 | protein channel activity(GO:0015266) |
| 0.0 | 1.6 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.2 | 1.4 | GO:0019763 | immunoglobulin receptor activity(GO:0019763) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 1.9 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 1.5 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 1.1 | PID FAS PATHWAY | FAS (CD95) signaling pathway |
| 0.0 | 0.8 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.0 | 0.7 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.0 | 0.6 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 0.5 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 0.5 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 0.3 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.7 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.0 | 2.3 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 2.3 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 1.9 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 1.4 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 1.2 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.0 | 1.1 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 1.0 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 0.8 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 0.8 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |