Project
Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for EZH2
Z-value: 1.32
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Transcription factors associated with EZH2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EZH2 | hg19_v2_chr7_-_148581251_148581347 | -0.49 | 5.7e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_205391178 Show fit | 3.47 |
ENST00000367153.4
ENST00000367151.2 ENST00000391936.2 ENST00000367149.3 |
LEM domain containing 1 |
|
| chr7_-_41740181 Show fit | 3.43 |
ENST00000442711.1
|
inhibin, beta A |
|
| chr8_-_7274385 Show fit | 2.72 |
ENST00000318157.2
|
defensin, beta 4B |
|
| chr3_-_195538728 Show fit | 2.54 |
ENST00000349607.4
ENST00000346145.4 |
mucin 4, cell surface associated |
|
| chr19_-_51456344 Show fit | 2.51 |
ENST00000336334.3
ENST00000593428.1 |
kallikrein-related peptidase 5 |
|
| chr19_-_51504852 Show fit | 2.49 |
ENST00000391806.2
ENST00000347619.4 ENST00000291726.7 ENST00000320838.5 |
kallikrein-related peptidase 8 |
|
| chr12_-_91576561 Show fit | 2.21 |
ENST00000547568.2
ENST00000552962.1 |
decorin |
|
| chr19_+_51152702 Show fit | 2.19 |
ENST00000425202.1
|
chromosome 19 open reading frame 81 |
|
| chr3_-_195538760 Show fit | 2.10 |
ENST00000475231.1
|
mucin 4, cell surface associated |
|
| chr13_-_20805109 Show fit | 2.04 |
ENST00000241124.6
|
gap junction protein, beta 6, 30kDa |
Network of associatons between targets according to the STRING database.
First level regulatory network of EZH2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.1 | GO:0010669 | epithelial structure maintenance(GO:0010669) |
| 0.5 | 7.1 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.7 | 4.3 | GO:0052565 | response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565) |
| 0.1 | 4.1 | GO:0071625 | vocalization behavior(GO:0071625) |
| 1.1 | 3.4 | GO:0060279 | regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279) |
| 0.6 | 3.4 | GO:0002225 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803) |
| 0.0 | 3.0 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
| 0.1 | 2.9 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.0 | 2.8 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.0 | 2.7 | GO:0006027 | glycosaminoglycan catabolic process(GO:0006027) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 5.3 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.0 | 4.8 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.7 | 4.6 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.2 | 4.1 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 1.2 | 3.6 | GO:0043512 | inhibin complex(GO:0043511) inhibin A complex(GO:0043512) |
| 0.0 | 3.6 | GO:0030666 | endocytic vesicle membrane(GO:0030666) |
| 0.1 | 3.3 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.2 | 2.8 | GO:0008091 | spectrin(GO:0008091) |
| 0.2 | 2.8 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.1 | 2.4 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 7.0 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.4 | 4.6 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.8 | 4.5 | GO:0030197 | extracellular matrix constituent, lubricant activity(GO:0030197) |
| 0.2 | 4.1 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.2 | 3.5 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 1.1 | 3.4 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.1 | 2.8 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.2 | 2.7 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.0 | 2.7 | GO:0030674 | protein binding, bridging(GO:0030674) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.2 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 9.1 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 5.4 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 5.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 3.9 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.1 | 3.8 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 3.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 3.4 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.1 | 3.3 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 3.2 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.3 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 4.4 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.1 | 4.0 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.1 | 4.0 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.3 | 3.8 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.0 | 3.8 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 3.5 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.1 | 2.7 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.1 | 2.7 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |
| 0.0 | 2.6 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |