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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for ETV1_ERF_FEV_ELF1
Z-value: 0.92
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Transcription factors associated with ETV1_ERF_FEV_ELF1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000006468.9 | ETS variant transcription factor 1 | |
| ENSG00000105722.5 | ETS2 repressor factor | |
| ENSG00000163497.2 | FEV transcription factor, ETS family member | |
| ENSG00000120690.9 | E74 like ETS transcription factor 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ELF1 | hg19_v2_chr13_-_41635512_41635576 | -0.51 | 3.7e-03 | Click! |
| ETV1 | hg19_v2_chr7_-_14026063_14026091 | 0.20 | 2.9e-01 | Click! |
| ERF | hg19_v2_chr19_-_42759300_42759324 | 0.18 | 3.5e-01 | Click! |
| FEV | hg19_v2_chr2_-_219850277_219850379 | 0.09 | 6.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ETV1_ERF_FEV_ELF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.0 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 0.1 | 12.3 | GO:0006413 | translational initiation(GO:0006413) |
| 0.1 | 10.6 | GO:0070126 | mitochondrial translational termination(GO:0070126) |
| 0.1 | 9.3 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.3 | 7.4 | GO:0035646 | endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757) |
| 0.9 | 7.1 | GO:0003065 | positive regulation of heart rate by epinephrine(GO:0003065) |
| 0.1 | 6.3 | GO:0006903 | vesicle targeting(GO:0006903) |
| 0.1 | 6.2 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.1 | 5.7 | GO:0006362 | transcription elongation from RNA polymerase I promoter(GO:0006362) |
| 0.1 | 5.7 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 13.6 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.3 | 10.7 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 10.7 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 10.3 | GO:0001726 | ruffle(GO:0001726) |
| 0.1 | 9.0 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.3 | 8.0 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.4 | 7.6 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.0 | 7.2 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 6.9 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.1 | 6.7 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 14.1 | GO:0003723 | RNA binding(GO:0003723) |
| 0.2 | 13.1 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.1 | 12.8 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 11.4 | GO:0005525 | GTP binding(GO:0005525) |
| 0.4 | 7.8 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.1 | 7.8 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 7.7 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.0 | 6.5 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 6.4 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.1 | 5.6 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.1 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.1 | 8.3 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.1 | 6.8 | PID E2F PATHWAY | E2F transcription factor network |
| 0.2 | 6.4 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.2 | 5.7 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.1 | 5.6 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 5.4 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 5.0 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 4.3 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.1 | 4.2 | SIG CHEMOTAXIS | Genes related to chemotaxis |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.9 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.1 | 9.7 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.5 | 9.3 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.1 | 9.3 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 0.3 | 8.4 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.1 | 8.1 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 7.8 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.1 | 7.0 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.2 | 6.5 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.1 | 5.4 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |